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B Samiey - One of the best experts on this subject based on the ideXlab platform.
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speeds of sound and isentropic compressibilities of binary mixtures of 1 Heptanol 1 2 dichloroethane 1 1 1 trichloroethane 1 1 2 2 tetrachloroethane trichloroethylene and tetrachloroethylene at 303 15 k comparison with theories
Physics and Chemistry of Liquids, 2007Co-Authors: H Iloukhani, B SamieyAbstract:Densities ρ, and speeds of sound u, of the binary mixtures of 1-Heptanol with 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, trichloroethylene, and tetrachloroethylene have been measured over the complete composition range at 303.15 K. Isentropic compressibility κs, and Isentropic compressibility deviations Δκs were calculated, and were correlated by a Redlich–Kister type function to determine the fitting parameters and the SDs. The results are consistent with the self-association of 1-Heptanol and the polar and nonpolar characters of used chloroethanes or chloroethylenes, which produce the dissociation of 1-Heptanol. Speeds of sound and isentropic compressibilities have been compared with calculated values from Jacobson free length theory, Schaaff collision factor theory, Nomoto relation, Junjie relation and Van Deal ideal mixing relation.
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excess molar volumes viscosities and speeds of sound of the ternary mixture 1 Heptanol 1 trichloroethylene 2 methylcyclohexane 3 at t 298 15 k
The Journal of Chemical Thermodynamics, 2007Co-Authors: H Iloukhani, B SamieyAbstract:Abstract Densities (ρ), viscosities (η), and speeds of sound (u) of the ternary mixture (1-Heptanol + trichloroethylene + methylcyclohexane) and the involved binary mixtures (1-Heptanol + trichloroethylene), (1-Heptanol + methylcyclohexane), and (trichloroethylene + methylcyclohexane) at 298.15 K were measured over the whole composition range. The data obtained are used to calculate excess molar volumes (VE), excess isobaric thermal expansivity (αE), viscosity deviations (Δη), excess Gibbs free energies of activation of viscous flow (ΔG∗E), and excess isentropic compressibilities ( κ S E ) of the binary and ternary mixtures. The data of the binary systems were fitted to the Redlich–Kister equation while the best correlation method for the ternary system was found using the Nagata equation. Viscosities, speeds of sound and isentropic compressibilities of the binary and ternary mixtures have been correlated by means of several empirical and semi-empirical equations. The best correlation method for viscosities of binary systems is found using the Iulan et al. equation and for the ternary system using the McAllister equation. The best correlation method for speeds of sound and isentropic compressibilities of the binary systems is found using the IMR and for the ternary system using the IMR and JR.
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studies of viscosities and excess molar volumes of the binary mixtures of 1 Heptanol 1 2 dichloroethane 1 1 1 trichloroethane 1 1 2 2 tetrachloroethane trichloroethylene and tetrachloroethylene at 293 15 298 15 and 303 15 k for the liquid region and at ambient pressure
Journal of Chemical & Engineering Data, 2005Co-Authors: H Iloukhani, B SamieyAbstract:Densities (ρ) and viscosities (η) of the binary mixtures of 1-Heptanol with 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, trichloroethylene, and tetrachloroethylene have been measured at (293.15, 298.15, and 303.15) K for the liquid region and at ambient pressure for the whole composition range. Excess molar volumes (V E), excess thermal expansivities (αE), and viscosity deviations (δη) were calculated and correlated by Redlich−Kister type function to determine the fitting parameters and the standard deviations. The results are consistent with the self-association of 1-Heptanol and the polar and nonpolar characters of used chloroethanes or chloroethylenes, which produce the dissociation of 1-Heptanol. The two-parameter Heric interaction model has also been used to correlate the kinematic viscosities of binary liquid mixtures with mole fractions.
H Iloukhani - One of the best experts on this subject based on the ideXlab platform.
