The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Ramazan Geyik - One of the best experts on this subject based on the ideXlab platform.
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the value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus urine specific gravity in differential diagnosis
Journal of General Internal Medicine, 2006Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan GeyikAbstract:When a patient with diabetes mellitus presents with worsening Polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of Polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low urine specific gravity (1.008). The low specific gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when urine specific gravity and urine osmolality normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the urine specific gravity in patients with Polyuria and diabetes mellitus to detect diabetes insipidus.
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the value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus
Journal of General Internal Medicine, 2006Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan GeyikAbstract:When a patient with diabetes mellitus presents with worsening Polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of Polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low urine specific gravity (1.008). The low specific gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when urine specific gravity and urine osmolaity normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the urine specific gravity in patients with Polyuria and diabetes mellitus to detect diabetes insipidus.
Eileen R Chasens - One of the best experts on this subject based on the ideXlab platform.
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sleep disordered breathing and nocturnal Polyuria nocturia and enuresis
Sleep Medicine Reviews, 2003Co-Authors: Mary Grace Umlauf, Eileen R ChasensAbstract:Abstract Although nocturnal voiding is frequently attributed to urologic disorders, nocturia and enuresis are also important symptoms of sleep-disordered breathing. However, Polyuria can be elicited by obstructive sleep apnea as well as bedrest, microgravity and other experimental conditions where the blood volume is shifted centrally to the upper body. The nocturnal Polyuria of sleep apnea is an evoked response to conditions of negative intrathoracic pressure due to inspiratory effort posed against a closed airway. The mechanism for this natriuretic response is the release of atrial natriuretic peptide due to cardiac distension caused by the negative pressure environment. This cardiac hormone increases sodium and water excretion and also inhibits other hormone systems that regulate fluid volume, vasopressin and the rennin-angiotensin-aldosterone complex. Treatment of sleep apnea and airway compromise has been shown to reverse nocturnal Polyuria and thereby reduce or eliminate nocturia and enuresis. Thus, careful evaluation of nocturia and enuresis for evidence of nocturnal Polyuria can increase the diagnostic certainty of referring primary care providers and sleep specialists. In addition, the resolution of these bothersome symptoms after treatment can contribute to patient satisfaction as well as reinforce treatment compliance.
Ersin Akarsu - One of the best experts on this subject based on the ideXlab platform.
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the value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus urine specific gravity in differential diagnosis
Journal of General Internal Medicine, 2006Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan GeyikAbstract:When a patient with diabetes mellitus presents with worsening Polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of Polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low urine specific gravity (1.008). The low specific gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when urine specific gravity and urine osmolality normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the urine specific gravity in patients with Polyuria and diabetes mellitus to detect diabetes insipidus.
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the value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus
Journal of General Internal Medicine, 2006Co-Authors: Ersin Akarsu, Hakan Buyukhatipoglu, Sebnem Aktaran, Ramazan GeyikAbstract:When a patient with diabetes mellitus presents with worsening Polyuria and polydipsia, what is a sensible, cost-effective approach? We report the unique coincidence of type 2 diabetes mellitus and diabetes insipidus. A 46-year-old woman with poorly controlled type 2 diabetes complained of Polyuria with a daily output of 5 L. Although urinalysis demonstrated significant glucosuria, diabetes insipidus was suspected owing to a low urine specific gravity (1.008). The low specific gravity persisted during a water deprivation test. Ultimately, diabetes insipidus was confirmed when urine specific gravity and urine osmolaity normalized following desmopressin administration. This case emphasizes the importance of accurately interpreting the urine specific gravity in patients with Polyuria and diabetes mellitus to detect diabetes insipidus.
Mary Grace Umlauf - One of the best experts on this subject based on the ideXlab platform.
