The Experts below are selected from a list of 84 Experts worldwide ranked by ideXlab platform
Guy Decaux - One of the best experts on this subject based on the ideXlab platform.
-
MANAGEMENT OF Hypotonic Hyponatremia
Acta Clinica Belgica, 2010Co-Authors: Guy Decaux, Wim Musch, Alain SoupartAbstract:The management of Hypotonic Hyponatremia depends on its cause and its severity. The cases of Hyponatremia with decreased, increased and normal extracellular fluid (ECF) volumes will be examined, followed by a brief mention concerning severe Hyponatremia.
-
the syndrome of inappropriate secretion of antidiuretic hormone siadh
Seminars in Nephrology, 2009Co-Authors: Guy DecauxAbstract:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a disorder of water balance characterized by Hypotonic Hyponatremia and impaired water excretion. The diagnosis of SIADH is based on the exclusion of other hyponatremic conditions, the presence of hyposmolality with inappropriate urine osmolality and a urine sodium concentration usually above 30 mEq/L. Some simple and readily available biologic parameters can be helpful in the diagnosis of SIADH (low urea and uric acid levels). The recent syndrome of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is also discussed and the association of asymptomatic Hyponatremia with falls and bone fractures.
-
Hypotonic Hyponatremia therapeutic and controversial aspects
Nephrologie, 1994Co-Authors: Guy Decaux, Alain SoupartAbstract:Inappropriately slow or excessive correction of severe ( 48 hr) Hyponatremia, the extrusion of intracerebral osmolytes decreases the brain size which returns to an almost normal volume. In this situation, an excessive correction (> 15-20 mEq/l/24 h) will lead to brain dehydration and brain demyelination also called "central pontine myelinolysis" or "osmotic demyelination syndrome" (ODS) could develop. Asymptomatic patients with chronic Hyponatremia are particularly at risk to develop brain demyelination, therefore, they must be corrected cautiously with frequent monitoring of the natremia and with a magnitude of correction not exceeding 15 mEq/l/24 h. The different therapeutic approach regarding to the origin of the Hyponatremia are considered.
Seong Hye Choi - One of the best experts on this subject based on the ideXlab platform.
-
Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Pramipexole in a Patient with Parkinson’s Disease
Korean Movement Disorders Society, 2011Co-Authors: Yoonjae Choi, Jeong Jin Park, Na Young Ryoo, So-hyun Kim, Changseok Song, Im-tae Han, Chang-gi Hong, Seong Hye ChoiAbstract:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic receptor in supraoptic nucleus. A 75-year-old woman with Parkinson’s disease developed asthenia, delirium, aggravated parkinsonian symptoms, and Hypotonic Hyponatremia along with the diagnostic criteria for SIADH during dose escalation of pramipexole. After pramipexole withdrawal, these symptoms disappeared, and sodium levels returned to normal values. The serum sodium levels of patients receiving pramipexole should be monitored, especially during dose escalation
-
syndrome of inappropriate antidiuretic hormone secretion associated with pramipexole in a patient with parkinson s disease
Journal of Movement Disorders, 2010Co-Authors: Yoonjae Choi, Jeong Jin Park, Na Young Ryoo, So-hyun Kim, Changseok Song, Im-tae Han, Chang-gi Hong, Seong Hye ChoiAbstract:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic receptor in supraoptic nucleus. A 75-year-old woman with Parkinson's disease developed asthenia, delirium, aggravated parkinsonian symptoms, and Hypotonic Hyponatremia along with the diagnostic criteria for SIADH during dose escalation of pramipexole. After pramipexole withdrawal, these symptoms disappeared, and sodium levels returned to normal values. The serum sodium levels of patients receiving pramipexole should be monitored, especially during dose escalation.
-
Corresponding author
2010Co-Authors: Case Report, Yoonjae Choi, Jeong Jin Park, Na Young Ryoo, So-hyun Kim, Changseok Song, Im-tae Han, Chang-gi Hong, Seong Hye ChoiAbstract:•- The authors have no financial conflicts of interest. Copyright © 2011 The Korean Movement Disorder Society The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic recep-tor in supraoptic nucleus. A 75-year-old woman with Parkinson’s disease developed asthenia, delirium, aggravated parkinsonian symptoms, and Hypotonic Hyponatremia along with the di-agnostic criteria for SIADH during dose escalation of pramipexole. After pramipexole with-drawal, these symptoms disappeared, and sodium levels returned to normal values. The serum sodium levels of patients receiving pramipexole should be monitored, especially during dose escalation. Journal of Movement Disorders 2011;4:46-48 Key Words: Pramipexole, SIADH, Hyponatremia. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered to be the most frequent cause of Hyponatremia.1 It is characterized by the following essential diag
Mathis Grossmann - One of the best experts on this subject based on the ideXlab platform.
-
patients presenting with severe Hypotonic Hyponatremia etiological factors assessment and outcomes
Hospital Practice, 2009Co-Authors: Rosemary Wong, Shane P Hamblin, Jeffrey D Zajac, Mathis GrossmannAbstract:AbstractBackground: Although hospital-acquired Hyponatremia is well described, severe community-acquired Hyponatremia has been studied less extensively. Aim: To assess characteristics and outcomes of patients admitted with severe Hypotonic Hyponatremia (SHH) (defined as serum sodium ≤ 120 mmol/L). Methods: All patients with serum sodium of ⪙ 120 mmol/L who were admitted to 2 large teaching hospitals from January 2000 to August 2007 were identified, and data were obtained from medical records. Main outcome measures were incidence of osmotic demyelination and mortality. Results: Two hundred fifty-five patients were admitted who had SHH (female to male ratio 2:1), and the mean age was 72 ± 14 years. The most common etiological factors were thiazide/indapamide diuretics (41%), syndrome of inappropriate antidiuretic hormone secretion (38%), and hypovolemia (24%). Inappropriately rapid correction of serum sodium (> 12 mmol/L over the first 24 hours) occurred in 37 patients (15%), with 4 patients (11%) developin...
