The Experts below are selected from a list of 24261 Experts worldwide ranked by ideXlab platform
Eric Vignon - One of the best experts on this subject based on the ideXlab platform.
-
Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive Hip Osteoarthritis
Annals of the rheumatic diseases, 2006Co-Authors: Patrick Garnero, Thierry Conrozier, Nadine Charni, Fabrice Juillet, Eric VignonAbstract:Objectives: Biochemical markers reflecting the degradation of the type II collagen helical (Helix-II) and type II collagen C telopeptides (CTX-II) have been developed. Aim: To investigate the association of rapidly destructive Hip Osteoarthritis with urinary Helix-II and urinary CTX-II. Patients and methods: 12 patients (mean age 70 years) meeting the criteria for rapidly destructive Hip Osteoarthritis and 28 patients with slowly progressive Hip Osteoarthritis (mean age 63 years) defined as x rays. Results: Helix-II levels were 41% (p = 0.002) higher in the 40 patients with Hip Osteoarthritis than in 75 healthy controls. Increased Helix-II levels were associated with decreased minimum joint space width of the Hip (r = −0.57, p = 0.001). Mean urinary Helix-II levels were 71% higher in rapidly destructive than in slowly progressive disease (mean (standard deviation (SD)) ng/mmol Cr: 396 (160) v 232 (118) ng/mmol; p = 0.002). When levels of Helix-II and CTX-II in the highest tertile were both included in a multivariate logistic regression model, high Helix-II level (OR; (95% CI) 5.73 (1.01 to 32.8)) after adjustment for age and body mass index and high CTX-II level (6.67 (1.14 to 39.0)) were, independently of each other, associated with a rapidly destructive disease. Conclusion: Increased urinary Helix-II levels are associated with rapidly destructive Hip Osteoarthritis, independently of urinary CTX-II. Measurement of Helix-II, alone or in combination with CTX-II, could be useful for the clinical investigation of patients with Hip Osteoarthritis.
-
Increased serum C-reactive protein levels by immunonephelometry in patients with rapidly destructive Hip Osteoarthritis.
Revue du rhumatisme (English ed.), 1998Co-Authors: Thierry Conrozier, C. Chappuis-cellier, M. Richard, Pierre Mathieu, S. Richard, Eric VignonAbstract:OBJECTIVE To compare serum C-reactive protein levels measured using a highly sensitive immunonephelometry method in patients with rapidly destructive versus slowly progressive Hip Osteoarthritis. METHODS Ten patients meeting criteria for rapidly destructive Hip Osteoarthritis were compared to 25 patients with slowly progressive Hip Osteoarthritis defined as less than 0.20 mm joint space loss over the last year. Serum C-reactive protein was assayed using an immunonephelometry method with a detection threshold of 0.17 mg/L and a coefficient of variation of less than 5%. RESULTS One patient in each group was excluded because of a C-reactive protein level greater than 15 mg/L. The mean C-reactive protein level in the remaining 33 patients was 3.05 +/- 3.46 mg/L (range, 0.10-14.9 mg/L). Mean C-reactive protein was significantly higher in the rapidly destructive group than in the slowly progressive group (5.61 +/- 4.75 versus 1.94 +/- 1.98 mg/L, P = 0.01), even after adjustment for potential confounding factors. CONCLUSION Our data suggest that rapidly destructive Hip Osteoarthritis may be associated with some degree of inflammation reflected by a small but significant increase in serum C-reactive protein levels.
-
Radiographic features predictive of radiographic progression of Hip Osteoarthritis.
Revue du rhumatisme (English ed.), 1997Co-Authors: Dougados M, Gueguen A, M. Nguyen, L. Berdah, M. Lequesne, Bernard Mazières, Eric VignonAbstract:OBJECTIVES To evaluate potential radiographic predictors of Hip Osteoarthritis progression. PATIENTS AND METHODS A prospective, longitudinal two-year study was conducted in patients meeting American College of Rheumatology criteria for Hip Osteoarthritis. Hip Osteoarthritis progression was defined as a greater than 0.5-mm decrease in joint space width measured using a magnifying glass marked at intervals of 0.1 mm, at the site of maximum joint space narrowing, by a single investigator who was blinded to the chronological order of the radiographs. Radiographic parameters determined at study entry were as follows: presence of osteophytes, osteosclerosis, and subchondral cysts; femoral head migration (superolateral, superomedial, concentric); and severity (joint space width in mm, Kellgren and Lawrence grade, subjective evaluation of joint space narrowing). RESULTS In the 463 study patients, joint space width decreased from 2.2 +/- 0.8 at baseline to 1.7 +/- 1.0 mm after two years (P < 0.0001). Radiographic progression was seen in 148 patients (32%). Radiologic parameters predictive of disease progression in the multivariate analyses were as follows: CONCLUSION Our data suggest that a number of baseline radiological features including distribution of joint space loss, subchondral bone production, and severity of joint space loss are predictive of progression of Hip Osteoarthritis.
