The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Richard Yanagihara - One of the best experts on this subject based on the ideXlab platform.
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Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
2016Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard YanagiharaAbstract:Background: The discovery of genetically distinct Hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of Hantaviruses and also predicts that other soricomorphs harbor Hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of Hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne Hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in Hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other Hantaviruses
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Short Report: Phylogenetically Distinct Hantaviruses in the Masked Shrew (Sorex cinereus) and Dusky Shrew (Sorex monticolus) in the United States
2015Co-Authors: Satoru Arai, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Cheryl A. Parmenter, Vivek R. Nerurkar, Terry L. Yates, Andrew Hope, Richard YanagiharaAbstract:Abstract. A limited search for Hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct Hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne Hantaviruses, named Ash River virus and Jemez Springs virus, respectively, challenges the long-held dogma that rodents are the sole reservoir hosts and forces a re-examination of their co-evolutionary history. Also, studies now underway are aimed at clarifying the epizootiology and pathogenicity of these new members of the genus Hantavirus. Based on phylogenetic analyses of full-length viral genomic sequences and host mitochondrial DNA (mtDNA) se-quences, Hantaviruses segregate into clades that parallel the evolution of murinae, arvicolinae, neotominae, and sigmo-dontinae rodents.1–4 Whether insectivores (or soricomorphs), which are sympatric with rodents, are involved in the evolu-tionary origins of Hantaviruses has not been systematically studied, despite previous reports of hantavirus antigens in tissues of the Eurasian common shrew (Sorex araneus), alpin
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expanded host diversity and global distribution of Hantaviruses implications for identifying and investigating previously unrecognized hantaviral diseases
2015Co-Authors: Richard Yanagihara, Jin-won SongAbstract:A once-exotic group of rodent-borne viruses, belonging to the Hantavirus genus of the Bunyaviridae family, gained widespread attention within the medical community and general public during an outbreak of a mysterious and lethal respiratory disease occurring among healthy young adults in the southwestern USA in 1993. The causative agent was identified as a hantavirus hosted by the North American deer mouse (Peromyscus maniculatus). Rodents (order Rodentia, families Muridae and Cricetidae) have long been known to harbor Hantaviruses, and new Hantaviruses continue to be found in rodents of multiple species in Europe, Asia, and the Americas. By contrast, Hantaviruses have just recently been detected in Africa, notably Sangassou virus in the African wood mouse (Hylomyscus simus) and Tigray virus in the Ethiopian white-footed mouse (Stenocephalemys albipes). In addition to rodents, genetically distinct Hantaviruses have been identified in shrews and moles (order Eulipotyphla, families Soricidae and Talpidae) and insectivorous bats (order Chiroptera) of numerous species from widely separated geographic regions. Phylogenetic analyses, based on partial and full-length genomes of rodent- and non-rodent-borne Hantaviruses, lend support to the concept that ancestral shrews, moles, and/or bats may have predated rodents as the reservoir hosts of primordial Hantaviruses. Thus, the rapidly changing global landscape of Hantaviruses is that of a genetically diverse virus group distributed across hosts of evolutionarily diverse taxonomic orders and ecological niches, with largely unknown biology, evolution, phylogeography, and pathogenicity. As with other still-orphan viruses, identifying and investigating diseases caused by one or more of these newfound Hantaviruses pose myriad challenges, but findings from such studies may better prepare the next generation of health-care providers to respond more rapidly to future outbreaks of previously unrecognized hantaviral diseases.
