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Jost B Jonas - One of the best experts on this subject based on the ideXlab platform.
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High Myopia in greater beijing school children in 2016
PLOS ONE, 2017Co-Authors: Yin Guo, Jia Li Duan, Li Juan Liu, Ying Sun, Ping Tang, Jost B JonasAbstract:Purpose To assess prevalence and associated factors of Myopia and High Myopia in schoolchildren in Greater Beijing. Methods The school-based, cross-sectional Greater Beijing School Children Myopia study was carried out in the year 2016 in 54 schools randomly selected from 15 districts in Beijing. Non-cycloplegic auto-refractometry of the right eyes was performed. Results The study included 35,745 (99.4%) out of 35,968 eligible pupils with a mean age of 12.6±3.4 years (range 6–18 years). Prevalence of Myopia defined as myopic refractive error of ≥-0.50 diopters (D),≥-1D,≥-6D,≥-8D and ≥-10D was 70.9%(95% confidence intervals (CI):70.5,71.4), 60.9% (95%CI:60.4,61.4), 8.6%(95%CI:8.4,8.9), 2.2%(95%CI:2.0,2.4), and 0.3% (95%CI:0.3,0.4), respectively. The frequency of High Myopia (≥-6D, ≥-8D, ≥-10D) increased from 1.5% (95%CI:1.0,2.0), 0.4% (95%CI:0.1,0.6) and 0.1% (95%CI:0.00,0.02), respectively in 10-year-olds to 19.4% (95%CI:17.3,21.6), 5.2% (95%CI:4.0,6.4) and 0.9% (95%CI:0.4,1.5), respectively, in 18-year-olds. Mean refractive error in the 18-year-olds was -3.74±2.56D (median:-3.63D;range:-19.6D to + 6.25D). Higher prevalence of High Myopia (≥-6D and ≥-8D) was correlated (all P<0.001) with older age (OR:1.18, and 1.15, respectively), female gender (OR: 1.44 and 1.40, respectively), Higher body mass index (OR: 1.02 and 1.03, respectively), taller body height (OR: 1.03 and 1.02, respectively), urban region of habitation (OR: 1.26 and 1.33, respectively) and Higher school type (OR:1.57 and 2.22, respectively). Prevalence of severe High Myopia (≥-10D) was associated only with older age (P<0.001; OR: 1.44; 95%CI: 1.31, 1.59) but not with any education-related parameter such as Higher school type (P = 0.48), urban region of habitation (P = 0.07) or female gender (P = 0.37). Conclusion In this most recent survey, prevalence of High Myopia (≥-6D:19.4%;≥-8D:5.2%;≥-10D:0.9%) in 18-year-old school children was Higher than in previous surveys from mainland China. In contrast to minor High Myopia and moderate High Myopia (defined as myopic refractive error of <-10D), severe High Myopia (myopic refractive error ≥-10D) was not strongly correlated with educational parameters.
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education related parameters in High Myopia adults versus school children
PLOS ONE, 2016Co-Authors: Jost B Jonas, Ya Xing Wang, Wen Jun Jiang, Vinay Nangia, Ajit Sinha, Dan Zhu, Yong Tao, Yin Guo, Qi Sheng YouAbstract:Purpose Since High Myopia in the younger generation may differ etiologically from High Myopia in older generations, we examined whether education-related parameters differ between High Myopia in today´s school children and High pathological Myopia in today´s elderly generation. Methods The investigation included the adult populations of the population-based Beijing Eye Study (BES) (3468 adults;mean age:64.6±9.8years;range:50–93years) and Central India Eye and Medical Study (CIEMS) (4711 adults;age:49.±13.2years;range:30–100years), and the children and teenager populations of the Shandong Children Eye Study (SCES) (6026 children;age:9.7±3.3years;range:4–18years;cycloplegic refractometry), Gobi Desert Children Eye Study (1565;age:11.9±3.5years;range:6–21 years;cycloplegic refractometry), Beijing Pediatric Eye Study (681 children;age:7.7±1.6years;range:5–13 years;non-cycloplegic refractometry,calculation of axial length to corneal curvature radius ratio), Beijing Children Eye Study (15066 children;age:13.2±3.4years;range:7–18years;non-cycloplegic refractometry), Beijing High School Teenager Eye Study (4677 children;age:16.9±0.7years;range:16–18years;non-cycloplegic refractometry). Results In the BES and CIEMS, educational level did not differ significantly between, or was significantly lower in the Highly myopic group (myopic refractive error ≥6 diopters) than in the non-Highly myopic group. In all non-adult study populations, Higher prevalence of High Myopia was significantly associated with Higher degree of education related parameters such as attendance of High-level schools, and more time spent for indoors near work versus time spent outdoors. Conclusions Comparing associations of old or genetic High Myopia in adults with new or acquired High Myopia in school children revealed that education-related parameters did not show a clear association with old or genetic High Myopia, while in contrast, new High Myopia showed strong associations with education. It confirms previous studies that the two forms of High Myopia not only differed in age of onset, but also in associations with education as well. The data support the notion of two types of High Myopia. Future studies may assess whether the risk of pathologic myopic maculopathy and High Myopia associated open-angle glaucoma differs between both types of High Myopia.