Eugene K. Wai - One of the best experts on this subject based on the ideXlab platform.
-
Systematic Review of the Prevalence of Radiographic Primary Hip Osteoarthritis
Clinical orthopaedics and related research, 2008Co-Authors: Simon Dagenais, Shawn Garbedian, Eugene K. WaiAbstract:Hip Osteoarthritis is a common cause of musculoskeletal pain in older adults and may result in decreased mobility and quality of life. Although the presentation of Hip Osteoarthritis varies, surgical management is required when the disease is severe, longstanding, and unresponsive to nonoperative treatments. For stakeholders to plan for the expected increased demand for surgical procedures related to Hip Osteoarthritis, including arthroplasty, it is important to first understand its prevalence. We conducted a systematic review by searching MEDLINE® and EMBASE to identify recent English language articles reporting on the prevalence of radiographic primary Hip Osteoarthritis in the general adult population; references including studies and primary studies from previous systematic reviews were also searched. This strategy yielded 23 studies reporting 39 estimates of overall prevalence ranging from 0.9% to 27% with a mean of 8.0% and a standard deviation of 7.0%. Heterogeneity was noted in study populations, eligibility criteria, age and gender distribution, type of radiographs, and method of diagnosis. Although the association between radiographic Hip Osteoarthritis and the need for eventual surgical management is still unclear, this study supports assertions that Hip Osteoarthritis is a prevalent condition whose treatment will continue to place important demands on health services.
Ray Marks - One of the best experts on this subject based on the ideXlab platform.
-
Non-Operative Management of Hip Osteoarthritis
2015Co-Authors: Ray MarksAbstract:This paper reviews several non-operative and non-pharmacologic management strategies advocated for alleviating the pain and disability experienced by people with Hip Osteoarthritis. It analyzes whether painful debilitating Hip Osteoarthritis, which has no effective cure and is often progressive, may be affected positively by non-operative interventions designed to control Osteoarthritis pain. Finally, it provides an integrated plan of management for ameliorating Hip Osteoarthritis pain and disability in light of this knowledge.
-
Body Mass Profiles Among Younger and Older Hip Osteoarthritis Cases Requiring Surgery Suggests Excess Body Mass Does Influence Disease Onset and Complication Rates Running title: Hip Osteoarthritis and body mass
2015Co-Authors: Ray Marks, R.j. MarksAbstract:The prevailing literature is inconsistent concerning the relationsHip of excess body mass to the onset and progression of disabling Hip Osteoarthritis, often deemed an age associated disease. We examined the distribution of body mass indices among a sample of severely disabled Hip Osteoarthritis patients relative to age, and surgical status. Data from the available records of 997 severely disabled Hip Osteoarthritis cases undergoing surgery subjected to correlational analyses showed more cases among the sample had body mass indices indicative of being overweight or obese than underweight or normal weight (p=.001). Those younger than 65 years of age were more likely on average to have higher body mass indices, than those over age 65 (p=.001), especially in the obese category. Those who were heavier were more likely to have one or more metabolic health conditions (p=.001), and those in the morbidly obese range were more likely to require surgery for severe complications (p=.001). Men were more likely to be overweight or obese than women in the sample (p=.001). These findings imply adults with severe disabling Hip Osteoarthritis, especially men, are more likely to exhibit high, rather than low or normal body weights, and these rates of obesity are negatively associated with age (p= 0.001). It also appears those who are heavier have a stronger chance of adverse outcomes and of having 1 or more metabolic health conditions. Efforts to prevent obesity at a young age, especially among males, may consequently help to delay, as well as allay, the extent of the disability experienced by the severely compromised Hip Osteoarthritis patient.
