The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Brigid L M Hogan - One of the best experts on this subject based on the ideXlab platform.
-
murine forkhead winged helix genes foxc1 mf1 and foxc2 mfh1 are required for the early organogenesis of the kidney and urinary tract
Development, 2000Co-Authors: Tsutomu Kume, Keyu Deng, Brigid L M HoganAbstract:The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a Hydroureter. Analysis of embryos reveals that Foxc1 homozygotes have ectopic mesonephric tubules and ectopic anterior ureteric buds. Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants compared with wild type. These findings support the hypothesis of Mackie and Stephens concerning the etiology of duplex kidney and Hydroureter in human infants with congenital kidney abnormalities (Mackie, G. G. and Stephens, F. G. (1975) J. Urol. 114, 274–280). Previous studies established that most Foxc1(lacZ)Foxc2(tm1) compound heterozygotes have the same spectrum of cardiovascular defects as single homozygous null mutants, demonstrating interaction between the two genes in the cardiovascular system. Here, we show that most compound heterozygotes have hypoplastic kidneys and a single Hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development.
-
Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.
Development, 2000Co-Authors: Tsutomu Kume, Keyu Deng, Brigid L M HoganAbstract:The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a Hydroureter. Analysis of embryos reveals that Foxc1 homozygotes have ectopic mesonephric tubules and ectopic anterior ureteric buds. Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants compared with wild type. These findings support the hypothesis of Mackie and Stephens concerning the etiology of duplex kidney and Hydroureter in human infants with congenital kidney abnormalities (Mackie, G. G. and Stephens, F. G. (1975) J. Urol. 114, 274–280). Previous studies established that most Foxc1(lacZ)Foxc2(tm1) compound heterozygotes have the same spectrum of cardiovascular defects as single homozygous null mutants, demonstrating interaction between the two genes in the cardiovascular system. Here, we show that most compound heterozygotes have hypoplastic kidneys and a single Hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development.
Tsutomu Kume - One of the best experts on this subject based on the ideXlab platform.
-
murine forkhead winged helix genes foxc1 mf1 and foxc2 mfh1 are required for the early organogenesis of the kidney and urinary tract
Development, 2000Co-Authors: Tsutomu Kume, Keyu Deng, Brigid L M HoganAbstract:The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a Hydroureter. Analysis of embryos reveals that Foxc1 homozygotes have ectopic mesonephric tubules and ectopic anterior ureteric buds. Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants compared with wild type. These findings support the hypothesis of Mackie and Stephens concerning the etiology of duplex kidney and Hydroureter in human infants with congenital kidney abnormalities (Mackie, G. G. and Stephens, F. G. (1975) J. Urol. 114, 274–280). Previous studies established that most Foxc1(lacZ)Foxc2(tm1) compound heterozygotes have the same spectrum of cardiovascular defects as single homozygous null mutants, demonstrating interaction between the two genes in the cardiovascular system. Here, we show that most compound heterozygotes have hypoplastic kidneys and a single Hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development.
-
Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.
Development, 2000Co-Authors: Tsutomu Kume, Keyu Deng, Brigid L M HoganAbstract:The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a Hydroureter. Analysis of embryos reveals that Foxc1 homozygotes have ectopic mesonephric tubules and ectopic anterior ureteric buds. Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants compared with wild type. These findings support the hypothesis of Mackie and Stephens concerning the etiology of duplex kidney and Hydroureter in human infants with congenital kidney abnormalities (Mackie, G. G. and Stephens, F. G. (1975) J. Urol. 114, 274–280). Previous studies established that most Foxc1(lacZ)Foxc2(tm1) compound heterozygotes have the same spectrum of cardiovascular defects as single homozygous null mutants, demonstrating interaction between the two genes in the cardiovascular system. Here, we show that most compound heterozygotes have hypoplastic kidneys and a single Hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development.
Keyu Deng - One of the best experts on this subject based on the ideXlab platform.
