The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Susana Vaz Nery - One of the best experts on this subject based on the ideXlab platform.
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extending helminth control beyond sth and schistosomiasis the case of human Hymenolepiasis
PLOS Neglected Tropical Diseases, 2013Co-Authors: Ricardo Soares J. Magalhães, Cláudia Fançony, Dina Gamboa, Archie C. A. Clements, Antonio Langa, Jose Carlos Sousafigueiredo, Susana Vaz NeryAbstract:Similarly to schistosomiasis, a single dose of PZQ eliminates the vast majority of Hymenolepis egg excretion [10–12]. However, it is likely that a PZQ gap exists in many communities being targeted by MDA in that the geographical location of Hymenolepis infections may not necessarily overlap with that of schistosomiasis. Guiding PZQ delivery solely on the basis of the distribution of schistosomiasis may miss communities endemic to Hymenolepis infection also in need of PZQ. This means that the populations at risk of Hymenolepiasis may need to also be identified so that PZQ delivery can be extended to those areas. In order to test our proposition, we have analysed data from a parasitic disease survey of 2,168 children aged #15 years, including 1,098 girls and 1,070 boys in the Dande municipality in Northern Angola. Previous analysis of this dataset revealed that children were at significantly increased risk of H. nana infection (prevalence of 6.2% [95% CI: 4.9–7.8%] in preschool children and 7.3% [95% CI: 5.8–9.0%] in school-age children) compared to adults (prevalence of 1.9% [95% CI: 1.1–3.1%]) [13]. Using these data, we aimed to describe the epidemiology of H. nana infection by quantifying the role of individual and household factors and the physical environment (land surface temperature, distance to irrigation canals and rivers) in H. nana infection; quantify the role of H. nana infection on morbidity outcomes such as anaemia, diarrhoea, abdominal pain, and growth; quantify the geographical variation in H. nana infection prevalence in children aged #15 years; generate the first high-resolution H. nana infection map; and compare this map with a preexisting S. haematobium
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Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis
2013Co-Authors: Ricardo Soares J. Magalhães, Cláudia Fançony, Dina Gamboa, António J. Langa, José Carlos Sousa-figueiredo, Archie C. A. Clements, Susana Vaz NeryAbstract:Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis
Ricardo Soares J. Magalhães - One of the best experts on this subject based on the ideXlab platform.
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extending helminth control beyond sth and schistosomiasis the case of human Hymenolepiasis
PLOS Neglected Tropical Diseases, 2013Co-Authors: Ricardo Soares J. Magalhães, Cláudia Fançony, Dina Gamboa, Archie C. A. Clements, Antonio Langa, Jose Carlos Sousafigueiredo, Susana Vaz NeryAbstract:Similarly to schistosomiasis, a single dose of PZQ eliminates the vast majority of Hymenolepis egg excretion [10–12]. However, it is likely that a PZQ gap exists in many communities being targeted by MDA in that the geographical location of Hymenolepis infections may not necessarily overlap with that of schistosomiasis. Guiding PZQ delivery solely on the basis of the distribution of schistosomiasis may miss communities endemic to Hymenolepis infection also in need of PZQ. This means that the populations at risk of Hymenolepiasis may need to also be identified so that PZQ delivery can be extended to those areas. In order to test our proposition, we have analysed data from a parasitic disease survey of 2,168 children aged #15 years, including 1,098 girls and 1,070 boys in the Dande municipality in Northern Angola. Previous analysis of this dataset revealed that children were at significantly increased risk of H. nana infection (prevalence of 6.2% [95% CI: 4.9–7.8%] in preschool children and 7.3% [95% CI: 5.8–9.0%] in school-age children) compared to adults (prevalence of 1.9% [95% CI: 1.1–3.1%]) [13]. Using these data, we aimed to describe the epidemiology of H. nana infection by quantifying the role of individual and household factors and the physical environment (land surface temperature, distance to irrigation canals and rivers) in H. nana infection; quantify the role of H. nana infection on morbidity outcomes such as anaemia, diarrhoea, abdominal pain, and growth; quantify the geographical variation in H. nana infection prevalence in children aged #15 years; generate the first high-resolution H. nana infection map; and compare this map with a preexisting S. haematobium
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Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis
2013Co-Authors: Ricardo Soares J. Magalhães, Cláudia Fançony, Dina Gamboa, António J. Langa, José Carlos Sousa-figueiredo, Archie C. A. Clements, Susana Vaz NeryAbstract:Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis
Hector H. Garcia - One of the best experts on this subject based on the ideXlab platform.
