The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform

Mark H Tuszynski - One of the best experts on this subject based on the ideXlab platform.

  • spinal cord Injury plasticity regeneration and the challenge of translational drug development
    Trends in Neurosciences, 2009
    Co-Authors: Armin Blesch, Mark H Tuszynski
    Abstract:

    Over the past three decades, multiple mechanisms limiting central nervous system regeneration have been identified. Here, we address plasticity arising from spared systems as a particularly important and often unrecognized mechanism that potentially contributes to functional recovery in studies of 'regeneration' after spinal cord Injury. We then discuss complexities involved in translating findings from animal models to Human clinical trials in spinal cord Injury; current strategies might be too limited in scope to yield detectable benefits in the complex and variable arena of Human Injury. Our animal models are imperfect, and the very variability that we attempt to control in the course of conducting rigorous research might, ironically, limit our ability to identify the most promising therapies in the Human arena. Therapeutic candidates are most likely to have a detectable effect in Human trials if they elicit benefits in severe contusion and larger animal models and pass the test of independent replication.

  • neurotrophic factors cellular bridges and gene therapy for spinal cord Injury
    The Journal of Physiology, 2001
    Co-Authors: Leonard L Jones, Martin Oudega, Mary Bartlett Bunge, Mark H Tuszynski
    Abstract:

    Injury to the adult mammalian spinal cord results in extensive axonal degeneration, variable amounts of neuronal loss, and often severe functional deficits. Restoration of controlled function depends on regeneration of these axons through an Injury site and the formation of functional synaptic connections. One strategy that has emerged for promoting axonal regeneration after spinal cord Injury is the implantation of autologous Schwann cells into sites of spinal cord Injury to support and guide axonal growth. Further, more recent experiments have shown that neurotrophic factors can also promote axonal growth, and, when combined with Schwann cell grafts, can further amplify axonal extension after Injury. Continued preclinical development of these approaches to neural repair may ultimately generate strategies that could be tested in Human Injury.

J Thunberg - One of the best experts on this subject based on the ideXlab platform.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience Letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

M Bergenheim - One of the best experts on this subject based on the ideXlab platform.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience Letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Edith Ribot-ciscar - One of the best experts on this subject based on the ideXlab platform.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience Letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Jp Roll - One of the best experts on this subject based on the ideXlab platform.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested.

  • Spontaneous bursting neuronal discharges recorded from peripheral nerve in Human: Injury discharges or not?
    Neuroscience Letters, 2004
    Co-Authors: M Bergenheim, Edith Ribot-ciscar, Jp Roll, J Thunberg
    Abstract:

    This paper deals with a spontaneous, bursting neuronal activity which can not be altered by any stimulation in the periphery or voluntary actions or by cognitive tasks. An initial description of such units led to the conclusion that this activity was generated ectopically at the site of a previous or present impalement of a nerve fibre. The aim of the current study was to record a larger number of these units by using microneurography, in order to characterise their firing properties and particularly, see if any subtypes of units could be identified. In conclusion, this paper suggests that some of these discharges could be related to an Injury of the nerve fibre, however most of them could not. Some hypothesis regarding the nature of these bursting activities are suggested. (C) 2003 Elsevier Ireland Ltd. All rights reserved.