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speeds of sound and isentropic compressibilities of binary mixtures of 1 Heptanol 1 2 dichloroethane 1 1 1 trichloroethane 1 1 2 2 tetrachloroethane trichloroethylene and tetrachloroethylene at 303 15 k comparison with theories
Physics and Chemistry of Liquids, 2007Co-Authors: H Iloukhani, B SamieyAbstract:Densities ρ, and speeds of sound u, of the binary mixtures of 1-Heptanol with 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, trichloroethylene, and tetrachloroethylene have been measured over the complete composition range at 303.15 K. Isentropic compressibility κs, and Isentropic compressibility deviations Δκs were calculated, and were correlated by a Redlich–Kister type function to determine the fitting parameters and the SDs. The results are consistent with the self-association of 1-Heptanol and the polar and nonpolar characters of used chloroethanes or chloroethylenes, which produce the dissociation of 1-Heptanol. Speeds of sound and isentropic compressibilities have been compared with calculated values from Jacobson free length theory, Schaaff collision factor theory, Nomoto relation, Junjie relation and Van Deal ideal mixing relation.
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excess molar volumes viscosities and speeds of sound of the ternary mixture 1 Heptanol 1 trichloroethylene 2 methylcyclohexane 3 at t 298 15 k
The Journal of Chemical Thermodynamics, 2007Co-Authors: H Iloukhani, B SamieyAbstract:Abstract Densities (ρ), viscosities (η), and speeds of sound (u) of the ternary mixture (1-Heptanol + trichloroethylene + methylcyclohexane) and the involved binary mixtures (1-Heptanol + trichloroethylene), (1-Heptanol + methylcyclohexane), and (trichloroethylene + methylcyclohexane) at 298.15 K were measured over the whole composition range. The data obtained are used to calculate excess molar volumes (VE), excess isobaric thermal expansivity (αE), viscosity deviations (Δη), excess Gibbs free energies of activation of viscous flow (ΔG∗E), and excess isentropic compressibilities ( κ S E ) of the binary and ternary mixtures. The data of the binary systems were fitted to the Redlich–Kister equation while the best correlation method for the ternary system was found using the Nagata equation. Viscosities, speeds of sound and isentropic compressibilities of the binary and ternary mixtures have been correlated by means of several empirical and semi-empirical equations. The best correlation method for viscosities of binary systems is found using the Iulan et al. equation and for the ternary system using the McAllister equation. The best correlation method for speeds of sound and isentropic compressibilities of the binary systems is found using the IMR and for the ternary system using the IMR and JR.
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studies of viscosities and excess molar volumes of the binary mixtures of 1 Heptanol 1 2 dichloroethane 1 1 1 trichloroethane 1 1 2 2 tetrachloroethane trichloroethylene and tetrachloroethylene at 293 15 298 15 and 303 15 k for the liquid region and at ambient pressure
Journal of Chemical & Engineering Data, 2005Co-Authors: H Iloukhani, B SamieyAbstract:Densities (ρ) and viscosities (η) of the binary mixtures of 1-Heptanol with 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, trichloroethylene, and tetrachloroethylene have been measured at (293.15, 298.15, and 303.15) K for the liquid region and at ambient pressure for the whole composition range. Excess molar volumes (V E), excess thermal expansivities (αE), and viscosity deviations (δη) were calculated and correlated by Redlich−Kister type function to determine the fitting parameters and the standard deviations. The results are consistent with the self-association of 1-Heptanol and the polar and nonpolar characters of used chloroethanes or chloroethylenes, which produce the dissociation of 1-Heptanol. The two-parameter Heric interaction model has also been used to correlate the kinematic viscosities of binary liquid mixtures with mole fractions.
Gary Tse - One of the best experts on this subject based on the ideXlab platform.
