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S H Pawar - One of the best experts on this subject based on the ideXlab platform.

  • water dispersible oleic acid coated fe3o4 nanoparticles for biomedical applications
    Journal of Magnetism and Magnetic Materials, 2015
    Co-Authors: P B Shete, R M Patil, B M Tiwale, S H Pawar
    Abstract:

    Abstract Fe3O4 magnetic nanoparticles (MNPs) have proved their tremendous potential to be used for various biomedical applications. Oleic acid (OA) is widely used in ferrite nanoparticle synthesis because it can form a dense protective monolayer, thereby producing highly uniform and monodispersed particles. Capping agents such as oleic acid are often used because they form a protective monolayer, which is strongly bonded to the surface of nanoparticles. This is necessary for making monodisperse and highly uniform MNPs. Coating of Fe3O4 MNPs with OA makes the particles dispersible only in organic solvents and consequently limits their use for biomedical applications. Hence, in this work, the OA coated MNPs were again functionalized with chitosan (CS), in order to impart hydrophilicity on their surface. All the morphological, magnetic, colloidal and cytotoxic characteristics of the resulting core–shells were studied thoroughly. Their heating induction ability was studied to predict their possible use in Hyperthermia Therapy of cancer. Specific absorption rate was found to be increased than that of bare MNPs.

  • study of ac magnetic heating characteristics of co0 5zn0 5fe2o4 nanoparticles for magnetic Hyperthermia Therapy
    Journal of Magnetism and Magnetic Materials, 2014
    Co-Authors: Dipali S Nikam, S V Jadhav, V M Khot, M R Phadatare, S H Pawar
    Abstract:

    Abstract Structural, magnetic properties and an alternating current (AC) magnetic heating characteristics of Co 0.5 Zn 0.5 Fe 2 O 4 nanoparticles (CZF NPs) have been investigated with respect to the possible application for magnetic Hyperthermia treatments. The Specific Absorption Rate (SAR) was measured in alternating magnetic fields of 167.5–335.2 Oe at fixed frequency of 265 kHz. CZF NPs were fabricated by the chemical co-precipitation method using sodium hydroxide (NaOH) as the precipitating agent. The morphology of the particles was analysed by Transmission Electron microscopy (TEM). The TEM reveals that the grains are nearly spherical in shape with average particles size of 19 nm. X-ray diffraction pattern indicated the sole existence of cubic spinel phase of CZF NPs. The magnetization (Ms) of CZF NPs was measured at room temperature (300 K) using a Vibrating Sample Magnetometer (VSM). The magnetic heating ability of NPs was studied with an induction heating system. A highest SAR value of 114.98 W/g for 5 mg/mL sample concentration (265 kHz, 335.2 Oe) was determined.

  • magnetic chitosan nanocomposite for Hyperthermia Therapy application preparation characterization and in vitro experiments
    Applied Surface Science, 2014
    Co-Authors: P B Shete, Nanasaheb D Thorat, R M Patil, R S Ningthoujam, S J Ghosh, A I Prasad, S H Pawar
    Abstract:

    Abstract Nanocrystals of magnetite (Fe 3 O 4 ) were prepared by alkaline precipitation. The precursor used for synthesis was ferrous chloride only and the reaction was carried out in absence of any oxidant. The synthesized pure phase magnetic nanoparticles (MNPs) were coated with a biocompatible polymer, chitosan (CS). FTIR and TGA confirm coating of CS on MNPs. Both bare and coated MNPs (Fe 3 O 4 and CS-Fe 3 O 4 ) show particle size 21.8 ± 5.3 and 15.1 ± 5.0 nm respectively. The magnetization values of both the MNPs are 51.68 and 49.96 emu/g at room temperature respectively. Negligible Coercivity and Remenance values at room temperature imply superparamagnetic behavior of the MNPs. The MNPs are studied for their induction heating abilities at 167.6, 251.4 and 335.2 Oe (equivalent to 13.3, 20.0 and 26.7 kA m −1 respectively), in order to use them in magnetic fluid Hyperthermia Therapy. At 335.2 Oe, CS coated nanoparticles (NPs) show maximum SAR of 118.85 W/g, while bare NPs show SAR of 79.32 W/g. Low cytotoxic effects of both the MNPs on L929 cell line proved their suitability for in vivo applications. NH 2 group rendered by CS can further be used for conjugation of biomolecules to make them suitable candidates for biosensing and targeted drug delivery.

