The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Jiro Maegawa - One of the best experts on this subject based on the ideXlab platform.
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brief report reconstruction of joint Hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage
Stem Cells, 2014Co-Authors: Mitsuru Mizuno, Takanori Takebe, Yuichiro Yabuki, Takahisa Matsuzaki, Lee Jeong Ik, Hiroshi Yoshikawa, Shinji Kobayashi, Seiichiro Nakabayashi, Jiro MaegawaAbstract:In healthy joints, Hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct Hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint Hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint Hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint Hyaline cartilage. This study suggested that joint Hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint Hyaline cartilage in patients with degenerative arthropathies. Stem Cells 2014;32:816–821
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brief report reconstruction of joint Hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage
Stem Cells, 2014Co-Authors: Mitsuru Mizuno, Takanori Takebe, Yuichiro Yabuki, Takahisa Matsuzaki, Hiroshi Yoshikawa, Shinji Kobayashi, Seiichiro Nakabayashi, Hiroomi Kan, Jiro MaegawaAbstract:In healthy joints, Hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct Hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint Hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint Hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint Hyaline cartilage. This study suggested that joint Hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint Hyaline cartilage in patients with degenerative arthropathies.
Seiichiro Nakabayashi - One of the best experts on this subject based on the ideXlab platform.
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brief report reconstruction of joint Hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage
Stem Cells, 2014Co-Authors: Mitsuru Mizuno, Takanori Takebe, Yuichiro Yabuki, Takahisa Matsuzaki, Lee Jeong Ik, Hiroshi Yoshikawa, Shinji Kobayashi, Seiichiro Nakabayashi, Jiro MaegawaAbstract:In healthy joints, Hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct Hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint Hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint Hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint Hyaline cartilage. This study suggested that joint Hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint Hyaline cartilage in patients with degenerative arthropathies. Stem Cells 2014;32:816–821
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brief report reconstruction of joint Hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage
Stem Cells, 2014Co-Authors: Mitsuru Mizuno, Takanori Takebe, Yuichiro Yabuki, Takahisa Matsuzaki, Hiroshi Yoshikawa, Shinji Kobayashi, Seiichiro Nakabayashi, Hiroomi Kan, Jiro MaegawaAbstract:In healthy joints, Hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct Hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint Hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint Hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint Hyaline cartilage. This study suggested that joint Hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint Hyaline cartilage in patients with degenerative arthropathies.
Peter A. Reichart - One of the best experts on this subject based on the ideXlab platform.
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Pulse or Hyaline ring granuloma. Review of the literature on etiopathogenesis of oral and extraoral lesions
Clinical Oral Investigations, 2010Co-Authors: Hans Peter Philipsen, Peter A. ReichartAbstract:Since the late 1950s, reports on an unusual giant-cell granulomatous lesion affecting the jaws, lungs, stomach and intestines have been published . Histopathologically, the lesions showed the presence of structureless Hyaline rings with multinucleated giant cells. The aim of this review was to summarize the literature on the etiopathogenesis of the so-called oral and extraoral pulse or Hyaline ring granuloma. Literature was searched using PubMed and Medline. In addition, hand search was performed. Search words were oral and extraoral Hyaline ring granuloma, giant-cell Hyaline angiopathy, pulse granuloma and chronic periostitis. Numerous terms for Hyaline ring granuloma have been introduced over time (1971–2008). One hundred seventy-three cases of oral Hyaline ring granuloma have been retrieved from the literature. In the mandible, 72.3% occurred . Two theories for etiopathogenesis have been proposed: (1) the origin of the Hyaline rings is due to a foreign material (pulse and legumes) having penetrated the oral mucosa or gastrointestinal tract and lungs (exogenous theory) and (2) the rings are due to Hyaline degenerative changes in walls of blood vessels (endogenous theory). Experimental production of oral and extraoral Hyaline ring granulomas is consistent with the exogenous origin. Particles or remains of leguminous cells having been implanted or aspirated into human tissues whether located to the oral cavity or throughout the entire digestive tract and respiratory system are thought to be causative. Pulse or Hyaline ring granulomas are rare but are well-defined oral and extraoral lesions due to implantation of the cellulose moiety of plant foods in contrast to the starch components.
Mitsuru Mizuno - One of the best experts on this subject based on the ideXlab platform.
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brief report reconstruction of joint Hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage
Stem Cells, 2014Co-Authors: Mitsuru Mizuno, Takanori Takebe, Yuichiro Yabuki, Takahisa Matsuzaki, Lee Jeong Ik, Hiroshi Yoshikawa, Shinji Kobayashi, Seiichiro Nakabayashi, Jiro MaegawaAbstract:In healthy joints, Hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct Hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint Hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint Hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint Hyaline cartilage. This study suggested that joint Hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint Hyaline cartilage in patients with degenerative arthropathies. Stem Cells 2014;32:816–821
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brief report reconstruction of joint Hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage
Stem Cells, 2014Co-Authors: Mitsuru Mizuno, Takanori Takebe, Yuichiro Yabuki, Takahisa Matsuzaki, Hiroshi Yoshikawa, Shinji Kobayashi, Seiichiro Nakabayashi, Hiroomi Kan, Jiro MaegawaAbstract:In healthy joints, Hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct Hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint Hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint Hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint Hyaline cartilage. This study suggested that joint Hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint Hyaline cartilage in patients with degenerative arthropathies.
Hans Peter Philipsen - One of the best experts on this subject based on the ideXlab platform.
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Pulse or Hyaline ring granuloma. Review of the literature on etiopathogenesis of oral and extraoral lesions
Clinical Oral Investigations, 2010Co-Authors: Hans Peter Philipsen, Peter A. ReichartAbstract:Since the late 1950s, reports on an unusual giant-cell granulomatous lesion affecting the jaws, lungs, stomach and intestines have been published . Histopathologically, the lesions showed the presence of structureless Hyaline rings with multinucleated giant cells. The aim of this review was to summarize the literature on the etiopathogenesis of the so-called oral and extraoral pulse or Hyaline ring granuloma. Literature was searched using PubMed and Medline. In addition, hand search was performed. Search words were oral and extraoral Hyaline ring granuloma, giant-cell Hyaline angiopathy, pulse granuloma and chronic periostitis. Numerous terms for Hyaline ring granuloma have been introduced over time (1971–2008). One hundred seventy-three cases of oral Hyaline ring granuloma have been retrieved from the literature. In the mandible, 72.3% occurred . Two theories for etiopathogenesis have been proposed: (1) the origin of the Hyaline rings is due to a foreign material (pulse and legumes) having penetrated the oral mucosa or gastrointestinal tract and lungs (exogenous theory) and (2) the rings are due to Hyaline degenerative changes in walls of blood vessels (endogenous theory). Experimental production of oral and extraoral Hyaline ring granulomas is consistent with the exogenous origin. Particles or remains of leguminous cells having been implanted or aspirated into human tissues whether located to the oral cavity or throughout the entire digestive tract and respiratory system are thought to be causative. Pulse or Hyaline ring granulomas are rare but are well-defined oral and extraoral lesions due to implantation of the cellulose moiety of plant foods in contrast to the starch components.
