The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Baolin Guo - One of the best experts on this subject based on the ideXlab platform.
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injectable dry cryogels with excellent blood sucking expansion and blood clotting to cease hemorrhage for lethal deep wounds coagulopathy and tissue regeneration
Chemical Engineering Journal, 2021Co-Authors: Xin Zhao, Baolin Guo, Yongping Liang, Zhanhai Yin, Dun Zhu, Yong HanAbstract:Abstract Designing expandable dry cryogels with biodegradability, rapid blood-sucking expansion and hemostasis for lethal non-compressible hemorrhage and coagulopathy hemorrhage still remains a challenge. Herein, we designed a series of antioxidant, photo-thermal and antibacterial expandable dry cryogels based on polydopamine crosslinked chitosan. The cryogels presented excellent antioxidant activity, outstanding NIR-enhanced antibacterial activity, rapid thrombin release, better blood clotting capacity, and higher blood cells/platelets adhesion and activation than Combat Gauze and gelatin sponge. Besides, all the cryogels showed less blood losses than Combat Gauze and gelatin sponge in mouse liver trauma model, and CS20/PDA4.5 (prepared by 20 mg chitosan and 4.5 mg dopamine) showed the least blood loss. Moreover, CS20/PDA4.5 presented much better hemostatic performance than Combat Gauze and gelatin sponge in rabbit liver non-compressible hemorrhage model with and without administrating anticoagulant. Especially, CS20/PDA4.5 presented excellent hemostatic performance in lethal non-compressible swine subclavian artery and vein transection model. Furthermore, the cryogel showed better wound healing performance than chitosan sponge and Tegaderm™ film. This facile approach opens up new avenue to develop expandable dry cryogels hemostats for lethal non-compressible hemorrhage, coagulopathy hemorrhage and tissue engineering.
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multifunctional tissue adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair
ACS Applied Materials & Interfaces, 2020Co-Authors: Zhiyi Zhang, Yongping Liang, Baolin GuoAbstract:Cryogels with tissue adhesion have great potential as wound dressings for rapid hemostasis for uncontrollable nonpressing surface hemorrhage and wound healing, but their use has not been reported previously. Herein, we designed a series of antibacterial and antioxidant tissue-adhesive cryogels based on quaternized chitosan (QCS) and polydopamine (PDA). These cryogels had good blood cell and platelet adhesion, enrichment, and activation properties for rapid nonpressing surface hemostasis and wound healing. The cryogels exhibited outstanding mechanical strength and easy removability, antioxidant activity, and NIR photothermal-enhanced antibacterial performance. The cryogels showed much better hemostasis than gauze and gelatin sponge in a standardized strip rat liver injury model, a standardized circular rabbit liver section model, and a pig skin laceration model. Furthermore, the excellent hemostatic performance of the QCS/PDA2.0 cryogel (containing 20 mg/mL QCS and 2.0 mg/mL PDA) for coagulopathic hemorrhages was confirmed in a standardized coagulation disorder rabbit circular liver section model. In addition, the QCS/PDA2.0 cryogel promoted rapid hemostasis in a deep noncompressible wound and a much better wound healing effect than a chitosan sponge and Tegaderm film in a full-thickness skin defect model. Overall, these multifunctional tissue-adhesive cryogels with excellent hemostatic performance and enhanced wound healing properties are suitable candidates for tissue-adhesive hemostat and wound healing dressings.
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electroactive anti oxidant polyurethane elastomers with shape memory property as non adherent wound dressing to enhance wound healing
Chemical Engineering Journal, 2019Co-Authors: Jing Chen, Peter X, Mengting Shi, Hualei Zhang, Baolin GuoAbstract:Abstract Development of wound dressings that not only have multiple advantages including good barrier properties, elasticity and shape memory properties, but also show anti-infection, anti-oxidative and promote cell adhesion, proliferation to enhance wound healing process, remains an ongoing challenge in the skin tissue engineering. Herein, we designed and synthesized a series of electroactive shape memory polyurethane-urea elastomers by combining the mechanical properties of polycaprolactone (PCL) segments, wettability of polyethylene glycol (PEG) segments and electroactivity of aniline trimer (AT) segments, as antibacterial, anti-oxidant and electroactive film dressing for cutaneous wound healing. The films displayed suitable hydrophilicity and swelling ratio, excellent mechanical and shape memory properties, electroactivity, free radical scavenging capacity, non-adherent property and biocompatibility. Excitingly, the electroactive film with an optimal concentration of 12 wt% AT promoted mouse fibroblasts (L929) adhesion and proliferation, and it also significantly accelerated in vivo wound healing process than no-electroactive film and commercial dressing (Tegaderm™ film) through promoting granulation tissue thickness and collagen deposition in a full-thickness skin defect model. Moreover, after loading with vancomycin as antibacterial agents, the rate of wound healing is further enhanced. In summary, the electroactive shape memory polyurethane-urea films significantly promoted in vivo wound healing process attributed to its multifunctional properties indicated that they are excellent candidates as film wound dressing.
