The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
D G Disler - One of the best experts on this subject based on the ideXlab platform.
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fat suppressed three dimensional spoiled gradient recalled mr imaging assessment of articular and physeal Hyaline Cartilage
American Journal of Roentgenology, 1997Co-Authors: D G DislerAbstract:Fat-suppressed 3D SPGR imaging is a widely available technique that allows accurate evaluation of Hyaline Cartilage. The use of this sequence is helpful in confirming suggestive findings on standard MR imaging sequences and often allows diagnosis of conditions that otherwise would have gone undetected.
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fat suppressed three dimensional spoiled gradient echo mr imaging of Hyaline Cartilage defects in the knee comparison with standard mr imaging and arthroscopy
American Journal of Roentgenology, 1996Co-Authors: D G Disler, T R Mccauley, C G Kelman, M D Fuchs, L M Ratner, C R Wirth, P P HospodarAbstract:The sensitivity of fat-suppressed three-dimensional spoiled gradient-echo (SPGR) images was compared with that of standard MR images for detecting Hyaline Cartilage defects of the knee, using arthroscopy as the standard of reference.We assessed 114 consecutive patients for Hyaline Cartilage defects of the knee with both standard MR imaging sequences and a sagittal fat-suppressed three-dimensional SPGR sequence. Of these patients, 48 with meniscal or ligament injury, or persistent symptoms, underwent subsequent arthroscopy. The standard MR images and SPGR images of these 48 patients were then retrospectively analyzed for articular defects in a blinded fashion by two independent observers. Sensitivity, specificity, and intraobserver and interobserver agreement were determined for the different imaging techniques.One fourth of the patients who went on to arthroscopy were shown to have isolated Hyaline Cartilage lesions that were clinically confused with meniscal tears and that were missed on the standard MR ...
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detection of knee Hyaline Cartilage defects using fat suppressed three dimensional spoiled gradient echo mr imaging comparison with standard mr imaging and correlation with arthroscopy
American Journal of Roentgenology, 1995Co-Authors: D G Disler, T R Mccauley, C R Wirth, M D FuchsAbstract:OBJECTIVE: A preliminary study was done to prospectively compare fat-suppressed three-dimensional spoiled gradient-echo (3D SPGR) MR imaging with standard MR imaging for detection of defects in the Hyaline Cartilage of the knee, using arthroscopy as the reference standard. SUBJECTS AND METHODS: We studied 43 consecutive patients referred by two orthopedic surgeons for MR imaging of the knee. Twelve had arthroscopic correlation; they formed the basis of our study. Hyaline Cartilage was imaged with a fat-suppressed 3D SPGR sequence with previously determined optimal imaging parameters. Our standard MR imaging study consisted of two-dimensional coronal T1-weighted spin-echo, sagittal dual-echo T2-weighted spin-echo, and axial multiplanar gradient-echo sequences. With arthroscopy as the reference standard, sensitivity and specificity of fat-suppressed 3D SPGR and standard MR images for detecting Cartilage tears were determined by articular surface (eight surfaces in each patient: medial and lateral patellar facets, trochlear facets, femoral condyles, and tibial plateaus). Statistically significant differences in sensitivity and specificity were determined. RESULTS: Arthroscopy showed 15 Cartilage defects in seven patients. The fat-suppressed 3D SPGR images had higher sensitivity (93%) than the standard MR images (53%, p = .03). Specificity was 94% for the fat-suppressed 3D SPGR images compared with 93% for the standard MR images (p > .05). The five false-positive articular surfaces on fat-suppressed 3D SPGR images were from focal signal change within the substance of the Cartilage without a contour defect. Smoothly contoured thinning and loss of the trilaminar appearance of the Hyaline Cartilage at the lateral femoral notch was shown in all subjects and was considered a normal finding. CONCLUSION: Fat-suppressed 3D SPGR imaging is more sensitive than standard MR imaging for the detection of abnormalities of the Hyaline Cartilage in the knee. Routine use of this technique may strengthen the role of MR imaging for noninvasive evaluation of internal derangements of the knee.
M D Fuchs - One of the best experts on this subject based on the ideXlab platform.
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fat suppressed three dimensional spoiled gradient echo mr imaging of Hyaline Cartilage defects in the knee comparison with standard mr imaging and arthroscopy
American Journal of Roentgenology, 1996Co-Authors: D G Disler, T R Mccauley, C G Kelman, M D Fuchs, L M Ratner, C R Wirth, P P HospodarAbstract:The sensitivity of fat-suppressed three-dimensional spoiled gradient-echo (SPGR) images was compared with that of standard MR images for detecting Hyaline Cartilage defects of the knee, using arthroscopy as the standard of reference.We assessed 114 consecutive patients for Hyaline Cartilage defects of the knee with both standard MR imaging sequences and a sagittal fat-suppressed three-dimensional SPGR sequence. Of these patients, 48 with meniscal or ligament injury, or persistent symptoms, underwent subsequent arthroscopy. The standard MR images and SPGR images of these 48 patients were then retrospectively analyzed for articular defects in a blinded fashion by two independent observers. Sensitivity, specificity, and intraobserver and interobserver agreement were determined for the different imaging techniques.One fourth of the patients who went on to arthroscopy were shown to have isolated Hyaline Cartilage lesions that were clinically confused with meniscal tears and that were missed on the standard MR ...