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low sensitivity and frequent cross reactions in commercially available antibody detection elisa assays for taenia solium cysticercosis
Tropical Medicine & International Health, 2018Co-Authors: Hector H. Garcia, Javier A Bustos, Yesenia Castillo, Isidro Gonzales, Herbert Saavedra, Louis Jacob, Oscar H Del Brutto, Patricia P Wilkins, Armando E Gonzalez, Robert H GilmanAbstract:OBJECTIVE To evaluate the diagnostic performance of two commercially available ELISA kits, Novalisa® and Ridascreen® , for the detection of antibodies to Taenia solium, compared to serological diagnosis of neurocysticercosis (NCC) by LLGP-EITB (electro-immunotransfer blot assay using lentil-lectin purified glycoprotein antigens). METHODS Archive serum samples from patients with viable NCC (n = 45) or resolved, calcified NCC (n = 45), as well as sera from patients with other cestode parasites (Hymenolepiasis, n = 45 and cystic hydatid disease, n = 45), were evaluated for cysticercosis antibody detection using two ELISA kits, Novalisa® and Ridascreen® . All NCC samples had previously tested positive, and all samples from heterologous infections were negative on LLGP-EITB for cysticercosis. Positive rates were calculated by kit and sample group and compared between the two kits. RESULTS Compared to LLGP-EITB, the sensitivity of both ELISA assays to detect specific antibodies in patients with viable NCC was low (44.4% and 22.2%), and for calcified NCC, it was only 6.7% and 4.5%. Sera from patients with cystic hydatid disease were highly cross-reactive in both ELISA assays (38/45, 84.4%; and 25/45, 55.6%). Sera from patients with Hymenolepiasis cross-reacted in five cases in one of the assays (11.1%) and in only one sample with the second assay (2.2%). CONCLUSIONS The performance of Novalisa® and Ridascreen® was poor. Antibody ELISA detection cannot be recommended for the diagnosis of neurocysticercosis.
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Hymenolepis nana Impact among Children in the Highlands of Cusco, Peru: An Emerging Neglected Parasite Infection.
The American journal of tropical medicine and hygiene, 2016Co-Authors: Miguel M. Cabada, Maria Luisa Morales, Martha Lopez, Spencer T. Reynolds, Elizabeth C. Vilchez, Andres G. Lescano, Eduardo Gotuzzo, Hector H. Garcia, Clinton A. WhiteAbstract:Abstract Hymenolepis nana is the most common cestode infection in the world. However, limited information is available regarding its impact on affected populations. We studied the epidemiology and symptoms associated with Hymenolepiasis among children 3–16 years old in 16 rural communities of the highlands of the Cusco region in Peru. Information on demographics, socioeconomic status, symptoms as reported by parents, and parasitological testing was obtained from the database of an ongoing Fasciola hepatica epidemiologic study. A total of 1,230 children were included in the study. Forty-five percent were infected with at least one pathogenic intestinal parasite. Giardia spp. (22.9%) was the most common, followed by Hymenolepis (17.4%), Fasciola (14.1%), Ascaris lumbricoides (6.1%), and Strongyloides stercoralis (2%). The prevalence of Hymenolepis infection varied by community, by other parasitic infections, and by socioeconomic status. However, only years of education of the mother, use of well water, and age less than 10 years were associated with Hymenolepis infection in the multivariate analysis. Hymenolepis nana infection was associated with diarrhea, jaundice, headaches, fever, and fatigue. Children with > 500 eggs/g of stool were more likely to have symptoms of weight loss, jaundice, diarrhea, and fever. Hymenolepis nana infection and age were the only factors retained in the multivariate analysis modeling diarrhea. Hymenolepiasis is a common gastrointestinal helminth in the Cusco region and is associated with significant morbidity in children in rural communities. The impact caused by the emergence of Hymenolepis as a prevalent intestinal parasite deserves closer scrutiny.
