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Sheila A. Conway - One of the best experts on this subject based on the ideXlab platform.
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Early Complications of High-Dose-Rate Brachytherapy in Soft Tissue Sarcoma: A Comparison With Traditional External-beam Radiotherapy
Clinical Orthopaedics and Related Research®, 2012Co-Authors: Cynthia L. Emory, Corey O. Montgomery, Benjamin K. Potter, Martin E. Keisch, Sheila A. ConwayAbstract:Background Radiotherapy and surgery are routinely utilized to treat extremity soft tissue sarcoma. Multiple radiation modalities have been described, each with advantages and disadvantages, without one modality demonstrating clear superiority over the others. Questions/purposes We determined the overall initial complication rate in patients receiving surgery and radiotherapy, which specific complications were found when comparing different modalities, and whether combination therapy increased the overall rate of complications compared with surgery and single-modality radiotherapy. Patients and Methods We retrospectively reviewed the records of 190 patients who received external-beam radiotherapy (141 patients), High-Dose-Rate Brachytherapy (37 patients), or both (12 patients). We evaluated 100 men and 90 women (mean age, 57 years; range, 18–94 years) for tumor size and subtype, comorbidities, stage, grade, margin of resection, type of adjuvant treatment, and complications. Minimum followup was 3 months (mean, 40 months; range, 3–155 months). Results The most frequent early complications in the High-Dose-Rate Brachytherapy cohort were infection, cellulitis, and seroma and/or hematoma. In the external-beam radiotherapy cohort, chronic edema, fibrosis, and chronic radiation dermatitis were more frequently encountered. The total number of early complications and overall incidence of major complications requiring further surgery were similar among the three cohorts, but a larger number of patients in the High-Dose-Rate Brachytherapy group required subsequent surgery for infection compared with the external-beam radiotherapy group. Conclusions High-Dose-Rate Brachytherapy decreases radiation exposure and allows shorter duration of treatment compared with traditional external-beam radiotherapy but has a higher perioperative wound complication rate. Level of Evidence Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Federico Collettini - One of the best experts on this subject based on the ideXlab platform.
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CT-guided High-Dose-Rate Brachytherapy (CT-HDRBT) of unresectable hepatocellular carcinoma (HCC)
2020Co-Authors: Federico CollettiniAbstract:Poster: "ECR 2015 / C-1563 / CT-guided High-Dose-Rate Brachytherapy (CT-HDRBT) of unresectable hepatocellular carcinoma (HCC)" by: "F. Collettini, B. Gebauer; Berlin/DE"
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Hepatocellular carcinoma: computed tomography-guided High-Dose-Rate Brachytherapy ablation of large and very large lesions
2020Co-Authors: Federico CollettiniAbstract:Poster: "ECR 2011 / C-1519 / Hepatocellular carcinoma: computed tomography-guided High-Dose-Rate Brachytherapy ablation of large and very large lesions" by: "F. Collettini1, A. Poellinger1, T. Denecke1, E. Schott1, T. Berg2, P. Wust1, B. Hamm1, B. Gebauer1; 1Berlin/DE, 2Leipzig/DE"
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CT-guided High-Dose-Rate Brachytherapy of unresectable hepatocellular carcinoma
Strahlentherapie Und Onkologie, 2014Co-Authors: Federico Collettini, Nadja Schreiber, Dirk Schnapauff, Timm Denecke, Peter Wust, Eckart Schott, Bernd Hamm, Bernhard GebauerAbstract:Purpose The purpose of the present study was to evaluate the clinical outcome of CT-guided High-Dose-Rate Brachytherapy (CT-HDRBT) in patients with unresectable hepatocellular carcinoma (HCC).
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CT-guided high dose rate Brachytherapy ablation of liver metastases
Imaging in Medicine, 2013Co-Authors: Federico Collettini, Bernhard GebauerAbstract:Over the past two decades, several methods for minimally invasive tumor ablation have been developed and tested clinically. CT-guided high dose rate Brachytherapy is an alternative radioablative technique that was introduced in clinical practice as a minimally treatment option almost 20 years ago with some crucial advantages over thermal ablation. This report reviews the current clinical status of percutaneous CT-guided high dose rate Brachytherapy of liver metastases.
