The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform
Gary V. Dahl - One of the best experts on this subject based on the ideXlab platform.
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Variation in xenobiotic transport and metabolism genes, Household Chemical exposures, and risk of childhood acute lymphoblastic leukemia
Cancer causes & control : CCC, 2012Co-Authors: Anand P. Chokkalingam, Catherine Metayer, Ghislaine Scelo, Jeffrey S. Chang, Kevin Y. Urayama, Melinda C. Aldrich, Neela Guha, Helen M. Hansen, Gary V. Dahl, Lisa F. BarcellosAbstract:Recent studies suggest that environmental exposures to pesticides, tobacco, and other xenobiotic Chemicals may increase risk of childhood acute lymphoblastic leukemia (ALL). We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with Household Chemical exposures previously found to be associated with childhood ALL risk. We conducted a population-based epidemiologic study of 377 cases and 448 controls in California, utilizing a haplotype-based approach to evaluate 42 xenobiotic transport and metabolism genes in conjunction with data on self-reported Household Chemical exposures. We identified significant associations of childhood ALL risk with haplotypes of ABCB1, ARNT, CYP2C8, CYP1A2, CYP1B1, and IDH1. In addition, certain haplotypes showed significant joint effects with self-reported Household Chemical exposures on risk of childhood ALL. Specifically, elevated risks associated with use of paints in the home (ever) and indoor insecticides (pre-birth) were limited to subjects carrying specific haplotypes of CYP2C8 and ABCB1, respectively. Our results provide support for a role of xenobiotic transport and metabolism pathways in risk of childhood ALL and indicate that genes in these pathways may modulate the risk of disease associated with use of common Household Chemicals. Additional studies are needed to confirm these findings and localize specific causal variants.
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variation in xenobiotic transport and metabolism genes Household Chemical exposures and risk of childhood acute lymphoblastic leukemia
Cancer Causes & Control, 2012Co-Authors: Anand P. Chokkalingam, Catherine Metayer, Ghislaine Scelo, Jeffrey S. Chang, Kevin Y. Urayama, Melinda C. Aldrich, Neela Guha, Helen M. Hansen, Gary V. DahlAbstract:Background Recent studies suggest that environmental exposures to pesticides, tobacco, and other xenobiotic Chemicals may increase risk of childhood acute lymphoblastic leukemia (ALL). We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with Household Chemical exposures previously found to be associated with childhood ALL risk.
Ghislaine Scelo - One of the best experts on this subject based on the ideXlab platform.
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Variation in xenobiotic transport and metabolism genes, Household Chemical exposures, and risk of childhood acute lymphoblastic leukemia
Cancer causes & control : CCC, 2012Co-Authors: Anand P. Chokkalingam, Catherine Metayer, Ghislaine Scelo, Jeffrey S. Chang, Kevin Y. Urayama, Melinda C. Aldrich, Neela Guha, Helen M. Hansen, Gary V. Dahl, Lisa F. BarcellosAbstract:Recent studies suggest that environmental exposures to pesticides, tobacco, and other xenobiotic Chemicals may increase risk of childhood acute lymphoblastic leukemia (ALL). We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with Household Chemical exposures previously found to be associated with childhood ALL risk. We conducted a population-based epidemiologic study of 377 cases and 448 controls in California, utilizing a haplotype-based approach to evaluate 42 xenobiotic transport and metabolism genes in conjunction with data on self-reported Household Chemical exposures. We identified significant associations of childhood ALL risk with haplotypes of ABCB1, ARNT, CYP2C8, CYP1A2, CYP1B1, and IDH1. In addition, certain haplotypes showed significant joint effects with self-reported Household Chemical exposures on risk of childhood ALL. Specifically, elevated risks associated with use of paints in the home (ever) and indoor insecticides (pre-birth) were limited to subjects carrying specific haplotypes of CYP2C8 and ABCB1, respectively. Our results provide support for a role of xenobiotic transport and metabolism pathways in risk of childhood ALL and indicate that genes in these pathways may modulate the risk of disease associated with use of common Household Chemicals. Additional studies are needed to confirm these findings and localize specific causal variants.
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variation in xenobiotic transport and metabolism genes Household Chemical exposures and risk of childhood acute lymphoblastic leukemia
Cancer Causes & Control, 2012Co-Authors: Anand P. Chokkalingam, Catherine Metayer, Ghislaine Scelo, Jeffrey S. Chang, Kevin Y. Urayama, Melinda C. Aldrich, Neela Guha, Helen M. Hansen, Gary V. DahlAbstract:Background Recent studies suggest that environmental exposures to pesticides, tobacco, and other xenobiotic Chemicals may increase risk of childhood acute lymphoblastic leukemia (ALL). We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with Household Chemical exposures previously found to be associated with childhood ALL risk.
Anand P. Chokkalingam - One of the best experts on this subject based on the ideXlab platform.
