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Richard Yanagihara - One of the best experts on this subject based on the ideXlab platform.

  • Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
    2016
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background: The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other hantaviruses

  • Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea)
    Scientific Reports, 2016
    Co-Authors: Se Hun Gu, Janusz Hejduk, Janusz Markowski, Marcin Markowski, Mukesh Kumar, Beata Sikorska, Paweł P. Liberski, Richard Yanagihara
    Abstract:

    Genetically distinct hantaviruses have been identified in five species of fossorial moles (order Eulipotyphla, family Talpidae) from Eurasia and North America. Here, we report the isolation and partial characterization of a highly divergent hantavirus, named Nova virus (NVAV), from lung tissue of a European mole ( Talpa europaea ), captured in central Poland in August 2013. Typical hantavirus-like particles, measuring 80–120 nm in diameter, were found in NVAV-infected Vero E6 cells by transmission electron microscopy. Whole-genome sequences of the isolate, designated NVAV strain Te34, were identical to that amplified from the original lung tissue and phylogenetic analysis of the full-length L, M and S segments, using maximum-likelihood and Bayesian methods, showed that NVAV was most closely related to hantaviruses harbored by insectivorous bats, consistent with an ancient evolutionary origin. Infant Swiss Webster mice, inoculated with NVAV by the intraperitoneal route, developed weight loss and hyperactivity, beginning at 16 days, followed by hind-limb paralysis and death. High NVAV RNA copies were detected in lung, liver, kidney, spleen and brain by quantitative real-time RT-PCR. Neuropathological examination showed astrocytic and microglial activation and neuronal loss. The first mole-borne hantavirus isolate will facilitate long-overdue studies on its infectivity and pathogenic potential in humans.

  • whole genome sequence of a novel hantavirus isolated from the european mole Talpa europaea
    Genome Announcements, 2015
    Co-Authors: Janusz Hejduk, Janusz Markowski, Marcin Markowski, Pawel P Liberski, Richard Yanagihara
    Abstract:

    ABSTRACT The complete genome sequence of Nova virus, a novel hantavirus isolated from a European mole (Talpa europaea) captured in central Poland, was determined. The availability of this sequence will facilitate the search for other mole-borne hantaviruses and will accelerate the acquisition of new knowledge about their phylogeography and evolutionary origin.

  • co circulation of soricid and talpid borne hantaviruses in poland
    Infection Genetics and Evolution, 2014
    Co-Authors: Janusz Hejduk, Hae Ji Kang, Janusz Markowski, Marcin Markowski, Pawel P Liberski, Beata Sikorska, Malgorzata Polatynska, Richard Yanagihara
    Abstract:

    Abstract Previously, we reported the discovery of a genetically distinct hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew (Neomys fodiens), as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus), in central Poland. In this expanded study of 133 shrews and 69 moles captured during 2010–2013 in central and southeastern Poland, we demonstrate the co-circulation of BOGV in the Eurasian water shrew and SWSV in the Eurasian common shrew, Eurasian pygmy shrew (Sorex minutus) and Mediterranean water shrew (Neomys anomalus). In addition, we found high prevalence of Nova virus (NVAV) infection in the European mole (Talpa europaea), with evidence of NVAV RNA in heart, lung, liver, kidney, spleen and intestine. The nucleotide and amino acid sequence variation of the L segment among the SWSV strains was 0–18.8% and 0–5.4%, respectively. And for the 38 NVAV strains from European moles captured in Huta Dlutowska, the L-segment genetic similarity ranged from 94.1%–100% at the nucleotide level and 96.3%–100% at the amino acid level. Phylogenetic analyses showed geographic-specific lineages of SWSV and NVAV in Poland, not unlike that of rodent-borne hantaviruses, suggesting long-standing host-specific adaptation. The co-circulation and distribution of BOGV, SWSV and NVAV in Poland parallels findings of multiple hantavirus species co-existing in their respective rodent reservoir species elsewhere in Europe. Also, the detection of SWSV in three syntopic shrew species resembles spill over events observed among some rodent-borne hantaviruses.