  • magnetic core shell structures for magnetic fluid Hyperthermia Therapy application
    New Journal of Chemistry, 2013
    Co-Authors: P B Shete, R M Patil, R S Ningthoujam, S J Ghosh, S H Pawar
    Abstract:

    Nanocrystals of magnetite (Fe3O4) were prepared by alkaline precipitation. The precursor used for synthesis was ferrous chloride alone and the reaction was carried out in the absence of any oxidant. The synthesized pure phase magnetic nanoparticles (MNPs) were coated with a biocompatible polymer, acrypol (AP). Fourier transform infrared and thermogravimetric studies confirmed coating of AP on MNPs. Bare and coated MNPs (Fe3O4 and AP–Fe3O4) showed particle sizes of 21.8 ± 5.3 and 14.2 ± 5.0 nm respectively. The magnetization values of the MNPs were 37.77 and 32.71 emu g−1 at room temperature respectively. Negligible coercivity and remanence values at room temperature implied superparamagnetic behavior of the MNPs. The induction heating abilities of MNPs at 167.6, 251.4 and 335.2 Oe (equivalent to 13.3, 20.0 and 26.7 kA m−1 respectively) were studied, in order to use them in magnetic fluid Hyperthermia Therapy. At 335.2 Oe, AP coated NPs showed a maximum specific absorption rate (SAR) of 95.8 W g−1, while bare NPs showed a SAR of 74.4 W g−1. Zeta potential values of bare and coated MNPs were measured at a pH range from 2 to 10 in water. Both the colloidal suspensions were found to be very stable at extreme pH values. However, higher zeta potential values of coated MNPs were assigned to their higher colloidal stability. Low cytotoxic effects of both the MNPs on the L929 cell line proved their suitability for in vivo applications.

Yufang Zhu - One of the best experts on this subject based on the ideXlab platform.

  • magnetic mesoporous silica nanoparticles coated with thermo responsive copolymer for potential chemo and magnetic Hyperthermia Therapy
    Microporous and Mesoporous Materials, 2018
    Co-Authors: Zhengfang Tian, Zhijun Ruan, Min Zhu, Yufang Zhu, Nobutaka Hanagata
    Abstract:

    Abstract We developed a potential chemo- and magnetic Hyperthermia therapeutic platform based on thermo-responsive copolymer coated magnetic mesoporous silica nanoparticles (MMSN@P(NIPAM-co-MAA)). The structure, magnetic heating capacity, drug release behavior, in vitro cytotoxicity, cell uptake, and synergistic therapeutic efficacy of MMSN@P(NIPAM-co-MAA) nanoparticles were investigated. The prepared superparamagnetic MMSN@P(NIPAM-co-MAA) nanoparticles had an average particle size of 255 ± 28 nm. The saturation magnetization was 6.2 emu/g and resulted in heat generation to Hyperthermia temperature under an alternating magnetic field within a short period. MMSN@P(NIPAM-co-MAA) nanoparticles could load doxorubicin hydrochloride (DOX), and exhibited temperature- and pH-responsive drug release behavior. Importantly, MMSN@P(NIPAM-co-MAA) nanoparticles had low cytotoxicity and were internalized by HeLa cells. The DOX-loaded nanoparticles showed a synergistic effect that combined chemo- and magnetic Hyperthermia Therapy, resulting in higher efficacy to kill cancer cells. Thus, MMSN@P(NIPAM-co-MAA) nanoparticles have great potential for cancer Therapy.

  • graphene quantum dots capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery magnetic Hyperthermia and photothermal Therapy
    Small, 2017
    Co-Authors: Xianxian Yao, Xingxing Niu, Ping Huang, Julia Grothe, Stefan Kaskel, Yufang Zhu
    Abstract:

    A multifunctional platform is reported for synergistic Therapy with controlled drug release, magnetic Hyperthermia, and photothermal Therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic Hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment. Furthermore, the MMSN/GQDs nanoparticles can efficiently generate heat to the Hyperthermia temperature under an alternating magnetic field or by near infrared irradiation. More importantly, breast cancer 4T1 cells as a model cellular system, the results indicate that compared with chemoTherapy, magnetic Hyperthermia or photothermal Therapy alone, the combined chemo-magnetic Hyperthermia Therapy or chemo-photothermal Therapy with the DOX-loaded MMSN/GQDs nanosystem exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the MMSN/GQDs multifunctional platform has great potential in cancer Therapy for enhancing the therapeutic efficiency.

Nanasaheb D Thorat - One of the best experts on this subject based on the ideXlab platform.

