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David N. Herndon - One of the best experts on this subject based on the ideXlab platform.

  • Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma
    American Journal of Physiology-Endocrinology and Metabolism, 2016
    Co-Authors: John O. Ogunbileje, David N. Herndon, Craig Porter, Tony Chao, Doaa R. Abdelrahman, Anastasia Papadimitriou, Maria Chondronikola, Teresa A. Zimmers, Paul T. Reidy, Blake B. Rasmussen
    Abstract:

    Burn trauma results in prolonged Hypermetabolism and skeletal muscle wasting. How Hypermetabolism contributes to muscle wasting in burn patients remains unknown. We hypothesized that oxidative stre...

  • IS THERE A DIFFERENCE IN CLINICAL OUTCOMES, INFLAMMATION AND Hypermetabolism BETWEEN SCALD AND FLAME BURN?
    Pediatric Critical Care Medicine, 2011
    Co-Authors: Robert Kraft, David N. Herndon, Gabriela A. Kulp, Fatemah Emdad, Felicia N. Williams, Hal K. Hawkins, Katrina R. Leonard, Marc G. Jeschke
    Abstract:

    OBJECTIVE:: Severe thermal injury induces inflammatory and hypermetabolic responses that are associated with morbidity and mortality. However, it is not known whether the causes of burns affect inflammation, Hypermetabolism, and morbidity. The aim of the present study was to determine whether there is a difference in degree of inflammation, Hypermetabolism, endocrine and acute-phase response, and clinical outcome between pediatric patients with scald and flame burns. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Children with burns requiring surgical intervention were enrolled in this epidemiologic study and divided into two groups, scald or flame burn. In a second assignment, we analyzed the study populations in representative subgroups containing individuals with third-degree burns of 40% to 60% total body surface area. We determined clinical outcomes, resting energy expenditures, cytokine profiles, acute-phase proteins, constitutive proteins, and hormone panels. Statistical analysis was evaluated by analysis of variance, Student's t test corrected with the Bonferroni post hoc test, and the propensity score. Statistical significance was set at p Language: en

  • persistence of muscle catabolism after severe burn
    Surgery, 2000
    Co-Authors: David W Hart, Steven E Wolf, Ronald P Mlcak, David L Chinkes, Peter I Ramzy, Michael K Obeng, Arny A Ferrando, Robert R Wolfe, David N. Herndon
    Abstract:

    Abstract Background: The hypermetabolic response to severe burn is characterized by muscle protein catabolism. Current opinion states that the hypermetabolic state resolves soon after complete wound closure. Clinically, we have witnessed that burned children appear to be hypermetabolic and catabolic long after full healing of their wounds. Our goal in this study was to determine scientifically if burn-associated Hypermetabolism persists after full wound healing. Methods: To determine the duration of muscle catabolism and systemic Hypermetabolism after severe burn in children, patients with > 40% total body surface area burns were enrolled in a prospective, longitudinal study; resting energy expenditure was measured by indirect calorimetry, muscle protein kinetics were determined by using stable isotopic methodology, and body composition was measured by dual-energy x-ray absorptiometry imaging. Data were collected at 6, 9, and 12 months after injury. Results: The mean total body surface area burned was 65% ± 13%, and the mean age was 7.6 ± 1.5 years. Resting energy expenditure was elevated above the predicted age-matched levels from the Harris-Benedict equation and incrementally declined throughout the 12-month study. The net protein balance and lean mass reflected catabolic persistence at 6 and 9 months after severe burn. Between 9 and 12 months, protein breakdown decreased, net protein balance improved, and lean body mass increased. Conclusions: In severely burned children, Hypermetabolism and catabolism remain exaggerated for at least 9 months after injury. This suggests that therapeutic attempts to manipulate the catabolic and hypermetabolic response to severe injury should be continued long after injury. (Surgery 2000;128:312-9.)

  • Acute Metabolic Response to Skin Injury Following Burn and the Potential Use of Growth Hormone
    Acute Catabolic State, 1996
    Co-Authors: D. A. Gilpin, David N. Herndon
    Abstract:

    The acute response to skin injury following burn is characterized by Hypermetabolism, increased cardiac output, lipolysis, gluconeogenesis, and proteolysis. This review will describe the early responses to thermal trauma and potential methods for modulating deleterious consequences of these responses.

Robert J H Miller - One of the best experts on this subject based on the ideXlab platform.