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gap junction inhibition by Heptanol increases ventricular arrhythmogenicity by reducing conduction velocity without affecting repolarization properties or myocardial refractoriness in langendorff perfused mouse hearts
Molecular Medicine Reports, 2016Co-Authors: Gary Tse, Vivian Tse, Jie Ming Yeo, Joseph Kwan, Bing SunAbstract:In the current study, arrhythmogenic effects of the gap junction inhibitor Heptanol (0.05 mM) were examined in Langendorff-perfused mouse hearts. Monophasic action potential recordings were obtained from the left ventricular epicardium during right ventricular pacing. Regular activity was observed both prior and subsequent to application of Heptanol in all of the 12 hearts studied during 8 Hz pacing. By contrast, induced ventricular tachycardia (VT) was observed after Heptanol treatment in 6/12 hearts using a S1S2 protocol (Fisher's exact test; P 0.05). Consequently, excitation wavelengths (λ; CV x ERP) were reduced from 9.1±0.6 to 6.5±0.6 mm (P 0.05). Together, these observations demonstrate for the first time, to the best of our knowledge, that inhibition of gap junctions alone using a low Heptanol concentration (0.05 mM) was able to reduce CV, which alone was sufficient to permit the induction of VT using premature stimulation by reducing λ, which therefore appears central in the determination of arrhythmic tendency.
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Restitution analysis of alternans using dynamic pacing and its comparison with S1S2 restitution in Heptanol-treated, hypokalaemic Langendorff-perfused mouse hearts.
Biomedical reports, 2016Co-Authors: Gary Tse, Sheung Ting Wong, Vivian Tse, Jie Ming YeoAbstract:Action potential duration (APD) and conduction velocity restitution explain the dependence of these parameters on the previous diastolic interval (DI). It is considered to be an adaptive mechanism for preserving diastole at fast heart rates. Hypokalaemia is known to induce ventricular arrhythmias that could be prevented by Heptanol, the gap junction uncoupler, mediated through increases in ventricular refractory period (VERP) without alterations in APDs. The present study investigated alternans and restitution properties during normokalaemia, hypokalaemia alone or hypokalaemia with Heptanol (0.1 mM) in Langendorff-perfused mouse hearts using a dynamic pacing protocol. APD90 alternans were elicited in the epicardium and endocardium during normokalaemia. Hypokalaemia increased the amplitudes of epicardial APD90 alternans when basic cycle lengths (BCLs) were ≤65 msec, which was associated with increases in maximum APD90 restitution gradients, critical DIs and APD90 heterogeneity. Heptanol (0.1 mM) did not exacerbate or reduce the APD90 alternans or alter these restitution parameters further. By contrast, endocardial APD90 alternans did not show increases in amplitudes during hypokalaemia at short BCLs studied, and restitution parameters were also unchanged. This was true whether in the presence or absence of 0.1 mM Heptanol. The study demonstrates that anti-arrhythmic effects of Heptanol exerted during hypokalaemia occurred despite exacerbation of APD90 alternans. This would suggest that even in the presence of arrhythmogenic APD90 alternans, arrhythmias could still be prevented by influencing VERP alone. Restitution data obtained here by dynamic pacing were compared to previous data from S1S2 pacing.
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ventricular anti arrhythmic effects of Heptanol in hypokalaemic langendorff perfused mouse hearts
Biomedical Reports, 2016Co-Authors: Gary Tse, Vivian Tse, Jie Ming YeoAbstract:Ventricular arrhythmic and electrophysiological properties were examined during normokalaemia (5.2 mM [K+]), hypokalaemia (3 mM [K+]) or hypokalaemia in the presence of 0.1 or 2 mM Heptanol in Langendorff-perfused mouse hearts. Left ventricular epicardial or endocardial monophasic action potential recordings were obtained during right ventricular pacing. Hypokalaemia induced ventricular premature beats (VPBs) in 5 of 7 and ventricular tachycardia (VT) in 6 of 7 hearts (P 0.05), reducing excitation wavelengths (λ, CV × VERP) from 7.9±1.1 to 5.1±0.3 mm (P 0.001). Heptanol (0.1 mM) prevented VT, restored effective refractory period (ERP) to 45.2±2.9 msec without altering CV or APD, returning λ to control values (P>0.05) and CI to 8.4±3.8 msec (P 0.05), returning λ and CI to control values (P>0.05). Anti-arrhythmic effects of Heptanol during hypokalaemia were explicable by ERP changes, scaling λ and CI.