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glaucomatous type optic discs in High Myopia
PLOS ONE, 2015Co-Authors: Natsuko Nagaoka, Jost B Jonas, Muka Moriyama, Kei Morohoshi, Noriaki Shimada, Takeshi Yoshida, Kyoko OhnomatsuiAbstract:Purpose To assess the prevalence of glaucoma in patients with High Myopia defined as myopic refractive error of >-8 diopters or axial length ≥26.5 mm.
Jun Akiba - One of the best experts on this subject based on the ideXlab platform.
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Prevalence of posterior vitreous detachment in High Myopia.
Ophthalmology, 1993Co-Authors: Jun AkibaAbstract:Background: Posterior vitreous detachment is known to develop early in High Myopia. However, the prevalence of posterior vitreous detachment in relation to patient age and degree of Myopia has not been studied by modern vitreous examination methods. Methods: The vitreous conditions of 224 eyes with High Myopia (>-6 diopters [D]) were examined biomicroscopically with a +90-D preset lens and a Goldmann threemirror contact lens. The vitreous conditions of 220 eyes with emmetropia (between −1 and +1 D) also were studied and served as controls. Results: In High Myopia, no patients 29 years of age or younger had posterior vitreous detachment. Thereafter, the prevalence of posterior vitreous detachment increased with age (i.e., 23%, 29%, 44%, and 72% in the fourth through seventh decades, respectively, and 100% of patients 70 years or older). Moreover, posterior vitreous detachment developed earlier in severe High Myopia (>−10 D) than in moderate High Myopia (>−6 to −10 D). In emmetropia, no patients 39 years of age or younger had posterior vitreous detachment, and its prevalence also increased with age (i.e., 8%, 23%, 44%, 74%, and 86% in the fifth through ninth decades, respectively). Conclusion: In High Myopia, posterior vitreous detachment develops increasingly with age and degree of Myopia. Although the sample size in each age group was small, the results suggested that posterior vitreous detachment may develop nearly 10 years earlier in Highly myopic than in emmetropic eyes.
Yin Guo - One of the best experts on this subject based on the ideXlab platform.