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Hantaviruses rediscovery and new beginnings
Virus Research, 2014Co-Authors: Richard Yanagihara, Hae Ji Kang, Satoru Arai, Jin-won SongAbstract:Virus and host gene phylogenies, indicating that antigenically distinct Hantaviruses (family Bunyaviridae, genus Hantavirus) segregate into clades, which parallel the molecular evolution of rodents belonging to the Murinae, Arvicolinae, Neotominae and Sigmodontinae subfamilies, suggested co-divergence of Hantaviruses and their rodent reservoirs. Lately, this concept has been vigorously contested in favor of preferential host switching and local host-specific adaptation. To gain insights into the host range, spatial and temporal distribution, genetic diversity and evolutionary origins of Hantaviruses, we employed reverse transcription-polymerase chain reaction to analyze frozen, RNAlater®-preserved and ethanol-fixed tissues from 1546 shrews (9 genera and 47 species), 281 moles (8 genera and 10 species) and 520 bats (26 genera and 53 species), collected in Europe, Asia, Africa and North America during 1980–2012. Thus far, we have identified 24 novel Hantaviruses in shrews, moles and bats. That these newfound Hantaviruses are geographically widespread and genetically more diverse than those harbored by rodents suggests that the evolutionary history of Hantaviruses is far more complex than previously conjectured. Phylogenetic analyses indicate four distinct clades, with the most divergent comprising Hantaviruses harbored by the European mole and insectivorous bats, with evidence for both co-divergence and host switching. Future studies will provide new knowledge about the transmission dynamics and pathogenic potential of these newly discovered, still-orphan, non-rodent-borne Hantaviruses.
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expanded host diversity and geographic distribution of Hantaviruses in sub saharan africa
Journal of Virology, 2014Co-Authors: Hae Ji Kang, William T Stanley, Jacob A Esselstyn, Richard YanagiharaAbstract:The recent discovery of Hantaviruses in shrews and bats in West Africa suggests that other genetically distinct Hantaviruses exist in East Africa. Genetic and phylogenetic analyses of newfound Hantaviruses, detected in archival tissues from the Geata mouse shrew (Myosorex geata) and Kilimanjaro mouse shrew ( Myosorex zinki) captured in Tanzania, expands the host diversity and geographic distribution of Hantaviruses and suggests that ancestral shrews and/or bats may have served as the original mammalian hosts of primordial Hantaviruses.
Jin-won Song - One of the best experts on this subject based on the ideXlab platform.
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meeting report tenth international conference on Hantaviruses
Antiviral Research, 2016Co-Authors: Anna Papa, Antti Vaheri, Jin-won Song, Jiro Arikawa, Detlev H. Krüger, Jan Clement, James W Leduc, Tatjana Avsicžupanc, Alemka Markotic, Mifang LiangAbstract:The 10th International Conference on Hantaviruses, organized by the International Society on Hantaviruses, was held from May 31-June 3, 2016 at Colorado State University, Fort Collins, CO, USA. These conferences have been held every three years since 1980. The current report summarizes research presented on all aspects of hantavirology: ecology and epidemiology, virus replication, phylogeny, pathogenesis, immune response, clinical studies, vaccines and therapeutics.
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Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
2016Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard YanagiharaAbstract:Background: The discovery of genetically distinct Hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of Hantaviruses and also predicts that other soricomorphs harbor Hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of Hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne Hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in Hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other Hantaviruses
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Short Report: Phylogenetically Distinct Hantaviruses in the Masked Shrew (Sorex cinereus) and Dusky Shrew (Sorex monticolus) in the United States
