The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Bernard Rousseau - One of the best experts on this subject based on the ideXlab platform.
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Ruthenium-catalyzed Hydrogen Isotope exchange of C(sp3)–H bonds directed by a sulfur atom
Chemical Communications, 2018Co-Authors: Serge Perato, Sébastien Garcia-argote, Céline Taglang, Luis Miguel Martinez-prieto, Céline Chollet, David-alexandre Buisson, Philippe Lesot, Vincent Dauvois, Bruno Chaudret, Bernard RousseauAbstract:We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a Hydrogen Isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
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Ruthenium-catalyzed Hydrogen Isotope exchange of C(sp 3 )–H bonds directed by a sulfur atom
Chemical Communications, 2018Co-Authors: Serge Perato, Sébastien Garcia-argote, Céline Taglang, Luis Miguel Martinez-prieto, Céline Chollet, David-alexandre Buisson, Philippe Lesot, Vincent Dauvois, Bruno Chaudret, Bernard RousseauAbstract:We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a Hydrogen Isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
Serge Perato - One of the best experts on this subject based on the ideXlab platform.
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Ruthenium-catalyzed Hydrogen Isotope exchange of C(sp3)–H bonds directed by a sulfur atom
Chemical Communications, 2018Co-Authors: Serge Perato, Sébastien Garcia-argote, Céline Taglang, Luis Miguel Martinez-prieto, Céline Chollet, David-alexandre Buisson, Philippe Lesot, Vincent Dauvois, Bruno Chaudret, Bernard RousseauAbstract:We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a Hydrogen Isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
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Ruthenium-catalyzed Hydrogen Isotope exchange of C(sp 3 )–H bonds directed by a sulfur atom
Chemical Communications, 2018Co-Authors: Serge Perato, Sébastien Garcia-argote, Céline Taglang, Luis Miguel Martinez-prieto, Céline Chollet, David-alexandre Buisson, Philippe Lesot, Vincent Dauvois, Bruno Chaudret, Bernard RousseauAbstract:We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a Hydrogen Isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
Bruno Chaudret - One of the best experts on this subject based on the ideXlab platform.
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NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines
Angewandte Chemie International Edition, 2020Co-Authors: Mégane Valero, Bruno Chaudret, Jens Atzrodt, Donia Bouzouita, Alberto Palazzolo, Christophe Dugave, Simon Tricard, Sophie Feuillastre, Grégory Pieters, Volker DerdauAbstract:The preparation of N-heterocyclic carbene-stabilized iridium nanoparticles and their application in Hydrogen Isotope exchange reactions is reported. These air-stable and easy-to-handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient Hydrogen Isotope incorporation on anilines using D-2 or T-2 as isotopic source. The usefulness of this transformation has been demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals.
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Ruthenium-catalyzed Hydrogen Isotope exchange of C(sp3)–H bonds directed by a sulfur atom
Chemical Communications, 2018Co-Authors: Serge Perato, Sébastien Garcia-argote, Céline Taglang, Luis Miguel Martinez-prieto, Céline Chollet, David-alexandre Buisson, Philippe Lesot, Vincent Dauvois, Bruno Chaudret, Bernard RousseauAbstract:We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a Hydrogen Isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
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Ruthenium-catalyzed Hydrogen Isotope exchange of C(sp 3 )–H bonds directed by a sulfur atom
Chemical Communications, 2018Co-Authors: Serge Perato, Sébastien Garcia-argote, Céline Taglang, Luis Miguel Martinez-prieto, Céline Chollet, David-alexandre Buisson, Philippe Lesot, Vincent Dauvois, Bruno Chaudret, Bernard RousseauAbstract:We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a Hydrogen Isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
David Hesk - One of the best experts on this subject based on the ideXlab platform.