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atrial anti arrhythmic effects of Heptanol in langendorff perfused mouse hearts
PLOS ONE, 2016Co-Authors: Gary Tse, Vivian Tse, Jie Ming Yeo, Bing SunAbstract:Acute effects of Heptanol (0.1 to 2 mM) on atrial electrophysiology were explored in Langendorff-perfused mouse hearts. Left atrial bipolar electrogram or monophasic action potential recordings were obtained during right atrial stimulation. Regular pacing at 8 Hz elicited atrial activity in 11 out of 11 hearts without inducing atrial arrhythmias. Programmed electrical stimulation using a S1S2 protocol provoked atrial tachy-arrhythmias in 9 of 17 hearts. In the initially arrhythmic group, 2 mM Heptanol exerted anti-arrhythmic effects (Fisher’s exact test, P 0.05), which led to increases in ERP/latency ratio from 1.4 ± 0.1 to 2.1 ± 0.2 and ERP/APD90 ratio from 1.0 ± 0.1 to 2.1 ± 0.2 (P 0.05), leaving both AERP/latency ratio (2.1 ± 0.3 vs. 1.9 ± 0.2; P > 0.05) and ERP/APD90 ratio (2.0 ± 0.2 vs. 2.1 ± 0.1; P > 0.05) unaltered. Lower Heptanol concentrations (0.1, 0.5 and 1 mM) did not alter arrhythmogenicity or the above parameters. The present findings contrast with known ventricular pro-arrhythmic effects of Heptanol associated with decreased ERP/latency ratio, despite increased ERP/APD ratio observed in both the atria and ventricles.
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Ventricular arrhythmogenesis following slowed conduction in Heptanol-treated, Langendorff-perfused mouse hearts
The Journal of Physiological Sciences, 2012Co-Authors: Gary Tse, Andrew A Grace, Sandeep S. Hothi, Christopher L.-h. HuangAbstract:Arrhythmogenic effects of slowed action potential conduction produced by the gap junction and sodium-channel inhibitor Heptanol (0.1–2 m M ) were explored in Langendorff-perfused mouse hearts. Monophasic action potential recordings showed that 2 m M Heptanol induced ventricular tachycardia in the absence of triggered activity arising from early or after-depolarizations during regular 8 Hz pacing and programmed electrical stimulation (PES). It also increased activation latencies and ventricular effective refractory periods (VERPs), but did not alter action potential duration (APD), thereby reducing local critical intervals for re-excitation given by APD_90 − VERP. Bipolar electrogram recordings showed that 2 m M Heptanol increased electrogram duration (EGD) and ratios of EGDs obtained at the longest to those obtained at the shortest S1S2 intervals studied during PES, suggesting increased dispersion of conduction velocities. These findings show, for the first time in the mouse heart, that slowed conduction induces reversible arrhythmogenic effects despite repolarization abnormalities expected to reduce arrhythmogenicity.
Hidenori Kosaka - One of the best experts on this subject based on the ideXlab platform.
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Combustion and emission characteristics of a common rail diesel engine run with n-Heptanol-methyl oleate mixtures
Energy, 2021Co-Authors: Ahmed I. El-seesy, Hidenori KosakaAbstract:Abstract The purpose of the current study is to inspect the influence of the addition of n-Heptanol with methyl oleate biodiesel fuel at various blending ratio on the combustion and emission parameters of a common rail diesel engine to attain their optimum ratio. The n-Heptanol is added at 10%, 20%, 30% and 40%, which are denoted as H10B, H20B, H30B, and H40B respectively. Studying these mixtures stability, all blends were kept under observation for more than one month, and they were stable at ambient conditions. The measured physicochemical properties of n-Heptanol-methyl oleate blends show that there is a reduction in their kinematic viscosity and cetane number. The results for methyl oleate illustrate that the peak pressure is slightly decreased by about 4%, while the soot and NOx emissions are diminished by about 2% and 6% respectively compared to pure diesel fuel. The soot and NOx emission are reduced by up to 90% and 15% respectively when adding n-Heptanol. The bsfc is enlarged by around 5% methyl oleate while it is enlarged by 15% for n-Heptanol- methyl oleate mixtures. It can be summarized from the combustion and emission results that the proposed mixing ratio of n-Heptanol and methyl oleate fuel is H20B.
