The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Raj Kumar Koiri - One of the best experts on this subject based on the ideXlab platform.
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Amelioratory effect of coenzyme Q10 on potential Human Carcinogen Microcystin-LR induced toxicity in mice.
Food and Chemical Toxicology, 2017Co-Authors: Yaqoob Lone, Mangla Bhide, Raj Kumar KoiriAbstract:Microcystins are a group of cyclic heptapeptide toxins produced by cyanobacteria. More than 100 microcystin analogues have been detected, among which microcystin-LR is the most abundant and toxic variant. Present study was designed to reveal whether potential Human Carcinogen microcystin-LR could imbalance the glycolytic-oxidative-nitrosative status of heart, kidney and spleen of mice and also to explore the amelioratory effect of coenzyme Q10 on microcystin-LR induced toxicity. Microcystin-LR was administered at a dose of 10 μg/kg bw/day, ip for 14 days in male mice. In microcystin-LR treated mice as compared to control, significant increase in the level of lipid peroxidation, hydrogen peroxide, lactate dehydrogenase, nitric oxide with a concomitant decrease in the level of glutathione was observed, suggesting microcystin-LR induced toxicity via induction of oxidative-nitrosative-glycolytic pathway. Although several studies have evaluated numerous antioxidants but still there is no effective chemoprotectant against microcystin-LR induced toxicity. When microcystin-LR treated mice were co-administered coenzyme Q10 (10 mg/kg bw/day, im) for 14 days, it was observed that coenzyme Q10 ameliorates microcystin-LR induced toxicity via modulation of glycolytic-oxidative-nitrosative stress pathway. Thus, the results suggest that coenzyme Q10 has a potential to be developed as preventive agent against microcystin-LR induced toxicity.
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An overview of the toxic effect of potential Human Carcinogen Microcystin-LR on testis.
Toxicology reports, 2015Co-Authors: Yaqoob Lone, Raj Kumar Koiri, Mangla BhideAbstract:Abstract The worldwide occurrence of cyanobacterial blooms due to water eutrophication evokes extreme concerns. These blooms produce cyanotoxins which are hazardous to living organisms. So far among these toxins, Microcystin-LR (MC-LR) is the most toxic and the most frequently encountered toxin produced by the cyanobacteria in the contaminated aquatic environment. Microcystin-LR is a potential Carcinogen for animals and Humans, and the International Agency for Research on Cancer has classified Microcystin-LR as a possible Human Carcinogen. After liver, testis has been considered as one of the most important target organs of Microcystin-LR toxicity. Microcystin-LR crosses the blood–testis barrier and interferes with DNA damage repair pathway and also increases expression of the proto-oncogenes, genes involved in the response to DNA damage, cell cycle arrest, and apoptosis in testis. Toxicity of MC-LR disrupts the motility and morphology of sperm and also affects the hormone levels of male reproductive system. MC-LR treated mice exhibit oxidative stress in testis through the alteration of antioxidant enzyme activity and also affect the histopathology of male reproductive system. In the present review, an attempt has been made to comprehensively address the impact of MC-LR toxicity on testis.
Mangla Bhide - One of the best experts on this subject based on the ideXlab platform.
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Amelioratory effect of coenzyme Q10 on potential Human Carcinogen Microcystin-LR induced toxicity in mice.