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sleep disordered breathing and nocturnal Polyuria nocturia and enuresis
Sleep Medicine Reviews, 2003Co-Authors: Mary Grace Umlauf, Eileen R ChasensAbstract:Abstract Although nocturnal voiding is frequently attributed to urologic disorders, nocturia and enuresis are also important symptoms of sleep-disordered breathing. However, Polyuria can be elicited by obstructive sleep apnea as well as bedrest, microgravity and other experimental conditions where the blood volume is shifted centrally to the upper body. The nocturnal Polyuria of sleep apnea is an evoked response to conditions of negative intrathoracic pressure due to inspiratory effort posed against a closed airway. The mechanism for this natriuretic response is the release of atrial natriuretic peptide due to cardiac distension caused by the negative pressure environment. This cardiac hormone increases sodium and water excretion and also inhibits other hormone systems that regulate fluid volume, vasopressin and the rennin-angiotensin-aldosterone complex. Treatment of sleep apnea and airway compromise has been shown to reverse nocturnal Polyuria and thereby reduce or eliminate nocturia and enuresis. Thus, careful evaluation of nocturia and enuresis for evidence of nocturnal Polyuria can increase the diagnostic certainty of referring primary care providers and sleep specialists. In addition, the resolution of these bothersome symptoms after treatment can contribute to patient satisfaction as well as reinforce treatment compliance.
J. Vande Walle - One of the best experts on this subject based on the ideXlab platform.
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The pathophysiology of monosymptomatic nocturnal enuresis with special emphasis on the circadian rhythm of renal physiology
European Journal of Pediatrics, 2016Co-Authors: Lien Dossche, J. Vande Walle, Charlotte Van HerzeeleAbstract:Nocturnal Polyuria in monosymptomatic nocturnal enuresis (MNE) has so far mainly been attributed to a disturbed circadian rhythm of renal water handling. Low vasopressin levels overnight correlate with absent maximal concentrating activity, resulting in an increased nocturnal diuresis with low urinary osmolality. Therefore, treatment with desmopressin is a rational choice. Unfortunately, 20 to 60 % of children with monosymptomatic enuresis are desmopressin-resistant. There is increasing evidence that other disturbed circadian rhythms might play a role in nocturnal Polyuria. This review focuses on renal aspects in the pathophysiology of nocturnal Polyuria in MNE, with special emphasis on circadian rhythms. Articles related to renal circadian rhythms and enuresis were searched through the PubMed library with the goal of providing a concise review. Conclusion : Nocturnal Polyuria can only partially be explained by blunted circadian rhythm of vasopressin secretion. Other alterations in the intrinsic renal circadian clock system also seem to be involved, especially in desmopressin-resistant enuresis. What is Known: • Disturbance in the circadian rhythm of arginine vasopressin secretion is related to nocturnal Polyuria in children with enuresis. • Desmopressin is recommended as a treatment for monosymptomatic nocturnal enuresis, working as a vasopressin analogue acting on V2 receptors in the collecting ducts of the kidney. What is New: • Other renal circadian rhythms might play a role in nocturnal Polyuria, especially in desmopressin-resistant case.
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nocturnal Polyuria excess of nocturnal urine production excess of definitions influence on renal function profile
The Journal of Urology, 2016Co-Authors: Ansofie Goessaert, J. Vande Walle, Ruud Bosch, Piet Hoebeke, Karel EveraertAbstract:Purpose: This study aimed to identify important differences in renal function profile, and potential water and sodium diuresis cutoffs among participants with nocturnal Polyuria according to nocturnal Polyuria definitions.Materials and Methods: This post hoc analysis was based on a prospective study in which participants completed a bladder diary, collected urine and provided a blood sample. With an age dependent nocturnal Polyuria index greater than 20% to 33% as the referent 4 definitions of nocturnal Polyuria were compared, including 1) nocturnal Polyuria index greater than 33%, 2) nocturnal urine production greater than 90 ml per hour and 3) greater than 10 ml/kg, and 4) nocturia index greater than 1.5.Results: In 112 male and female participants significant differences in baseline characteristics and bladder diary parameters were found according to definition. Diuresis rate, free water clearance and sodium clearance had similar 24-hour courses in the subgroups with and without Polyuria by each defini...
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sleep fragmentation and periodic limb movements in children with monosymptomatic nocturnal enuresis and Polyuria
Pediatric Nephrology, 2015Co-Authors: Karlien Dhondt, Charlotte Van Herzeele, Ann Raes, Piet Hoebeke, Sanne Roels, Luitzen Albert Groen, J. Vande WalleAbstract:Background Children with nocturnal enuresis (NE) have been found to have sleep fragmentation and a high incidence of periodic limb movements in sleep (PLMS). This study explored the association of monosymptomatic NE and Polyuria in relation to fluid intake, bladder volume, number of wet nights, and number of nights with Polyuria to the frequency of PLMS and cortical arousals during sleep.