  • high prevalence of nova hantavirus infection in the european mole Talpa europaea in france
    Epidemiology and Infection, 2014
    Co-Authors: Jerome Dormion, Jeanpierre Hugot, Richard Yanagihara
    Abstract:

    Received 23 May 2013; Final revision 31 July 2013; Accepted 13 August 2013SUMMARYRecent discovery of genetically distinct hantaviruses in shrews and moles (order Soricomorpha,family Soricidae and Talpidae) has challenged the conventional view that rodents serve as theprincipal reservoir hosts. Nova virus (NVAV), previously identified in archival liver tissue ofa single European mole (Talpa europaea) from Hungary, represents one of the most highlydivergent hantaviruses identified to date. To ascertain the spatial distribution and geneticdiversity of NVAV, we employed RT–PCR to analyse lungs from 94 moles, captured in twolocations in France, during October 2012 to March 2013. NVAV was detected in more than60% of moles at each location, suggesting efficient enzootic virus transmission and confirmingthat this mole species serves as the reservoir host. Although the pathogenic potential of NVAVis unknown, the widespread geographical distribution of the European mole might pose ahantavirus exposure risk for humans.Key words: France, hantavirus, mole, phylogeny, Talpa.Rodents of multiple species in Europe, notablythe bank vole (Myodes glareolus), common vole(Microtus arvalis), field vole (Microtus agrestis),yellow-necked field mouse (Apodemus flavicollis),Black Sea field mouse (Apodemus ponticus) andstriped field mouse (Apodemus agrarius), harbourgenetically distinct hantaviruses (genus Hantavirus,family Bunyaviridae) [1–3]. Some of these hanta-viruses, such as Puumala virus and Dobrava virus,cause haemorrhagic fever with renal syndrome(HFRS) in Europe, while others, such as Tula virusand Tatenale virus, are not known to be pathogenic.As evidenced by the detection of HFRS antigensby enzyme immunoassay, shrews and moles (orderSoricomorpha, family Soricidae and Talpidae), cap-tured in European Russia, were suspected of servingas reservoir hosts of hantaviruses more than 30 yearsago [4, 5]. Although the specificity of such antigen-detection methods is uncertain, recent studies, usingsensitive molecular-based technology, have unequi-vocally demonstrated that the hantaviruses hostedby several soricomorph species in Europe are farmore genetically diverse than rodent-borne hanta-viruses [6–11].To date, one of the most highly divergent lineagesof hantaviruses is represented by Nova virus

Hae Ji Kang - One of the best experts on this subject based on the ideXlab platform.

  • Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
    2016
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background: The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other hantaviruses

  • co circulation of soricid and talpid borne hantaviruses in poland
    Infection Genetics and Evolution, 2014
    Co-Authors: Janusz Hejduk, Hae Ji Kang, Janusz Markowski, Marcin Markowski, Pawel P Liberski, Beata Sikorska, Malgorzata Polatynska, Richard Yanagihara
    Abstract:

    Abstract Previously, we reported the discovery of a genetically distinct hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew (Neomys fodiens), as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus), in central Poland. In this expanded study of 133 shrews and 69 moles captured during 2010–2013 in central and southeastern Poland, we demonstrate the co-circulation of BOGV in the Eurasian water shrew and SWSV in the Eurasian common shrew, Eurasian pygmy shrew (Sorex minutus) and Mediterranean water shrew (Neomys anomalus). In addition, we found high prevalence of Nova virus (NVAV) infection in the European mole (Talpa europaea), with evidence of NVAV RNA in heart, lung, liver, kidney, spleen and intestine. The nucleotide and amino acid sequence variation of the L segment among the SWSV strains was 0–18.8% and 0–5.4%, respectively. And for the 38 NVAV strains from European moles captured in Huta Dlutowska, the L-segment genetic similarity ranged from 94.1%–100% at the nucleotide level and 96.3%–100% at the amino acid level. Phylogenetic analyses showed geographic-specific lineages of SWSV and NVAV in Poland, not unlike that of rodent-borne hantaviruses, suggesting long-standing host-specific adaptation. The co-circulation and distribution of BOGV, SWSV and NVAV in Poland parallels findings of multiple hantavirus species co-existing in their respective rodent reservoir species elsewhere in Europe. Also, the detection of SWSV in three syntopic shrew species resembles spill over events observed among some rodent-borne hantaviruses.

  • divergent lineage of a novel hantavirus in the banana pipistrelle neoromicia nanus in cote d ivoire
    Virology Journal, 2012
    Co-Authors: Laarni Sumibcay, Hae Ji Kang, Joseph A. Cook, Jin-won Song, Blaise Kadjo, Burton K Lim, Richard Yanagihara
    Abstract:

    Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassue village in Cote d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassue virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.

