The Experts below are selected from a list of 117 Experts worldwide ranked by ideXlab platform

Feng Tian - One of the best experts on this subject based on the ideXlab platform.

  • correction a rapid Hemostatic Sponge based on large mesoporous silica nanoparticles and n alkylated chitosan
    Nanoscale, 2020
    Co-Authors: Zihao Chen, Lei Han, Changjun Liu, Chao Shan, Kun Yang, Chunlai Wang, Feng Tian
    Abstract:

    Correction for ‘A rapid Hemostatic Sponge based on large, mesoporous silica nanoparticles and N-alkylated chitosan’ by Zihao Chen et al., Nanoscale, 2018, 10, 20234–20245, DOI: 10.1039/C8NR07865C.

  • a rapid Hemostatic Sponge based on large mesoporous silica nanoparticles and n alkylated chitosan
    Nanoscale, 2018
    Co-Authors: Zihao Chen, Lei Han, Changjun Liu, Chao Shan, Kun Yang, Chunlai Wang, Feng Tian
    Abstract:

    Rapid bleeding control is increasingly important in current civilian and military emergency medicine, but the rapid hemostasis achieved with current Hemostatic products is often unsafe. In this study, mesoporous silica nanoparticles (MSNs) with large pores were coordinated with a glycerol-modified N-alkylated chitosan Sponge (GACS) to develop a rapid and safe Hemostatic Sponge. Due to its coagulation-promoting structure, MSN–GACS exhibited unique Hemostatic potency in serial in vitro coagulation tests. In addition to enhanced platelet adhesion and whole blood absorption, MSN–GACS exhibited better biocompatibility than Combat Gauze (CG), which is popular in the US military. Furthermore, in rabbit femoral artery and liver injury in vivo models, MSN–GACS showed better Hemostatic efficiency and lower cardiovascular toxicity than CG. In conclusion, MSN–GACS is an excellent prehospital Hemostatic agent for first-aid applications.

Pete X - One of the best experts on this subject based on the ideXlab platform.

  • injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing
    Nature Communications, 2018
    Co-Authors: Xi Zhao, Aoli Guo, Yongping Liang, Pete X
    Abstract:

    Developing injectable antibacterial and conductive shape memory Hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin Sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better Hemostatic capability than gauze and gelatin Hemostatic Sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent Hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better Hemostatic ability than Combat Gauze in standardized circular liver bleeding model.

Ron Ofri - One of the best experts on this subject based on the ideXlab platform.

  • analgesic effects of intraorbital insertion of an absorbable gelatin Hemostatic Sponge soaked with 1 ropivacaine solution following enucleation in dogs
    Javma-journal of The American Veterinary Medical Association, 2019
    Co-Authors: Yael Shilobenjamini, Shira A Slav, Nili Kahane, Yishai Kushnir, Havi Sarfaty, Ron Ofri
    Abstract:

    OBJECTIVE To evaluate analgesic effects and complications associated with intraorbital insertion of an absorbable gelatin Hemostatic Sponge (AGHS) soaked with 1% ropivacaine solution following enuc...

  • analgesic effects of intraorbital insertion of an absorbable gelatin Hemostatic Sponge soaked with 1 ropivacaine solution following enucleation in dogs
    Javma-journal of The American Veterinary Medical Association, 2019
    Co-Authors: Yael Shilobenjamini, Shira A Slav, Nili Kahane, Yishai Kushnir, Havi Sarfaty, Ron Ofri
    Abstract:

    OBJECTIVE To evaluate analgesic effects and complications associated with intraorbital insertion of an absorbable gelatin Hemostatic Sponge (AGHS) soaked with 1% ropivacaine solution following enucleation in dogs. ANIMALS 20 client-owned dogs undergoing enucleation. PROCEDURES Dogs were randomly assigned to receive an AGHS soaked with 1% ropivacaine solution (n = 10) or saline (0.9% NaCl) solution (control group; 10) inserted intraorbitally prior to skin closure following enucleation. Carprofen (2 mg/kg [0.9 mg/lb]) was administered SC once after orotracheal extubation and then PO twice a day for 5 days. During the postoperative recovery period, apparent pain level was scored at various points with a modified short-form Glasgow Composite Pain Scale (score range, 0 to 19), and methadone was administered for rescue analgesia if any score was ≥ 5. After dogs returned home, owners recorded their behavior and apparent pain level for the first 3 days following enucleation. RESULTS At extubation, the median (range) pain score was significantly higher in the control group (8 [2 to 14]) versus the ropivacaine group (3 [1 to 7]). A greater proportion of dogs in the control group received methadone (7/10 vs 1/10) and had crying or attention-seeking behavior on the first day following enucleation (7/10 vs 1/10). No complications were observed in either group. CONCLUSIONS AND CLINICAL RELEVANCE Addition of intraorbital insertion of a ropivacaine-soaked AGHS to the analgesic protocol for dogs undergoing enucleation provided better analgesia than was achieved without this treatment as measured immediately and the first day after surgery, with no noted adverse effects.