-
Disabling Hip Osteoarthritis and Cardiovascular Pathology: Presence and Impact
International Journal of Health, 2013Co-Authors: Ray MarksAbstract:Objective: This study examined: 1) the extent to which cases with disabling end-stage Hip Osteoarthritis would exhibit co-occurring cardiovascular health conditions; 2) the pre and post-surgical impact of the presence of one or more of these health conditions on walking ability. Methods: First, a frequency analysis of the various cardiovascular health conditions listed among 1000 end-stage Hip Osteoarthritis cases was conducted. Second, a sub-sample of 823 uncomplicated surgical cases was specifically examined. Third, a matched sub-sample of 60 cases with and without cooccurring cardiovascular conditions were compared as regards pain, and their ability to functional physically before and after surgery. Results: Almost 50% of cases initially examined had one or more cardiovascular conditions. Among the 10 categories listed, the most common was high blood pressure, found in 28% cases. Significant (p < .05) associations between having one or more cardiovascular comorbidities and high body mass indices were observed, and co-occurring cardiovascular disease independently predicted walking capacity before and after surgery. Key conclusions: Patients with disabling Hip Osteoarthritis may exhibit high rates of comorbid cardiovascular health conditions. Those presenting with one or more of cardiovascular condition, may have poorer mobility, both before and after surgery than those with no cardiovascular conditions.
-
Comorbid depression and anxiety impact Hip Osteoarthritis disability.
Disability and health journal, 2009Co-Authors: Ray MarksAbstract:Abstract Background Hip Osteoarthritis, a common age-associated condition, produces considerable disability that may be influenced by a variety of factors other than age. This study examines the magnitude and impact of the presence of comorbid and/or concurrent depression and anxiety symptoms on the disability experienced before and immediately after total Hip replacement surgery for end-stage Osteoarthritis—a very understudied, albeit potentially important area for improving the health and well-being of adults with this disabling condition. Methods The available records of 1,000 Hip Osteoarthritis surgical candidates were examined for any historical/concurrent evidence of depression/anxiety. Additional data on medical comorbidities, pain, function, and discharge destination were extracted. Selected subgroup comparisons between those with depression and anxiety disorder histories and those with no such history and their preoperative and immediate postoperative functional outcomes were conducted. Results (1) Nine percent (90 patients) of the cohort reported having a prior mood disorder. An additional 9% reported anxiety symptoms and 0.8% reported feeling depressed prior to surgery. (2) Those with depression and anxiety histories were more impaired before surgery and tended to recover more slowly than those with no such history ( p Conclusion Almost 20% of end-stage Hip Osteoarthritis cases undergoing replacement surgery may have mood disorder histories and/or prevailing symptoms of emotional distress that may exaggerate preoperative Hip Osteoarthritis disability and slow the postoperative recovery process. Examining the cognitive as well as the physical status of adults undergoing Hip replacement surgery for Osteoarthritis and individualizing, rather than promoting generic intervention approaches, is indicated in efforts to optimize outcomes and minimize impairments and disability for adults with this condition.
-
Hip Surgery Candidates: A Comparative Study of Hip Osteoarthritis and Prior Hip Fracture Patient Characteristics
The open orthopaedics journal, 2008Co-Authors: Ray MarksAbstract:Aim: To assess similarities and differences in patient-related characteristics before and after surgery for painful disabling Hip Osteoarthritis among elderly subgroups with and without a trauma history. Method: First, a cohort of 1000 hospitalized patients were assessed for trends in: perceived duration of the condition, pain intensity, functional performance ability, walking distance, body mass, and comorbidity characteristics among other fac- tors. Then, the most salient of these patient-related characteristics were compared between 42 cases of Hip Osteoarthritis without a trauma history and 42 cases with a trauma history matched for age and gender, using medical records and stan- dard data recording and analysis procedures. Results: Hip Osteoarthritis cases with a prior Hip fracture history had a longer duration of disability, and were more im- paired functionally before surgery (p < 0.05) than those with no such history. They also had lower leg muscle strength and used more assistive devices. Conclusion: Patients undergoing Hip replacement surgery for painful Hip Osteoarthritis who have a Hip fracture history are likely to be more impaired and disabled than those with no such history.
Thierry Conrozier - One of the best experts on this subject based on the ideXlab platform.
-
Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive Hip Osteoarthritis
Annals of the rheumatic diseases, 2006Co-Authors: Patrick Garnero, Thierry Conrozier, Nadine Charni, Fabrice Juillet, Eric VignonAbstract:Objectives: Biochemical markers reflecting the degradation of the type II collagen helical (Helix-II) and type II collagen C telopeptides (CTX-II) have been developed. Aim: To investigate the association of rapidly destructive Hip Osteoarthritis with urinary Helix-II and urinary CTX-II. Patients and methods: 12 patients (mean age 70 years) meeting the criteria for rapidly destructive Hip Osteoarthritis and 28 patients with slowly progressive Hip Osteoarthritis (mean age 63 years) defined as x rays. Results: Helix-II levels were 41% (p = 0.002) higher in the 40 patients with Hip Osteoarthritis than in 75 healthy controls. Increased Helix-II levels were associated with decreased minimum joint space width of the Hip (r = −0.57, p = 0.001). Mean urinary Helix-II levels were 71% higher in rapidly destructive than in slowly progressive disease (mean (standard deviation (SD)) ng/mmol Cr: 396 (160) v 232 (118) ng/mmol; p = 0.002). When levels of Helix-II and CTX-II in the highest tertile were both included in a multivariate logistic regression model, high Helix-II level (OR; (95% CI) 5.73 (1.01 to 32.8)) after adjustment for age and body mass index and high CTX-II level (6.67 (1.14 to 39.0)) were, independently of each other, associated with a rapidly destructive disease. Conclusion: Increased urinary Helix-II levels are associated with rapidly destructive Hip Osteoarthritis, independently of urinary CTX-II. Measurement of Helix-II, alone or in combination with CTX-II, could be useful for the clinical investigation of patients with Hip Osteoarthritis.