2015Co-Authors: Satoru Arai, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Cheryl A. Parmenter, Vivek R. Nerurkar, Terry L. Yates, Andrew Hope, Richard YanagiharaAbstract:Abstract. A limited search for Hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct Hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne Hantaviruses, named Ash River virus and Jemez Springs virus, respectively, challenges the long-held dogma that rodents are the sole reservoir hosts and forces a re-examination of their co-evolutionary history. Also, studies now underway are aimed at clarifying the epizootiology and pathogenicity of these new members of the genus Hantavirus. Based on phylogenetic analyses of full-length viral genomic sequences and host mitochondrial DNA (mtDNA) se-quences, Hantaviruses segregate into clades that parallel the evolution of murinae, arvicolinae, neotominae, and sigmo-dontinae rodents.1–4 Whether insectivores (or soricomorphs), which are sympatric with rodents, are involved in the evolu-tionary origins of Hantaviruses has not been systematically studied, despite previous reports of hantavirus antigens in tissues of the Eurasian common shrew (Sorex araneus), alpin
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expanded host diversity and global distribution of Hantaviruses implications for identifying and investigating previously unrecognized hantaviral diseases
2015Co-Authors: Richard Yanagihara, Jin-won SongAbstract:A once-exotic group of rodent-borne viruses, belonging to the Hantavirus genus of the Bunyaviridae family, gained widespread attention within the medical community and general public during an outbreak of a mysterious and lethal respiratory disease occurring among healthy young adults in the southwestern USA in 1993. The causative agent was identified as a hantavirus hosted by the North American deer mouse (Peromyscus maniculatus). Rodents (order Rodentia, families Muridae and Cricetidae) have long been known to harbor Hantaviruses, and new Hantaviruses continue to be found in rodents of multiple species in Europe, Asia, and the Americas. By contrast, Hantaviruses have just recently been detected in Africa, notably Sangassou virus in the African wood mouse (Hylomyscus simus) and Tigray virus in the Ethiopian white-footed mouse (Stenocephalemys albipes). In addition to rodents, genetically distinct Hantaviruses have been identified in shrews and moles (order Eulipotyphla, families Soricidae and Talpidae) and insectivorous bats (order Chiroptera) of numerous species from widely separated geographic regions. Phylogenetic analyses, based on partial and full-length genomes of rodent- and non-rodent-borne Hantaviruses, lend support to the concept that ancestral shrews, moles, and/or bats may have predated rodents as the reservoir hosts of primordial Hantaviruses. Thus, the rapidly changing global landscape of Hantaviruses is that of a genetically diverse virus group distributed across hosts of evolutionarily diverse taxonomic orders and ecological niches, with largely unknown biology, evolution, phylogeography, and pathogenicity. As with other still-orphan viruses, identifying and investigating diseases caused by one or more of these newfound Hantaviruses pose myriad challenges, but findings from such studies may better prepare the next generation of health-care providers to respond more rapidly to future outbreaks of previously unrecognized hantaviral diseases.
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Hantaviruses rediscovery and new beginnings
Virus Research, 2014Co-Authors: Richard Yanagihara, Hae Ji Kang, Satoru Arai, Jin-won SongAbstract:Virus and host gene phylogenies, indicating that antigenically distinct Hantaviruses (family Bunyaviridae, genus Hantavirus) segregate into clades, which parallel the molecular evolution of rodents belonging to the Murinae, Arvicolinae, Neotominae and Sigmodontinae subfamilies, suggested co-divergence of Hantaviruses and their rodent reservoirs. Lately, this concept has been vigorously contested in favor of preferential host switching and local host-specific adaptation. To gain insights into the host range, spatial and temporal distribution, genetic diversity and evolutionary origins of Hantaviruses, we employed reverse transcription-polymerase chain reaction to analyze frozen, RNAlater®-preserved and ethanol-fixed tissues from 1546 shrews (9 genera and 47 species), 281 moles (8 genera and 10 species) and 520 bats (26 genera and 53 species), collected in Europe, Asia, Africa and North America during 1980–2012. Thus far, we have identified 24 novel Hantaviruses in shrews, moles and bats. That these newfound Hantaviruses are geographically widespread and genetically more diverse than those harbored by rodents suggests that the evolutionary history of Hantaviruses is far more complex than previously conjectured. Phylogenetic analyses indicate four distinct clades, with the most divergent comprising Hantaviruses harbored by the European mole and insectivorous bats, with evidence for both co-divergence and host switching. Future studies will provide new knowledge about the transmission dynamics and pathogenic potential of these newly discovered, still-orphan, non-rodent-borne Hantaviruses.
Satoru Arai - One of the best experts on this subject based on the ideXlab platform.