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adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full thickness skin regeneration during wound healing
Small, 2019Co-Authors: Yongping Liang, Xin Zhao, Baojun Chen, Zhanhai Yin, Peter X, Baolin GuoAbstract:Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self-healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full-thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full-thickness skin repair.
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Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing
Biomaterials, 2017Co-Authors: Xin Zhao, Yusheng Qiu, Baolin Guo, Ruonan Dong, Hao Wu, Peter X. MaAbstract:Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive self-healed hydrogels based on quaternized chitosan-g-polyaniline (QCSP) and benzaldehyde group functionalized poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-FA) as antibacterial, anti-oxidant and electroactive dressing for cutaneous wound healing. These hydrogels presented good self-healing, electroactivity, free radical scavenging capacity, antibacterial activity, adhesiveness, conductivity, swelling ratio, and biocompatibility. Interestingly, the hydrogel with an optimal crosslinker concentration of 1.5 wt% PEGS-FA showed excellent in vivo blood clotting capacity, and it significantly enhanced in vivo wound healing process in a full-thickness skin defect model than quaternized chitosan/PEGS-FA hydrogel and commercial dressing (Tegaderm™ film) by upregulating the gene expression of growth factors including VEGF, EGF and TGF-β and then promoting granulation tissue thickness and collagen deposition. Taken together, the antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.
Yongping Liang - One of the best experts on this subject based on the ideXlab platform.
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injectable dry cryogels with excellent blood sucking expansion and blood clotting to cease hemorrhage for lethal deep wounds coagulopathy and tissue regeneration
Chemical Engineering Journal, 2021Co-Authors: Xin Zhao, Baolin Guo, Yongping Liang, Zhanhai Yin, Dun Zhu, Yong HanAbstract:Abstract Designing expandable dry cryogels with biodegradability, rapid blood-sucking expansion and hemostasis for lethal non-compressible hemorrhage and coagulopathy hemorrhage still remains a challenge. Herein, we designed a series of antioxidant, photo-thermal and antibacterial expandable dry cryogels based on polydopamine crosslinked chitosan. The cryogels presented excellent antioxidant activity, outstanding NIR-enhanced antibacterial activity, rapid thrombin release, better blood clotting capacity, and higher blood cells/platelets adhesion and activation than Combat Gauze and gelatin sponge. Besides, all the cryogels showed less blood losses than Combat Gauze and gelatin sponge in mouse liver trauma model, and CS20/PDA4.5 (prepared by 20 mg chitosan and 4.5 mg dopamine) showed the least blood loss. Moreover, CS20/PDA4.5 presented much better hemostatic performance than Combat Gauze and gelatin sponge in rabbit liver non-compressible hemorrhage model with and without administrating anticoagulant. Especially, CS20/PDA4.5 presented excellent hemostatic performance in lethal non-compressible swine subclavian artery and vein transection model. Furthermore, the cryogel showed better wound healing performance than chitosan sponge and Tegaderm™ film. This facile approach opens up new avenue to develop expandable dry cryogels hemostats for lethal non-compressible hemorrhage, coagulopathy hemorrhage and tissue engineering.
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multifunctional tissue adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair
ACS Applied Materials & Interfaces, 2020Co-Authors: Zhiyi Zhang, Yongping Liang, Baolin GuoAbstract:Cryogels with tissue adhesion have great potential as wound dressings for rapid hemostasis for uncontrollable nonpressing surface hemorrhage and wound healing, but their use has not been reported previously. Herein, we designed a series of antibacterial and antioxidant tissue-adhesive cryogels based on quaternized chitosan (QCS) and polydopamine (PDA). These cryogels had good blood cell and platelet adhesion, enrichment, and activation properties for rapid nonpressing surface hemostasis and wound healing. The cryogels exhibited outstanding mechanical strength and easy removability, antioxidant activity, and NIR photothermal-enhanced antibacterial performance. The cryogels showed much better hemostasis than gauze and gelatin sponge in a standardized strip rat liver injury model, a standardized circular rabbit liver section model, and a pig skin laceration model. Furthermore, the excellent hemostatic performance of the QCS/PDA2.0 cryogel (containing 20 mg/mL QCS and 2.0 mg/mL PDA) for coagulopathic hemorrhages was confirmed in a standardized coagulation disorder rabbit circular liver section model. In addition, the QCS/PDA2.0 cryogel promoted rapid hemostasis in a deep noncompressible wound and a much better wound healing effect than a chitosan sponge and Tegaderm film in a full-thickness skin defect model. Overall, these multifunctional tissue-adhesive cryogels with excellent hemostatic performance and enhanced wound healing properties are suitable candidates for tissue-adhesive hemostat and wound healing dressings.