-
murine forkhead winged helix genes foxc1 mf1 and foxc2 mfh1 are required for the early organogenesis of the kidney and urinary tract
Development, 2000Co-Authors: Tsutomu Kume, Keyu Deng, Brigid L M HoganAbstract:The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a Hydroureter. Analysis of embryos reveals that Foxc1 homozygotes have ectopic mesonephric tubules and ectopic anterior ureteric buds. Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants compared with wild type. These findings support the hypothesis of Mackie and Stephens concerning the etiology of duplex kidney and Hydroureter in human infants with congenital kidney abnormalities (Mackie, G. G. and Stephens, F. G. (1975) J. Urol. 114, 274–280). Previous studies established that most Foxc1(lacZ)Foxc2(tm1) compound heterozygotes have the same spectrum of cardiovascular defects as single homozygous null mutants, demonstrating interaction between the two genes in the cardiovascular system. Here, we show that most compound heterozygotes have hypoplastic kidneys and a single Hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development.
-
Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.
Development, 2000Co-Authors: Tsutomu Kume, Keyu Deng, Brigid L M HoganAbstract:The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually identical DNA-binding domains and overlapping expression patterns in various embryonic tissues. Foxc1/Mf1 is disrupted in the mutant, congenital hydrocephalus (Foxc1/Mf1(ch)), which has multiple developmental defects. We show here that, depending on the genetic background, most Foxc1 homozygous mutants are born with abnormalities of the metanephric kidney, including duplex kidneys and double ureters, one of which is a Hydroureter. Analysis of embryos reveals that Foxc1 homozygotes have ectopic mesonephric tubules and ectopic anterior ureteric buds. Moreover, expression in the intermediate mesoderm of Glial cell-derived neurotrophic factor (Gdnf), a primary inducer of the ureteric bud, is expanded more anteriorly in Foxc1 homozygous mutants compared with wild type. These findings support the hypothesis of Mackie and Stephens concerning the etiology of duplex kidney and Hydroureter in human infants with congenital kidney abnormalities (Mackie, G. G. and Stephens, F. G. (1975) J. Urol. 114, 274–280). Previous studies established that most Foxc1(lacZ)Foxc2(tm1) compound heterozygotes have the same spectrum of cardiovascular defects as single homozygous null mutants, demonstrating interaction between the two genes in the cardiovascular system. Here, we show that most compound heterozygotes have hypoplastic kidneys and a single Hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development.
Yvonne Espada - One of the best experts on this subject based on the ideXlab platform.
-
imaging diagnosis radiography and ultrasonography of bilateral congenital ureterovesical junction stenosis causing hydronephrosis and Hydroureter in a ferret mustela putorius furo
Veterinary Radiology & Ultrasound, 2017Co-Authors: Laura Vilalta, Yvonne Espada, Elisabet Dominguez, Raul Altuzarra, Neus Sibera, Rosa Novellas, Jaime MartorellAbstract:An 8-month-old neutered male ferret was presented for vaccination and preventive treatment for adrenal gland disease. Abdominal ultrasound revealed severe bilateral hydronephrosis and Hydroureter. Excretory urography and negative contrast cystography showed bilateral ureterovesical junction stenosis. Positive retrograde cystography demonstrated right ureteral reflux. A subcutaneous ureteral bypass was placed in the left kidney; however, it had to be removed 3 months later due to an obstruction and persistent urinary tract infection. Bilateral ureteroneocystotomy was performed. Although congenital strictures are uncommon in veterinary patients, they should be included in the differential diagnosis in ferrets presenting with hydronephrosis and Hydroureter of undetermined cause.
-
IMAGING DIAGNOSIS—RADIOGRAPHY AND ULTRASONOGRAPHY OF BILATERAL CONGENITAL URETEROVESICAL JUNCTION STENOSIS CAUSING HYDRONEPHROSIS AND Hydroureter IN A FERRET (MUSTELA PUTORIUS FURO)
Veterinary Radiology & Ultrasound, 2016Co-Authors: Laura Vilalta, Yvonne Espada, Elisabet Dominguez, Raul Altuzarra, Neus Sibera, Rosa Novellas, Jaime MartorellAbstract:An 8-month-old neutered male ferret was presented for vaccination and preventive treatment for adrenal gland disease. Abdominal ultrasound revealed severe bilateral hydronephrosis and Hydroureter. Excretory urography and negative contrast cystography showed bilateral ureterovesical junction stenosis. Positive retrograde cystography demonstrated right ureteral reflux. A subcutaneous ureteral bypass was placed in the left kidney; however, it had to be removed 3 months later due to an obstruction and persistent urinary tract infection. Bilateral ureteroneocystotomy was performed. Although congenital strictures are uncommon in veterinary patients, they should be included in the differential diagnosis in ferrets presenting with hydronephrosis and Hydroureter of undetermined cause.