  • quantitative assessment of cardiac Hypermetabolism and perfusion for diagnosis of cardiac sarcoidosis
    Journal of Nuclear Cardiology, 2020
    Co-Authors: Robert J H Miller, Sebastien Cadet, Payam Pournazari, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean W Hayes, John D Friedman
    Abstract:

    BACKGROUND Quantitative assessment of cardiac Hypermetabolism from 18Flourodeoxy glucose (FDG) positron emission tomography (PET) may improve diagnosis of cardiac sarcoidosis (CS). We assessed different approaches for quantification of cardiac Hypermetabolism and perfusion in patients with suspected CS. METHODS AND RESULTS Consecutive patients undergoing 18FDG PET assessment for possible CS between January 2014 and March 2019 were included. Cardiac Hypermetabolism was quantified using maximal standardized uptake value (SUVMAX), cardiometabolic activity (CMA) and volume of inflammation, using relative thresholds (1.3× and 1.5× left ventricular blood pool [LVBP] activity), and absolute thresholds (SUVMAX > 2.7 and 4.1). Diagnosis of CS was established using the Japanese Ministry of Health and Wellness criteria. In total, 69 patients were studied, with definite or possible CS in 29(42.0%) patients. CMA above 1.5× LVBP SUVMAX had the highest area under the receiver operating characteristic curve (AUC 0.92). Quantitative parameters using relative thresholds had higher AUC compared to absolute thresholds (p < 0.01). Interobserver variability was low for CMA, with excellent agreement regarding absence of activity (Kappa 0.970). CONCLUSIONS Quantitation with scan-specific thresholds has superior diagnostic accuracy compared to absolute thresholds. Based on the potential clinical benefit, programs should consider quantification of cardiac Hypermetabolism when interpreting 18F-FDG PET studies for CS.

  • Quantitative Assessment of Cardiac Hypermetabolism and Perfusion for Diagnosis of Cardiac Sarcoidosis
    Journal of Nuclear Cardiology, 2020
    Co-Authors: Robert J H Miller, Sebastien Cadet, Payam Pournazari, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean Hayes, John Friedman, Louise Thomson
    Abstract:

    Background Quantitative assessment of cardiac Hypermetabolism from ^18Flourodeoxy glucose (FDG) positron emission tomography (PET) may improve diagnosis of cardiac sarcoidosis (CS). We assessed different approaches for quantification of cardiac Hypermetabolism and perfusion in patients with suspected CS. Methods and results Consecutive patients undergoing ^18FDG PET assessment for possible CS between January 2014 and March 2019 were included. Cardiac Hypermetabolism was quantified using maximal standardized uptake value (SUV_MAX), cardiometabolic activity (CMA) and volume of inflammation, using relative thresholds (1.3× and 1.5× left ventricular blood pool [LVBP] activity), and absolute thresholds (SUV_MAX > 2.7 and 4.1). Diagnosis of CS was established using the Japanese Ministry of Health and Wellness criteria. In total, 69 patients were studied, with definite or possible CS in 29(42.0%) patients. CMA above 1.5× LVBP SUV_MAX had the highest area under the receiver operating characteristic curve (AUC 0.92). Quantitative parameters using relative thresholds had higher AUC compared to absolute thresholds ( p  

  • QUANTITATIVE ASSESSMENT OF MYOCARDIAL Hypermetabolism AND PERFUSION FOR DIAGNOSIS OF CARDIAC SARCOIDOSIS
    Journal of the American College of Cardiology, 2020
    Co-Authors: Robert J H Miller, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean W Hayes, John D Friedman, Louise Thomson, Balaji Tamarappoo, Daniel S. Berman
    Abstract:

    Quantitative assessment of myocardial Hypermetabolism may improve diagnosis in suspected cardiac sarcoidosis (CS). However, the optimal method has not been established. We assessed several methods for quantification in patients with known or suspected CS. Consecutive patients undergoing positron

Marc G. Jeschke - One of the best experts on this subject based on the ideXlab platform.

  • Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent Hypermetabolism after trauma
    Journal of Cellular and Molecular Medicine, 2019
    Co-Authors: Li Diao, Yusef Yousuf, Saeid Amini-nik, Marc G. Jeschke
    Abstract:

    Prolonged and persistent Hypermetabolism and excessive inflammatory response after severe trauma is detrimental and associated with poor outcome. The predisposing pathology or signals mediating this complex response are essentially unknown. As the liver is the central organ mediating the systemic metabolic responses and considering that adult hepatic stem cells are on top of the hierarchy of cell differentiation and may pass epigenetic information to their progeny, we asked whether liver progenitor cells are activated, signal Hypermetabolism upon post-traumatic cellular stress responses, and pass this to differentiated progeny. We generated Sox9CreERT2 : ROSA26 EYFP mice to lineage-trace the periportal ductal progenitor cells (PDPCs) and verify the fate of these cells post-burn. We observed increased proliferation of PDPCs and their progeny peaking around two weeks post-burn, concomitant with the hepatomegaly and the cellular stress responses. We then sorted out PDPCs, PDPC-derived hepatocytes and mature hepatocytes, compared their transcriptome and showed that PDPCs and their progeny present a significant up-regulation in signalling pathways associated with inflammation and metabolic activation, contributing to persistent hypermetabolic and hyper-inflammatory state. Furthermore, concomitant down-regulation of LXR signalling in PDPCs and their progeny implicates the therapeutic potential of early and short-term administration of LXR agonists in ameliorating such persistent Hypermetabolism.

  • Postburn Hypermetabolism: Past, Present, and Future.
    Journal of Burn Care & Research, 2016
    Co-Authors: Marc G. Jeschke
    Abstract:

    Hypermetabolism is the ubiquitous response to a severe burn injury, which was first described in the nineteenth century. Despite identification of important components of this complex response, Hypermetabolism is still not well understood in its entirety. This article describes this incredibly fascinating response and the understanding we have gained over the past 100 years. Additionally, this article describes novel insights and delineates treatment options to modulate postburn Hypermetabolism with the goal to improve outcomes of burn patients.

  • Therapeutic Approaches to Combatting Hypermetabolism inSevere Burn Injuries
    Journal of Intensive and Critical Care, 2015
    Co-Authors: Nazihah Bakhtyar, Thibacg Sivayoganathan, Marc G. Jeschke
    Abstract:

    The complex pathophysiologic response of Hypermetabolism plays a central role for the acute and long term outcomes in severely burned patients. Burns encompassing greater than 20% total body surface area (TBSA) are characterized by stress, insulin resistance, hyperglycemia, lipolysis and catabolism. The objective of this review is to discuss landmark studies in the field of Hypermetabolism postburn with regards to the current best practice for efficacious burn care and to investigate the pros and cons of those treatments. Different modalities were identified from the literature to ameliorate the hypermetabolic condition. These include early excision and closure of the burn wounds, external thermoregulation, adequate nutritional supplementation, exercise and the utilization of various pharmacologic treatments. Furthermore, we included future avenues of research with regards to treating the complex condition of Hypermetabolism and determining how we can create personalized treatments for the unique set of hypermetabolic conditions presented in each patient.

  • IS THERE A DIFFERENCE IN CLINICAL OUTCOMES, INFLAMMATION AND Hypermetabolism BETWEEN SCALD AND FLAME BURN?
    Pediatric Critical Care Medicine, 2011
    Co-Authors: Robert Kraft, David N. Herndon, Gabriela A. Kulp, Fatemah Emdad, Felicia N. Williams, Hal K. Hawkins, Katrina R. Leonard, Marc G. Jeschke
    Abstract:

    OBJECTIVE:: Severe thermal injury induces inflammatory and hypermetabolic responses that are associated with morbidity and mortality. However, it is not known whether the causes of burns affect inflammation, Hypermetabolism, and morbidity. The aim of the present study was to determine whether there is a difference in degree of inflammation, Hypermetabolism, endocrine and acute-phase response, and clinical outcome between pediatric patients with scald and flame burns. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Children with burns requiring surgical intervention were enrolled in this epidemiologic study and divided into two groups, scald or flame burn. In a second assignment, we analyzed the study populations in representative subgroups containing individuals with third-degree burns of 40% to 60% total body surface area. We determined clinical outcomes, resting energy expenditures, cytokine profiles, acute-phase proteins, constitutive proteins, and hormone panels. Statistical analysis was evaluated by analysis of variance, Student's t test corrected with the Bonferroni post hoc test, and the propensity score. Statistical significance was set at p Language: en

Louise Thomson - One of the best experts on this subject based on the ideXlab platform.

