The Experts below are selected from a list of 207 Experts worldwide ranked by ideXlab platform
Muriel Thomas - One of the best experts on this subject based on the ideXlab platform.
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Human Growth Hormone.
Pharmacological Reviews, 1994Co-Authors: Jeannine S. Strobl, Muriel ThomasAbstract:Human Growth Hormone (hGH) was discovered over three decades ago, and evidence of its therapeutic effectiveness was quickly recognized. Until recently, however, the therapeutic use of hGH was limited due to its scarcity and relatively high cost. Prior to recombinant-DNA-dervived (rDNA) hGH, the only source was from the pituitary glands of cadavers. In the human pituitary gland, approximately 10% of the dry weight of pituitary tissue is Growth Hormone.
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Human Growth Hormone.
Pharmacological reviews, 1994Co-Authors: Jeannine S. Strobl, Muriel ThomasAbstract:The study of human Growth Hormone is a little more than 100 years old. Growth Hormone, first identified for its dramatic effect on longitudinal Growth, is now known to exert generalized effects on protein, lipid, and carbohydrate metabolism. Additional roles for Growth Hormone in human physiology are likely to be discovered in the areas of sleep research and reproduction. Furthermore, there is some indication that Growth Hormone also may be involved in the regulation of immune function, mental well-being, and the aging process. Recombinant DNA technology has provided an abundant and safe, albeit expensive, supply of human Growth Hormone for human use, but the pharmacological properties of Growth Hormone are poor. Most Growth Hormone-deficient individuals exhibit a secretory defect rather than a primary defect in Growth Hormone production, however, and advances in our understanding of the neuroendocrine regulation of Growth Hormone secretion have established the basis for the use of drugs to stimulate release of endogenously synthesized Growth Hormone. This promises to be an important area for future drug development.
Thomas Moshang - One of the best experts on this subject based on the ideXlab platform.
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Expanded spectrum of recombinant human Growth Hormone therapy.
Current Opinion in Pediatrics, 2002Co-Authors: Murray J. Henwood, Adda Grimberg, Thomas MoshangAbstract:The efficacy of recombinant human Growth Hormone in the treatment of Growth Hormone deficiency is well established. In recent years, the use of recombinant human Growth Hormone as a therapeutic modality has greatly increased and has expanded beyond the realm of replacement for Growth Hormone deficiency. Recombinant human Growth Hormone has been employed to ameliorate Growth failure in multiple other disorders. For some, like Turner syndrome, recombinant human Growth Hormone has become the standard of care. For others, the ultimate benefit of recombinant human Growth Hormone remains to be determined. Although recent investigations provide encouraging short-term data, it is important to recognize that the impact of recombinant human Growth Hormone therapy on adult height has not been established in a number of conditions.
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Treatment of Growth Hormone Deficiency With a Sustained-Release Growth Hormone Formulation • 462
Pediatric Research, 1998Co-Authors: Thomas Moshang, Edward O. Reiter, Bernard L. Silverman, Kathleen M. Ford, Graham Downing, James Frane, Jeffrey L. Cleland, Scott D. Putney, Kenneth M. AttieAbstract:Treatment of Growth Hormone Deficiency With a Sustained-Release Growth Hormone Formulation • 462
H. Matsuda - One of the best experts on this subject based on the ideXlab platform.
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Urinary excretion of human Growth Hormone in children with short stature: correlation with pituitary secretion of human Growth Hormone.
The Journal of pediatrics, 1992Co-Authors: K Kida, Y Kaino, Masahiko Ikeuchi, M. Hayashi, Y. Goto, H. MatsudaAbstract:Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of human Growth Hormone. Correlations between the levels of human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary human Growth Hormone levels in short children. The concentration and total amount of human Growth Hormone in the urine correlated significantly with the peak concentration of serum human Growth Hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of human Growth Hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of human Growth Hormone in the morning urine also correlated significantly with the peak concentration of serum human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of human Growth Hormone in the urine differed significantly among children with human Growth Hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of human Growth Hormone in the urine may be used to assess secretion of human Growth Hormone, serving as a screening test for human Growth Hormone deficiency in children.
Jeannine S. Strobl - One of the best experts on this subject based on the ideXlab platform.
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Human Growth Hormone.
Pharmacological Reviews, 1994Co-Authors: Jeannine S. Strobl, Muriel ThomasAbstract:Human Growth Hormone (hGH) was discovered over three decades ago, and evidence of its therapeutic effectiveness was quickly recognized. Until recently, however, the therapeutic use of hGH was limited due to its scarcity and relatively high cost. Prior to recombinant-DNA-dervived (rDNA) hGH, the only source was from the pituitary glands of cadavers. In the human pituitary gland, approximately 10% of the dry weight of pituitary tissue is Growth Hormone.
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Human Growth Hormone.
Pharmacological reviews, 1994Co-Authors: Jeannine S. Strobl, Muriel ThomasAbstract:The study of human Growth Hormone is a little more than 100 years old. Growth Hormone, first identified for its dramatic effect on longitudinal Growth, is now known to exert generalized effects on protein, lipid, and carbohydrate metabolism. Additional roles for Growth Hormone in human physiology are likely to be discovered in the areas of sleep research and reproduction. Furthermore, there is some indication that Growth Hormone also may be involved in the regulation of immune function, mental well-being, and the aging process. Recombinant DNA technology has provided an abundant and safe, albeit expensive, supply of human Growth Hormone for human use, but the pharmacological properties of Growth Hormone are poor. Most Growth Hormone-deficient individuals exhibit a secretory defect rather than a primary defect in Growth Hormone production, however, and advances in our understanding of the neuroendocrine regulation of Growth Hormone secretion have established the basis for the use of drugs to stimulate release of endogenously synthesized Growth Hormone. This promises to be an important area for future drug development.
K Kida - One of the best experts on this subject based on the ideXlab platform.
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Urinary excretion of human Growth Hormone in children with short stature: correlation with pituitary secretion of human Growth Hormone.
The Journal of pediatrics, 1992Co-Authors: K Kida, Y Kaino, Masahiko Ikeuchi, M. Hayashi, Y. Goto, H. MatsudaAbstract:Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of human Growth Hormone. Correlations between the levels of human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary human Growth Hormone levels in short children. The concentration and total amount of human Growth Hormone in the urine correlated significantly with the peak concentration of serum human Growth Hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of human Growth Hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of human Growth Hormone in the morning urine also correlated significantly with the peak concentration of serum human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of human Growth Hormone in the urine differed significantly among children with human Growth Hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of human Growth Hormone in the urine may be used to assess secretion of human Growth Hormone, serving as a screening test for human Growth Hormone deficiency in children.
