The Experts below are selected from a list of 23127 Experts worldwide ranked by ideXlab platform
Lirong Yang - One of the best experts on this subject based on the ideXlab platform.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols using a low cost solid super acid as a racemization catalyst
Tetrahedron Letters, 2013Co-Authors: Gang Xu, Jianping Wu, Yongjun Chen, Yongmei Cheng, Liang Wang, Lirong YangAbstract:A new, efficient dynamic kinetic resolution (DKR) of secondary aromatic alcohols using self-made solid super acid TiO2/SO42- as a racemization catalyst was developed. Low-cost and easily produced TiO2/SO42- showed excellent racemization activity. When coupled with the lipase, Novozym 435, Good Biocompatibility was observed, and optically pure aromatic acetate (>99%) was obtained with a high yield. It is noteworthy that the system could be reused more than 10 times with little loss of yield or reduction in the enantiomeric excess (ee) value of product.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols with low cost and easily available acid resins as racemization catalysts
Tetrahedron Letters, 2010Co-Authors: Yongmei Cheng, Chensheng Zhang, Jianping Wu, Gang Xu, Lirong YangAbstract:Abstract A new and efficient dynamic kinetic resolution (DKR) process of secondary aromatic alcohols was developed with acid resins as racemization catalysts. Acid resin CD8604 was shown to have excellent racemization activity and Good Biocompatibility. When employing CD8604 and complex acyl donors as racemization catalyst and acyl donor, respectively, enantiomerically pure aromatic acetate was obtained with excellent yield and ee values through the DKR process. It is noteworthy that the system could be reused more than 10 times with little loss of yield and ee value.
Gang Xu - One of the best experts on this subject based on the ideXlab platform.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols using a low cost solid super acid as a racemization catalyst
Tetrahedron Letters, 2013Co-Authors: Gang Xu, Jianping Wu, Yongjun Chen, Yongmei Cheng, Liang Wang, Lirong YangAbstract:A new, efficient dynamic kinetic resolution (DKR) of secondary aromatic alcohols using self-made solid super acid TiO2/SO42- as a racemization catalyst was developed. Low-cost and easily produced TiO2/SO42- showed excellent racemization activity. When coupled with the lipase, Novozym 435, Good Biocompatibility was observed, and optically pure aromatic acetate (>99%) was obtained with a high yield. It is noteworthy that the system could be reused more than 10 times with little loss of yield or reduction in the enantiomeric excess (ee) value of product.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols with low cost and easily available acid resins as racemization catalysts
Tetrahedron Letters, 2010Co-Authors: Yongmei Cheng, Chensheng Zhang, Jianping Wu, Gang Xu, Lirong YangAbstract:Abstract A new and efficient dynamic kinetic resolution (DKR) process of secondary aromatic alcohols was developed with acid resins as racemization catalysts. Acid resin CD8604 was shown to have excellent racemization activity and Good Biocompatibility. When employing CD8604 and complex acyl donors as racemization catalyst and acyl donor, respectively, enantiomerically pure aromatic acetate was obtained with excellent yield and ee values through the DKR process. It is noteworthy that the system could be reused more than 10 times with little loss of yield and ee value.