  • evolutionary insights from a genetically divergent hantavirus harbored by the european common mole Talpa europaea
    PLOS ONE, 2009
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary.

Sesé Carmen - One of the best experts on this subject based on the ideXlab platform.

  • The small mammals (Eulipotyphla, Chiroptera, Rodentia and Lagomorpha) from the Late Pleistocene site of the cave of El Castillo (Cantabria, Spain).
    Consejo Superior de Investigaciones Científicas (España), 2017
    Co-Authors: Sesé Carmen
    Abstract:

    [ES] El material de micromamíferos del yacimiento del Pleistoceno Superior de la cueva de El Castillo, objeto de estudio detallado en este trabajo, proviene de los niveles auriñacienses 18b y 18c (datados en 40.000-45.000 BP), nivel 19, y niveles musterienses 20b, 20c, 20d, 20e (datados en 41.000-49.000 BP), 21a y 21b. La asociación de micromamíferos es la siguiente: Erinaceus europaeus, Crocidura russula, Sorex coronatus, Sorex minutus, Neomys fodiens, Talpa europaea, Galemys pyrenaicus, cf. Miniopterus schreibersii, Chiroptera indet., Pliomys lenki, Microtus arvalis - Microtus agrestis, Microtus lusitanicus, Microtus oeconomus, Chionomys nivalis, Arvicola terrestris, Apodemus sylvaticus - Apodemus flavicollis y Lepus sp. La mayoría de estas especies están presen¬tes en la fauna actual de Cantabria, excepto Pliomys lenki que se extinguió en el último tercio del Pleistoceno Superior, y Microtus oeconomus, que persistió en la península ibérica durante el Holoceno bien avanzado hasta su desaparición en tiempos históricos, y que actualmente está en regiones euroasiáticas más septentrionales. Hay una gran continuidad de la gran mayoría de los taxones en todos los niveles. La fauna en su conjunto parece indicar un medio predominantemente abierto, por lo general de praderas húmedas (y en mucha menor medida praderas secas) con una buena cobertura vegetal a nivel del suelo, en el que habría también algunas zonas arboladas o boscosas, y algún curso de agua. Los indicadores termófilos son escasos y poco abundantes, lo que podría indicar que el clima podría ser algo menos templado que en otros periodos del Pleistoceno Superior y quizás también que actualmente en la zona.[EN] The micromammals remains from the Late Pleistocene site of the cave of El Castillo studied here in detail, came from the Aurignacian levels 18b and 18c (dated in 40.000-45.000 BP), level 19, and the Musterian levels 20b, 20c, 20d, 20e (dated in 41.000-49.000 BP), 21a and 21b. The micromammal association is the following: Erinaceus europaeus, Crocidura russula, Sorex coronatus, Sorex minutus, Neomys fodiens, Talpa europaea, Galemys pyrenaicus, cf. Miniopterus schreibersii, Chiroptera indet., Pliomys lenki, Microtus arvalis - Microtus agrestis, Microtus lusitanicus, Microtus oeconomus, Chionomys nivalis, Arvicola terrestris, Apodemus sylvaticus - Apodemus flavicollis and Lepus sp. Most of these species are in the present fauna of Cantabria, except Pliomys lenki that got extinct in the last third of the Upper Pleistocene, and Microtus oeconomus that disappeared from the Iberian Peninsula during the Holocene, in historical times, and is nowadays present in northern Euroasiatic regions. There is a great continuity of most of the taxa in all the levels. The faunal association seems to indicate a mainly open environment, in general with wet meadows (and few dry meadows), with good vegetation cover in the soil, with perhaps also some tree-covered areas, and some watercourses. The thermophiles indicators are very scarce, which could indicate that the climate could be a lesser temperate than other Upper Pleistocene periods and the present-day climate in the area.Peer reviewe

  • The micromammals (Rodentia, Insectivora,Lagomorpha and Chiroptera) from the late Upper Pleistocene site of the cave of Las Aguas (Cantabria, North of Spain)
    Ministerio de Educación Cultura y Deporte (España), 2016
    Co-Authors: Sesé Carmen
    Abstract:

