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Takashi Hirota - One of the best experts on this subject based on the ideXlab platform.
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polycyclic n heterocyclic compounds part 84 reaction of n pyrido 3 2 4 5 thieno 3 2 d pyrimidin 4 yl amidines or n pyrido 2 3 4 5 furo 3 2 d pyrimidin 4 yl amidines with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2015Co-Authors: Kensuke Okuda, Naoto Uramaru, Takashi HirotaAbstract:The reactions of nine N-(pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with Hydroxylamine Hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3-b]pyridin-3-yl]formamide oximes (11). Reaction of six N-(pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-yl)amidines (12) with Hydroxylamine Hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.
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Polycyclic N‐Heterocyclic Compounds. Part 84: Reaction of N‐(pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4‐yl)amidines or N‐(pyrido[2′,3′:4,5]furo[3,2‐d]pyrimidin‐4‐yl)amidines with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2014Co-Authors: Kensuke Okuda, Naoto Uramaru, Takashi HirotaAbstract:The reactions of nine N-(pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with Hydroxylamine Hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3-b]pyridin-3-yl]formamide oximes (11). Reaction of six N-(pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-yl)amidines (12) with Hydroxylamine Hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.
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Polycyclic N‐Heterocyclic Compounds, Part 72: Reaction of N‐([1]Benzofuro (or Benzothieno)[3,2‐d]pyrimidin‐4‐yl)formamidine and N‐(Pyrido[2,3‐d]pyrimidin‐4‐yl)formamidine Derivatives with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2012Co-Authors: Kensuke Okuda, Kiyoko Tsuchie, Takashi HirotaAbstract:The reactions of N-([1]benzofuro[3,2-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure of the 1,2,4-oxadiazole to give N-[2-([1,2,4]oxadiazol-5-yl)[1]benzofuran-3-yl)formamide oximes. N-([1]Benzothieno[3,2-d]pyrimidin-4-yl)formamidines and N-(pyrido[2,3-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave similar results.
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polycyclic n heterocyclic compounds part 72 reaction of n 1 benzofuro or benzothieno 3 2 d pyrimidin 4 yl formamidine and n pyrido 2 3 d pyrimidin 4 yl formamidine derivatives with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2012Co-Authors: Kensuke Okuda, Kiyoko Tsuchie, Takashi HirotaAbstract:The reactions of N-([1]benzofuro[3,2-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure of the 1,2,4-oxadiazole to give N-[2-([1,2,4]oxadiazol-5-yl)[1]benzofuran-3-yl)formamide oximes. N-([1]Benzothieno[3,2-d]pyrimidin-4-yl)formamidines and N-(pyrido[2,3-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave similar results.
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polycyclic n heterocyclic compounds part 67 reaction of 6 7 substituted n quinazolin 4 yl amidine derivatives with Hydroxylamine Hydrochloride formation of in vitro inhibitors of pentosidine
ChemInform, 2012Co-Authors: Kensuke Okuda, Hideki Muroyama, Takashi HirotaAbstract:The synthesis of a variety of oxadiazolylphenyl formamide oxime derivatives (V), (VI), (IX) proceeds via reaction of N-(quinazolin-4-yl)amidine derivatives with Hydroxylamine Hydrochloride.
Kensuke Okuda - One of the best experts on this subject based on the ideXlab platform.
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polycyclic n heterocyclic compounds part 84 reaction of n pyrido 3 2 4 5 thieno 3 2 d pyrimidin 4 yl amidines or n pyrido 2 3 4 5 furo 3 2 d pyrimidin 4 yl amidines with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2015Co-Authors: Kensuke Okuda, Naoto Uramaru, Takashi HirotaAbstract:The reactions of nine N-(pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with Hydroxylamine Hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3-b]pyridin-3-yl]formamide oximes (11). Reaction of six N-(pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-yl)amidines (12) with Hydroxylamine Hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.
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Polycyclic N‐Heterocyclic Compounds. Part 84: Reaction of N‐(pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4‐yl)amidines or N‐(pyrido[2′,3′:4,5]furo[3,2‐d]pyrimidin‐4‐yl)amidines with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2014Co-Authors: Kensuke Okuda, Naoto Uramaru, Takashi HirotaAbstract:The reactions of nine N-(pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with Hydroxylamine Hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3-b]pyridin-3-yl]formamide oximes (11). Reaction of six N-(pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-yl)amidines (12) with Hydroxylamine Hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.
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Polycyclic N‐Heterocyclic Compounds, Part 72: Reaction of N‐([1]Benzofuro (or Benzothieno)[3,2‐d]pyrimidin‐4‐yl)formamidine and N‐(Pyrido[2,3‐d]pyrimidin‐4‐yl)formamidine Derivatives with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2012Co-Authors: Kensuke Okuda, Kiyoko Tsuchie, Takashi HirotaAbstract:The reactions of N-([1]benzofuro[3,2-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure of the 1,2,4-oxadiazole to give N-[2-([1,2,4]oxadiazol-5-yl)[1]benzofuran-3-yl)formamide oximes. N-([1]Benzothieno[3,2-d]pyrimidin-4-yl)formamidines and N-(pyrido[2,3-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave similar results.