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Combustion and emission characteristics of a rapid compression-expansion machine operated with N-Heptanol-methyl oleate biodiesel blends
Renewable Energy, 2020Co-Authors: Ahmed I. El-seesy, Zafer Kayatas, Meshack Hawi, Hidenori KosakaAbstract:Abstract In the current study, the n-Heptanol is mixed with methyl oleate biodiesel fuel at different blends which are 10%, 20% and 40% (by volume) n-Heptanol+90%, 80%, 60% methyl oleate fuel (H10B, H20B, and H40B) to examine the combustion and exhaust emission characteristics of a rapid compression-expansion machine (RCEM). The RCEM is operated under diesel engine condition with fixed inlet air properties. The findings for methyl oleate show that the peak pressure is slightly reduced, while soot and NOx emissions are reduced by about 60% and 3% respectively compared to pure diesel fuel. Furthermore, the blending of n-Heptanol with methyl oleate fuel leads to a considerable reduction in the soot emission by about 75% and the NOx emission is reduced by 6% compared to pure methyl oleate fuel. The flame images confirm that there is a reduction in flame temperatures for methyl oleate compared to pure diesel fuel. Additionally, the combustion process is retarded with increasing the blending ratio of n-Heptanol in the fuel mixture. Based on the combustion and emission characteristics, the recommended blending ratio of n-Heptanol and methyl oleate fuel is H20B.
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combustion and emission characteristics of a common rail diesel engine and rcem fueled by n Heptanol diesel blends and carbon nanomaterial additives
Energy Conversion and Management, 2019Co-Authors: Hidenori Kosaka, Ahmed I Elseesy, Hamdy Hassan, Susumu SatoAbstract:Abstract In the current investigation, the carbon nanomaterials, mainly graphene oxide (GO), graphene nanoplatelets (GNPs), and multiwalled carbon nanotubes (MWCNTs) were added into diesel fuel, 20% (by volume) n-Heptanol + 80% diesel fuel (H20D), and 40% (by volume) n-Heptanol + 60% diesel fuel (H40D) to investigate the combustion and exhaust emission characteristics of a common rail diesel engine and rapid compression-expansion machine (RCEM). The dose level of 50 mg/L of GO, GNPs, and MWCNTs was dispersed into diesel fuel, H20D and H40D mixtures utilizing ultrasonication system. The common rail diesel engine was operated under different loads and a fixed speed of 1000 rpm while the RCEM was run under diesel engine condition with fixed inlet air properties. The findings for H20D and H40D blends illustrated that the brake specific fuel consumption was increased by approximately 10%, while soot and NOx emission were reduced by about 40% and 12% respectively compared to pure diesel fuel. Moreover, the addition of carbon nanomaterials into diesel fuel, H20D, and H40D led to a substantial reduction in the specific fuel consumption by about 15% and the common rail engine soot emission was decreased by 60% whereas NOx was increased by 20% compared to base fuel. Combustion parameters for RCEM confirmed that there was a reduction in flame temperatures for H20D and H40D blends compared to diesel fuel. Additionally, there was a significant enhancement in the flame temperatures with the addition of carbon nanomaterials. According to combustion and emission results, the recommended blending ration of n-Heptanol and diesel fuel is H20D.
Bing Sun - One of the best experts on this subject based on the ideXlab platform.
