The Experts below are selected from a list of 7017 Experts worldwide ranked by ideXlab platform
B Cribier - One of the best experts on this subject based on the ideXlab platform.
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anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas microcystic adnexal carcinoma syringomatous carcinoma and squamoid eccrine ductal carcinoma
2015Co-Authors: Eric Frouin, Marie Dominique Vignonpennamen, B Balme, Benedicte Cavelierballoy, Ute Zimmermann, N Ortonne, Agnes Carlotti, L Pinquier, Josette Andre, B CribierAbstract:Background Microcystic adnexal carcinoma (MAC), syringomatous carcinoma (SC) and “Squamoid eccrine ductal carcinoma” (SEDC) are rare sclerosing adnexal tumours. Objective To understand the Histogenesis of these tumours and possible clinical implications. Methods We conducted a retrospective study of 30 cases, 18 MAC, 5 SC and 7 SEDC reviewed and classified by a panel of dermatopathology experts, with immunohistochemical analysis of keratins, including K77, a new keratin specific of eccrine ducts, and PHLDA1 expressed in adnexal structures. Results There was a strong female predominance, with only five cases occurring in men. Patients with MAC and SC were younger (mean age 56 and 47 years) than those with SEDC (mean age 81 years). The most common localization was the cheek in SC and SEDC and the periocular area in MAC. Two cases of SEDC were found in organ transplant patients. No recurrence or metastases were observed after complete surgery of MAC, or SC (mean follow-up 7.2 years and 4.7 years), whereas one case of SEDC recurred and another could not be fully excised. MAC and SC had similar histological features, except for cysts. In MAC, calcifications, granulomas, connection to follicles, keratin expression pattern, PHLDA1 positivity and K77 negativity indicated a follicular Histogenesis, whereas in SC, K77 positivity and keratin expression pattern were consistent with a differentiation towards eccrine apparatus. SEDC was composed of strands centred by ducts and nests with squamous differentiation and displayed K77 ductal positivity in all cases, a finding consistent with an eccrine origin. Conclusion Our study demonstrated that MAC and SC have similar clinical characteristics, although Histogenesis differs and show arguments for the individualization of SEDC.
Jan F Silverman - One of the best experts on this subject based on the ideXlab platform.
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kras oncogene mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas osteoclastoma of the pancreas and pancreatic duct adenocarcinoma
1997Co-Authors: Christopher D Gocke, David J Dabbs, Floyd A Benko, Jan F SilvermanAbstract:Giant cell neoplasms of the pancreas are rare tumors of uncertain Histogenesis. Mutation of the KRAS oncogene is common in typical pancreatic duct adenocarcinoma. We have analyzed DNA from five pancreatic tumors with giant cells for mutations in the KRAS oncogene and found alterations of the second position of codon 12 in each case (four G > A transitions and one G > C transversion). The common mutation pattern in tumors with giant cells and duct adenocarcinoma suggests a common route to malignant transformation and may indicate a shared Histogenesis. We also tested 11 cases of malignant fibrous histiocytoma, a histological mimic of pleomorphic giant cell tumor, for mutations in the KRAS oncogene. The absence of KRAS mutations in each of the malignant fibrous histiocytomas (MFHs) and in other histologically similar tumors may provide assistance in the differential diagnosis of pleomorphic pancreatic tumors.
Eric Frouin - One of the best experts on this subject based on the ideXlab platform.
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anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas microcystic adnexal carcinoma syringomatous carcinoma and squamoid eccrine ductal carcinoma
2015Co-Authors: Eric Frouin, Marie Dominique Vignonpennamen, B Balme, Benedicte Cavelierballoy, Ute Zimmermann, N Ortonne, Agnes Carlotti, L Pinquier, Josette Andre, B CribierAbstract:Background Microcystic adnexal carcinoma (MAC), syringomatous carcinoma (SC) and “Squamoid eccrine ductal carcinoma” (SEDC) are rare sclerosing adnexal tumours. Objective To understand the Histogenesis of these tumours and possible clinical implications. Methods We conducted a retrospective study of 30 cases, 18 MAC, 5 SC and 7 SEDC reviewed and classified by a panel of dermatopathology experts, with immunohistochemical analysis of keratins, including K77, a new keratin specific of eccrine ducts, and PHLDA1 expressed in adnexal structures. Results There was a strong female predominance, with only five cases occurring in men. Patients with MAC and SC were younger (mean age 56 and 47 years) than those with SEDC (mean age 81 years). The most common localization was the cheek in SC and SEDC and the periocular area in MAC. Two cases of SEDC were found in organ transplant patients. No recurrence or metastases were observed after complete surgery of MAC, or SC (mean follow-up 7.2 years and 4.7 years), whereas one case of SEDC recurred and another could not be fully excised. MAC and SC had similar histological features, except for cysts. In MAC, calcifications, granulomas, connection to follicles, keratin expression pattern, PHLDA1 positivity and K77 negativity indicated a follicular Histogenesis, whereas in SC, K77 positivity and keratin expression pattern were consistent with a differentiation towards eccrine apparatus. SEDC was composed of strands centred by ducts and nests with squamous differentiation and displayed K77 ductal positivity in all cases, a finding consistent with an eccrine origin. Conclusion Our study demonstrated that MAC and SC have similar clinical characteristics, although Histogenesis differs and show arguments for the individualization of SEDC.
Antoine Touzé - One of the best experts on this subject based on the ideXlab platform.
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Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review
2019Co-Authors: Thibault Kervarrec, Mahtab Samimi, Serge Guyétant, Bhavishya Sarma, Jeremy Chéret, Emmanuelle Blanchard, Patricia Berthon, David Schrama, Roland Houben, Antoine TouzéAbstract:Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyomavirus (MCPyV) integration into the host genome as the main event leading to MCC oncogenesis. However, despite identification of this crucial viral oncogenic trigger, the nature of the cell in which MCC oncogenesis occurs is actually unknown. In fact, several hypotheses have been proposed. Despite the large similarity in phenotype features between MCC tumor cells and physiological Merkel cells (MCs), a specialized subpopulation of the epidermis acting as mechanoreceptor of the skin, several points argue against the hypothesis that MCC derives directly from MCs. Alternatively, MCPyV integration could occur in another cell type and induce acquisition of an MC-like phenotype. Accordingly, an epithelial as well as a fibroblastic or B-cell origin of MCC has been proposed mainly based on phenotype similarities shared by MCC and these potential ancestries. The aim of this present review is to provide a comprehensive review of the current knowledge of the Histogenesis of MCC.
Nirag Jhala - One of the best experts on this subject based on the ideXlab platform.
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solid pseudopapillary tumor of the pancreas a review of salient clinical and pathologic features
2008Co-Authors: Amy L Adams, Gene P Siegal, Nirag JhalaAbstract:Solid pseudopapillary tumor (SPT) of the pancreas is a rare tumor of uncertain Histogenesis characterized, as the name suggests, by a cystic and solid pattern of growth with formation of pseudopapillae. Accounting for only a small percentage of pancreatic neoplasms, SPT occurs primarily in young wom