Food and Chemical Toxicology, 2017Co-Authors: Yaqoob Lone, Mangla Bhide, Raj Kumar KoiriAbstract:Microcystins are a group of cyclic heptapeptide toxins produced by cyanobacteria. More than 100 microcystin analogues have been detected, among which microcystin-LR is the most abundant and toxic variant. Present study was designed to reveal whether potential Human Carcinogen microcystin-LR could imbalance the glycolytic-oxidative-nitrosative status of heart, kidney and spleen of mice and also to explore the amelioratory effect of coenzyme Q10 on microcystin-LR induced toxicity. Microcystin-LR was administered at a dose of 10 μg/kg bw/day, ip for 14 days in male mice. In microcystin-LR treated mice as compared to control, significant increase in the level of lipid peroxidation, hydrogen peroxide, lactate dehydrogenase, nitric oxide with a concomitant decrease in the level of glutathione was observed, suggesting microcystin-LR induced toxicity via induction of oxidative-nitrosative-glycolytic pathway. Although several studies have evaluated numerous antioxidants but still there is no effective chemoprotectant against microcystin-LR induced toxicity. When microcystin-LR treated mice were co-administered coenzyme Q10 (10 mg/kg bw/day, im) for 14 days, it was observed that coenzyme Q10 ameliorates microcystin-LR induced toxicity via modulation of glycolytic-oxidative-nitrosative stress pathway. Thus, the results suggest that coenzyme Q10 has a potential to be developed as preventive agent against microcystin-LR induced toxicity.
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An overview of the toxic effect of potential Human Carcinogen Microcystin-LR on testis.
Toxicology reports, 2015Co-Authors: Yaqoob Lone, Raj Kumar Koiri, Mangla BhideAbstract:Abstract The worldwide occurrence of cyanobacterial blooms due to water eutrophication evokes extreme concerns. These blooms produce cyanotoxins which are hazardous to living organisms. So far among these toxins, Microcystin-LR (MC-LR) is the most toxic and the most frequently encountered toxin produced by the cyanobacteria in the contaminated aquatic environment. Microcystin-LR is a potential Carcinogen for animals and Humans, and the International Agency for Research on Cancer has classified Microcystin-LR as a possible Human Carcinogen. After liver, testis has been considered as one of the most important target organs of Microcystin-LR toxicity. Microcystin-LR crosses the blood–testis barrier and interferes with DNA damage repair pathway and also increases expression of the proto-oncogenes, genes involved in the response to DNA damage, cell cycle arrest, and apoptosis in testis. Toxicity of MC-LR disrupts the motility and morphology of sperm and also affects the hormone levels of male reproductive system. MC-LR treated mice exhibit oxidative stress in testis through the alteration of antioxidant enzyme activity and also affect the histopathology of male reproductive system. In the present review, an attempt has been made to comprehensively address the impact of MC-LR toxicity on testis.
Yaqoob Lone - One of the best experts on this subject based on the ideXlab platform.
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Amelioratory effect of coenzyme Q10 on potential Human Carcinogen Microcystin-LR induced toxicity in mice.
Food and Chemical Toxicology, 2017Co-Authors: Yaqoob Lone, Mangla Bhide, Raj Kumar KoiriAbstract:Microcystins are a group of cyclic heptapeptide toxins produced by cyanobacteria. More than 100 microcystin analogues have been detected, among which microcystin-LR is the most abundant and toxic variant. Present study was designed to reveal whether potential Human Carcinogen microcystin-LR could imbalance the glycolytic-oxidative-nitrosative status of heart, kidney and spleen of mice and also to explore the amelioratory effect of coenzyme Q10 on microcystin-LR induced toxicity. Microcystin-LR was administered at a dose of 10 μg/kg bw/day, ip for 14 days in male mice. In microcystin-LR treated mice as compared to control, significant increase in the level of lipid peroxidation, hydrogen peroxide, lactate dehydrogenase, nitric oxide with a concomitant decrease in the level of glutathione was observed, suggesting microcystin-LR induced toxicity via induction of oxidative-nitrosative-glycolytic pathway. Although several studies have evaluated numerous antioxidants but still there is no effective chemoprotectant against microcystin-LR induced toxicity. When microcystin-LR treated mice were co-administered coenzyme Q10 (10 mg/kg bw/day, im) for 14 days, it was observed that coenzyme Q10 ameliorates microcystin-LR induced toxicity via modulation of glycolytic-oxidative-nitrosative stress pathway. Thus, the results suggest that coenzyme Q10 has a potential to be developed as preventive agent against microcystin-LR induced toxicity.