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Treatment for liver metastasis from renal cell carcinoma with computed-tomography-guided High-Dose-Rate Brachytherapy (CT-HDRBT): a case series
World Journal of Urology, 2012Co-Authors: Dominik Geisel, Federico Collettini, Timm Denecke, Peter Wust, Bernd Hamm, Christian Grieser, Anne Flörcken, Bernhard GebauerAbstract:Purpose To retrospectively analyze the clinical outcome of patients with hepatic metastases from renal cell carcinoma who were treated with computed-tomography-guided High-Dose-Rate Brachytherapy (CT-HDRBT).
Bernhard Gebauer - One of the best experts on this subject based on the ideXlab platform.
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Tumor Seeding along the Puncture Tract in CT-Guided Interstitial High-Dose-Rate Brachytherapy.
Journal of Vascular and Interventional Radiology, 2020Co-Authors: Laura Büttner, Bernhard Gebauer, Dirk Schnapauff, Timm Denecke, Peter Wust, Willie M. Lüdemann, Martin Jonczyk, Gero Wieners, G BöningAbstract:Abstract Purpose To quantify the occurrence of tumor seeding in computed tomography (CT)-guided High-Dose-Rate Brachytherapy (HDRBT) and to identify potential risk factors. Materials and Methods CT-HDRBT is a minimally invasive therapeutic option for local ablation of unresectable tumors. The procedure involves CT-guided placement of an enclosed catheter and High-Dose-Rate Brachytherapy using iridium-192. Transcutaneous puncture of a tumor with subsequent retraction of the applicator has the potential risk of tumor seeding along the puncture tract. A total of 1,765 consecutive CT-HDRBT procedures were performed at this center between 2006 and 2017 and were retrospectively analyzed. In addition, a distinction was made between whether the puncture tract was irradiated or not. Follow-up imaging datasets were evaluated for tumor seeding along the former puncture tracts. Descriptive and exploratory statistical analyses of the data were performed. Results Tumor seeding was observed in 25 cases (25 of 1,765 cases [1.5%]). A total of 0.008 cases occurred per person-age. Patient age was identified as a potential risk factor with an odds ratio of 1.046 (95% confidence interval, 1.003–1.091; P = .04). There were no differences between whether the puncture tract was irradiated or not (P = .552). Conclusions Tumor seeding along the puncture tract can occur in CT-HDRBT but is rare.
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CT-guided High-Dose-Rate Brachytherapy of unresectable hepatocellular carcinoma
Strahlentherapie Und Onkologie, 2014Co-Authors: Federico Collettini, Nadja Schreiber, Dirk Schnapauff, Timm Denecke, Peter Wust, Eckart Schott, Bernd Hamm, Bernhard GebauerAbstract:Purpose The purpose of the present study was to evaluate the clinical outcome of CT-guided High-Dose-Rate Brachytherapy (CT-HDRBT) in patients with unresectable hepatocellular carcinoma (HCC).
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CT-guided high dose rate Brachytherapy ablation of liver metastases
Imaging in Medicine, 2013Co-Authors: Federico Collettini, Bernhard GebauerAbstract:Over the past two decades, several methods for minimally invasive tumor ablation have been developed and tested clinically. CT-guided high dose rate Brachytherapy is an alternative radioablative technique that was introduced in clinical practice as a minimally treatment option almost 20 years ago with some crucial advantages over thermal ablation. This report reviews the current clinical status of percutaneous CT-guided high dose rate Brachytherapy of liver metastases.
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Treatment for liver metastasis from renal cell carcinoma with computed-tomography-guided High-Dose-Rate Brachytherapy (CT-HDRBT): a case series
World Journal of Urology, 2012Co-Authors: Dominik Geisel, Federico Collettini, Timm Denecke, Peter Wust, Bernd Hamm, Christian Grieser, Anne Flörcken, Bernhard GebauerAbstract:Purpose To retrospectively analyze the clinical outcome of patients with hepatic metastases from renal cell carcinoma who were treated with computed-tomography-guided High-Dose-Rate Brachytherapy (CT-HDRBT).