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Variation in xenobiotic transport and metabolism genes, Household Chemical exposures, and risk of childhood acute lymphoblastic leukemia
Cancer causes & control : CCC, 2012Co-Authors: Anand P. Chokkalingam, Catherine Metayer, Ghislaine Scelo, Jeffrey S. Chang, Kevin Y. Urayama, Melinda C. Aldrich, Neela Guha, Helen M. Hansen, Gary V. Dahl, Lisa F. BarcellosAbstract:Recent studies suggest that environmental exposures to pesticides, tobacco, and other xenobiotic Chemicals may increase risk of childhood acute lymphoblastic leukemia (ALL). We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with Household Chemical exposures previously found to be associated with childhood ALL risk. We conducted a population-based epidemiologic study of 377 cases and 448 controls in California, utilizing a haplotype-based approach to evaluate 42 xenobiotic transport and metabolism genes in conjunction with data on self-reported Household Chemical exposures. We identified significant associations of childhood ALL risk with haplotypes of ABCB1, ARNT, CYP2C8, CYP1A2, CYP1B1, and IDH1. In addition, certain haplotypes showed significant joint effects with self-reported Household Chemical exposures on risk of childhood ALL. Specifically, elevated risks associated with use of paints in the home (ever) and indoor insecticides (pre-birth) were limited to subjects carrying specific haplotypes of CYP2C8 and ABCB1, respectively. Our results provide support for a role of xenobiotic transport and metabolism pathways in risk of childhood ALL and indicate that genes in these pathways may modulate the risk of disease associated with use of common Household Chemicals. Additional studies are needed to confirm these findings and localize specific causal variants.
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variation in xenobiotic transport and metabolism genes Household Chemical exposures and risk of childhood acute lymphoblastic leukemia
Cancer Causes & Control, 2012Co-Authors: Anand P. Chokkalingam, Catherine Metayer, Ghislaine Scelo, Jeffrey S. Chang, Kevin Y. Urayama, Melinda C. Aldrich, Neela Guha, Helen M. Hansen, Gary V. DahlAbstract:Background Recent studies suggest that environmental exposures to pesticides, tobacco, and other xenobiotic Chemicals may increase risk of childhood acute lymphoblastic leukemia (ALL). We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with Household Chemical exposures previously found to be associated with childhood ALL risk.
Julie A. Ross - One of the best experts on this subject based on the ideXlab platform.
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Maternal exposure to Household Chemicals and risk of infant leukemia: a report from the Children's Oncology Group.
Cancer causes & control : CCC, 2011Co-Authors: Megan E. Slater, Logan G. Spector, Leslie L. Robison, Amy M. Linabery, Kimberly J. Johnson, Joanne M. Hilden, Nyla A. Heerema, Julie A. RossAbstract:Utilizing data from the largest study to date, we examined associations between maternal preconception/prenatal exposure to Household Chemicals and infant acute leukemia. We present data from a Children's Oncology Group case-control study of 443 infants (<1 year of age) diagnosed with acute leukemia [including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)] between 1996 and 2006 and 324 population controls. Mothers recalled Household Chemical use 1 month before and throughout pregnancy. We used unconditional logistic regression adjusted for birth year, maternal age, and race/ethnicity to calculate odds ratios (ORs) and 95% confidence intervals (CIs). We did not find evidence for an association between infant leukemia and eight of nine Chemical categories. However, exposure to petroleum products during pregnancy was associated with AML (OR = 2.54; 95% CI:1.40-4.62) and leukemia without mixed lineage leukemia (MLL) gene rearrangements ("MLL-") (OR = 2.69; 95% CI: 1.47-4.93). No associations were observed for exposure in the month before pregnancy. Gestational exposure to petroleum products was associated with infant leukemia, particularly AML, and MLL- cases. Benzene is implicated as a potential carcinogen within this exposure category, but a clear biological mechanism has yet to be elucidated.
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Child and Maternal Household Chemical Exposure and the Risk of Acute Leukemia in Children with Down's Syndrome: A Report from the Children's Oncology Group
American journal of epidemiology, 2006Co-Authors: Lucy E. Alderton, Logan G. Spector, Cindy K. Blair, Michelle A. Roesler, Andrew F. Olshan, Leslie L. Robison, Julie A. RossAbstract:Compared with the general pediatric population, children with Down's syndrome have a much higher risk of acute leukemia. This case-control study was designed to explore potential risk factors for acute lymphoblastic leukemia and acute myeloid leukemia in children with Down's syndrome living in the United States or Canada. Mothers of 158 children with Down's syndrome and acute leukemia (97 acute lymphoblastic leukemia, 61 acute myeloid leukemia) diagnosed between January 1997 and October 2002 and mothers of 173 children with Down's syndrome but without leukemia were interviewed by telephone. Positive associations were found between acute lymphoblastic leukemia and maternal exposure to professional pest exterminations (odds ratio = 2.25, 95% confidence interval: 1.13, 4.49), to any pesticide (odds ratio = 2.18, 95% confidence interval: 1.08, 4.39), and to any Chemical (odds ratio = 2.72, 95% confidence interval: 1.17, 6.35). Most of the associations with acute myeloid leukemia were nonsignificant, and odds ratios were generally near or below 1.0. This exploratory study suggests that Household Chemical exposure may play a role in the development of acute lymphoblastic leukemia in children with Down's syndrome.