Yongmei Cheng - One of the best experts on this subject based on the ideXlab platform.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols using a low cost solid super acid as a racemization catalyst
Tetrahedron Letters, 2013Co-Authors: Gang Xu, Jianping Wu, Yongjun Chen, Yongmei Cheng, Liang Wang, Lirong YangAbstract:A new, efficient dynamic kinetic resolution (DKR) of secondary aromatic alcohols using self-made solid super acid TiO2/SO42- as a racemization catalyst was developed. Low-cost and easily produced TiO2/SO42- showed excellent racemization activity. When coupled with the lipase, Novozym 435, Good Biocompatibility was observed, and optically pure aromatic acetate (>99%) was obtained with a high yield. It is noteworthy that the system could be reused more than 10 times with little loss of yield or reduction in the enantiomeric excess (ee) value of product.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols with low cost and easily available acid resins as racemization catalysts
Tetrahedron Letters, 2010Co-Authors: Yongmei Cheng, Chensheng Zhang, Jianping Wu, Gang Xu, Lirong YangAbstract:Abstract A new and efficient dynamic kinetic resolution (DKR) process of secondary aromatic alcohols was developed with acid resins as racemization catalysts. Acid resin CD8604 was shown to have excellent racemization activity and Good Biocompatibility. When employing CD8604 and complex acyl donors as racemization catalyst and acyl donor, respectively, enantiomerically pure aromatic acetate was obtained with excellent yield and ee values through the DKR process. It is noteworthy that the system could be reused more than 10 times with little loss of yield and ee value.
Qingsong Ye - One of the best experts on this subject based on the ideXlab platform.
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3d printed β tcp scaffold with sphingosine 1 phosphate coating promotes osteogenesis and inhibits inflammation
Biochemical and Biophysical Research Communications, 2019Co-Authors: Lan Xiao, Ashwin Nanda, Chun Xu, Qingsong YeAbstract:Traditional treatments for bone repair with allografts and autografts are limited by the source of bone substitutes. Bone tissue engineering via a cell-based bone tissue scaffold is a new strategy for treatment against large bone defects with many advantages, such as the accessibility of biomaterials, Good Biocompatibility and osteoconductivity; however, the inflammatory immune response is still an issue that impacts osteogenesis. Sphingosine 1-phosphate (S1P) is a cell-derived sphingolipid that can mediate cell proliferation, immunoregulation and bone regeneration. We hypothesised that coating S1P on a β-Tricalcium phosphate (β-TCP) scaffold could regulate the immune response and increase osteogenesis. We tested the immunoregulation capability on macrophages and the osteogenic capability on rat bone marrow stromal cells of the coated scaffolds, which showed Good Biocompatibility. Additionally, the coated scaffolds exhibited dose-dependent inhibition of inflammatory-related gene expression. A high concentration of S1P (0.5 μM) upregulated osteogenic-related gene expression of OPN, OCN and RUNX2, which also significantly increased the alkaline phosphatase activity, as compared with the control group. In conclusion, S1P coated β-TCP scaffold could inhibit inflammation and promote bone regeneration.
Jianping Wu - One of the best experts on this subject based on the ideXlab platform.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols using a low cost solid super acid as a racemization catalyst
Tetrahedron Letters, 2013Co-Authors: Gang Xu, Jianping Wu, Yongjun Chen, Yongmei Cheng, Liang Wang, Lirong YangAbstract:A new, efficient dynamic kinetic resolution (DKR) of secondary aromatic alcohols using self-made solid super acid TiO2/SO42- as a racemization catalyst was developed. Low-cost and easily produced TiO2/SO42- showed excellent racemization activity. When coupled with the lipase, Novozym 435, Good Biocompatibility was observed, and optically pure aromatic acetate (>99%) was obtained with a high yield. It is noteworthy that the system could be reused more than 10 times with little loss of yield or reduction in the enantiomeric excess (ee) value of product.
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highly efficient dynamic kinetic resolution of secondary aromatic alcohols with low cost and easily available acid resins as racemization catalysts
Tetrahedron Letters, 2010Co-Authors: Yongmei Cheng, Chensheng Zhang, Jianping Wu, Gang Xu, Lirong YangAbstract:Abstract A new and efficient dynamic kinetic resolution (DKR) process of secondary aromatic alcohols was developed with acid resins as racemization catalysts. Acid resin CD8604 was shown to have excellent racemization activity and Good Biocompatibility. When employing CD8604 and complex acyl donors as racemization catalyst and acyl donor, respectively, enantiomerically pure aromatic acetate was obtained with excellent yield and ee values through the DKR process. It is noteworthy that the system could be reused more than 10 times with little loss of yield and ee value.