-
Increased serum C-reactive protein levels by immunonephelometry in patients with rapidly destructive Hip Osteoarthritis.
Revue du rhumatisme (English ed.), 1998Co-Authors: Thierry Conrozier, C. Chappuis-cellier, M. Richard, Pierre Mathieu, S. Richard, Eric VignonAbstract:OBJECTIVE To compare serum C-reactive protein levels measured using a highly sensitive immunonephelometry method in patients with rapidly destructive versus slowly progressive Hip Osteoarthritis. METHODS Ten patients meeting criteria for rapidly destructive Hip Osteoarthritis were compared to 25 patients with slowly progressive Hip Osteoarthritis defined as less than 0.20 mm joint space loss over the last year. Serum C-reactive protein was assayed using an immunonephelometry method with a detection threshold of 0.17 mg/L and a coefficient of variation of less than 5%. RESULTS One patient in each group was excluded because of a C-reactive protein level greater than 15 mg/L. The mean C-reactive protein level in the remaining 33 patients was 3.05 +/- 3.46 mg/L (range, 0.10-14.9 mg/L). Mean C-reactive protein was significantly higher in the rapidly destructive group than in the slowly progressive group (5.61 +/- 4.75 versus 1.94 +/- 1.98 mg/L, P = 0.01), even after adjustment for potential confounding factors. CONCLUSION Our data suggest that rapidly destructive Hip Osteoarthritis may be associated with some degree of inflammation reflected by a small but significant increase in serum C-reactive protein levels.
Kharma C. Foucher - One of the best experts on this subject based on the ideXlab platform.
-
Gait asymmetries in unilateral symptomatic Hip Osteoarthritis and their association with radiographic severity and pain.
Hip international : the journal of clinical and experimental research on hip pathology and therapy, 2018Co-Authors: Gary J. Farkas, Kharma C. Foucher, Bryan R. Schlink, Louis Fogg, Markus A. Wimmer, Najia ShakoorAbstract:Introduction:Little is known about the loading patterns in unilateral Hip Osteoarthritis (OA) and their relationsHip to radiographic severity and pain. We aimed to examine the loading patterns at t...
-
Sex-specific Hip Osteoarthritis-associated gait abnormalities: Alterations in dynamic Hip abductor function differ in men and women
Clinical Biomechanics, 2017Co-Authors: Kharma C. FoucherAbstract:Abstract Background Hip Osteoarthritis results in abnormal gait mechanics, but it is not known whether abnormalities are the same in men and women. The hypothesis tested was that gait abnormalities are different in men and women with Hip Osteoarthritis vs. sex-specific asymptomatic groups. Methods 150 subjects with mild through severe radiographic Hip Osteoarthritis and 159 asymptomatic subjects were identified from an Institutional Review Board-approved motion analysis data repository. Sagittal plane Hip range of motion and peak external moments about the Hip, in all three planes, averaged from normal speed walking trials, were compared for men and women, with and without Hip Osteoarthritis using analysis of variance. Findings There were significant sex by group interactions for the external peak Hip adduction and external rotation moments ( P = 0.009–0.045). Although asymptomatic women had peak adduction and external rotation moments that were respectively 12% higher and 23% lower than asymptomatic men ( P = 0.026–0.037), these variables did not differ between men and women with Hip Osteoarthritis ( P ≥ 0.684). The Osteoarthritis vs. asymptomatic group difference in the peak Hip adduction moment was 45% larger in women than in men. The Osteoarthritis vs. asymptomatic group difference in the peak Hip external rotation moment was 55% larger for men than for women ( P Interpretation Normal sex differences in gait were not seen in Hip Osteoarthritis. Sex-specific adaptations may reflect different aspects of Hip abductor function. Men and women with Hip Osteoarthritis may require different interventions to improve function.