The Experts below are selected from a list of 1575 Experts worldwide ranked by ideXlab platform
Leila Cuttle - One of the best experts on this subject based on the ideXlab platform.
-
development and characterization of a novel antimicrobial sterile Hydrogel Dressing for burn wounds single step production with gamma irradiation creates silver nanoparticles and radical polymerization
Journal of Pharmaceutical Sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Leila Cuttle, Philip Martin Barber, Sirirat Rengpipat, Vijay T. JohnAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Development and Characterization of a Novel, Antimicrobial, Sterile Hydrogel Dressing for Burn Wounds: Single‐Step Production with Gamma Irradiation Creates Silver Nanoparticles and Radical Polymerization
Journal of pharmaceutical sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Philip Martin Barber, Sirirat Rengpipat, Vijay T. John, Leila CuttleAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Antimicrobial efficacy of a novel silver Hydrogel Dressing compared to two common silver burn wound Dressings: Acticoat™ and PolyMem Silver(®).
Burns : journal of the International Society for Burn Injuries, 2013Co-Authors: Benjawan Boonkaew, Roy M. Kimble, Margit Kempf, Pitt Supaphol, Leila CuttleAbstract:A novel burn wound Hydrogel Dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel Dressing to two commercially available silver Dressings; Acticoat™ and PolyMem Silver®. Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead® Baclight™ bacterial viability assay. Burn wound pathogens (P. aeruginosa, MSSA, A. baumannii and C. albicans) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9-18.4 mm. It reduced the microbial inocula below the limit of detection (10 2 CFU/ml) and reduced viability by 99% within 4 h. PolyMem Silver® had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead® Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver Hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94-99% after 24 h exposure. These results support the possibility of using this novel silver Hydrogel as a burn wound Dressing in the future.
Benjawan Boonkaew - One of the best experts on this subject based on the ideXlab platform.
-
development and characterization of a novel antimicrobial sterile Hydrogel Dressing for burn wounds single step production with gamma irradiation creates silver nanoparticles and radical polymerization
Journal of Pharmaceutical Sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Leila Cuttle, Philip Martin Barber, Sirirat Rengpipat, Vijay T. JohnAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Development and Characterization of a Novel, Antimicrobial, Sterile Hydrogel Dressing for Burn Wounds: Single‐Step Production with Gamma Irradiation Creates Silver Nanoparticles and Radical Polymerization
Journal of pharmaceutical sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Philip Martin Barber, Sirirat Rengpipat, Vijay T. John, Leila CuttleAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Antimicrobial efficacy of a novel silver Hydrogel Dressing compared to two common silver burn wound Dressings: Acticoat™ and PolyMem Silver(®).
Burns : journal of the International Society for Burn Injuries, 2013Co-Authors: Benjawan Boonkaew, Roy M. Kimble, Margit Kempf, Pitt Supaphol, Leila CuttleAbstract:A novel burn wound Hydrogel Dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel Dressing to two commercially available silver Dressings; Acticoat™ and PolyMem Silver®. Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead® Baclight™ bacterial viability assay. Burn wound pathogens (P. aeruginosa, MSSA, A. baumannii and C. albicans) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9-18.4 mm. It reduced the microbial inocula below the limit of detection (10 2 CFU/ml) and reduced viability by 99% within 4 h. PolyMem Silver® had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead® Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver Hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94-99% after 24 h exposure. These results support the possibility of using this novel silver Hydrogel as a burn wound Dressing in the future.
Pitt Supaphol - One of the best experts on this subject based on the ideXlab platform.
-
development and characterization of a novel antimicrobial sterile Hydrogel Dressing for burn wounds single step production with gamma irradiation creates silver nanoparticles and radical polymerization
Journal of Pharmaceutical Sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Leila Cuttle, Philip Martin Barber, Sirirat Rengpipat, Vijay T. JohnAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Development and Characterization of a Novel, Antimicrobial, Sterile Hydrogel Dressing for Burn Wounds: Single‐Step Production with Gamma Irradiation Creates Silver Nanoparticles and Radical Polymerization
Journal of pharmaceutical sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Philip Martin Barber, Sirirat Rengpipat, Vijay T. John, Leila CuttleAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Antimicrobial efficacy of a novel silver Hydrogel Dressing compared to two common silver burn wound Dressings: Acticoat™ and PolyMem Silver(®).
