The Experts below are selected from a list of 3399 Experts worldwide ranked by ideXlab platform
Ma Jie - One of the best experts on this subject based on the ideXlab platform.
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the mechanism of atorvastatin on the prevention of Heart Muscle Ischemia reperfusion injury
Proceeding of Clinical Medicine, 2009Co-Authors: Ma JieAbstract:Objective:To observe the role of two ATP-sensitive K+channels in the protective effect of atorvastatin(ATV)on myocardial Ischemia-reperfusion injury(IRI).Methods:Thirty-two rabbits were randomly divided into four groups:control group,ATV group,ATV+5-HD(A1),ATV+HMR1883(A2).All rabbis were subjected to 30 min Ischemia and 30 min reperfusion.The max rate of rise of left ventricular pressure(±dp/dtmax) and left ventricular end-diastolic pressure(LVEDP) were detected during the experiment.Results:Compared with the control group,the indexes of Heart function were improved significantly(P0.05) in the ATV group and the A2 group.And there was no statistically significant between the control group and A1 group(P0.05).Conclusion:The mitochondrial KATP channel is likely involved in the protective mechanism that against myocardial IRI in rabbits of ATV.
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the effects of atorvastatin on the prevention of Heart Muscle Ischemia reperfusion injury in rabbits
China Medical Herald, 2009Co-Authors: Ma JieAbstract:Objective:To observe the effect of atorvastatin(ATV) on myocardial Ischemia-reperfusion injury and the role of two ATP-sensitive K+ channels.Methods:Thirty-two rabbits were randomly divided into four groups,control group,ATV group,ATV+5-HD(A1) group,ATV+HMR1883(A2) group.All rabbits were subjected to 30 min Ischemia and 30 min reperfusion.The max rate of rise of left ventricular pressure(±dp/dtmax) and left ventricular end-diastolic pressure(LVEDP) were detected during the experiment.At the end of reperfusion,the area of necrosis and area of Ischemia were determined by Evans blue and TTC staining.Results:Compared with the control group,the indexes of Heart function were improved significantly and infarct size(AN/AAR) were reduced(P0.05) in ATV group and A2 group.And this effect was blocked by 5-HD.There was no statistically significant between the control group and A1 group(P0.05).Conclusion:Atorvastatin exerts an early cardio protective effect against myocardial Ischemia reperfusion in rabbits and mitochondrial KATP channel is likely involved in this protective mechanism.
Li Jian - One of the best experts on this subject based on the ideXlab platform.
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The effects of fluvastatin on the prevention of Heart Muscle Ischemia reperfusion injury in rabbits
Journal of Chinese Physician, 2006Co-Authors: Li JianAbstract:Objective To investigate the effects and mechanism of different dosage of fluvastatin on the prevention of Heart Muscle Ischemia reperfusion injury in rabbits.Method Thirty-five rabbits were randomly divided into 5 groups with 7 rabbits in each: sham group,myocardial Ischemia reperfusion control group,low dosage of fluvastatin pretreatment group (2 mg/kg,Group F1),middle dosage of fluvastatin pretreatment group(5 mg/kg,Group F2) and large dosage of fluvastatin pretreatment group(20 mg/kg,Group F3).The left ventricular systolic pressure(LVSP),the max rate of rise of left ventricular pressure(±dp/dt_(-max)) and left ventricular end-diastolic pressure(LVEDP) were detected during the experiment.At the end of reperfusion,the infarct size and area at risk were defined by Evans blue and TTC staining,and the levels of myocardial nitrogen monoxidum(NO) and nitricoxide synthase(NOS) were measured.Result Compared with the Ischemia reperfusion group,the indexes of Heart function improved significantly,the level of myocardial NO was increased significantly and the myocardial infarct size was decreased significantly in the groups F2 and F3.There was no significant difference between the group F1 and Ischemia reperfusion group.Conclusion Fluvastatin exerts a cardioprotective effect against myocardial Ischemia reperfusion injury in rabbits.NO is likely involved in this protective mechanism.
W U Yunliang - One of the best experts on this subject based on the ideXlab platform.