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molecular phylogeny of a genetically divergent hantavirus harbored by the geoffroy s rousette rousettus amplexicaudatus a frugivorous bat species in the philippines
Infection Genetics and Evolution, 2016Co-Authors: Satoru Arai, Satoshi Taniguchi, Keita Aoki, Yasuhiro Yoshikawa, Shigeru Kyuwa, Keiko Tanakataya, Joseph S Masangkay, Tsutomu Omatsu, Roberto Puentespina, Shumpei WatanabeAbstract:The recent discovery of genetically distinct Hantaviruses in multiple species of shrews and moles (order Eulipotyphla, families Soricidae and Talpidae) prompted a further exploration of their host diversification and geographic distribution by analyzing lung tissues from 376 fruit bats representing six genera (order Chiroptera, suborder Yinpterochiroptera, family Pteropodidae), collected in the Republic of the Philippines during 2008 to 2013. Hantavirus RNA was detected by RT-PCR in one of 15 Geoffroy's rousettes (Rousettus amplexicaudatus), captured in Quezon Memorial National Park on Luzon Island in 2009. Phylogenetic analyses of the S, M and L segments, using maximum-likelihood and Bayesian methods, showed that the newfound hantavirus, designated Quezon virus (QZNV), shared a common ancestry with Hantaviruses hosted by insectivorous bats, in keeping with their evolutionary relationships and suggests that ancestral bats may have served as the early or original mammalian hosts of primordial Hantaviruses. As the first hantavirus detected in a megabat or flying fox species, QZNV extends our knowledge about the reservoir host range.
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Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
2016Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard YanagiharaAbstract:Background: The discovery of genetically distinct Hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of Hantaviruses and also predicts that other soricomorphs harbor Hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of Hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne Hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in Hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other Hantaviruses
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Short Report: Phylogenetically Distinct Hantaviruses in the Masked Shrew (Sorex cinereus) and Dusky Shrew (Sorex monticolus) in the United States
2015Co-Authors: Satoru Arai, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Cheryl A. Parmenter, Vivek R. Nerurkar, Terry L. Yates, Andrew Hope, Richard YanagiharaAbstract:Abstract. A limited search for Hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct Hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne Hantaviruses, named Ash River virus and Jemez Springs virus, respectively, challenges the long-held dogma that rodents are the sole reservoir hosts and forces a re-examination of their co-evolutionary history. Also, studies now underway are aimed at clarifying the epizootiology and pathogenicity of these new members of the genus Hantavirus. Based on phylogenetic analyses of full-length viral genomic sequences and host mitochondrial DNA (mtDNA) se-quences, Hantaviruses segregate into clades that parallel the evolution of murinae, arvicolinae, neotominae, and sigmo-dontinae rodents.1–4 Whether insectivores (or soricomorphs), which are sympatric with rodents, are involved in the evolu-tionary origins of Hantaviruses has not been systematically studied, despite previous reports of hantavirus antigens in tissues of the Eurasian common shrew (Sorex araneus), alpin
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Hantaviruses rediscovery and new beginnings
Virus Research, 2014Co-Authors: Richard Yanagihara, Hae Ji Kang, Satoru Arai, Jin-won SongAbstract:Virus and host gene phylogenies, indicating that antigenically distinct Hantaviruses (family Bunyaviridae, genus Hantavirus) segregate into clades, which parallel the molecular evolution of rodents belonging to the Murinae, Arvicolinae, Neotominae and Sigmodontinae subfamilies, suggested co-divergence of Hantaviruses and their rodent reservoirs. Lately, this concept has been vigorously contested in favor of preferential host switching and local host-specific adaptation. To gain insights into the host range, spatial and temporal distribution, genetic diversity and evolutionary origins of Hantaviruses, we employed reverse transcription-polymerase chain reaction to analyze frozen, RNAlater®-preserved and ethanol-fixed tissues from 1546 shrews (9 genera and 47 species), 281 moles (8 genera and 10 species) and 520 bats (26 genera and 53 species), collected in Europe, Asia, Africa and North America during 1980–2012. Thus far, we have identified 24 novel Hantaviruses in shrews, moles and bats. That these newfound Hantaviruses are geographically widespread and genetically more diverse than those harbored by rodents suggests that the evolutionary history of Hantaviruses is far more complex than previously conjectured. Phylogenetic analyses indicate four distinct clades, with the most divergent comprising Hantaviruses harbored by the European mole and insectivorous bats, with evidence for both co-divergence and host switching. Future studies will provide new knowledge about the transmission dynamics and pathogenic potential of these newly discovered, still-orphan, non-rodent-borne Hantaviruses.