Burns : journal of the International Society for Burn Injuries, 2013Co-Authors: Benjawan Boonkaew, Roy M. Kimble, Margit Kempf, Pitt Supaphol, Leila CuttleAbstract:A novel burn wound Hydrogel Dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel Dressing to two commercially available silver Dressings; Acticoat™ and PolyMem Silver®. Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead® Baclight™ bacterial viability assay. Burn wound pathogens (P. aeruginosa, MSSA, A. baumannii and C. albicans) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9-18.4 mm. It reduced the microbial inocula below the limit of detection (10 2 CFU/ml) and reduced viability by 99% within 4 h. PolyMem Silver® had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead® Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver Hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94-99% after 24 h exposure. These results support the possibility of using this novel silver Hydrogel as a burn wound Dressing in the future.
Margit Kempf - One of the best experts on this subject based on the ideXlab platform.
-
development and characterization of a novel antimicrobial sterile Hydrogel Dressing for burn wounds single step production with gamma irradiation creates silver nanoparticles and radical polymerization
Journal of Pharmaceutical Sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Leila Cuttle, Philip Martin Barber, Sirirat Rengpipat, Vijay T. JohnAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Development and Characterization of a Novel, Antimicrobial, Sterile Hydrogel Dressing for Burn Wounds: Single‐Step Production with Gamma Irradiation Creates Silver Nanoparticles and Radical Polymerization
Journal of pharmaceutical sciences, 2014Co-Authors: Benjawan Boonkaew, Margit Kempf, Pitt Supaphol, Philip Martin Barber, Sirirat Rengpipat, Vijay T. John, Leila CuttleAbstract:Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound Dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) Hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused Hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile Hydrogel Dressing and a reduction of silver ions to form SNPs infused in the Hydrogel in a one-step process. About 80% of the total silver was released from the Hydrogels after 72 h immersion in simulated body fluid solution; therefore, they could be used on wounds for up to 3 days. All the Hydrogels were found to be nontoxic to normal human dermal fibroblast cells. The silver-loaded Hydrogels had good inhibitory action against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Results from a pilot study on a porcine burn model showed that the 5-mM silver Hydrogel was efficient at preventing bacterial colonization of wounds, and the results were comparable to the commercially available silver Dressings (Acticoat(TM) , PolyMem Silver(®) ). These results support its use as a potential burn wound Dressing.
-
Antimicrobial efficacy of a novel silver Hydrogel Dressing compared to two common silver burn wound Dressings: Acticoat™ and PolyMem Silver(®).
Burns : journal of the International Society for Burn Injuries, 2013Co-Authors: Benjawan Boonkaew, Roy M. Kimble, Margit Kempf, Pitt Supaphol, Leila CuttleAbstract:A novel burn wound Hydrogel Dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel Dressing to two commercially available silver Dressings; Acticoat™ and PolyMem Silver®. Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead® Baclight™ bacterial viability assay. Burn wound pathogens (P. aeruginosa, MSSA, A. baumannii and C. albicans) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9-18.4 mm. It reduced the microbial inocula below the limit of detection (10 2 CFU/ml) and reduced viability by 99% within 4 h. PolyMem Silver® had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead® Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver Hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94-99% after 24 h exposure. These results support the possibility of using this novel silver Hydrogel as a burn wound Dressing in the future.
Jo Dumville - One of the best experts on this subject based on the ideXlab platform.