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polycyclic n heterocyclic compounds part 72 reaction of n 1 benzofuro or benzothieno 3 2 d pyrimidin 4 yl formamidine and n pyrido 2 3 d pyrimidin 4 yl formamidine derivatives with Hydroxylamine Hydrochloride
Journal of Heterocyclic Chemistry, 2012Co-Authors: Kensuke Okuda, Kiyoko Tsuchie, Takashi HirotaAbstract:The reactions of N-([1]benzofuro[3,2-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure of the 1,2,4-oxadiazole to give N-[2-([1,2,4]oxadiazol-5-yl)[1]benzofuran-3-yl)formamide oximes. N-([1]Benzothieno[3,2-d]pyrimidin-4-yl)formamidines and N-(pyrido[2,3-d]pyrimidin-4-yl)formamidines with Hydroxylamine Hydrochloride gave similar results.
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polycyclic n heterocyclic compounds part 67 reaction of 6 7 substituted n quinazolin 4 yl amidine derivatives with Hydroxylamine Hydrochloride formation of in vitro inhibitors of pentosidine
ChemInform, 2012Co-Authors: Kensuke Okuda, Hideki Muroyama, Takashi HirotaAbstract:The synthesis of a variety of oxadiazolylphenyl formamide oxime derivatives (V), (VI), (IX) proceeds via reaction of N-(quinazolin-4-yl)amidine derivatives with Hydroxylamine Hydrochloride.
J B Goodenough - One of the best experts on this subject based on the ideXlab platform.
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synthesis and characterization of reduced molybdenum oxides with Hydroxylamine Hydrochloride in aqueous solutions
IEEE Journal of Solid-state Circuits, 1999Co-Authors: V Manivannan, Robin S Tichy, J B GoodenoughAbstract:Abstract Reduction of ammonium molybdate, (NH 4 ) 6 Mo 7 O 24 ·4H 2 O, with Hydroxylamine Hydrochloride. NH 2 OH·HCl, at ambient temperature in aqueous solutions results in amorphous MoO 3 · n H 2 O oxide. Subsequent heat treatment of this oxide yields Mo 1− δ O 2 or a hydrogen molybdenum bronze, H x MoO 3 ( x ≅1), both crystalline in nature. The samples have been characterized by X-ray diffraction, differential scanning calorimetry, scanning and transmission electron microscopies, thermogravimetric analysis, infrared spectroscopy, and galvanostatic electrochemical characterization.
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synthesis of reduced transition metal oxides with Hydroxylamine Hydrochloride
Inorganic Chemistry, 1998Co-Authors: V Manivannan, J B GoodenoughAbstract:Addition of aqueous Hydroxylamine Hydrochloride in aqueous solutions of ammonium (MO4)n- salts at a fixed pH, maintained by adding HCl drops, has yielded amorphous, reduced oxides of intermediate valence such as VO2, Cr2O3, Fe3O4, MoO2, and (NH4)0.33WO3. The as-prepared products crystallize on heating to 300−500 °C.
Wei Wang - One of the best experts on this subject based on the ideXlab platform.
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base mediated one pot synthesis of 1 2 4 oxadiazoles from nitriles aldehydes and Hydroxylamine Hydrochloride without addition of extra oxidant
Organic and Biomolecular Chemistry, 2016Co-Authors: Wei Wang, Hao Xu, Yuanqing Xu, Tao Ding, Wenkai Zhang, Haibo ChangAbstract:A simple base-mediated one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from nitriles, aldehydes and Hydroxylamine Hydrochloride has been developed, in which the aldehydes act as both substrates and oxidants. The reactions include three sequential procedures: base-promoted intermolecular addition of Hydroxylamine to nitrile to lead to amidoxime, treatment of the amidoxime with an aldehyde to form 4,5-dihydro-1,2,4-oxadiazole, and oxidization of the 4,5-dihydro-1,2,4-oxadiazole by using another aldehyde to afford 1,2,4-oxadiazole. This method represents a direct and simple protocol for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles.
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transition metal free synthesis of primary amides from aldehydes and Hydroxylamine Hydrochloride
Tetrahedron Letters, 2014Co-Authors: Wei Wang, Xuemei Zhao, Jingli Wang, Xin Geng, Junfang Gong, Maoping SongAbstract:Primary aromatic amides can be synthesized from aldehydes and Hydroxylamine Hydrochloride in the presence of Cs2CO3. Various aromatic aldehydes (include some heteroaromatic aldehydes) are able to generate the corresponding aromatic amides in moderate to excellent yields.
Yongmin Liang - One of the best experts on this subject based on the ideXlab platform.
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lewis acid mediated tandem reaction of propargylic alcohols with Hydroxylamine Hydrochloride to give α β unsaturated amides and alkenyl nitriles
ChemInform, 2016Co-Authors: Xianrong Song, Jia Wang, Xinxing Wu, Yongmin LiangAbstract:New strategies extend the application of Hydroxylamine Hydrochloride to the chemistry of propargylic alcohols.
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lewis acid mediated tandem reaction of propargylic alcohols with Hydroxylamine Hydrochloride to give α β unsaturated amides and alkenyl nitriles
Journal of Organic Chemistry, 2015Co-Authors: Xianrong Song, Jia Wang, Xinxing Wu, Yongmin LiangAbstract:We have developed a highly selective method for the synthesis of α,β-unsaturated amides and alkenyl nitriles from readily available propargylic alcohols. The reaction proceeded smoothly under the neutral conditions with Hydroxylamine Hydrochloride (NH2OH·HCl) as the nitrogen source. The development of these new strategies has significantly extended the application of Hydroxylamine Hydrochloride to the chemistry of propargylic alcohols. Moreover, both secondary and tertiary alcohols have been highly regioselectively transformed to the desired products with good functional group compatibility.