    [EN] The micromammals (orders Rodentia, Insectivora, Lagomorpha and Chiroptera) from the cave of Las Aguas site of the end of the upper Pleistocene are here studied for the first time. The fauna comes from the following drillings and levels: vestibule, drilling squares G6-G7: levels A, B (14.440-15.030 BP), C (14.740-17.630 BP) and D; drilling square N1: levels A, B (14.750 BP) and C, and drilling square M3: level B. The list of micromammals of the site is the following: Apodemus sp., Arvicola terrestris, Microtus arvalis-Microtus agrestis, Microtus oeconomus, Microtus lusitanicus, Chionomys nivalis, Sorex araneus, Neomys fodiens, Crocidura russula, Talpa europaea, Erinaceus europaeus, cf. Lepus sp. and Miniopterus schreibersii. All these taxa live nowadays in the cantabrian region except: Sorex araneus which distribution in the Iberian Peninsula has reduced to the north of Catalonia and Microtus oeconomus that is not in Spain but in northern Euroasiatic regions. The most abundant species in almost all the levels is Arvicola terrestris (between the 48,7 % and the 35,4 %). After Arvicola terrestris, the most abundant taxa in decreasing order with high and very similar percentages are: Microtus arvalis-Microtus agrestis and Microtus oeconomus. The paleoenvironmental study of the faunal assemblage suggests a mainly open and humid environment and a cold climate. [ES] En ese trabajo se estudian por primera vez los micromamíferos (órdenes Rodentia, Insectivora, Lagomorpha y Chiroptera) del yacimiento del final del Pleistoceno superior de la cueva de Las Aguas (Cantabria, norte de España). La fauna procede de los siguientes sondeos y niveles: vestíbulo, sondeo cuadros G6-G7: niveles A, B (14.440-15.030 BP), C (14.740-17.630 BP) y D; sondeo cuadro N1’: niveles A, B (14.750 BP) y C; y sondeo cuadro M3: nivel B. La relación de micromamíferos del yacimiento es la siguiente: Apodemus sp., Arvicola terrestris, Microtus arvalis-Microtus agrestis, Microtus oeconomus, Microtus lusitanicus, Chionomys nivalis, Sorex araneus, Neomys fodiens, Crocidura russula, Talpa europaea, Erinaceus europaeus, cf. Lepus sp. y Miniopterus schreibersii. Todos estos taxones viven actualmente en la región cantábrica excepto: Sorex araneus, cuya distribución se ha reducido en la península al norte de Cataluña y Microtus oeconomus que no está en España sino en regiones más septentrionales de Eurasia. La especie más abundante en casi todos los niveles del yacimiento es Arvicola terrestris (con porcentajes que varían entre el 48,7 % y el 35,4 %), siguiéndole en abundancia por orden decreciente con porcentajes muy altos y bastante similares Microtus arvalis-Microtus agrestis y Microtus oeconomus. El estudio paleoambiental de la asociación de micromamíferos del yacimiento sugiere un medio fundamentalmente abierto y húmedo y un clima frío.Peer reviewe

  • The micromammals (Rodentia, Insectivora and Lagomorpha) from the late Upper Pleistocene site of the cave of Cualventi (Cantabria, North of Spain)
    Ministerio de Educación Cultura y Deporte (España), 2016
    Co-Authors: Sesé Carmen
    Abstract:

    [EN] The micromammals (orders Rodentia, Insectivora and Lagomorpha) from the cave of Cualventi site of the end of the upper Pleistocene are here studied for the first time. The fauna comes from the levels D, E (dated in 14.580-15.950 BP) and F, from which the E level is the richest with a MNI of 1489 out of a total MNI of the site of 1640. The list of micromammals of the site is the following: Apodemus cf. flavicollis, Arvicola terrestris, Microtus arvalis-Microtus agrestis, Microtus oeconomus, Microtus lusitanicus, Chionomys nivalis, Sorex araneus, Sorex minutus, Neomys fodiens, Crocidura russula, Talpa europaea, Erinaceus europaeus and cf. Lepus sp. It has been also registered Glis glis but without a secure stratigraphical context. All these taxa live nowadays in the cantabrian region except: Sorex araneus which distribution in the Iberian Peninsula has reduced to the north of Catalonia and Microtus oeconomus that is not in Spain but in northern Euroasiatic regions. The most abundant species in all the levels is Talpa europaea (between the 41,8 % and the 30,2 %) with difference as regards to the rest of the taxa. After Talpa europaea, the most abundant taxa with high percentages in decreasing order are: Microtus oeconomus, Arvicola terrestris and Microtus arvalis-Microtus agrestis. The paleoenvironmental study of the faunal assemblage suggests a mainly open and humid environment and a cold climate. [ES] En ese trabajo se estudian por primera vez los micromamíferos (órdenes Rodentia, Insectivora y Lagomorpha) del yacimiento del final del Pleistoceno superior de la cueva de Cualventi (Cantabria, norte de España). La fauna procede de los niveles D, E (datado en 14.580-15.950 BP) y F, de los cuales el más rico es el E con un NMI de 1489 sobre un NMI total del yacimiento de 1640. La relación de micromamíferos del yacimiento es la siguiente: Apodemus cf. flavicollis, Arvicola terrestris, Microtus arvalis-Microtus agrestis, Microtus oeconomus, Microtus lusitanicus, Chionomys nivalis, Sorex araneus, Sorex minutus, Neomys fodiens, Crocidura russula, Talpa europaea, Erinaceus europaeus y cf. Lepus sp. Además de estas especies se registra también Glis glis, pero sin contexto estratigráfico seguro. Todos estos taxones viven actualmente en la región cantábrica excepto: Sorex araneus, cuya distribución se ha reducido en la península ibérica al norte de Cataluña y Microtus oeconomus, que no está en España sino en regiones más septentrionales de Eurasia. La especie más abundante en todos los niveles del yacimiento, con diferencia respecto a las demás, es Talpa europaea (entre el 41,8 % y el 30,2 %), siguiéndole en abundancia por orden decreciente y con porcentajes muy altos: Microtus oeconomus, Arvicola terrestris y Microtus arvalis-Microtus agrestis. El estudio paleoambiental de la asociación de micromamíferos del yacimiento sugiere un medio fundamentalmente abierto y húmedo, y un clima frío.Peer reviewe

Laarni Sumibcay - One of the best experts on this subject based on the ideXlab platform.

  • Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
    2016
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background: The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other hantaviruses

  • divergent lineage of a novel hantavirus in the banana pipistrelle neoromicia nanus in cote d ivoire
    Virology Journal, 2012
    Co-Authors: Laarni Sumibcay, Hae Ji Kang, Joseph A. Cook, Jin-won Song, Blaise Kadjo, Burton K Lim, Richard Yanagihara
    Abstract:

    Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassue village in Cote d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassue virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.

  • evolutionary insights from a genetically divergent hantavirus harbored by the european common mole Talpa europaea
    PLOS ONE, 2009
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary.

Jin-won Song - One of the best experts on this subject based on the ideXlab platform.

  • Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 2009
    2016
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background: The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary. Methodology/Principal Findings: Pair-wise alignment and comparison of the full-length S- and L-genomic segments indicated moderately low sequence similarity of 54–65 % and 46–63 % at the nucleotide and amino acid levels, respectively, between NVAV and representative rodent- and soricid-borne hantaviruses. Despite the high degree of sequence divergence, the predicted secondary structure of the NVAV nucleocapsid protein exhibited the characteristic coiled-coil domains at the amino-terminal end, and the L-segment motifs, typically found in hantaviruses, were well conserved. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that NVAV formed a distinct clade that was evolutionarily distant from all other hantaviruses

  • divergent lineage of a novel hantavirus in the banana pipistrelle neoromicia nanus in cote d ivoire
    Virology Journal, 2012
    Co-Authors: Laarni Sumibcay, Hae Ji Kang, Joseph A. Cook, Jin-won Song, Blaise Kadjo, Burton K Lim, Richard Yanagihara
    Abstract:

    Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassue village in Cote d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassue virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.

  • evolutionary insights from a genetically divergent hantavirus harbored by the european common mole Talpa europaea
    PLOS ONE, 2009
    Co-Authors: Hae Ji Kang, Satoru Arai, Andrew G. Hope, Joseph A. Cook, Jin-won Song, Shannon N. Bennett, Laarni Sumibcay, Gabor Mocz, Richard Yanagihara
    Abstract:

    Background The discovery of genetically distinct hantaviruses in shrews (Order Soricomorpha, Family Soricidae) from widely separated geographic regions challenges the hypothesis that rodents (Order Rodentia, Family Muridae and Cricetidae) are the primordial reservoir hosts of hantaviruses and also predicts that other soricomorphs harbor hantaviruses. Recently, novel hantavirus genomes have been detected in moles of the Family Talpidae, including the Japanese shrew mole (Urotrichus talpoides) and American shrew mole (Neurotrichus gibbsii). We present new insights into the evolutionary history of hantaviruses gained from a highly divergent hantavirus, designated Nova virus (NVAV), identified in the European common mole (Talpa europaea) captured in Hungary.