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An overview of the toxic effect of potential Human Carcinogen Microcystin-LR on testis.
Toxicology reports, 2015Co-Authors: Yaqoob Lone, Raj Kumar Koiri, Mangla BhideAbstract:Abstract The worldwide occurrence of cyanobacterial blooms due to water eutrophication evokes extreme concerns. These blooms produce cyanotoxins which are hazardous to living organisms. So far among these toxins, Microcystin-LR (MC-LR) is the most toxic and the most frequently encountered toxin produced by the cyanobacteria in the contaminated aquatic environment. Microcystin-LR is a potential Carcinogen for animals and Humans, and the International Agency for Research on Cancer has classified Microcystin-LR as a possible Human Carcinogen. After liver, testis has been considered as one of the most important target organs of Microcystin-LR toxicity. Microcystin-LR crosses the blood–testis barrier and interferes with DNA damage repair pathway and also increases expression of the proto-oncogenes, genes involved in the response to DNA damage, cell cycle arrest, and apoptosis in testis. Toxicity of MC-LR disrupts the motility and morphology of sperm and also affects the hormone levels of male reproductive system. MC-LR treated mice exhibit oxidative stress in testis through the alteration of antioxidant enzyme activity and also affect the histopathology of male reproductive system. In the present review, an attempt has been made to comprehensively address the impact of MC-LR toxicity on testis.
J Ashby - One of the best experts on this subject based on the ideXlab platform.
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Mutagenicity of the Human bladder Carcinogen 4-aminobiphenyl to the bladder of MutaMouse transgenic mice.
Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis, 1998Co-Authors: K Fletcher, H Tinwell, J AshbyAbstract:The Human Carcinogen 4-aminobiphenyl (4AB) was evaluated in the MutaMouse transgenic mouse mutation assay. A single oral dose of 75 mg/kg induced 6.9-, 1.8- and 2.2-fold increases in the mutation frequency (MF) in the bladder, liver and bone marrow, respectively. Ten daily oral doses of 10 mg/kg 4AB increased the MF in the bladder, liver and bone marrow by 13.7-, 4.8- 2.4-fold the control value, respectively. The repeat dosing protocol was therefore more sensitive than the single dose protocol. Assessment of DNA samples prepared from pooled liver homogenates clearly indicated the increase in MF observed in the individual liver samples obtained from both groups of 4AB-treated mice.
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Activity of the Human Carcinogen MeCCNU in the mouse bone marrow micronucleus assay.
Environmental and molecular mutagenesis, 1991Co-Authors: H Tinwell, J AshbyAbstract:The nitrosourea mustard MeCCNU is the most recent organic chemical to be classified as a Human Carcinogen by IARC. MeCCNU gave a strong positive response when tested in the mouse bone marrow micronucleus assay. Activity was evident using either ip injection or oral gavage of the test chemical. These results further support the correlation between Human Carcinogens and their genotoxicity.
Paul J Villeneuve - One of the best experts on this subject based on the ideXlab platform.
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Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men
ISEE Conference Abstracts, 2013Co-Authors: Linda Kachuri, Shelley A. Harris, Marie-Élise Parent, Kenneth C. Johnson, Paul J VilleneuveAbstract:Background: Crystalline silica is a highly prevalent occupational exposure and recognized Human Carcinogen, however its association with lung cancer remains contentious. Aims: We investigated the r...
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occupational exposure to asbestos and lung cancer in men evidence from a population based case control study in eight canadian provinces
BMC Cancer, 2012Co-Authors: Shelley A. Harris, Marie-Élise Parent, Paul J Villeneuve, Kenneth C. JohnsonAbstract:Background Asbestos is classified as a Human Carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in population-based settings where there is a greater variety in the types of occupations, and exposures.
