The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
Jeremy B. Morgan - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed, Enantioselective Heine Reaction.
ACS catalysis, 2016Co-Authors: Molly Punk, Charlotte Merkley, Katlyn Kennedy, Jeremy B. MorganAbstract:Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine Reaction. The first catalytic, enantioselective Heine Reaction is reported for meso-N-acylaziridines where a palladium(II)–diphosphine complex is employed. The highly enantioenriched oxazoline products are valuable organic synthons and potential ligands for transition-metal catalysis.
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phosphine catalyzed Heine Reaction
ChemInform, 2012Co-Authors: Allen Martin, Kathleen V. Casto, William A. Morris, Jeremy B. MorganAbstract:Oxazolines (V) are formed as a single regioisomer in all cases and the aziridine (VIII) rearranges without any loss of optical purity.
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Phosphine‐Catalyzed Heine Reaction.
ChemInform, 2012Co-Authors: Allen Martin, Kathleen V. Casto, William A. Morris, Jeremy B. MorganAbstract:Oxazolines (V) are formed as a single regioisomer in all cases and the aziridine (VIII) rearranges without any loss of optical purity.
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Phosphine-Catalyzed Heine Reaction
Synfacts, 2011Co-Authors: Allen Martin, Kathleen V. Casto, William A. Morris, Jeremy B. MorganAbstract:Aziridines are important synthetic intermediates which readily undergo ring-opening Reactions. It is demonstrated that electron-rich phosphines are efficient catalysts for the regioselective rearrangement of N-acylaziridines to oxazolines. The Reactions occur in excellent yield under neutral conditions. Evidence is provided for an addition/elimination mechanism by generation of a phosphonium intermediate. Similar intermediates may be useful for the development of alternate aziridine ring-opening processes and stereoselective synthesis with enantiopure phosphines.
Molly Punk - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed, Enantioselective Heine Reaction.
ACS catalysis, 2016Co-Authors: Molly Punk, Charlotte Merkley, Katlyn Kennedy, Jeremy B. MorganAbstract:Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine Reaction. The first catalytic, enantioselective Heine Reaction is reported for meso-N-acylaziridines where a palladium(II)–diphosphine complex is employed. The highly enantioenriched oxazoline products are valuable organic synthons and potential ligands for transition-metal catalysis.
Jetze J Tepe - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of 2 imidazolines via the ring expansion of imidoyl chlorides with aziridines
Journal of Organic Chemistry, 2011Co-Authors: Michael R Kuszpit, William D Wulff, Jetze J TepeAbstract:We herein report a simple and convenient one-pot synthesis of highly substituted 2-imidazolines in a regiocontrolled and stereospecific matter through the ring expansion Reaction of an imidoyl chloride with an aziridine, analogous to the Heine Reaction.
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One-PotSynthesisof2-ImidazolinesviatheRingExpansionofImidoyl Chlorides with Aziridines
2011Co-Authors: Michael R Kuszpit, William D Wulff, Jetze J TepeAbstract:We herein report a simple and convenient one-pot synthesis of highly substituted 2-imidazolines in a regiocontrolled and stereospecific matter through the ring expansion Reaction of an imidoyl chloride with an aziridine, analogous to the Heine Reaction.
Charlotte Merkley - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed, Enantioselective Heine Reaction.
ACS catalysis, 2016Co-Authors: Molly Punk, Charlotte Merkley, Katlyn Kennedy, Jeremy B. MorganAbstract:Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine Reaction. The first catalytic, enantioselective Heine Reaction is reported for meso-N-acylaziridines where a palladium(II)–diphosphine complex is employed. The highly enantioenriched oxazoline products are valuable organic synthons and potential ligands for transition-metal catalysis.
Katlyn Kennedy - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed, Enantioselective Heine Reaction.
ACS catalysis, 2016Co-Authors: Molly Punk, Charlotte Merkley, Katlyn Kennedy, Jeremy B. MorganAbstract:Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine Reaction. The first catalytic, enantioselective Heine Reaction is reported for meso-N-acylaziridines where a palladium(II)–diphosphine complex is employed. The highly enantioenriched oxazoline products are valuable organic synthons and potential ligands for transition-metal catalysis.