Cynthia L. Emory - One of the best experts on this subject based on the ideXlab platform.
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Early Complications of High-Dose-Rate Brachytherapy in Soft Tissue Sarcoma: A Comparison With Traditional External-beam Radiotherapy
Clinical Orthopaedics and Related Research®, 2012Co-Authors: Cynthia L. Emory, Corey O. Montgomery, Benjamin K. Potter, Martin E. Keisch, Sheila A. ConwayAbstract:Background Radiotherapy and surgery are routinely utilized to treat extremity soft tissue sarcoma. Multiple radiation modalities have been described, each with advantages and disadvantages, without one modality demonstrating clear superiority over the others. Questions/purposes We determined the overall initial complication rate in patients receiving surgery and radiotherapy, which specific complications were found when comparing different modalities, and whether combination therapy increased the overall rate of complications compared with surgery and single-modality radiotherapy. Patients and Methods We retrospectively reviewed the records of 190 patients who received external-beam radiotherapy (141 patients), High-Dose-Rate Brachytherapy (37 patients), or both (12 patients). We evaluated 100 men and 90 women (mean age, 57 years; range, 18–94 years) for tumor size and subtype, comorbidities, stage, grade, margin of resection, type of adjuvant treatment, and complications. Minimum followup was 3 months (mean, 40 months; range, 3–155 months). Results The most frequent early complications in the High-Dose-Rate Brachytherapy cohort were infection, cellulitis, and seroma and/or hematoma. In the external-beam radiotherapy cohort, chronic edema, fibrosis, and chronic radiation dermatitis were more frequently encountered. The total number of early complications and overall incidence of major complications requiring further surgery were similar among the three cohorts, but a larger number of patients in the High-Dose-Rate Brachytherapy group required subsequent surgery for infection compared with the external-beam radiotherapy group. Conclusions High-Dose-Rate Brachytherapy decreases radiation exposure and allows shorter duration of treatment compared with traditional external-beam radiotherapy but has a higher perioperative wound complication rate. Level of Evidence Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Martin E. Keisch - One of the best experts on this subject based on the ideXlab platform.
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Early Complications of High-Dose-Rate Brachytherapy in Soft Tissue Sarcoma: A Comparison With Traditional External-beam Radiotherapy
Clinical Orthopaedics and Related Research®, 2012Co-Authors: Cynthia L. Emory, Corey O. Montgomery, Benjamin K. Potter, Martin E. Keisch, Sheila A. ConwayAbstract:Background Radiotherapy and surgery are routinely utilized to treat extremity soft tissue sarcoma. Multiple radiation modalities have been described, each with advantages and disadvantages, without one modality demonstrating clear superiority over the others. Questions/purposes We determined the overall initial complication rate in patients receiving surgery and radiotherapy, which specific complications were found when comparing different modalities, and whether combination therapy increased the overall rate of complications compared with surgery and single-modality radiotherapy. Patients and Methods We retrospectively reviewed the records of 190 patients who received external-beam radiotherapy (141 patients), High-Dose-Rate Brachytherapy (37 patients), or both (12 patients). We evaluated 100 men and 90 women (mean age, 57 years; range, 18–94 years) for tumor size and subtype, comorbidities, stage, grade, margin of resection, type of adjuvant treatment, and complications. Minimum followup was 3 months (mean, 40 months; range, 3–155 months). Results The most frequent early complications in the High-Dose-Rate Brachytherapy cohort were infection, cellulitis, and seroma and/or hematoma. In the external-beam radiotherapy cohort, chronic edema, fibrosis, and chronic radiation dermatitis were more frequently encountered. The total number of early complications and overall incidence of major complications requiring further surgery were similar among the three cohorts, but a larger number of patients in the High-Dose-Rate Brachytherapy group required subsequent surgery for infection compared with the external-beam radiotherapy group. Conclusions High-Dose-Rate Brachytherapy decreases radiation exposure and allows shorter duration of treatment compared with traditional external-beam radiotherapy but has a higher perioperative wound complication rate. Level of Evidence Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.