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gap junction inhibition by Heptanol increases ventricular arrhythmogenicity by reducing conduction velocity without affecting repolarization properties or myocardial refractoriness in langendorff perfused mouse hearts
Molecular Medicine Reports, 2016Co-Authors: Gary Tse, Vivian Tse, Jie Ming Yeo, Joseph Kwan, Bing SunAbstract:In the current study, arrhythmogenic effects of the gap junction inhibitor Heptanol (0.05 mM) were examined in Langendorff-perfused mouse hearts. Monophasic action potential recordings were obtained from the left ventricular epicardium during right ventricular pacing. Regular activity was observed both prior and subsequent to application of Heptanol in all of the 12 hearts studied during 8 Hz pacing. By contrast, induced ventricular tachycardia (VT) was observed after Heptanol treatment in 6/12 hearts using a S1S2 protocol (Fisher's exact test; P 0.05). Consequently, excitation wavelengths (λ; CV x ERP) were reduced from 9.1±0.6 to 6.5±0.6 mm (P 0.05). Together, these observations demonstrate for the first time, to the best of our knowledge, that inhibition of gap junctions alone using a low Heptanol concentration (0.05 mM) was able to reduce CV, which alone was sufficient to permit the induction of VT using premature stimulation by reducing λ, which therefore appears central in the determination of arrhythmic tendency.
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atrial anti arrhythmic effects of Heptanol in langendorff perfused mouse hearts
PLOS ONE, 2016Co-Authors: Gary Tse, Vivian Tse, Jie Ming Yeo, Bing SunAbstract:Acute effects of Heptanol (0.1 to 2 mM) on atrial electrophysiology were explored in Langendorff-perfused mouse hearts. Left atrial bipolar electrogram or monophasic action potential recordings were obtained during right atrial stimulation. Regular pacing at 8 Hz elicited atrial activity in 11 out of 11 hearts without inducing atrial arrhythmias. Programmed electrical stimulation using a S1S2 protocol provoked atrial tachy-arrhythmias in 9 of 17 hearts. In the initially arrhythmic group, 2 mM Heptanol exerted anti-arrhythmic effects (Fisher’s exact test, P 0.05), which led to increases in ERP/latency ratio from 1.4 ± 0.1 to 2.1 ± 0.2 and ERP/APD90 ratio from 1.0 ± 0.1 to 2.1 ± 0.2 (P 0.05), leaving both AERP/latency ratio (2.1 ± 0.3 vs. 1.9 ± 0.2; P > 0.05) and ERP/APD90 ratio (2.0 ± 0.2 vs. 2.1 ± 0.1; P > 0.05) unaltered. Lower Heptanol concentrations (0.1, 0.5 and 1 mM) did not alter arrhythmogenicity or the above parameters. The present findings contrast with known ventricular pro-arrhythmic effects of Heptanol associated with decreased ERP/latency ratio, despite increased ERP/APD ratio observed in both the atria and ventricles.
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Heptanol decreases the incidence of ischemia induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts
Biomedical Reports, 2014Co-Authors: Bing Sun, Jinfa JiangAbstract:Heptanol is a type of gap junction inhibitor that decreases electrical conduction velocity. However, little is known regarding the effects of Heptanol on the arrhythmias induced by regional myocardial ischemia. This study aimed to investigate the effects of Heptanol on ventricular arrhythmias and the underlying mechanisms. On the Langendorff apparatus, isolated hearts of Sprague-Dawley rats underwent 30 min of ischemia, with or without pretreatment with Heptanol (0.1, 0.3 or 0.5 mM), 15 min prior to the induction of regional ischemia through ligation of the left anterior descending coronary artery. The incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) were recorded after ligation. Heptanol decreased the incidence of ventricular arrhythmias (45% in the control group vs. 10% in the 0.1 mM group, 0% in the 0.3 mM group and 0% in the 0.5 mM group, P<0.05), whereas it prolonged the PR interval, QT interval and monophasic action potential duration at 90% repolarization (MAPD90). As evaluated with immunofluorescence microscopy, Heptanol was able to partly reverse the downregulation of connexin 43 (Cx43) induced by ischemia. The results of the reverse transcription-polymerase chain reaction were consistent with those of immunofluorescence. In conclusion, Heptanol significantly decreased the incidence of VT and VF induced by regional ischemia and prolonged the PR interval, QT interval and MAPD90. Heptanol also partly reversed the downregulation of Cx43 induced by ischemia.