Growth Inhibitor

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Tapan K Gupta - One of the best experts on this subject based on the ideXlab platform.

  • cristobalite Growth Inhibitor in pyrex borosilicate glass gallium oxide
    Journal of Materials Research, 1993
    Co-Authors: Jauho Jean, Tapan K Gupta
    Abstract:

    The effect of gallium oxide on cristobalite formation in Pyrex borosilicate glass has been studied. XRD results show that with 20 vol% gallium oxide, the precipitation of cristobalite at 800°C is completely prevented. This result is further evidenced by the linear thermal expansion measurement, in which, in contrast to the system without a sufficient amount of gallium oxide (0-10 vol%), the thermal expansion coefficient of the composite with 20 vol% gallium oxide remains unchanged with sintering time at the temperature investigated and, moreover, is very close to the theoretically calculated value

  • Cristobalite Growth Inhibitor in Pyrex borosilicate glass—gallium oxide
    Journal of Materials Research, 1993
    Co-Authors: Jauho Jean, Tapan K Gupta
    Abstract:

    The effect of gallium oxide on cristobalite formation in Pyrex borosilicate glass has been studied. XRD results show that with 20 vol.% gallium oxide, the precipitation of cristobalite at 800 °C is completely prevented. This result is further evidenced by the linear thermal expansion measurement, in which, in contrast to the system without a sufficient amount of gallium oxide (0–10 vol.%), the thermal expansion coefficient of the composite with 20 vol.% gallium oxide remains unchanged with sintering time at the temperature investigated and, moreover, is very close to the theoretically calculated value.

Jauho Jean - One of the best experts on this subject based on the ideXlab platform.

  • cristobalite Growth Inhibitor in pyrex borosilicate glass gallium oxide
    Journal of Materials Research, 1993
    Co-Authors: Jauho Jean, Tapan K Gupta
    Abstract:

    The effect of gallium oxide on cristobalite formation in Pyrex borosilicate glass has been studied. XRD results show that with 20 vol% gallium oxide, the precipitation of cristobalite at 800°C is completely prevented. This result is further evidenced by the linear thermal expansion measurement, in which, in contrast to the system without a sufficient amount of gallium oxide (0-10 vol%), the thermal expansion coefficient of the composite with 20 vol% gallium oxide remains unchanged with sintering time at the temperature investigated and, moreover, is very close to the theoretically calculated value

  • Cristobalite Growth Inhibitor in Pyrex borosilicate glass—gallium oxide
    Journal of Materials Research, 1993
    Co-Authors: Jauho Jean, Tapan K Gupta
    Abstract:

    The effect of gallium oxide on cristobalite formation in Pyrex borosilicate glass has been studied. XRD results show that with 20 vol.% gallium oxide, the precipitation of cristobalite at 800 °C is completely prevented. This result is further evidenced by the linear thermal expansion measurement, in which, in contrast to the system without a sufficient amount of gallium oxide (0–10 vol.%), the thermal expansion coefficient of the composite with 20 vol.% gallium oxide remains unchanged with sintering time at the temperature investigated and, moreover, is very close to the theoretically calculated value.

Tomisaburo Kakuno - One of the best experts on this subject based on the ideXlab platform.

  • Purification and properties of Growth Inhibitor from normal rabbit serum.
    Journal of biochemistry, 1991
    Co-Authors: Takashi Kimura, Kaoru Miyazaki, Keisuke Mashima, Jinpei Yamashita, Takekazu Horio, Tomisaburo Kakuno
    Abstract:

    It was previously found that rabbit serum contains a Growth-Inhibitory substance for a tumorigenic rat liver cell line RSV-BRL. In the present study, the Growth Inhibitor was purified from normal rabbit serum to show a homogeneous protein band with a molecular weight (Mr) of 56 k on SDS-polyacrylamide gel electrophoresis under non-reducing conditions. The purified Growth Inhibitor, tentatively named rabbit serum-derived Growth Inhibitor (RSGI), potently inhibited the Growth of RSV-BRL and nine kinds of other cell lines including three human tumor cell lines at a concentration of 20 ng/ml or higher. The Growth-Inhibitory effect of RSGI was reversible and appeared to be cytostatic rather than cytotoxic. RSGI was stable to heating at 56 degrees C for 30 min or treatment with 0.1 M 2-mercaptoethanol, but labile to heating at 100 degrees C for 3 min or treatment with 1 M acetic acid (pH 2.3), 6 M urea, 50% (v/v) 1-propanol, or 0.1% (w/v) trypsin. These properties of RSGI suggested that it was different from type beta transforming Growth factors, tumor necrosis factor-alpha, and other known Growth-regulatory factors.

Lijuan Feng - One of the best experts on this subject based on the ideXlab platform.

  • Advancement in the research on vascular endothelial Growth Inhibitor (VEGI)
    Targeted oncology, 2012
    Co-Authors: Lijiao Duan, Ganggang Yang, Ruigang Zhang, Lijuan Feng
    Abstract:

    Vascular endothelial Growth Inhibitor (VEGI), also known as tumor necrosis factor superfamily member 15 or TNF ligand-related molecule 1, is identified as one kind of antiangiogenic cytokine that belongs to the tumor necrosis factor superfamily. VEGI includes three isoforms: VEGI-174, VEGI-192, and VEGI-251. VEGI can activate multiple signaling pathways including nuclear factor-kappaB, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. Moreover, it suppresses endothelial cell proliferation, angiopoiesis, and tumor Growth. Genetic engineering techniques have been used to produce recombinant human vascular endothelial Growth Inhibitor, and great progress has been made in its application for curing cancer. VEGI could serve as a potential target in the development of angiogenesis-based cancer therapy, and this paper briefly summarizes the progress of the research on VEGI.