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detection of knee Hyaline Cartilage defects using fat suppressed three dimensional spoiled gradient echo mr imaging comparison with standard mr imaging and correlation with arthroscopy
American Journal of Roentgenology, 1995Co-Authors: D G Disler, T R Mccauley, C R Wirth, M D FuchsAbstract:OBJECTIVE: A preliminary study was done to prospectively compare fat-suppressed three-dimensional spoiled gradient-echo (3D SPGR) MR imaging with standard MR imaging for detection of defects in the Hyaline Cartilage of the knee, using arthroscopy as the reference standard. SUBJECTS AND METHODS: We studied 43 consecutive patients referred by two orthopedic surgeons for MR imaging of the knee. Twelve had arthroscopic correlation; they formed the basis of our study. Hyaline Cartilage was imaged with a fat-suppressed 3D SPGR sequence with previously determined optimal imaging parameters. Our standard MR imaging study consisted of two-dimensional coronal T1-weighted spin-echo, sagittal dual-echo T2-weighted spin-echo, and axial multiplanar gradient-echo sequences. With arthroscopy as the reference standard, sensitivity and specificity of fat-suppressed 3D SPGR and standard MR images for detecting Cartilage tears were determined by articular surface (eight surfaces in each patient: medial and lateral patellar facets, trochlear facets, femoral condyles, and tibial plateaus). Statistically significant differences in sensitivity and specificity were determined. RESULTS: Arthroscopy showed 15 Cartilage defects in seven patients. The fat-suppressed 3D SPGR images had higher sensitivity (93%) than the standard MR images (53%, p = .03). Specificity was 94% for the fat-suppressed 3D SPGR images compared with 93% for the standard MR images (p > .05). The five false-positive articular surfaces on fat-suppressed 3D SPGR images were from focal signal change within the substance of the Cartilage without a contour defect. Smoothly contoured thinning and loss of the trilaminar appearance of the Hyaline Cartilage at the lateral femoral notch was shown in all subjects and was considered a normal finding. CONCLUSION: Fat-suppressed 3D SPGR imaging is more sensitive than standard MR imaging for the detection of abnormalities of the Hyaline Cartilage in the knee. Routine use of this technique may strengthen the role of MR imaging for noninvasive evaluation of internal derangements of the knee.
Dong-an Wang - One of the best experts on this subject based on the ideXlab platform.
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Decellularized tissue engineered Hyaline Cartilage graft for articular Cartilage repair.
Biomaterials, 2020Co-Authors: Yon Jin Chuah, Yvonne Peck, Pengfei He, Dong-an WangAbstract:Abstract Articular Cartilage repair has been a long-standing challenge in orthopaedic medicine due to the limited self-regenerative capability of Cartilage tissue. Currently, Cartilage lesions are often treated by microfracture or autologous chondrocyte implantation (ACI). However, these treatments are frequently reported to result in a mixture of the desired Hyaline Cartilage and mechanically inferior fibroCartilage. In this study, by combining the advantages of Cartilage tissue engineering and decellularization technology, we developed a decellularized allogeneic Hyaline Cartilage graft, named dLhCG, which achieved superior efficacy in articular Cartilage repair and surpassed living autologous chondrocyte-based cartilaginous engraftment and ACI. By the 6-month time point after implantation in porcine knee joints, the fine morphology, composition, phenotype, microstructure and mechanical properties of the regenerated Hyaline-like cartilaginous neo-tissue have been demonstrated via histology, biochemical assays, DNA microarrays and mechanical tests. The articular cartilaginous engraftment with allogeneic dLhCG was indicated to be well consistent, compatible and integrated with the native Cartilage of the host. The successful repair of articular chondral defects in large animal models suggests the readiness of allogeneic dLhCG for clinical trials.
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full scale osteochondral regeneration by sole graft of tissue engineered Hyaline Cartilage without co engraftment of subchondral bone substitute
Advanced Healthcare Materials, 2020Co-Authors: Yvonne Peck, Yon Jin Chuah, Dong-an Wang, Pengfei He, Jian YangAbstract:: In this study, full-scale osteochondral defects are hypothesized, which penetrate the articular Cartilage layer and invade into subchondral bones, and can be fixed by sole graft of tissue-engineered Hyaline Cartilage without co-engraftment of any subchondral bone substitute. It is hypothesized that given a finely regenerated articular Cartilage shielding on top, the restoration of subchondral bones can be fulfilled via spontaneous self-remodeling in situ. Hence, the key challenge of osteochondral regeneration lies in restoration of the non-self-regenerative articular Cartilage. Here, traumatic osteochondral lesions to be repaired in rabbit knee models are endeavored using novel tissue-engineered Hyaline-like Cartilage grafts that are produced by 3D cultured porcine chondrocytes in vitro. Comparative trials are conducted in animal models that are implanted with living Hyaline Cartilage grafts (LhCG) and decellularized LhCG (dLhCG). Sound osteochondral regeneration is gradually revealed from both LhCG and dLhCG-implanted samples 50-100 d after implantation. Quality regeneration in both zones of articular Cartilage and subchondral bones are validated by the restored osteochondral composition, structure, phenotype, and mechanical property, which validate the hypothesis of this study.