  • Quantitative Assessment of Cardiac Hypermetabolism and Perfusion for Diagnosis of Cardiac Sarcoidosis
    Journal of Nuclear Cardiology, 2020
    Co-Authors: Robert J H Miller, Sebastien Cadet, Payam Pournazari, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean Hayes, John Friedman, Louise Thomson
    Abstract:

    Background Quantitative assessment of cardiac Hypermetabolism from ^18Flourodeoxy glucose (FDG) positron emission tomography (PET) may improve diagnosis of cardiac sarcoidosis (CS). We assessed different approaches for quantification of cardiac Hypermetabolism and perfusion in patients with suspected CS. Methods and results Consecutive patients undergoing ^18FDG PET assessment for possible CS between January 2014 and March 2019 were included. Cardiac Hypermetabolism was quantified using maximal standardized uptake value (SUV_MAX), cardiometabolic activity (CMA) and volume of inflammation, using relative thresholds (1.3× and 1.5× left ventricular blood pool [LVBP] activity), and absolute thresholds (SUV_MAX > 2.7 and 4.1). Diagnosis of CS was established using the Japanese Ministry of Health and Wellness criteria. In total, 69 patients were studied, with definite or possible CS in 29(42.0%) patients. CMA above 1.5× LVBP SUV_MAX had the highest area under the receiver operating characteristic curve (AUC 0.92). Quantitative parameters using relative thresholds had higher AUC compared to absolute thresholds ( p  

  • QUANTITATIVE ASSESSMENT OF MYOCARDIAL Hypermetabolism AND PERFUSION FOR DIAGNOSIS OF CARDIAC SARCOIDOSIS
    Journal of the American College of Cardiology, 2020
    Co-Authors: Robert J H Miller, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean W Hayes, John D Friedman, Louise Thomson, Balaji Tamarappoo, Daniel S. Berman
    Abstract:

    Quantitative assessment of myocardial Hypermetabolism may improve diagnosis in suspected cardiac sarcoidosis (CS). However, the optimal method has not been established. We assessed several methods for quantification in patients with known or suspected CS. Consecutive patients undergoing positron

John D Friedman - One of the best experts on this subject based on the ideXlab platform.

  • quantitative assessment of cardiac Hypermetabolism and perfusion for diagnosis of cardiac sarcoidosis
    Journal of Nuclear Cardiology, 2020
    Co-Authors: Robert J H Miller, Sebastien Cadet, Payam Pournazari, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean W Hayes, John D Friedman
    Abstract:

    BACKGROUND Quantitative assessment of cardiac Hypermetabolism from 18Flourodeoxy glucose (FDG) positron emission tomography (PET) may improve diagnosis of cardiac sarcoidosis (CS). We assessed different approaches for quantification of cardiac Hypermetabolism and perfusion in patients with suspected CS. METHODS AND RESULTS Consecutive patients undergoing 18FDG PET assessment for possible CS between January 2014 and March 2019 were included. Cardiac Hypermetabolism was quantified using maximal standardized uptake value (SUVMAX), cardiometabolic activity (CMA) and volume of inflammation, using relative thresholds (1.3× and 1.5× left ventricular blood pool [LVBP] activity), and absolute thresholds (SUVMAX > 2.7 and 4.1). Diagnosis of CS was established using the Japanese Ministry of Health and Wellness criteria. In total, 69 patients were studied, with definite or possible CS in 29(42.0%) patients. CMA above 1.5× LVBP SUVMAX had the highest area under the receiver operating characteristic curve (AUC 0.92). Quantitative parameters using relative thresholds had higher AUC compared to absolute thresholds (p < 0.01). Interobserver variability was low for CMA, with excellent agreement regarding absence of activity (Kappa 0.970). CONCLUSIONS Quantitation with scan-specific thresholds has superior diagnostic accuracy compared to absolute thresholds. Based on the potential clinical benefit, programs should consider quantification of cardiac Hypermetabolism when interpreting 18F-FDG PET studies for CS.

  • QUANTITATIVE ASSESSMENT OF MYOCARDIAL Hypermetabolism AND PERFUSION FOR DIAGNOSIS OF CARDIAC SARCOIDOSIS
    Journal of the American College of Cardiology, 2020
    Co-Authors: Robert J H Miller, Adele Pope, E Kransdorf, Michele A Hamilton, J Patel, Sean W Hayes, John D Friedman, Louise Thomson, Balaji Tamarappoo, Daniel S. Berman
    Abstract:

    Quantitative assessment of myocardial Hypermetabolism may improve diagnosis in suspected cardiac sarcoidosis (CS). However, the optimal method has not been established. We assessed several methods for quantification in patients with known or suspected CS. Consecutive patients undergoing positron