  • multimodal superparamagnetic nanoparticles with unusually enhanced specific absorption rate for synergetic cancer therapeutics and magnetic resonance imaging
    ACS Applied Materials & Interfaces, 2016
    Co-Authors: Nanasaheb D Thorat, Raghvendra A Bohara, Victor Malgras, Syed A M Tofail, Tansir Ahamad, Saad M Alshehri, Yusuke Yamauchi
    Abstract:

    Superparamagnetic nanoparticles (SPMNPs) used for magnetic resonance imaging (MRI) and magnetic fluid Hyperthermia (MFH) cancer Therapy frequently face trade off between a high magnetization saturation and their good colloidal stability, high specific absorption rate (SAR), and most importantly biological compatibility. This necessitates the development of new nanomaterials, as MFH and MRI are considered to be one of the most promising combined noninvasive treatments. In the present study, we investigated polyethylene glycol (PEG) functionalized La1–xSrxMnO3 (LSMO) SPMNPs for efficient cancer Hyperthermia Therapy and MRI application. The superparamagnetic nanomaterial revealed excellent colloidal stability and biocompatibility. A high SAR of 390 W/g was observed due to higher colloidal stability leading to an increased Brownian and Neel’s spin relaxation. Cell viability of PEG capped nanoparticles is up to 80% on different cell lines tested rigorously using different methods. PEG coating provided excellen...

  • magnetic chitosan nanocomposite for Hyperthermia Therapy application preparation characterization and in vitro experiments
    Applied Surface Science, 2014
    Co-Authors: P B Shete, Nanasaheb D Thorat, R M Patil, R S Ningthoujam, S J Ghosh, A I Prasad, S H Pawar
    Abstract:

    Abstract Nanocrystals of magnetite (Fe 3 O 4 ) were prepared by alkaline precipitation. The precursor used for synthesis was ferrous chloride only and the reaction was carried out in absence of any oxidant. The synthesized pure phase magnetic nanoparticles (MNPs) were coated with a biocompatible polymer, chitosan (CS). FTIR and TGA confirm coating of CS on MNPs. Both bare and coated MNPs (Fe 3 O 4 and CS-Fe 3 O 4 ) show particle size 21.8 ± 5.3 and 15.1 ± 5.0 nm respectively. The magnetization values of both the MNPs are 51.68 and 49.96 emu/g at room temperature respectively. Negligible Coercivity and Remenance values at room temperature imply superparamagnetic behavior of the MNPs. The MNPs are studied for their induction heating abilities at 167.6, 251.4 and 335.2 Oe (equivalent to 13.3, 20.0 and 26.7 kA m −1 respectively), in order to use them in magnetic fluid Hyperthermia Therapy. At 335.2 Oe, CS coated nanoparticles (NPs) show maximum SAR of 118.85 W/g, while bare NPs show SAR of 79.32 W/g. Low cytotoxic effects of both the MNPs on L929 cell line proved their suitability for in vivo applications. NH 2 group rendered by CS can further be used for conjugation of biomolecules to make them suitable candidates for biosensing and targeted drug delivery.

Yuanyi Zheng - One of the best experts on this subject based on the ideXlab platform.

  • hollow magnetic nanocatalysts drive starvation chemodynamic Hyperthermia synergistic Therapy for tumor
    ACS Nano, 2020
    Co-Authors: Xiaojun Cai, Yuanyi Zheng, Weiwei Ying, Yang Zhang, Wei Gao, Gang Wang, Lei Chen, Zheying Meng, Xianfang Lin
    Abstract:

    Magnetic Hyperthermia Therapy (MHT) has been considered as an excellent alternative for treatment of deep tumor tissue; however, up-regulation of heat shock proteins (HSPs) impairs its hyperthermal therapeutic effect. Reactive oxygen species (ROS) and competitive consumption of ATP are important targets that can block excessive HSP generation. We developed a magnetic nanocatalytic system comprised of glucose oxidase (GOD)-loaded hollow iron oxide nanocatalysts (HIONCs) to drive starvation-chemodynamic-Hyperthermia synergistic Therapy for tumor treatment. The Fe2+ present in HIONCs contributed to ROS generation via the Fenton reaction, relieving thermo-resistance and inducing cell apoptosis by chemodynamic action. The Fenton effect was enhanced through the conditions created by increased MHT-related temperature, GOD-mediated H2O2 accumulation, and elevated tumor microenvironment acidity. The HIONCs catalase-like activity facilitated conversion of H2O2 to oxygen, thereby replenishing the oxygen levels. We further demonstrated that locally injected HIONCs-GOD effectively inhibited tumor growth in PC3 tumor-bearing mice. This study presents a multifunctional nanocarrier system driving starvation-chemodynamic-magnetic-thermal synergistic Therapy via ROS and oxygen modulation for prostate tumor treatment.

