The Experts below are selected from a list of 2730 Experts worldwide ranked by ideXlab platform
Colin J R Stewart - One of the best experts on this subject based on the ideXlab platform.
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prognostic value of mitotic counts and ki 67 immunoreactivity in adult type Granulosa Cell Tumour of the ovary
Journal of Clinical Pathology, 2008Co-Authors: Esther Leuverink, Barbara A Brennan, Maxine L Crook, Dorota A Doherty, Ian Hammond, Sukeerat Ruba, Colin J R StewartAbstract:Aims: The identification of reliable prognostic factors in patients with ovarian stage 1 adult-type Granulosa Cell Tumour (GCT) has proved problematic. Some reports have suggested that proliferation indices may be of value, but the data are conflicting and the methods of assessment often poorly defined. In this study the mitotic activity and Ki-67 immunohistochemistry was assessed in a series of GCT using carefully specified methodology, and the findings were correlated with clinicopathological findings. Methods: Tumour proliferation was assessed in 38 primary GCT by counting mitotic figures in 50 high-power fields (×500 magnification) with results expressed as a mean count per 2 mm 2 standardised area. The number of mitotic figures and Ki-67 immunoreactive Cells per 10 000 Tumour Cells was also assessed using an ocular Cell counting graticule. The results were correlated with Tumour stage at presentation and with the development of Tumour recurrence. Results: Twenty-nine patients were stage 1 at presentation, and nine patients had high-stage disease (extra-ovarian spread). Nine patients with initial stage 1 disease developed metastases, and 20 patients had no evidence of recurrence over a mean follow-up period of 11.1 years. There was no significant correlation between any of the proliferation indices or with clinical outcomes. Conclusions: These results suggest that proliferation assessment is of limited value in the pathological assessment of GCT. Future studies should carefully specify the methods of assessing Cell proliferation to ensure a reliable comparison of results.
Thirunavukkarasu Arun Babu - One of the best experts on this subject based on the ideXlab platform.
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Late Recurrence of Granulosa Cell Tumour Involving the Retroperitoneum and Spleen
Indian Journal of Gynecologic Oncology, 2020Co-Authors: Padmapriya Balakrishnan, Vijayan Sharmila, Thirunavukkarasu Arun BabuAbstract:Granulosa Cell Tumour of the ovary is a sex-cord stromal Tumour that accounts for 2–5% of all ovarian neoplasms. It is a low-grade malignant Tumour that is often diagnosed in early stages and has a favourable prognosis. The peculiarity of this Tumour is its tendency for late recurrence, and the mean time to recurrence is 5–10 years after initial diagnosis. The risk of late recurrence necessitates long-term follow-up of treated patients. We report an unusual case of late recurrence of Granulosa Cell Tumour involving the retroperitoneum and spleen after 20 years of initial treatment.
Oliver A Garden - One of the best experts on this subject based on the ideXlab platform.
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serum anti mullerian hormone concentrations before and after treatment of an ovarian Granulosa Cell Tumour in a cat
Journal of Feline Medicine and Surgery Open Reports, 2017Co-Authors: Laura A Heaps, Christopher J Scudder, Vicky J Lipscomb, Simon L Priestnall, Balazs Szladovits, Robert C Fowkes, Sarah Steinbach, H M Martineau, Oliver A GardenAbstract:CASE SUMMARY A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian Granulosa Cell Tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat's clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Mullerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to <1% of the original value. RELEVANCE AND NOVEL INFORMATION Serum AMH measurement may represent a novel diagnostic and monitoring tool for functional ovarian neoplasms in cats.
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Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian Granulosa Cell Tumour in a cat
SAGE Publishing, 2017Co-Authors: Laura A Heaps, Christopher J Scudder, Vicky J Lipscomb, Sarah Ml Steinbach, Simon L Priestnall, Henny Martineau, Balazs Szladovits, Robert C Fowkes, Oliver A GardenAbstract:Case summary A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian Granulosa Cell Tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat’s clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Müllerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to
Marek Grabiec - One of the best experts on this subject based on the ideXlab platform.
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bilateral aggressive malignant Granulosa Cell Tumour with essentially different immunophenotypes in primary and metastatic lesions comprising predominantly sarcomatoid and fibrothecomatous patterns looking for prognostic markers a case report
Archives of Medical Science, 2011Co-Authors: Wojciech Jozwicki, Anna A Brozyna, Malgorzata Walentowicz, Marek GrabiecAbstract:We present an unusual case of a young woman with rare bilateral, very aggressive ovarian Granulosa Cell Tumour (GCT), comprised of Granulosa, sarcomatoid and fibrothecomatous fields with significantly different immunostaining of primary and metastatic Tumours showing stronger WT1, Bcl2, fascin and EGFR expression in metastases. Despite radical surgery and chemotherapy the Tumour recurred rapidly and the patient died 16 months later. Such results clearly demonstrate the usefulness of immunostaining for the above markers as prognostic/predictive factors and the need for careful assessment of the immunoprofile of both primary and metastatic Tumours, which can be useful for therapy and follow-up planning in GCT cases.
James H Segars - One of the best experts on this subject based on the ideXlab platform.
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pseudo isolated fsh deficiency caused by an inhibin b secreting Granulosa Cell Tumour case report
Human Reproduction, 2003Co-Authors: A Krishnan, Cynthia M Murdock, Jay E Allard, M Cisar, E Reid, Lynnette K Nieman, James H SegarsAbstract:Isolated FSH deficiency due to a mutation in the FSHbeta subunit is characterized by an extremely low serum FSH concentration. We report a patient who presented with an FSH of 0.8 mIU/ml and infertility associated with anovulation. Endocrinological assessment and immunohistochemistry revealed that a Granulosa Cell Tumour was secreting inhibin B and suppressing FSH; however, LH and estradiol were within their normal ranges. Upon removal of the Tumour, inhibin B decreased and FSH levels rose to normal values. The patient subsequently conceived and delivered successfully. Based on this case and on those previously described in the literature, we suggest that inhibin B levels should be evaluated in anovulatory patients having a clinical presentation consistent with functional hypothalamic amenorrhoea and very low to normal values of FSH.
