The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
J M Mascaro - One of the best experts on this subject based on the ideXlab platform.
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lymphoproliferative nature of Granulomatous Slack Skin clonal rearrangement of the t cell receptor s gene
Archives of Dermatology, 1992Co-Authors: Susana Puig, P Iranzo, J Palou, Rosa M Marti, Teresa Estrach, J M MascaroAbstract:To the Editor.— Granulomatous Slack Skin (GSS), an infrequent disorder characterized by progressively pendulous Skin folds in flexural areas, 1-4 has been considered autoimmune or inflammatory. 2,3 Some cases have been associated with Hodgkin's disease. 2 A histologic aspect similar to mycosis fungoides has been reported, 1,5 which suggests that GSS could be a special variety of cutaneous T-cell lymphoma. Immunophenotype studies 5 and clonal rearrangement of the T-cell β-receptor gene 4 have shown the lymphoproliferative nature of this disease. Report of a Case.— In June 1989, a 66-year-old man presented with a submammary tumor that became enlarged during the previous 3 years. He had appreciable hyperpigmentation on the lumbosacral region and on the lower limbs. Later, a left supraclavicular nodule and night fever developed. The findings from the clinical examination revealed generalized poikiloderma and hyperpigmentation, a bulky fold under the left armpit, and pendulous indurated Skin formations in the
Ayse Tuba Kendi - One of the best experts on this subject based on the ideXlab platform.
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a case of Granulomatous Slack Skin cutaneous t cell lymphoma pet ct imaging findings
BJR|case reports, 2015Co-Authors: Ayse Tuba Kendi, Sareeta Parker, Douglas Parker, Bruce J BarronAbstract:A 24-year-old female presented with Granulomatous Slack Skin (GSS) cutaneous T-cell lymphoma. The patient underwent systemic chemotherapy. Owing to the development of several chemotherapy-related complications, therapy was discontinued. Subsequently, disease progression was noted clinically. Our patient’s disease progression was clearly demonstrated by 18F-fludeoxyglucose positron emission tomography (PET)/CT findings. PET/CT imaging findings of GSS have not yet previously been reported. In this report, we present PET/CT characteristics of a patient with GSS.
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A case of Granulomatous Slack Skin cutaneous T-cell lymphoma: PET/CT imaging findings
British Institute of Radiology, 2015Co-Authors: Ayse Tuba Kendi, Sareeta Parker, Douglas Parker, B BarronAbstract:A 24-year-old female presented with Granulomatous Slack Skin (GSS) cutaneous T-cell lymphoma. The patient underwent systemic chemotherapy. Owing to the development of several chemotherapy-related complications, therapy was discontinued. Subsequently, disease progression was noted clinically. Our patient's disease progression was clearly demonstrated by 18F-fludeoxyglucose positron emission tomography (PET)/CT findings. PET/CT imaging findings of GSS have not yet previously been reported. In this report, we present PET/CT characteristics of a patient with GSS
Qinping Yang - One of the best experts on this subject based on the ideXlab platform.
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Granulomatous Slack Skin assessment of disease progression and treatment response using positron emission tomography computed tomography
Clinical Lymphoma Myeloma & Leukemia, 2009Co-Authors: Youyu Sheng, Lianjun Chen, Zhemin Huang, Zhanglei Mu, Jincheng Kong, Qinping YangAbstract:Granulomatous Slack Skin (GSS) is an extremely rare subtype of cutaneous T-cell lymphoma. A 14-year-old boy had suffered from progressive infiltrative erythema and plaques that gradually evolved into lax masses and pendulous Skin on his axilla, anterior wall of the abdomen, bilateral inguinal region, and thighs. Histopathologic examination of the Skin lesion and inguinal lymph node demonstrated Granulomatous infiltration with multinucleated giant cells. Positron emission tomography (PET)/computed tomography (CT) scan was performed after acute exacerbation and exhibited slightly high fluorodeoxyglucose (FDG) distribution of Skin lesions, without any evidence of abnormality in the metabolism of FDG in lymph nodes or other extralymphatic organs. Concurrent use of corticosteroid and recombinant interferon-α successfully controlled the disease, and posttreatment PET/CT scan confirmed the response to the therapy with decreased levels of FDG uptake. PET/CT is suggested to be helpful in the assessment of disease progression and treatment response in the management of patients with GSS.
Jurgen Fuller - One of the best experts on this subject based on the ideXlab platform.
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Granulomatous Slack Skin or Granulomatous mycosis fungoides a case report complete response to percutaneous radiation and interferon alpha
Journal of Cancer Research and Clinical Oncology, 2002Co-Authors: Uwe Wollina, Tim Graefe, Jurgen FullerAbstract:A 46-year-old man presented with circumscribed inflammatory poikilodermatic lesions of loose Skin on the upper arm. Histologic examination disclosed a heavy lymphocytic infiltrate of the whole dermis and the upper part of the subcutaneous fat tissue with a predominant T-helper phenotype and about 10% of Mac 387-positive macrophages and some scattered multinucleated giant cells. Lymphocytic cells were aligned along the epidermal basement membrane and showed focal epidermotropism. In part these cells had multilobular nuclei. The diagnosis of Granulomatous mycosis fungoides versus early Granulomatous Slack Skin was made. The patient was treated with a combination of radiotherapy (total dose 36 Gy) and interferon-α as a maintenance treatment which resulted in complete remission and disease-free survival of 27 months up to now.
N Sepp - One of the best experts on this subject based on the ideXlab platform.
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Granulomatous Slack Skin a distinct disorder or a variant of mycosis fungoides
Acta Dermato-venereologica, 2001Co-Authors: Gerda Topar, Bernhard Zelger, Matthias Schmuth, Nikolaus Romani, J Thaler, N SeppAbstract:About 75% of cutaneous lymphomas belong to the group of T-cell lymphomas. Mycosis fungoides is the most common entity in this group. Granulomatous Slack Skin is a rare form of cutaneous T-cell lymphoma closely related to mycosis fungoides. We present here a patient with areas of lax Skin for several years who developed a generalized erythroderma with associated immunoactivation and a deterioration in his general condition. This report discusses clinically and histologically the differential diagnoses, namely Granulomatous Slack Skin and Granulomatous mycosis fungoides, and suggests that these 2 disorders are only variants in the broad spectrum of a single disease.