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anti oxidant electroactive and antibacterial nanofibrous wound dressings based on poly e caprolactone quaternized chitosan graft polyaniline for full thickness skin wound healing
Chemical Engineering Journal, 2020Co-Authors: Jiahui He, Yongping LiangAbstract:Abstract Developing a novel nanofibrous wound dressing with multi-functional properties, integrating suitable mechanical property, electroactivity, anti-oxidant and inherent antibacterial activity to promote wound healing process is urgently desired, which could meet the increasing requirements of clinical needs. Herein, a series of antibacterial, anti-oxidant and electroactive nanofibrous membranes were fabricated by electrospinning poly(e-caprolactone) (PCL) and quaternized chitosan-graft-polyaniline (QCSP) polymer solutions which combined the good mechanical property of PCL and multi-functionality of QCSP. The nanofibrous wound dressings exhibited electroactivity, similar mechanical properties to soft tissue, free radical scavenging capacity, antibacterial property, and biocompatibility. In particular, PCL/QCSP15 (15 wt% of QCSP in the sample) showed a good balanced ability between antibacterial activity and cell proliferation, which significantly accelerated the healing process of wound in a mouse full-thickness wounds defect model than commercial dressing (Tegaderm™ Film) and pure PCL (PCL/QCSP0) nanofibrous membrane. Moreover, the histopathological examination and immunofluorescence staining showed that the wounds treated by PCL/QCSP15 nanofiber dressing exhibited higher collagen deposition, granulation tissue thickness, and more angiogenesis. In one word, these antibacterial, anti-oxidant, electroactivity nanofibrous membranes showed promising applications for full-thickness skin repair.
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adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full thickness skin regeneration during wound healing
Small, 2019Co-Authors: Yongping Liang, Xin Zhao, Baojun Chen, Zhanhai Yin, Peter X, Baolin GuoAbstract:Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self-healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full-thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full-thickness skin repair.
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injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing
Nature Communications, 2018Co-Authors: Xi Zhao, Aoli Guo, Yongping Liang, Pete XAbstract:Developing injectable antibacterial and conductive shape memory hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better hemostatic capability than gauze and gelatin hemostatic sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better hemostatic ability than Combat Gauze in standardized circular liver bleeding model.
Guang Yang - One of the best experts on this subject based on the ideXlab platform.
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biodegradable and electroactive regenerated bacterial cellulose mxene ti3c2tx composite hydrogel as wound dressing for accelerating skin wound healing under electrical stimulation
Advanced Healthcare Materials, 2020Co-Authors: Lin Mao, Yihua Gao, Li Wang, Weiwei Zhao, Haoyan Cheng, Lin Xia, Shangxian Xie, Zhijun Shi, Guang YangAbstract:Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity. An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
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biodegradable and electroactive regenerated bacterial cellulose mxene ti 3 c 2 t x composite hydrogel as wound dressing for accelerating skin wound healing under electrical stimulation
Advanced Healthcare Materials, 2020Co-Authors: Lin Mao, Yihua Gao, Li Wang, Weiwei Zhao, Haoyan Cheng, Lin Xia, Shangxian Xie, Zhijun Shi, Guang YangAbstract:Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity. An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
Ruben J Azocar - One of the best experts on this subject based on the ideXlab platform.
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Correction to: The effect of Tegaderm™ versus EyeGard® on eyelid erythema during general anesthesia: a randomized-controlled trial
Canadian Journal of Anesthesia Journal canadien d'anesthésie, 2020Co-Authors: Dan M Drzymalski, Katelyn Ward, Josephine M Hernandez, Joyce Hoot, Feishiuann Clarissa Yang, Shiuchung Au, Ruben J AzocarAbstract:In the article entitled: “The effect of Tegaderm™ versus EyeGard® on eyelid erythema during general anesthesia: a randomized-controlled trial” published online and in the May 2020 print issue of the Journal, Can J Anesth 2020; DOI: 10.1007/s12630-020-01588-6, the trial registration date in the abstract should read 25 May, 2018 (instead of 8 June, 2018).