Sang-bum Hong - One of the best experts on this subject based on the ideXlab platform.
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lung function in patients with lung injury due to Household Chemical inhalation post hoc analysis of a prospective nationwide cohort
Respirology, 2017Co-Authors: Won-young Kim, Soonyoung Park, Hwa Jung Kim, Eun Jin Chae, Jin Won Huh, Chae-man Lim, Younsuck Koh, Sang-bum HongAbstract:Background and objective Inhalation exposure to Household Chemicals can result in serious health problems, although the long-term outcomes are unclear. We evaluated the changes in lung function after home humidifier disinfectant (HD) exposure. Methods This post hoc analysis of a prospective nationwide cohort involved patients with inhalation lung injury due to HD. Patients underwent spirometric measurements at onset and annually thereafter. Results Forty subjects met the eligibility criteria. Overall, mean forced vital capacity (FVC) increased significantly during the first 3 years from 2.10 ± 0.74 to 3.06 ± 1.08 L. Mean forced expiratory volume in 1 s (FEV 1) also rose from 1.84 ± 0.63 to 2.62 ± 0.88 L. Both variables then stabilized. However, in 19 (48%) patients, the FVCs did not normalize. Compared to subjects with an FVC at onset of <2.5 L, subjects with onset FVC ≥2.5 L exhibited significantly more improvement in percent predicted FVC over time (group × time interaction: P < 0.001). Patients with lower exposure also exhibited increasing percent predicted FVC over time, whereas more exposed patients showed a plateau starting at year 1. On multivariate analysis, onset FVC < 2.5 L associated significantly with <80% predicted FVC at year 4 (adjusted OR: 20.33; 95% CI: 1.10–376.53; P = 0.04). Conclusion Half of the patients with inhalation injury exhibited stabilization of lung function within several years of onset. However, lung function was impaired in the remaining patients. This impairment associated with lung function at onset and exposure intensity.
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Lung function in patients with lung injury due to Household Chemical inhalation: Post hoc analysis of a prospective nationwide cohort
Respirology (Carlton Vic.), 2016Co-Authors: Won-young Kim, Soonyoung Park, Hwa Jung Kim, Eun Jin Chae, Jin Won Huh, Chae-man Lim, Younsuck Koh, Sang-bum HongAbstract:Background and objective Inhalation exposure to Household Chemicals can result in serious health problems, although the long-term outcomes are unclear. We evaluated the changes in lung function after home humidifier disinfectant (HD) exposure. Methods This post hoc analysis of a prospective nationwide cohort involved patients with inhalation lung injury due to HD. Patients underwent spirometric measurements at onset and annually thereafter. Results Forty subjects met the eligibility criteria. Overall, mean forced vital capacity (FVC) increased significantly during the first 3 years from 2.10 ± 0.74 to 3.06 ± 1.08 L. Mean forced expiratory volume in 1 s (FEV 1) also rose from 1.84 ± 0.63 to 2.62 ± 0.88 L. Both variables then stabilized. However, in 19 (48%) patients, the FVCs did not normalize. Compared to subjects with an FVC at onset of
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Inhalation Lung Injury Associated with Humidifier Disinfectants in Adults.
Journal of Korean medical science, 2016Co-Authors: Jin Won Huh, Chae-man Lim, Sang-bum Hong, Kyung Hyun, Hyun Jung Koo, Jin Jang, Moo Song Lee, Domyung Paek, Dong-uk Park, Younsuck KohAbstract:We recently established a novel disease entity presented as progressive respiratory failure associated with the inhalation of humidifier disinfectants. In April 2011, we encountered a series of peripartum patients with complaints of respiratory distress of unknown etiology, which was an uncommon phenomenon. Accordingly, we created a multidisciplinary team comprising intensivists, radiologists, pathologists, epidemiologists, and the Korea Centers for Disease Control and Prevention (KCDC). Further, we defined the disease entity and performed a case-control study, epidemiologic investigation, and animal study to determine the etiology. The study findings indicated that the lung injury outbreak was related to the inhalation of humidifier disinfectants and showed that Household Chemical inhalation can cause severe respiratory failure. Following the withdrawal of humidifier disinfectants from the Korean market in 2012, no such cases were reported. This tragic event is a warning that appropriate safety regulations and monitoring for potential toxic Household Chemicals are critical to protect public health.