  • a ph and magnetic dual response hydrogel for synergistic chemo magnetic Hyperthermia tumor Therapy
    RSC Advances, 2018
    Co-Authors: Xiaohan Zhou, L W Wang, Xiaojun Cai, Fengjuan Wang, Yi Ling, Hangrong Chen, Zhigang Wang, Yuanyi Zheng
    Abstract:

    To overcome the toxicity of chemoTherapy, increasing attention has been paid to local drug delivery systems (DDSs). pH-Sensitive hydrogels have emerged as promising DDS materials in the biomedical field due to their remarkable characteristics. However, the pH environment in tumor varies from person to person, which makes the applicability of systems based on pH challenging. In this study, we developed a contractible hydroxypropyl methyl cellulose (HPMC)/Fe3O4 hydrogel with dual-response pH and magnetic properties aiming to overcome the limitations of pH-sensitive hydrogel drug delivery systems and further increase their efficiency in tumor Therapy. The HPMC/Fe3O4 hydrogel could act as a drug delivery system that combines pH-sensitive triggering and magnetic dual-response drug release for synergistic chemo-magnetic Hyperthermia Therapy. The drug delivery profile of the HPMC/Fe3O4/doxorubicin hydrochloride (DOX) hydrogel was determined in vitro and revealed a remarkable pH-sensitive performance. After synergistic chemo-magnetic Hyperthermia treatment, mice with 4T1 breast cancer xenografts recovered without any recurrence or metastasis, demonstrating the synergistic effect of chemoTherapy and magnetic Hyperthermia Therapy. Meanwhile, reduced toxicity and superior anticancer effects were achieved due to the combined effect of the pH and magnetic Hyperthermia response properties. This study demonstrated the high efficacy and low toxicity of the improved design of HPMC/Fe3O4 for drug delivery, which may provide a promising approach for the application of chemo-magnetic Hyperthermia cancer Therapy.

Saif Ullah Awan - One of the best experts on this subject based on the ideXlab platform.

  • peg coated folic acid modified superparamagnetic mnfe2o4 nanoparticles for Hyperthermia Therapy and drug delivery
    Materials Chemistry and Physics, 2013
    Co-Authors: Saqlain A Shah, A Majeed, K Rashid, Saif Ullah Awan
    Abstract:

    Abstract Superparamagnetic iron oxide-based nanoparticles (SPIONS) have attracted an enormous attention for their potential use in biomedical applications due to their good biocompatibility and low toxicity. Current study is about doxorubicin-loaded multifunctional MnFe2O4 nanoparticles surface-modified with polyethylene glycol (PEG) & folic acid (FA) for multimodal cancer Therapy. Infrared spectroscopy and thermogravimetric data confirmed this surface modification. Nanoparticles were of moderate colloidal dispersion due to PEG coating. Composite nanoparticles having mean diameter of about 22 nm were of core–shell structure having about 31% (wt) organic shell over the (remaining) magnetic core. MnFe2O4 core of about 16 nm was superparamagnetic due to the pseudo-single domain structure. Drug loading & releasing were efficient in the initial 8 h and gradual in later hours. Magnetic heating was studied by exposing the magnetic fluid to high frequency magnetic field. Temperature of the fluid rose to 45 °C from 25 °C in about 22 min, which is an effective and appropriate temperature for the localized Hyperthermia treatment of cancer.

  • thermo responsive copolymer coated mnfe2o4 magnetic nanoparticles for Hyperthermia Therapy and controlled drug delivery
    Materials Chemistry and Physics, 2012
    Co-Authors: Saqlain A Shah, M H Asdi, M U Hashmi, M F Umar, Saif Ullah Awan
    Abstract:

    Abstract This study is about multifunctional magnetic nanoparticles surface-modified with bilayer oleic acid, and coated with a thermo-responsive copolymer poly(N-isopropylacrylamide-co-acrylamide) by emulsion polymerization, for controlled drug delivery and magnetic Hyperthermia applications. Nanoparticles were loaded with anticancer drug doxorubicin into the copolymer chains at 25 °C. Composite nanoparticles (hydrated) of average diameter 45 nm were of core–shell structure having magnetic core of about 18 nm and shell was composed of organic compounds and water. Magnetic core was superparamagnetic lacking coercive force and remanance due to the pseudo-single domain nanostructure. Lower critical solution temperature (LCST) of the thermo-responsive copolymer was observed to be around 39 °C. Below this temperature, copolymer was hydrophilic, hydrated and swelled. But above LCST, copolymer became hydrophobic, dehydrated and shrank in volume. UV visible spectrophotometer was used to investigate the drug loading and releasing profile at different temperatures as well as under magnetic heating. There was almost absence of drug release at around 37 °C (normal body temperature). Drug was released at temperatures above LCST, which is significant for controlled drug delivery. Magnetic heat-generation was studied by exposing the magnetic fluid to alternating magnetic field of 7.2 kA m−1 having frequency 70 kHz. A simple magnetic capturing system (simulating a blood vessel) was used to analyze the capturing of magnetic nanoparticles under various applied fields for drug targeting purpose.