P P Hospodar - One of the best experts on this subject based on the ideXlab platform.
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fat suppressed three dimensional spoiled gradient echo mr imaging of Hyaline Cartilage defects in the knee comparison with standard mr imaging and arthroscopy
American Journal of Roentgenology, 1996Co-Authors: D G Disler, T R Mccauley, C G Kelman, M D Fuchs, L M Ratner, C R Wirth, P P HospodarAbstract:The sensitivity of fat-suppressed three-dimensional spoiled gradient-echo (SPGR) images was compared with that of standard MR images for detecting Hyaline Cartilage defects of the knee, using arthroscopy as the standard of reference.We assessed 114 consecutive patients for Hyaline Cartilage defects of the knee with both standard MR imaging sequences and a sagittal fat-suppressed three-dimensional SPGR sequence. Of these patients, 48 with meniscal or ligament injury, or persistent symptoms, underwent subsequent arthroscopy. The standard MR images and SPGR images of these 48 patients were then retrospectively analyzed for articular defects in a blinded fashion by two independent observers. Sensitivity, specificity, and intraobserver and interobserver agreement were determined for the different imaging techniques.One fourth of the patients who went on to arthroscopy were shown to have isolated Hyaline Cartilage lesions that were clinically confused with meniscal tears and that were missed on the standard MR ...
C R Wirth - One of the best experts on this subject based on the ideXlab platform.
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fat suppressed three dimensional spoiled gradient echo mr imaging of Hyaline Cartilage defects in the knee comparison with standard mr imaging and arthroscopy
American Journal of Roentgenology, 1996Co-Authors: D G Disler, T R Mccauley, C G Kelman, M D Fuchs, L M Ratner, C R Wirth, P P HospodarAbstract:The sensitivity of fat-suppressed three-dimensional spoiled gradient-echo (SPGR) images was compared with that of standard MR images for detecting Hyaline Cartilage defects of the knee, using arthroscopy as the standard of reference.We assessed 114 consecutive patients for Hyaline Cartilage defects of the knee with both standard MR imaging sequences and a sagittal fat-suppressed three-dimensional SPGR sequence. Of these patients, 48 with meniscal or ligament injury, or persistent symptoms, underwent subsequent arthroscopy. The standard MR images and SPGR images of these 48 patients were then retrospectively analyzed for articular defects in a blinded fashion by two independent observers. Sensitivity, specificity, and intraobserver and interobserver agreement were determined for the different imaging techniques.One fourth of the patients who went on to arthroscopy were shown to have isolated Hyaline Cartilage lesions that were clinically confused with meniscal tears and that were missed on the standard MR ...
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detection of knee Hyaline Cartilage defects using fat suppressed three dimensional spoiled gradient echo mr imaging comparison with standard mr imaging and correlation with arthroscopy
American Journal of Roentgenology, 1995Co-Authors: D G Disler, T R Mccauley, C R Wirth, M D FuchsAbstract:OBJECTIVE: A preliminary study was done to prospectively compare fat-suppressed three-dimensional spoiled gradient-echo (3D SPGR) MR imaging with standard MR imaging for detection of defects in the Hyaline Cartilage of the knee, using arthroscopy as the reference standard. SUBJECTS AND METHODS: We studied 43 consecutive patients referred by two orthopedic surgeons for MR imaging of the knee. Twelve had arthroscopic correlation; they formed the basis of our study. Hyaline Cartilage was imaged with a fat-suppressed 3D SPGR sequence with previously determined optimal imaging parameters. Our standard MR imaging study consisted of two-dimensional coronal T1-weighted spin-echo, sagittal dual-echo T2-weighted spin-echo, and axial multiplanar gradient-echo sequences. With arthroscopy as the reference standard, sensitivity and specificity of fat-suppressed 3D SPGR and standard MR images for detecting Cartilage tears were determined by articular surface (eight surfaces in each patient: medial and lateral patellar facets, trochlear facets, femoral condyles, and tibial plateaus). Statistically significant differences in sensitivity and specificity were determined. RESULTS: Arthroscopy showed 15 Cartilage defects in seven patients. The fat-suppressed 3D SPGR images had higher sensitivity (93%) than the standard MR images (53%, p = .03). Specificity was 94% for the fat-suppressed 3D SPGR images compared with 93% for the standard MR images (p > .05). The five false-positive articular surfaces on fat-suppressed 3D SPGR images were from focal signal change within the substance of the Cartilage without a contour defect. Smoothly contoured thinning and loss of the trilaminar appearance of the Hyaline Cartilage at the lateral femoral notch was shown in all subjects and was considered a normal finding. CONCLUSION: Fat-suppressed 3D SPGR imaging is more sensitive than standard MR imaging for the detection of abnormalities of the Hyaline Cartilage in the knee. Routine use of this technique may strengthen the role of MR imaging for noninvasive evaluation of internal derangements of the knee.