Koji Hasegawa - One of the best experts on this subject based on the ideXlab platform.

  • a gravitropic stimulation induced Growth Inhibitor β isoxazolin 5 on 2yl alanine is a possible mediator of negative gravitropic bending of epicotyls in etiolated pisum sativum seedlings
    Plant Growth Regulation, 2017
    Co-Authors: Tsuyoshi Hasegawa, Hideyuki Shigemori, Koji Hasegawa, Junichi Ueda, Yume Omiya, Mayumi Koide, Kensuke Miyamoto
    Abstract:

    Negative gravitropic bending and its possible mediator in etiolated Alaska pea seedlings were intensively studied in comparison with seedlings of an agravitropic mutant, ageotropum. When 3.5-day-old etiolated Alaska seedlings were horizontally placed, the Growth suppression at the upper side of the epicotyls began 10 min after the onset of the gravitropic stimulation, whereas the Growth acceleration at the lower side began at 30 min, resulting in negative gravitropic bending. In contrast, no gravitropic bending was observed in the etiolated ageotropum seedlings, for which the epicotyls show an automorphogenesis-like Growth. Strenuous efforts to identify a possible mediator that induces the gravitropic bending resulted in successfully identifying β-(isoxazolin-5-on-2yl)-alanine (βIA). The unilateral application of βIA to the etiolated Alaska epicotyls substantially induced epicotyl bending toward the application site, indicating that βIA could act as a Growth Inhibitor. Analyses of the distribution of βIA in the upper and lower flanks of the etiolated Alaska epicotyls revealed that its content rapidly increased twice in the upper flanks compared with that in the lower ones in response to gravitropic stimulation, whereas its content in the lower flanks was almost equal to that in the vertical control. In etiolated ageotropum epicotyls, an almost equal amount of βIA was distributed in the upper and lower flanks of epicotyls. These results suggest that a gravitropic stimulation increases βIA in the upper flank, resulting in the negative gravitropic bending of epicotyls via the suppression of the Growth rate at the upper side of epicotyls in the etiolated Alaska pea seedlings.

  • isolation and structure elucidation of a potent Growth Inhibitor helian from blue light illuminated sunflower helianthus annuus hypocotyls
    Heterocycles, 2007
    Co-Authors: Tsuyoshi Hasegawa, Kiyotake Suenaga, Kosumi Yamada, Hideyuki Shigemori, Shigenori Togo, Yosuke Hisamatsu, Mitsuhiro Sekiguchi, Koji Hasegawa
    Abstract:

    A potent Growth Inhibitor was isolated from blue light-illuminated sunflower (Helianthus annuus) hypocotyls and identified as 8-β-D-glucopyranosyloxy)-3-hydroxy-1,9,14-pentadecatriene-4,6-diyne (1, designated "helian") from analysis of its 1 H and 13 C NMR spectra, and HRFABMS. Helian 1 showed plant Growth-Inhibitory activity at concentrations higher than 2.6 x 10 -6 mol/L for the cress root Growth test. The amount of helian was higher in the illuminated halves than in the shaded ones in phototropically stimulated sunflower hypocotyls. These results suggest that this new potent Growth Inhibitor, helian, may play an important role on phototropism of sunflower hypocotyls.

  • isolation and identification of lateral bud Growth Inhibitor indole 3 aldehyde involved in apical dominance of pea seedlings
    Phytochemistry, 2002
    Co-Authors: Eri Nakajima, Kosumi Yamada, Hideyuki Shigemori, Hiroshi Nakano, Koji Hasegawa
    Abstract:

    A lateral bud Growth Inhibitor was isolated from etiolated pea seedlings and identified as indole-3-aldehyde. The indole-3-aldehyde content was significantly higher in the diffusates from explants with apical bud and indole-3-acetic acid treated decapitated explants, in which apical dominance is maintained, than in those from decapitated ones releasing apical dominance. When the indole-3-aldehyde was applied to the cut surface of etiolated decapitated plants or directly to the lateral buds, it inhibited outGrowth of the latter. These results suggest that indole-3-aldehyde plays an important role as a lateral bud Growth Inhibitor in apical dominance of pea seedlings.

  • A Growth Inhibitor, R-(−)-3-hydroxy-β-ionone, from lightgrown shoots of a dwarf cultivar of Phaseolus vulgaris
    Phytochemistry, 1993
    Co-Authors: Hisashi Kato-noguchi, Seiji Kosemura, Shosuke Yamamura, Koji Hasegawa
    Abstract:

    Abstract A Growth Inhibitor which might be involved in light-induced Growth inhibition of bean hypocotyl was isolated from light-grown dwarf bean shoots ( Phaseolus vulgaris cv Morocco) and its structure was determined by spectral data as R -(−)-3-hydroxy-β-ionone. It inhibited the Growth of hypocotyls of lettuce seedlings and hypocotyl segments of dwarf bean seedlings at concentrations greater than 0.03 μM, and its Inhibitory activity was higher than ABA.