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hymenolepis nana infection symptoms and response to nitazoxanide in field conditions
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2007Co-Authors: Juan C Chero, Mayuko Saito, Javier A Bustos, Eladio M Blanco, Guillermo Gonzalvez, Hector H. GarciaAbstract:A matched case-control study on clinical symptoms of Hymenolepis nana and an open trial of nitazoxanide treatment were conducted in a village on the northern coast of Peru. Interview data were obtained from 25 individuals with Hymenolepiasis only and 46 matched controls. Individuals with other intestinal helminths or giardiasis were excluded. Twenty nitazoxanide-treated cases were followed with stool examination a month later. There were no significant differences between groups in the prevalence of symptoms except headache, which was less frequent in the cases. Treatment efficacy was 75%. Hymenolepiasis in this community did not have significant impact on specific symptoms.
Xing-quan Zhu - One of the best experts on this subject based on the ideXlab platform.
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The complete mitochondrial genome of the dwarf tapeworm Hymenolepis nana--a neglected zoonotic helminth.
Parasitology research, 2015Co-Authors: Tian Cheng, Guo-hua Liu, Rui-qing Lin, Hui-qun Song, Xing-quan ZhuAbstract:Hymenolepis nana, commonly known as the dwarf tapeworm, is one of the most common tapeworms of humans and rodents and can cause Hymenolepiasis. Although this zoonotic tapeworm is of socio-economic significance in many countries of the world, its genetics, systematics, epidemiology, and biology are poorly understood. In the present study, we sequenced and characterized the complete mitochondrial (mt) genome of H. nana. The mt genome is 13,764 bp in size and encodes 36 genes, including 12 protein-coding genes, 2 ribosomal RNA, and 22 transfer RNA genes. All genes are transcribed in the same direction. The gene order and genome content are completely identical with their congener Hymenolepis diminuta. Phylogenetic analyses based on concatenated amino acid sequences of 12 protein-coding genes by Bayesian inference, Maximum likelihood, and Maximum parsimony showed the division of class Cestoda into two orders, supported the monophylies of both the orders Cyclophyllidea and Pseudophyllidea. Analyses of mt genome sequences also support the monophylies of the three families Taeniidae, Hymenolepididae, and Diphyllobothriidae. This novel mt genome provides a useful genetic marker for studying the molecular epidemiology, systematics, and population genetics of the dwarf tapeworm and should have implications for the diagnosis, prevention, and control of Hymenolepiasis in humans.
Archie C. A. Clements - One of the best experts on this subject based on the ideXlab platform.
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extending helminth control beyond sth and schistosomiasis the case of human Hymenolepiasis
PLOS Neglected Tropical Diseases, 2013Co-Authors: Ricardo Soares J. Magalhães, Cláudia Fançony, Dina Gamboa, Archie C. A. Clements, Antonio Langa, Jose Carlos Sousafigueiredo, Susana Vaz NeryAbstract:Similarly to schistosomiasis, a single dose of PZQ eliminates the vast majority of Hymenolepis egg excretion [10–12]. However, it is likely that a PZQ gap exists in many communities being targeted by MDA in that the geographical location of Hymenolepis infections may not necessarily overlap with that of schistosomiasis. Guiding PZQ delivery solely on the basis of the distribution of schistosomiasis may miss communities endemic to Hymenolepis infection also in need of PZQ. This means that the populations at risk of Hymenolepiasis may need to also be identified so that PZQ delivery can be extended to those areas. In order to test our proposition, we have analysed data from a parasitic disease survey of 2,168 children aged #15 years, including 1,098 girls and 1,070 boys in the Dande municipality in Northern Angola. Previous analysis of this dataset revealed that children were at significantly increased risk of H. nana infection (prevalence of 6.2% [95% CI: 4.9–7.8%] in preschool children and 7.3% [95% CI: 5.8–9.0%] in school-age children) compared to adults (prevalence of 1.9% [95% CI: 1.1–3.1%]) [13]. Using these data, we aimed to describe the epidemiology of H. nana infection by quantifying the role of individual and household factors and the physical environment (land surface temperature, distance to irrigation canals and rivers) in H. nana infection; quantify the role of H. nana infection on morbidity outcomes such as anaemia, diarrhoea, abdominal pain, and growth; quantify the geographical variation in H. nana infection prevalence in children aged #15 years; generate the first high-resolution H. nana infection map; and compare this map with a preexisting S. haematobium
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Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis
2013Co-Authors: Ricardo Soares J. Magalhães, Cláudia Fançony, Dina Gamboa, António J. Langa, José Carlos Sousa-figueiredo, Archie C. A. Clements, Susana Vaz NeryAbstract:Extending Helminth Control beyond STH and Schistosomiasis: The Case of Human Hymenolepiasis