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an analysis of efficiency of atorvastatin on the prevention of Heart Muscle Ischemia reperfusion injury
China Modern Doctor, 2011Co-Authors: W U YunliangAbstract:Objective Evaluation of atorvastatin on myocardial Ischemia reperfusion injury process,improvement of cardiac function and myocardial protective effects.Methods 30 healthy male rabbits were randomly divided into 3 groups:sham operation group,Ischemia reperfusion group(I/R group),atorvastatin group(treatment group),1 hour before surgery with atropine treatment group were fed saline with 10mg/kg atorvastatin,left anterior descending coronary artery ligation after 30 minutes,open 1 hour to make rabbit model of Ischemia-reperfusion;by measured using physiological recording cardiac function,by Evans blue + 1% triphenyl tetrazolium chloride(TTC) staining,double isolated necrosis in ischemic myocardium.Results Sham perfusion before and after the LVSP,LVEDP,± dp/dtmax,were no significant differences(P0.05),I/R group and treatment group were significantly different(P0.05);compared with the sham operation group,I/R group and treatment group LVEDP increased significantly(P0.05),LVSP and ± dp/dtmax decreased significantly(P0.05);I/R group compared with the treatment group decreased LVSP and ± dp/dtmax was no significant difference(P0.05),but LVEDP increased and myocardial infarction rates declined significantly(P0.05).Conclusion Effect of atorvastatin on myocardial Ischemia and reperfusion injury.
Dong Gui-rong - One of the best experts on this subject based on the ideXlab platform.
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The Experimental Study of Effectiveness on Energy Metabolism of Cardiac Muscle of Acute Heart Muscle Ischemia Rabbits by Means of "Neiguan" Electroacupuncture
Journal of Clinical Acupuncture and Moxibustion, 2010Co-Authors: Dong Gui-rongAbstract:Objective:To observe the effectiveness on energy metabolism of cardiac Muscle through the experimental study on acute Heart Muscle Ischemia rabbits by means of "Neiguan" electro-acupuncture.And To discuss the relationship between acupuncture point and internal organs.Methods:40 healthy New Zealand rabbits were selected into 5 parts of the research: normal group,sodium chloride group,model group,one side acupuncture group and two sides acupuncture group,duplicate Heart Ischemia model on rabbits by means of PPI auditive vein injection continuously.Take tissue of cardiac Muscle to observe the change of energy metabolism under electron microscope.Results:1.After PPI auditive vein injection on rabbits,the gray scale numerical value of glycogen,SDH and ATP compared with acupuncture group were decreased under microscope(P0.05),after acupuncture the gray scale numerical value were increased by comparison with model group(P0.05).2.The therapeutic efficacy of two sides acupuncture group is more obvious than that of one side acupuncture group.Conclusion:1.Enzyme of energy metabolism changed when it bccame Heart Muscle Ischemia.The condition of Heart Muscle Ischemia were improved and the abnormality change of Heart Muscle enzyme were retrieved when electro-acupuncture on "Neiguan".2.The material activity of energy metabolism were reinforced by electro-acupuncture on "Neiguan".3.The stimulation on meridians had regulative effects on the corresponding zang-fu function.
Nawrocka Dominika - One of the best experts on this subject based on the ideXlab platform.
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Występowanie Ostrych Zespołów Wieńcowych u osób poniżej 45 roku życia: przyczyny, zagrożenia, profilaktyka
2017Co-Authors: Nawrocka DominikaAbstract:The aim of this thesis is making people aware how serious Acute Coronary Syndrome is. Risk factors were emphasized because they cause damage to human’s organism and they are a reason of circulation system diseases. At the thesis was noticed that cardiac infraction, commonly known as Heart attack, afflict more and more people under 45. Bad habits and genetic predisposition are main causes of cardiac infraction. The main source for the thesis are Central Statistics Office researches to support theory of morbidity under 45. Second chapter focuses on details about cardiac infraction within the scope of areas of Heart walls. On the other hand third chapter was oriented on treatment which is really developed these days. Modern medicine guarantee fast and successful treatment of a patient as well as appropriate diagnosis and further prophylaxis to avoid next Heart Muscle Ischemia. The role of paramedics in the thesis is emphasized because they as first have direct contact with patient and do interview and physical examination to post a diagnosis and save human’s life on the basis of symptoms and expertise