-
patients presenting with severe Hypotonic Hyponatremia etiological factors assessment and outcomes
Hospital Practice, 2009Co-Authors: Rosemary Wong, Shane P Hamblin, Jeffrey D Zajac, Mathis GrossmannAbstract:Background: Although hospital-acquired Hyponatremia is well described, severe community-acquired Hyponatremia has been studied less extensively. Aim: To assess characteristics and outcomes of patie...
Yoonjae Choi - One of the best experts on this subject based on the ideXlab platform.
-
Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Pramipexole in a Patient with Parkinson’s Disease
Korean Movement Disorders Society, 2011Co-Authors: Yoonjae Choi, Jeong Jin Park, Na Young Ryoo, So-hyun Kim, Changseok Song, Im-tae Han, Chang-gi Hong, Seong Hye ChoiAbstract:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic receptor in supraoptic nucleus. A 75-year-old woman with Parkinson’s disease developed asthenia, delirium, aggravated parkinsonian symptoms, and Hypotonic Hyponatremia along with the diagnostic criteria for SIADH during dose escalation of pramipexole. After pramipexole withdrawal, these symptoms disappeared, and sodium levels returned to normal values. The serum sodium levels of patients receiving pramipexole should be monitored, especially during dose escalation
-
syndrome of inappropriate antidiuretic hormone secretion associated with pramipexole in a patient with parkinson s disease
Journal of Movement Disorders, 2010Co-Authors: Yoonjae Choi, Jeong Jin Park, Na Young Ryoo, So-hyun Kim, Changseok Song, Im-tae Han, Chang-gi Hong, Seong Hye ChoiAbstract:The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic receptor in supraoptic nucleus. A 75-year-old woman with Parkinson's disease developed asthenia, delirium, aggravated parkinsonian symptoms, and Hypotonic Hyponatremia along with the diagnostic criteria for SIADH during dose escalation of pramipexole. After pramipexole withdrawal, these symptoms disappeared, and sodium levels returned to normal values. The serum sodium levels of patients receiving pramipexole should be monitored, especially during dose escalation.
-
Corresponding author
2010Co-Authors: Case Report, Yoonjae Choi, Jeong Jin Park, Na Young Ryoo, So-hyun Kim, Changseok Song, Im-tae Han, Chang-gi Hong, Seong Hye ChoiAbstract:•- The authors have no financial conflicts of interest. Copyright © 2011 The Korean Movement Disorder Society The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can be caused by a variety of drugs. Dopaminergic drugs might enhance the secretion of the antidiuretic hormone arginine vasopressin by reducing γ-amino butyric acid release through the dopaminergic recep-tor in supraoptic nucleus. A 75-year-old woman with Parkinson’s disease developed asthenia, delirium, aggravated parkinsonian symptoms, and Hypotonic Hyponatremia along with the di-agnostic criteria for SIADH during dose escalation of pramipexole. After pramipexole with-drawal, these symptoms disappeared, and sodium levels returned to normal values. The serum sodium levels of patients receiving pramipexole should be monitored, especially during dose escalation. Journal of Movement Disorders 2011;4:46-48 Key Words: Pramipexole, SIADH, Hyponatremia. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered to be the most frequent cause of Hyponatremia.1 It is characterized by the following essential diag
Gary L Robertson - One of the best experts on this subject based on the ideXlab platform.
-
regulation of arginine vasopressin in the syndrome of inappropriate antidiuresis
The American Journal of Medicine, 2006Co-Authors: Gary L RobertsonAbstract:Abstract The syndrome of inappropriate antidiuresis (SIAD) is a disorder of sodium and water balance characterized by Hypotonic Hyponatremia and impaired water excretion in the absence of renal insufficiency, adrenal insufficiency, or any recognized stimulus for the antidiuretic hormone arginine vasopressin (AVP). Hyponatremia is primarily a result of excessive water retention caused by a combination of excessive intake and inappropriate antidiuresis. It is sometimes aggravated by a sodium deficiency caused by decreased intake and/or a secondary natriuresis triggered by and largely corrective of the increase in extracellular volume. Hence, there is neither edema nor signs of hypovolemia. Inappropriate antidiuresis is usually due to administration or endogenous production of AVP or another vasopressin receptor agonist such as desmopressin. Endogenous production can be either ectopic (from a tumor) or eutopic (from the neurohypophysis). The latter apparently is induced by a wide variety of diseases, drugs, or injuries and is divisible into 3 different types of abnormal AVP release during hypertonic saline infusion: high, erratic fluctuations unrelated to increases in plasma sodium (type A); a slow constant "leak" that is also unaffected by increases in plasma sodium (type B); and rapid progressive increases in plasma AVP that correlate closely with plasma sodium as it rises toward the normal range (type C or "reset osmostat"). In 5% to 10% of patients, there is no demonstrable abnormality in the osmoregulation of AVP (type D) and the cause of inappropriate antidiuresis is unclear. In some children it appears to be due to an activating mutation of the V 2 receptor (V 2 R). In other patients, it may be due to abnormal control of aquaporin-2 water channels in renal collecting tubules or production of an antidiuretic principle other than AVP. These different types of osmoregulatory dysfunction underlying SIAD may result in marked differences in clinical presentation or response to therapy with fluid restriction, hypertonic saline infusion, or vasopressin antagonists.