Xiaoying Wang - One of the best experts on this subject based on the ideXlab platform.

  • corn stalk agnps modified chitin composite Hemostatic Sponge with high absorbency rapid shape recovery and promoting wound healing ability
    Chemical Engineering Journal, 2021
    Co-Authors: Qimeng Jiang, Bichong Luo, Xiaoying Wang
    Abstract:

    Abstract Uncontrolled hemorrhage before hospitalization and infection are two great challenges for the safety of human life. Although chitin (CH) is a kind of effective Hemostatic materials, it presents poor softness and antibacterial activity, which hinders its potential application. Herein, for the first time, loose corn stalk (CS) and silver nanoparticles (AgNPs) were used to adjust the dense structures and poor antibacterial activities of solo chitin Sponge. And then the crosslinked CH/CS/AgNPs Sponge was used as antibacterial Hemostatic material. The results show that the blood absorbing ratio of CH/CS/AgNPs was 2.4-fold and 2.7-fold higher than those of solo CH and commercial polyvinyl formal Sponge (PVF), respectively. In vitro blood clotting index (19%) of CH/CS/AgNPs was also lower than those of solo CH (45%) and PVF (65%). In vivo rat liver injury results further indicate that the Sponge had high Hemostatic efficiency without causing inflammation. Besides, the cytotoxicity assay and hemolysis (3.18%) exhibited favorable biocompatibility and nontoxicity. Notably, the Sponge showed excellent antibacterial properties against E. coli and S. aureus and the wound closure rate treated by CH/CS/AgNPs Sponge reached to 76.5% after 11 days. This work proposes new ideas for the study of antibacterial Hemostatic materials by introducing agricultural waste into medical Hemostatic field.

Zihao Chen - One of the best experts on this subject based on the ideXlab platform.

  • correction a rapid Hemostatic Sponge based on large mesoporous silica nanoparticles and n alkylated chitosan
    Nanoscale, 2020
    Co-Authors: Zihao Chen, Lei Han, Changjun Liu, Chao Shan, Kun Yang, Chunlai Wang, Feng Tian
    Abstract:

    Correction for ‘A rapid Hemostatic Sponge based on large, mesoporous silica nanoparticles and N-alkylated chitosan’ by Zihao Chen et al., Nanoscale, 2018, 10, 20234–20245, DOI: 10.1039/C8NR07865C.

  • a rapid Hemostatic Sponge based on large mesoporous silica nanoparticles and n alkylated chitosan
    Nanoscale, 2018
    Co-Authors: Zihao Chen, Lei Han, Changjun Liu, Chao Shan, Kun Yang, Chunlai Wang, Feng Tian
    Abstract:

    Rapid bleeding control is increasingly important in current civilian and military emergency medicine, but the rapid hemostasis achieved with current Hemostatic products is often unsafe. In this study, mesoporous silica nanoparticles (MSNs) with large pores were coordinated with a glycerol-modified N-alkylated chitosan Sponge (GACS) to develop a rapid and safe Hemostatic Sponge. Due to its coagulation-promoting structure, MSN–GACS exhibited unique Hemostatic potency in serial in vitro coagulation tests. In addition to enhanced platelet adhesion and whole blood absorption, MSN–GACS exhibited better biocompatibility than Combat Gauze (CG), which is popular in the US military. Furthermore, in rabbit femoral artery and liver injury in vivo models, MSN–GACS showed better Hemostatic efficiency and lower cardiovascular toxicity than CG. In conclusion, MSN–GACS is an excellent prehospital Hemostatic agent for first-aid applications.