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Reconstructing the evolutionary origins and phylogeography of Hantaviruses
Trends in Microbiology, 2014Co-Authors: Shannon N. Bennett, Hae Ji Kang, Satoru Arai, Hun Gu, Richard YanagiharaAbstract:Rodents have long been recognized as the principal reservoirs of Hantaviruses. However, with the discovery of genetically distinct and phylogenetically divergent lineages of Hantaviruses in multiple species of shrews, moles, and insectivorous bats from widely separated geographic regions, a far more complex landscape of hantavirus host distribution, evolution, and phylogeography is emerging. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne Hantaviruses and newly detected non-rodent-borne Hantaviruses, indicate an Asian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial Hantaviruses.
Hae Ji Kang - One of the best experts on this subject based on the ideXlab platform.
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Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
2016Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard YanagiharaAbstract:Background: The discovery of genetically distinct Hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of Hantaviruses and also predicts that other soricomorphs harbor Hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of Hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne Hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in Hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other Hantaviruses
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Hantaviruses rediscovery and new beginnings
Virus Research, 2014Co-Authors: Richard Yanagihara, Hae Ji Kang, Satoru Arai, Jin-won SongAbstract:Virus and host gene phylogenies, indicating that antigenically distinct Hantaviruses (family Bunyaviridae, genus Hantavirus) segregate into clades, which parallel the molecular evolution of rodents belonging to the Murinae, Arvicolinae, Neotominae and Sigmodontinae subfamilies, suggested co-divergence of Hantaviruses and their rodent reservoirs. Lately, this concept has been vigorously contested in favor of preferential host switching and local host-specific adaptation. To gain insights into the host range, spatial and temporal distribution, genetic diversity and evolutionary origins of Hantaviruses, we employed reverse transcription-polymerase chain reaction to analyze frozen, RNAlater®-preserved and ethanol-fixed tissues from 1546 shrews (9 genera and 47 species), 281 moles (8 genera and 10 species) and 520 bats (26 genera and 53 species), collected in Europe, Asia, Africa and North America during 1980–2012. Thus far, we have identified 24 novel Hantaviruses in shrews, moles and bats. That these newfound Hantaviruses are geographically widespread and genetically more diverse than those harbored by rodents suggests that the evolutionary history of Hantaviruses is far more complex than previously conjectured. Phylogenetic analyses indicate four distinct clades, with the most divergent comprising Hantaviruses harbored by the European mole and insectivorous bats, with evidence for both co-divergence and host switching. Future studies will provide new knowledge about the transmission dynamics and pathogenic potential of these newly discovered, still-orphan, non-rodent-borne Hantaviruses.
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expanded host diversity and geographic distribution of Hantaviruses in sub saharan africa
Journal of Virology, 2014Co-Authors: Hae Ji Kang, William T Stanley, Jacob A Esselstyn, Richard YanagiharaAbstract:The recent discovery of Hantaviruses in shrews and bats in West Africa suggests that other genetically distinct Hantaviruses exist in East Africa. Genetic and phylogenetic analyses of newfound Hantaviruses, detected in archival tissues from the Geata mouse shrew (Myosorex geata) and Kilimanjaro mouse shrew ( Myosorex zinki) captured in Tanzania, expands the host diversity and geographic distribution of Hantaviruses and suggests that ancestral shrews and/or bats may have served as the original mammalian hosts of primordial Hantaviruses.
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Reconstructing the evolutionary origins and phylogeography of Hantaviruses
Trends in Microbiology, 2014Co-Authors: Shannon N. Bennett, Hae Ji Kang, Satoru Arai, Hun Gu, Richard YanagiharaAbstract:Rodents have long been recognized as the principal reservoirs of Hantaviruses. However, with the discovery of genetically distinct and phylogenetically divergent lineages of Hantaviruses in multiple species of shrews, moles, and insectivorous bats from widely separated geographic regions, a far more complex landscape of hantavirus host distribution, evolution, and phylogeography is emerging. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne Hantaviruses and newly detected non-rodent-borne Hantaviruses, indicate an Asian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial Hantaviruses.