-
The Cochrane Library - Hydrogel Dressings for treating pressure ulcers
The Cochrane database of systematic reviews, 2015Co-Authors: Jo Dumville, Nikki Stubbs, Samantha Keogh, Rachel Walker, Zhenmi LiuAbstract:Background Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and there are many different Dressing options including Hydrogel Dressings. A clear and current overview of the current evidence is required to facilitate decision-making regarding Dressing use for the treatment of pressure ulcers. Objectives To assess the effects of Hydrogel Dressings on the healing of pressure ulcers in any care setting. Search methods We searched the following databases: the Cochrane Wounds Group Specialised Register (searched 19 June 2014); The Cochrane Central Register of Controlled Trials (CENTRAL; 2014, Issue 5); Ovid MEDLINE (1946 to June Week 2 2014); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, 23 June 2014); Ovid EMBASE (1974 to 20 June 2014); and EBSCO CINAHL (1982 to 18 June 2014). There were no restrictions based on language or date of publication. Selection criteria Published or unpublished randomised controlled trials (RCTs) comparing the effects of Hydrogel Dressings with alternative wound Dressings or no Dressing in the treatment of pressure ulcers (stage II or above). Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction. Main results We included eleven studies (523 participants) in this review. Ten studies had two arms and one had three arms that were all relevant to this review. Three studies compared a Hydrogel Dressing with a basic wound contact Dressing; three studies compared a Hydrogel Dressing with a hydrocolloid Dressing; three studies compared a Hydrogel Dressing with another Hydrogel Dressing; one study compared a Hydrogel Dressing with a foam Dressing; one study compared a Hydrogel Dressing with a dextranomer paste Dressing and one study compared a Hydrogel Dressing with a topical treatment (collagenase). Limited data were available for analyses in this review: we conducted no meta-analyses. Where data were available there was no evidence of a difference between Hydrogel and alternative treatments in terms of complete wound healing or adverse events. One small study reported that using Hydrogel Dressings was, on average, less costly than hydrocolloid Dressings, but this estimate was imprecise and its methodology was not clear. All included studies were small, had short follow-up times and were at unclear risk of bias. Authors' conclusions It is not clear if Hydrogel Dressings are more or less effective than other treatments in healing pressure ulcers or if different Hydrogels have different effects, Most trials in this field are very small and poorly reported so that risk of bias is unclear.
-
Hydrogel Dressings for treating pressure ulcers (Review)
'Wiley', 2015Co-Authors: Jo Dumville, Stubbs Nikki, Keogh Samantha, Walker Rachel, Liu ZhenmiAbstract:Free to read Background Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and there are many different Dressing options including Hydrogel Dressings. A clear and current overview of the current evidence is required to facilitate decision-making regarding Dressing use for the treatment of pressure ulcers. Objectives To assess the effects of Hydrogel Dressings on the healing of pressure ulcers in any care setting. Search methods We searched the following databases: the Cochrane Wounds Group Specialised Register (searched 19 June 2014); The Cochrane Central Register of Controlled Trials (CENTRAL; 2014, Issue 5); Ovid MEDLINE (1946 to June Week 2 2014); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, 23 June 2014); Ovid EMBASE (1974 to 20 June 2014); and EBSCO CINAHL (1982 to 18 June 2014). There were no restrictions based on language or date of publication. Selection criteria Published or unpublished randomised controlled trials (RCTs) comparing the effects of Hydrogel Dressings with alternative wound Dressings or no Dressing in the treatment of pressure ulcers (stage II or above). Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction. Main results We included eleven studies (523 participants) in this review. Ten studies had two arms and one had three arms that were all relevant to this review. Three studies compared a Hydrogel Dressing with a basic wound contact Dressing; three studies compared a Hydrogel Dressing with a hydrocolloid Dressing; three studies compared a Hydrogel Dressing with another Hydrogel Dressing; one study compared a Hydrogel Dressing with a foam Dressing; one study compared a Hydrogel Dressing with a dextranomer paste Dressing and one study compared a Hydrogel Dressing with a topical treatment (collagenase). Limited data were available for analyses in this review: we conducted no meta-analyses. Where data were available there was no evidence of a difference between Hydrogel and alternative treatments in terms of complete wound healing or adverse events. One small study reported that using Hydrogel Dressings was, on average, less costly than hydrocolloid Dressings, but this estimate was imprecise and its methodology was not clear. All included studies were small, had short follow-up times and were at unclear risk of bias. Authors' conclusions It is not clear if Hydrogel Dressings are more or less effective than other treatments in healing pressure ulcers or if different Hydrogels have different effects, Most trials in this field are very small and poorly reported so that risk of bias is unclear