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Base Metal‐Catalyzed Hydrogen Isotope Exchange
Journal of Labelled Compounds and Radiopharmaceuticals, 2020Co-Authors: Haifeng Yang, David HeskAbstract:Hydrogen Isotope exchange (HIE) has played an increasingly important role in deuteration and tritiation of compounds in the pharmaceutical industry. Transition metal-catalyzed HIE methods have gained considerable attention in the past decades, and most of these methods were comprehensively reviewed in 2010 in a special JLCR issue. It covered a wide variety of HIE catalysis systems involving precious metal catalysts, and a relatively small percentage of base metal catalysts, with a major focus on heterogeneous nickel. While base metal catalysts have remained underdeveloped for HIE chemistry relative to second and third row transition metal catalysts, in recent years, the first examples of homogeneous iron, nickel, and cobalt catalysts have been introduced to the field. Hence, in this review, we describe the recent development of base metal catalysts for HIE and their applications in isotopic labeling of pharmaceutical compounds. These research efforts have resulted in the development of labeling approaches that complement traditional methods in terms of activity and selectivity, thus diversifying the methodologies available for Isotope chemists.
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Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals
ACS Catalysis, 2018Co-Authors: Haifeng Yang, David Hesk, Nelo R. Rivera, Cayetana Zarate, W. Neil Palmer, Paul J. ChirikAbstract:A nickel-catalyzed method for the site-selective Hydrogen Isotope exchange (HIE) of C(sp2)–H bonds in nitrogen heteroarenes is described and applied to the tritiation of pharmaceuticals. The α-diim...
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Rhodium‐ and ruthenium‐catalysed Hydrogen Isotope exchange
Journal of Labelled Compounds and Radiopharmaceuticals, 2010Co-Authors: William J. S. Lockley, David HeskAbstract:Metal-catalysed Hydrogen Isotope exchange has been widely used in the preparation of deuterium- and tritium-labelled compounds. This review details the development and utility of homogeneous and heterogeneous rhodium and ruthenium catalysts for the preparation of deuterium- and tritium-labelled compounds by Hydrogen Isotope exchange methodology. Copyright © 2010 John Wiley & Sons, Ltd.
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rhodium and ruthenium catalysed Hydrogen Isotope exchange
Journal of Labelled Compounds and Radiopharmaceuticals, 2010Co-Authors: William J. S. Lockley, David HeskAbstract:Metal-catalysed Hydrogen Isotope exchange has been widely used in the preparation of deuterium- and tritium-labelled compounds. This review details the development and utility of homogeneous and heterogeneous rhodium and ruthenium catalysts for the preparation of deuterium- and tritium-labelled compounds by Hydrogen Isotope exchange methodology. Copyright © 2010 John Wiley & Sons, Ltd.
Paul J. Chirik - One of the best experts on this subject based on the ideXlab platform.
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Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals
ACS Catalysis, 2018Co-Authors: Haifeng Yang, David Hesk, Nelo R. Rivera, Cayetana Zarate, W. Neil Palmer, Paul J. ChirikAbstract:A nickel-catalyzed method for the site-selective Hydrogen Isotope exchange (HIE) of C(sp2)–H bonds in nitrogen heteroarenes is described and applied to the tritiation of pharmaceuticals. The α-diim...
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cobalt catalyzed stereoretentive Hydrogen Isotope exchange of c sp3 h bonds
ACS Catalysis, 2017Co-Authors: Neil W Palmer, Paul J. ChirikAbstract:Cobalt dialkyl complexes bearing α-diimine ligands proved to be active precatalysts for the nondirected, C(sp3)–H selective Hydrogen Isotope exchange (HIE) of alkylarenes using D2 gas as the deuterium source. Alkylarenes with a variety of substitution patterns and heteroatom substituents on the arene ring were successfully labeled, enabling high levels of incorporation into primary, secondary, and tertiary benzylic C(sp3)–H bonds. In some cases, the HIE proceeded with high diastereoselectivity and application of the cobalt-catalyzed method to enantioenriched substrates with benzylic stereocenters provided enantioretentive Hydrogen Isotope exchange at tertiary carbons.