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divergent lineage of a novel hantavirus in the banana pipistrelle neoromicia nanus in cote d ivoire
Virology Journal, 2012Co-Authors: Laarni Sumibcay, Hae Ji Kang, Joseph A. Cook, Jin-won Song, Blaise Kadjo, Burton K Lim, Richard YanagiharaAbstract:Recently identified Hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassue village in Cote d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassue virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne Hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for Hantaviruses, now underway, will provide critical insights into the evolution and diversification of Hantaviruses.
Shannon N. Bennett - One of the best experts on this subject based on the ideXlab platform.
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Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
2016Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard YanagiharaAbstract:Background: The discovery of genetically distinct Hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of Hantaviruses and also predicts that other soricomorphs harbor Hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of Hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne Hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in Hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other Hantaviruses
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Short Report: Phylogenetically Distinct Hantaviruses in the Masked Shrew (Sorex cinereus) and Dusky Shrew (Sorex monticolus) in the United States
2015Co-Authors: Satoru Arai, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Cheryl A. Parmenter, Vivek R. Nerurkar, Terry L. Yates, Andrew Hope, Richard YanagiharaAbstract:Abstract. A limited search for Hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct Hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne Hantaviruses, named Ash River virus and Jemez Springs virus, respectively, challenges the long-held dogma that rodents are the sole reservoir hosts and forces a re-examination of their co-evolutionary history. Also, studies now underway are aimed at clarifying the epizootiology and pathogenicity of these new members of the genus Hantavirus. Based on phylogenetic analyses of full-length viral genomic sequences and host mitochondrial DNA (mtDNA) se-quences, Hantaviruses segregate into clades that parallel the evolution of murinae, arvicolinae, neotominae, and sigmo-dontinae rodents.1–4 Whether insectivores (or soricomorphs), which are sympatric with rodents, are involved in the evolu-tionary origins of Hantaviruses has not been systematically studied, despite previous reports of hantavirus antigens in tissues of the Eurasian common shrew (Sorex araneus), alpin
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Reconstructing the evolutionary origins and phylogeography of Hantaviruses
Trends in Microbiology, 2014Co-Authors: Shannon N. Bennett, Hae Ji Kang, Satoru Arai, Hun Gu, Richard YanagiharaAbstract:Rodents have long been recognized as the principal reservoirs of Hantaviruses. However, with the discovery of genetically distinct and phylogenetically divergent lineages of Hantaviruses in multiple species of shrews, moles, and insectivorous bats from widely separated geographic regions, a far more complex landscape of hantavirus host distribution, evolution, and phylogeography is emerging. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne Hantaviruses and newly detected non-rodent-borne Hantaviruses, indicate an Asian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial Hantaviruses.
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shared ancestry between a newfound mole borne hantavirus and Hantaviruses harbored by cricetid rodents
Journal of Virology, 2011Co-Authors: Hae Ji Kang, Andrew G. Hope, Joseph A. Cook, Shannon N. Bennett, Richard YanagiharaAbstract:Discovery of genetically distinct Hantaviruses in multiple species of shrews (order Soricomorpha, family Soricidae) and moles (family Talpidae) contests the conventional view that rodents (order Rodentia, families Muridae and Cricetidae) are the principal reservoir hosts and suggests that the evolutionary history of Hantaviruses is far more complex than previously hypothesized. We now report on Rockport virus (RKPV), a hantavirus identified in archival tissues of the eastern mole (Scalopus aquaticus) collected in Rockport, TX, in 1986. Pairwise comparison of the full-length S, M, and L genomic segments indicated moderately low sequence similarity between RKPV and other soricomorph-borne Hantaviruses. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that RKPV shared a most recent common ancestor with cricetid-rodent-borne Hantaviruses. Distributed widely across the eastern United States, the fossorial eastern mole is sympatric and syntopic with cricetid rodents known to harbor Hantaviruses, raising the possibility of host-switching events in the distant past. Our findings warrant more-detailed investigations on the dynamics of spillover and cross-species transmission of present-day Hantaviruses within communities of rodents and moles.
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evolutionary insights from a genetically divergent hantavirus harbored by the european common mole talpa europaea
PLOS ONE, 2009Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard YanagiharaAbstract:Background The discovery of genetically distinct Hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of Hantaviruses and also predicts that other soricomorphs harbor Hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of Hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary.