-
Hydrogel Dressings for treating pressure ulcers (Review)
John Wiley & Sons, 2015Co-Authors: Jo Dumville, Stubbs Nikki, Keogh Samantha, Walker Rachel, Liu ZhenmiAbstract:Background: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and there are many different Dressing options including Hydrogel Dressings. A clear and current overview of the current evidence is required to facilitate decision-making regarding Dressing use for the treatment of pressure ulcers. Objectives: To assess the effects of Hydrogel Dressings on the healing of pressure ulcers in any care setting. Search methods: We searched the following databases: the Cochrane Wounds Group Specialised Register (searched 19 June 2014); The Cochrane Central Register of Controlled Trials (CENTRAL; 2014, Issue 5); Ovid MEDLINE (1946 to June Week 2 2014); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, 23 June 2014); Ovid EMBASE (1974 to 20 June 2014); and EBSCO CINAHL (1982 to 18 June 2014). There were no restrictions based on language or date of publication. Selection criteria: Published or unpublished randomised controlled trials (RCTs) comparing the effects of Hydrogel Dressings with alternative wound Dressings or no Dressing in the treatment of pressure ulcers (stage II or above). Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction. Main results: We included eleven studies (523 participants) in this review. Ten studies had two arms and one had three arms that were all relevant to this review. Three studies compared a Hydrogel Dressing with a basic wound contact Dressing; three studies compared a Hydrogel Dressing with a hydrocolloid Dressing; three studies compared a Hydrogel Dressing with another Hydrogel Dressing; one study compared a Hydrogel Dressing with a foam Dressing; one study compared a Hydrogel Dressing with a dextranomer paste Dressing and one study compared a Hydrogel Dressing with a topical treatment (collagenase). Limited data were available for analyses in this review: we conducted no meta-analyses. Where data were available there was no evidence of a difference between Hydrogel and alternative treatments in terms of complete wound healing or adverse events. One small study reported that using Hydrogel Dressings was, on average, less costly than hydrocolloid Dressings, but this estimate was imprecise and its methodology was not clear. All included studies were small, had short follow-up times and were at unclear risk of bias. Authors' conclusions: It is not clear if Hydrogel Dressings are more or less effective than other treatments in healing pressure ulcers or if different Hydrogels have different effects, Most trials in this field are very small and poorly reported so that risk of bias is unclear.Full Tex
-
Hydrogel Dressings for healing diabetic foot ulcers.
The Cochrane database of systematic reviews, 2013Co-Authors: Jo Dumville, Susan O'meara, Sohan Deshpande, Katharine SpeakAbstract:Foot ulcers in people with diabetes are a prevalent and serious global health issue. Dressings form a key part of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrogel Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. To assess the effects of Hydrogel wound Dressings compared with alternative Dressings or none on the healing of foot ulcers in people with diabetes. For this first update, in April 2013, we searched the following databases the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. There were no restrictions based on language or date of publication. Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrogel with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. Two review authors independently performed study selection, risk of bias assessment and data extraction. We included five studies (446 participants) in this review. Meta analysis of three studies comparing Hydrogel Dressings with basic wound contract Dressings found significantly greater healing with Hydrogel: risk ratio (RR) 1.80, 95% confidence interval (CI) 1.27 to 2.56. The three pooled studies had different follow-up times (12 weeks, 16 weeks and 20 weeks) and also evaluated ulcers of different severities (grade 3 and 4; grade 2 and grade unspecified). One study compared a Hydrogel Dressing with larval therapy and found no statistically significant difference in the number of ulcers healed and another found no statistically significant difference in healing between Hydrogel and platelet-derived growth factor. There was also no statistically significant difference in number of healed ulcers between two different brands of Hydrogel Dressing. All included studies were small and at unclear risk of bias and there was some clinical heterogeneity with studies including different ulcer grades. No included studies compared Hydrogel with other advanced wound Dressings. There is some evidence to suggest that Hydrogel Dressings are more effective in healing (lower grade) diabetic foot ulcers than basic wound contact Dressings however this finding is uncertain due to risk of bias in the original studies. There is currently no research evidence to suggest that Hydrogel is more effective than larval therapy or platelet-derived growth factors in healing diabetic foot ulcers, nor that one brand of Hydrogel is more effective than another in ulcer healing. No RCTs comparing Hydrogel Dressings with other advanced Dressing types were found.