-
bilateral Hydroureter and hydronephrosis in a nine year old female german shepherd dog
Journal of Small Animal Practice, 1999Co-Authors: Ruiz R De Gopegui, Yvonne Espada, Natalia MajoAbstract:: A nine-year-old female German shepherd dog was presented in severe renal failure. Clinical and ultrasonographic examination revealed the presence of adrenal neoplasia, bilateral Hydroureter and hydronephrosis but no evidence of urolithiasis or bladder neoplasia. In the absence of anuria, therapy for the renal failure was attempted but the azotaemia did not improve. Remarkably, bilateral Hydroureter appeared to have been induced by a past routine surgical procedure--ovariohysterectomy.
-
Bilateral Hydroureter and hydronephrosis in a nine‐year‐old female German shepherd dog
Journal of Small Animal Practice, 1999Co-Authors: Ruiz R De Gopegui, Yvonne Espada, Natalia MajoAbstract:: A nine-year-old female German shepherd dog was presented in severe renal failure. Clinical and ultrasonographic examination revealed the presence of adrenal neoplasia, bilateral Hydroureter and hydronephrosis but no evidence of urolithiasis or bladder neoplasia. In the absence of anuria, therapy for the renal failure was attempted but the azotaemia did not improve. Remarkably, bilateral Hydroureter appeared to have been induced by a past routine surgical procedure--ovariohysterectomy.
Jaime Martorell - One of the best experts on this subject based on the ideXlab platform.
-
imaging diagnosis radiography and ultrasonography of bilateral congenital ureterovesical junction stenosis causing hydronephrosis and Hydroureter in a ferret mustela putorius furo
Veterinary Radiology & Ultrasound, 2017Co-Authors: Laura Vilalta, Yvonne Espada, Elisabet Dominguez, Raul Altuzarra, Neus Sibera, Rosa Novellas, Jaime MartorellAbstract:An 8-month-old neutered male ferret was presented for vaccination and preventive treatment for adrenal gland disease. Abdominal ultrasound revealed severe bilateral hydronephrosis and Hydroureter. Excretory urography and negative contrast cystography showed bilateral ureterovesical junction stenosis. Positive retrograde cystography demonstrated right ureteral reflux. A subcutaneous ureteral bypass was placed in the left kidney; however, it had to be removed 3 months later due to an obstruction and persistent urinary tract infection. Bilateral ureteroneocystotomy was performed. Although congenital strictures are uncommon in veterinary patients, they should be included in the differential diagnosis in ferrets presenting with hydronephrosis and Hydroureter of undetermined cause.
-
IMAGING DIAGNOSIS—RADIOGRAPHY AND ULTRASONOGRAPHY OF BILATERAL CONGENITAL URETEROVESICAL JUNCTION STENOSIS CAUSING HYDRONEPHROSIS AND Hydroureter IN A FERRET (MUSTELA PUTORIUS FURO)
Veterinary Radiology & Ultrasound, 2016Co-Authors: Laura Vilalta, Yvonne Espada, Elisabet Dominguez, Raul Altuzarra, Neus Sibera, Rosa Novellas, Jaime MartorellAbstract:An 8-month-old neutered male ferret was presented for vaccination and preventive treatment for adrenal gland disease. Abdominal ultrasound revealed severe bilateral hydronephrosis and Hydroureter. Excretory urography and negative contrast cystography showed bilateral ureterovesical junction stenosis. Positive retrograde cystography demonstrated right ureteral reflux. A subcutaneous ureteral bypass was placed in the left kidney; however, it had to be removed 3 months later due to an obstruction and persistent urinary tract infection. Bilateral ureteroneocystotomy was performed. Although congenital strictures are uncommon in veterinary patients, they should be included in the differential diagnosis in ferrets presenting with hydronephrosis and Hydroureter of undetermined cause.