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High Myopia in greater beijing school children in 2016
PLOS ONE, 2017Co-Authors: Yin Guo, Jia Li Duan, Li Juan Liu, Ying Sun, Ping Tang, Jost B JonasAbstract:Purpose To assess prevalence and associated factors of Myopia and High Myopia in schoolchildren in Greater Beijing. Methods The school-based, cross-sectional Greater Beijing School Children Myopia study was carried out in the year 2016 in 54 schools randomly selected from 15 districts in Beijing. Non-cycloplegic auto-refractometry of the right eyes was performed. Results The study included 35,745 (99.4%) out of 35,968 eligible pupils with a mean age of 12.6±3.4 years (range 6–18 years). Prevalence of Myopia defined as myopic refractive error of ≥-0.50 diopters (D),≥-1D,≥-6D,≥-8D and ≥-10D was 70.9%(95% confidence intervals (CI):70.5,71.4), 60.9% (95%CI:60.4,61.4), 8.6%(95%CI:8.4,8.9), 2.2%(95%CI:2.0,2.4), and 0.3% (95%CI:0.3,0.4), respectively. The frequency of High Myopia (≥-6D, ≥-8D, ≥-10D) increased from 1.5% (95%CI:1.0,2.0), 0.4% (95%CI:0.1,0.6) and 0.1% (95%CI:0.00,0.02), respectively in 10-year-olds to 19.4% (95%CI:17.3,21.6), 5.2% (95%CI:4.0,6.4) and 0.9% (95%CI:0.4,1.5), respectively, in 18-year-olds. Mean refractive error in the 18-year-olds was -3.74±2.56D (median:-3.63D;range:-19.6D to + 6.25D). Higher prevalence of High Myopia (≥-6D and ≥-8D) was correlated (all P<0.001) with older age (OR:1.18, and 1.15, respectively), female gender (OR: 1.44 and 1.40, respectively), Higher body mass index (OR: 1.02 and 1.03, respectively), taller body height (OR: 1.03 and 1.02, respectively), urban region of habitation (OR: 1.26 and 1.33, respectively) and Higher school type (OR:1.57 and 2.22, respectively). Prevalence of severe High Myopia (≥-10D) was associated only with older age (P<0.001; OR: 1.44; 95%CI: 1.31, 1.59) but not with any education-related parameter such as Higher school type (P = 0.48), urban region of habitation (P = 0.07) or female gender (P = 0.37). Conclusion In this most recent survey, prevalence of High Myopia (≥-6D:19.4%;≥-8D:5.2%;≥-10D:0.9%) in 18-year-old school children was Higher than in previous surveys from mainland China. In contrast to minor High Myopia and moderate High Myopia (defined as myopic refractive error of <-10D), severe High Myopia (myopic refractive error ≥-10D) was not strongly correlated with educational parameters.
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education related parameters in High Myopia adults versus school children
PLOS ONE, 2016Co-Authors: Jost B Jonas, Ya Xing Wang, Wen Jun Jiang, Vinay Nangia, Ajit Sinha, Dan Zhu, Yong Tao, Yin Guo, Qi Sheng YouAbstract:Purpose Since High Myopia in the younger generation may differ etiologically from High Myopia in older generations, we examined whether education-related parameters differ between High Myopia in today´s school children and High pathological Myopia in today´s elderly generation. Methods The investigation included the adult populations of the population-based Beijing Eye Study (BES) (3468 adults;mean age:64.6±9.8years;range:50–93years) and Central India Eye and Medical Study (CIEMS) (4711 adults;age:49.±13.2years;range:30–100years), and the children and teenager populations of the Shandong Children Eye Study (SCES) (6026 children;age:9.7±3.3years;range:4–18years;cycloplegic refractometry), Gobi Desert Children Eye Study (1565;age:11.9±3.5years;range:6–21 years;cycloplegic refractometry), Beijing Pediatric Eye Study (681 children;age:7.7±1.6years;range:5–13 years;non-cycloplegic refractometry,calculation of axial length to corneal curvature radius ratio), Beijing Children Eye Study (15066 children;age:13.2±3.4years;range:7–18years;non-cycloplegic refractometry), Beijing High School Teenager Eye Study (4677 children;age:16.9±0.7years;range:16–18years;non-cycloplegic refractometry). Results In the BES and CIEMS, educational level did not differ significantly between, or was significantly lower in the Highly myopic group (myopic refractive error ≥6 diopters) than in the non-Highly myopic group. In all non-adult study populations, Higher prevalence of High Myopia was significantly associated with Higher degree of education related parameters such as attendance of High-level schools, and more time spent for indoors near work versus time spent outdoors. Conclusions Comparing associations of old or genetic High Myopia in adults with new or acquired High Myopia in school children revealed that education-related parameters did not show a clear association with old or genetic High Myopia, while in contrast, new High Myopia showed strong associations with education. It confirms previous studies that the two forms of High Myopia not only differed in age of onset, but also in associations with education as well. The data support the notion of two types of High Myopia. Future studies may assess whether the risk of pathologic myopic maculopathy and High Myopia associated open-angle glaucoma differs between both types of High Myopia.
