The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
A M Katz - One of the best experts on this subject based on the ideXlab platform.
-
The cardiomyopathy of overload: an unnatural Growth Response.
European heart journal, 1995Co-Authors: A M KatzAbstract:The poor prognosis in heart failure, which can be reproduced by overloading the normal heart, may reflect molecular abnormalities associated with cardiac hypertrophy. Because terminally differentiated adult cardiac myocytes have little or no capacity to divide, overload-induced hypertrophy represents an unnatural Growth Response. The mechanism by which this unnatural Growth Response shortens survival remains speculative, but may involve apoptosis caused when overload reactivates Growth factors to which the adult heart cannot respond with normal cell division. The ability of converting enzyme inhibitors and nitrates, which have Growth inhibitory as well as vasodilator effects, to improve prognosis in heart failure may reflect the ability of these drugs to modify this unnatural Growth Response.
-
Cell death in the failing heart: role of an unnatural Growth Response to overload.
Clinical cardiology, 1995Co-Authors: A M KatzAbstract:Hypertrophy of the overloaded heart, characterized by an increased number of sarcomeres, provides an adaptive, short-term Response. However, when cardiac overload is long-standing, the hypertrophic Response appears to cause shortened myocyte survival. The mechanisms responsible for the deleterious effects of chronic myocardial hypertrophy may include a maladaptive Growth Response of the mature heart. Because terminally differentiated adult cardiac myocytes have little or no capacity to divide, stimuli that promote Growth in the overloaded adult heart cannot lead to normal cell division. Instead, overload initiates an unnatural Growth Response that appears to shorten cardiac myocyte survival, possibly because the same Growth factors that mediate the hypertrophic Response of the adult heart can also induce programmed cell death (apoptosis). The converting enzyme inhibitors and nitrates, which have Growth-inhibitory as well as vasodilator effects, may improve prognosis in heart failure by inhibiting the production of transcription factors. These transcription factors stimulate both the unnatural Growth Response to overload and stimuli that lead to apoptosis. Since both beta-adrenergic agonists and cytokines, such as tumor necrosis factor-alpha, can stimulate production of similar transcription factors, evidence suggests that beta blockers and vesnarinone improve the prognosis in patients with heart failure possibly because of their ability to inhibit maladaptive Growth.
Hafiz Maherali - One of the best experts on this subject based on the ideXlab platform.
-
Is there an association between root architecture and mycorrhizal Growth Response
The New phytologist, 2014Co-Authors: Hafiz MaheraliAbstract:Summary The symbiosis between arbuscular mycorrhizal (AM) fungi and plants is evolutionarily widespread. The Response of plant Growth to inoculation by these fungi (mycorrhizal Growth Response; MGR) is highly variable, ranging from positive to negative. Some of this variation is hypothesized to be associated with root structure and function. Specifically, species with a coarse root architecture, and thus a limited intrinsic capacity to absorb soil nutrients, are expected to derive the greatest Growth benefit from inoculation with AM fungi. To test this hypothesis, previously published literature and phylogenetic information were combined in a meta-analysis to examine the magnitude and direction of relationships among several root architectural traits and MGR. Published studies differed in the magnitude and direction of relationships between root architecture and MGR. However, when combined, the overall relationship between MGR and allocation to roots, root diameter, root hair length and root hair density did not differ significantly from zero. These findings indicate that possessing coarse roots is not necessarily a predictor of plant Growth Response to AM fungal colonization. Root architecture is therefore unlikely to limit the evolution of variation in MGR.
Brian P. Kavanagh - One of the best experts on this subject based on the ideXlab platform.
-
Early Growth Response factor-1 in acute lung injury.
American Journal of Physiology-lung Cellular and Molecular Physiology, 2007Co-Authors: Nicola Ngiam, Martin Post, Brian P. KavanaghAbstract:early Growth Response factor-1 (EGR1), a nuclear transcription factor, was discovered ∼15 years ago and belongs to a larger family of early Response genes. It appears to function as a convergence point for many signaling pathways, including those involved in inflammation and apoptosis, and its
A Sghirlanzoni - One of the best experts on this subject based on the ideXlab platform.
-
cranial nerve involvement in cmt disease type 1 due to early Growth Response 2 gene mutation
Neurology, 2000Co-Authors: David Pareyson, Franco Taroni, Sara Botti, Michela Morbin, S Baratta, Giuseppe Lauria, Claudia Ciano, A SghirlanzoniAbstract:Mutations in the gene coding for the Schwann cell transcription factor early Growth Response 2 (EGR2), which seems to regulate myelinogenesis and hindbrain development, have been observed in few cases of inherited neuropathy. The authors describe a unique combination of cranial nerve deficits in one member of a Charcot-Marie-Tooth 1 family carrying an EGR2 mutation (Arg381His). This finding further supports the role of EGR2 in cranial nerve development.
Patrick H. Masson - One of the best experts on this subject based on the ideXlab platform.
-
Quantitative Trait Loci for Root Growth Response to Cadaverine in Arabidopsis
Polyamines, 2018Co-Authors: Nicole M. Gibbs, Laura Vaughn Rouhana, Patrick H. MassonAbstract:Root Growth architecture is a major determinant of agricultural productivity and plant fitness in natural ecosystems. Here we describe the methods used in a Quantitative Trait Loci (QTL) study that allowed the identification of ORGANIC CATION TRANSPORTER 1 (OCT1) as a determinant of root Growth Response to cadaverine treatment in Arabidopsis thaliana. This protocol screens natural accessions to characterize the variation in root Growth Response to the naturally occurring polyamine cadaverine, then uses recombination mapping to identify loci that are responsible for the variation existing between two accessions with contrasting phenotypes.
-
Quantitative Trait Loci for Root Growth Response to Cadaverine in Arabidopsis
Polyamines, 2018Co-Authors: Nicole M. Gibbs, Laura Vaughn Rouhana, Patrick H. MassonAbstract:Root Growth architecture is a major determinant of agricultural productivity and plant fitness in natural ecosystems. Here we describe the methods used in a Quantitative Trait Loci (QTL) study that allowed the identification of ORGANIC CATION TRANSPORTER 1 (OCT1) as a determinant of root Growth Response to cadaverine treatment in Arabidopsis thaliana. This protocol screens natural accessions to characterize the variation in root Growth Response to the naturally occurring polyamine cadaverine, then uses recombination mapping to identify loci that are responsible for the variation existing between two accessions with contrasting phenotypes.