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the effect of Tegaderm versus eyegard on eyelid erythema during general anesthesia a randomized controlled trial
Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 2020Co-Authors: Dan M Drzymalski, Katelyn Ward, Josephine M Hernandez, Joyce Hoot, Feishiuann Clarissa Yang, Shiuchung Au, Ruben J AzocarAbstract:PURPOSE: Application of adhesive tape to the eyelids during general anesthesia decreases the risk of corneal abrasion but may increase the risk of eyelid injury. The aim of this study was to determine if there is a difference in eyelid erythema when covering the eyelid with either Tegaderm or an EyeGard(R). METHODS: We conducted a prospective, randomized, double-blind, split-face study of patients undergoing general anesthesia at an urban tertiary care academic medical centre. Each patient was randomized to having one eyelid covered with Tegaderm and the other with EyeGard. Photographs were taken prior to extubation and evaluated by three dermatologists. The primary outcome was the incidence of postoperative eyelid erythema. Secondary outcomes included the incidence of corneal abrasion and patient satisfaction. RESULTS: A total of 151 patients were included in our final analysis. Erythema was present on 117 (77%) eyelids covered with Tegaderm and 105 (70%) eyelids covered with EyeGard (% difference, 8; 95% confidence interval, 2 to 14; P = 0.03). No corneal abrasions were reported. The median [interquartile range] patient satisfaction score with eyelid condition was similar with Tegaderm vs EyeGard (5 [5-5] vs 5 [5-5], respectively; P = 0.84). CONCLUSION: We found a small increase in postoperative eyelid erythema when using Tegaderm compared with EyeGard. While EyeGard could decrease the risk of eyelid erythema, this should be balanced against other potential benefits of Tegaderm such as protection from fluids leaking onto the cornea. TRIAL REGISTRATION: www.ClinicalTrials.gov (NCT03549429); registered 8 June, 2018.
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the effect of Tegaderm versus eyegard on eyelid erythema during general anesthesia a randomized controlled trial
Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 2020Co-Authors: Dan M Drzymalski, Katelyn Ward, Josephine M Hernandez, Joyce Hoot, Feishiuann Clarissa Yang, Ruben J AzocarAbstract:Application of adhesive tape to the eyelids during general anesthesia decreases the risk of corneal abrasion but may increase the risk of eyelid injury. The aim of this study was to determine if there is a difference in eyelid erythema when covering the eyelid with either Tegaderm™ or an EyeGard®. We conducted a prospective, randomized, double-blind, split-face study of patients undergoing general anesthesia at an urban tertiary care academic medical centre. Each patient was randomized to having one eyelid covered with Tegaderm and the other with EyeGard. Photographs were taken prior to extubation and evaluated by three dermatologists. The primary outcome was the incidence of postoperative eyelid erythema. Secondary outcomes included the incidence of corneal abrasion and patient satisfaction. A total of 151 patients were included in our final analysis. Erythema was present on 117 (77%) eyelids covered with Tegaderm and 105 (70%) eyelids covered with EyeGard (% difference, 8; 95% confidence interval, 2 to 14; P = 0.03). No corneal abrasions were reported. The median [interquartile range] patient satisfaction score with eyelid condition was similar with Tegaderm vs EyeGard (5 [5–5] vs 5 [5–5], respectively; P = 0.84). We found a small increase in postoperative eyelid erythema when using Tegaderm compared with EyeGard. While EyeGard could decrease the risk of eyelid erythema, this should be balanced against other potential benefits of Tegaderm such as protection from fluids leaking onto the cornea. www.ClinicalTrials.gov (NCT03549429); registered 8 June, 2018.
Lin Mao - One of the best experts on this subject based on the ideXlab platform.
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biodegradable and electroactive regenerated bacterial cellulose mxene ti3c2tx composite hydrogel as wound dressing for accelerating skin wound healing under electrical stimulation
Advanced Healthcare Materials, 2020Co-Authors: Lin Mao, Yihua Gao, Li Wang, Weiwei Zhao, Haoyan Cheng, Lin Xia, Shangxian Xie, Zhijun Shi, Guang YangAbstract:Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity. An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
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biodegradable and electroactive regenerated bacterial cellulose mxene ti 3 c 2 t x composite hydrogel as wound dressing for accelerating skin wound healing under electrical stimulation
Advanced Healthcare Materials, 2020Co-Authors: Lin Mao, Yihua Gao, Li Wang, Weiwei Zhao, Haoyan Cheng, Lin Xia, Shangxian Xie, Zhijun Shi, Guang YangAbstract:Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity. An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