Qi Sheng You - One of the best experts on this subject based on the ideXlab platform.
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education related parameters in High Myopia adults versus school children
PLOS ONE, 2016Co-Authors: Jost B Jonas, Ya Xing Wang, Wen Jun Jiang, Vinay Nangia, Ajit Sinha, Dan Zhu, Yong Tao, Yin Guo, Qi Sheng YouAbstract:Purpose Since High Myopia in the younger generation may differ etiologically from High Myopia in older generations, we examined whether education-related parameters differ between High Myopia in today´s school children and High pathological Myopia in today´s elderly generation. Methods The investigation included the adult populations of the population-based Beijing Eye Study (BES) (3468 adults;mean age:64.6±9.8years;range:50–93years) and Central India Eye and Medical Study (CIEMS) (4711 adults;age:49.±13.2years;range:30–100years), and the children and teenager populations of the Shandong Children Eye Study (SCES) (6026 children;age:9.7±3.3years;range:4–18years;cycloplegic refractometry), Gobi Desert Children Eye Study (1565;age:11.9±3.5years;range:6–21 years;cycloplegic refractometry), Beijing Pediatric Eye Study (681 children;age:7.7±1.6years;range:5–13 years;non-cycloplegic refractometry,calculation of axial length to corneal curvature radius ratio), Beijing Children Eye Study (15066 children;age:13.2±3.4years;range:7–18years;non-cycloplegic refractometry), Beijing High School Teenager Eye Study (4677 children;age:16.9±0.7years;range:16–18years;non-cycloplegic refractometry). Results In the BES and CIEMS, educational level did not differ significantly between, or was significantly lower in the Highly myopic group (myopic refractive error ≥6 diopters) than in the non-Highly myopic group. In all non-adult study populations, Higher prevalence of High Myopia was significantly associated with Higher degree of education related parameters such as attendance of High-level schools, and more time spent for indoors near work versus time spent outdoors. Conclusions Comparing associations of old or genetic High Myopia in adults with new or acquired High Myopia in school children revealed that education-related parameters did not show a clear association with old or genetic High Myopia, while in contrast, new High Myopia showed strong associations with education. It confirms previous studies that the two forms of High Myopia not only differed in age of onset, but also in associations with education as well. The data support the notion of two types of High Myopia. Future studies may assess whether the risk of pathologic myopic maculopathy and High Myopia associated open-angle glaucoma differs between both types of High Myopia.
Junming Wang - One of the best experts on this subject based on the ideXlab platform.
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Schlemm's canal and trabecular meshwork morphology in High Myopia.
Ophthalmic and Physiological Optics, 2018Co-Authors: Zhiqi Chen, Liugui Chen, Yinwei Song, Mu Li, Yan Xiang, Hong Zhang, Wei Chen, Junming WangAbstract:PURPOSE:Myopes have a Higher risk for open-angle glaucoma; however, the reason is not clear. This study aims to explore the morphologic alterations of Schlemm's canal and trabecular meshwork size in Highly myopic eyes. METHODS:Forty myopic eyes from 40 patients with High Myopia and 40 control eyes from 40 subjects with low Myopia, emmetropia or low hyperopia were enrolled. Optical coherence tomography (OCT) was used to image Schlemm's canal and trabecular meshwork size. The correlations between the morphological alterations of Schlemm's canal and trabecular meshwork, spherical equivalent refractive error, axial length, and intraocular pressure were analysed. RESULTS:Subjects with High Myopia had a significantly larger Schlemm's canal diameter in the nasal (188.1 ± 85.6 μm vs 127.4 ± 46.7 μm, P 0.05), while Schlemm's canal area showed a significant negative correlation with intraocular pressure (r = -0.33, P = 0.039). CONCLUSIONS:This study reports for the first time that eyes with High Myopia have a larger Schlemm's canal diameter and area, as well as decreased trabecular meshwork thickness, which may help to understand the close association between High Myopia and open-angle glaucoma. Schlemm's canal and trabecular meshwork analysis by OCT images may help to characterise the underlying pathophysiological mechanisms involved in High Myopia.