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Guillaume Fond - One of the best experts on this subject based on the ideXlab platform.
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Hypovitaminosis D is associated with negative symptoms, suicide risk, agoraphobia, impaired functional remission, and antidepressant consumption in schizophrenia
European Archives of Psychiatry and Clinical Neuroscience, 2019Co-Authors: Guillaume Fond, M. Faugere, C. Faget-agius, M. Cermolacce, R. Richieri, L. Boyer, C. LançonAbstract:Hypovitaminosis D has been associated with, respectively, major depressive disorder, schizophrenia (SZ), and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objective was to determine the prevalence of Hypovitaminosis D and associated factors in a non-selected multicentric sample of SZ subjects in day hospital. Hypovitaminosis D was defined by blood vitamin D level
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Hypovitaminosis D is associated with depression and anxiety in schizophrenia: results from the national FACE-SZ cohort. Running title: Hypovitaminosis D, depression and anxiety in schizophrenia
Psychiatry Research, 2018Co-Authors: Guillaume Fond, Ophélia Godin, Franck Schürhoff, Fabrice Berna, E. Bulzacka, M. Andrianarisoa, Lore Brunel, Bruno Aouizerate, Delphine Capdevielle, Isabelle ChereauAbstract:Objective Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of Hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors. Methods A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46–0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01–0.66], p = 0.02) compared to patients with Hypovitaminosis D. Conclusion Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with Hypovitaminosis D remain insufficiently treated.
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Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.
Psychiatry research, 2018Co-Authors: Guillaume Fond, Ophélia Godin, Franck Schürhoff, Fabrice Berna, E. Bulzacka, M. Andrianarisoa, Lore Brunel, Bruno Aouizerate, Delphine Capdevielle, Isabelle ChereauAbstract:Abstract Objective Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of Hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors. Methods A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level Results Hypovitaminosis D has been found in 21.4% of the subjects and none of them had received vitamin D supplementation in the previous 12 months. In multivariate analysis, Hypovitaminosis D has been significantly associated with respectively higher depressive symptoms (aOR = 1.18 [1.03–1.35], p = 0.02) and current anxiety disorder (aOR = 6.18 [2.15–17.75], p = 0.001), independently of age and gender. No association of Hypovitaminosis D with respectively positive and negative symptoms, cognitive scores or other biological variables has been found (all p > 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46–0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01–0.66], p = 0.02) compared to patients with Hypovitaminosis D. Conclusion Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with Hypovitaminosis D remain insufficiently treated.
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Mood disorders are associated with a more severe Hypovitaminosis D than schizophrenia
Psychiatry Research-neuroimaging, 2015Co-Authors: Raoul Belzeaux, Laurent Boyer, El Chérif Ibrahim, Francois Feron, Marion Leboyer, Guillaume FondAbstract:Patients with psychiatric disorders display high levels of Hypovitaminosis D (o50 nmol/L). It remains unclear whether it is associated with specific diagnoses. To further explore vitamin D status in psychiatric inpatients, 82 individuals with mood disorders or schizophrenia/schizoaffective disorders were included. Hypovitaminosis D was significantly lower in patients with mood disorders than patients with schizophrenia (standardized β coefficient ¼0.385, p¼0.007). Further studies are warranted to determine specific causes of Hypovitaminosis D and the interest of supplementation.
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Mood disorders are associated with a more severe Hypovitaminosis D than schizophrenia.
Psychiatry research, 2015Co-Authors: Raoul Belzeaux, Laurent Boyer, El Chérif Ibrahim, Francois Feron, Marion Leboyer, Guillaume FondAbstract:Patients with psychiatric disorders display high levels of Hypovitaminosis D (
Mitsuyasu Itoh - One of the best experts on this subject based on the ideXlab platform.
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Hypovitaminosis d in type 2 diabetes mellitus association with microvascular complications and type of treatment
Endocrine Journal, 2006Co-Authors: Atsushi Suzuki, M Kotake, Yasunaga Ono, Taiya Kato, Naohisa Oda, Nobuki Hayakawa, Shuji Hashimoto, Mitsuyasu ItohAbstract:The prevalence of Hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of Hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of Hypovitaminosis D (<20 ng/ml) was 70.6%. Serum concentrations of 25-OHD were associated with HbA1c (P = 0.013), age (P = 0.070) and serum albumin (P<0.001), but were not related to BMI or the duration of diabetes. The levels of 25-OHD were significantly lower in the population with apparent microvascular complications, although serum creatinine levels were below 2.0 mg/dl. Serum 25-OHD concentrations in the group treated with insulin (15.4 ± 6.5 ng/ml) was lower than those in the patients treated with diet alone (20.8 ± 7.6 ng/ml) and with oral hypoglycemic agents (17.3 ± 7.0 ng/ml). Furthermore, the highest incidence of osteoporotic fracture and/or back deformity was observed in insulin-treated patients with Hypovitaminosis D. In conclusion, these results suggest that microvascular complications and insulin treatment in type 2 diabetes patients are associated with the co-existence of Hypovitaminosis D, and that Hypovitaminosis D in insulin-treated patients is possibly related to the risk of osteoporotic fracture.
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Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment.
Endocrine journal, 2006Co-Authors: Atsushi Suzuki, M Kotake, Yasunaga Ono, Taiya Kato, Naohisa Oda, Nobuki Hayakawa, Shuji Hashimoto, Mitsuyasu ItohAbstract:The prevalence of Hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of Hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of Hypovitaminosis D (
Atsushi Suzuki - One of the best experts on this subject based on the ideXlab platform.
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Hypovitaminosis d in type 2 diabetes mellitus association with microvascular complications and type of treatment
Endocrine Journal, 2006Co-Authors: Atsushi Suzuki, M Kotake, Yasunaga Ono, Taiya Kato, Naohisa Oda, Nobuki Hayakawa, Shuji Hashimoto, Mitsuyasu ItohAbstract:The prevalence of Hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of Hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of Hypovitaminosis D (<20 ng/ml) was 70.6%. Serum concentrations of 25-OHD were associated with HbA1c (P = 0.013), age (P = 0.070) and serum albumin (P<0.001), but were not related to BMI or the duration of diabetes. The levels of 25-OHD were significantly lower in the population with apparent microvascular complications, although serum creatinine levels were below 2.0 mg/dl. Serum 25-OHD concentrations in the group treated with insulin (15.4 ± 6.5 ng/ml) was lower than those in the patients treated with diet alone (20.8 ± 7.6 ng/ml) and with oral hypoglycemic agents (17.3 ± 7.0 ng/ml). Furthermore, the highest incidence of osteoporotic fracture and/or back deformity was observed in insulin-treated patients with Hypovitaminosis D. In conclusion, these results suggest that microvascular complications and insulin treatment in type 2 diabetes patients are associated with the co-existence of Hypovitaminosis D, and that Hypovitaminosis D in insulin-treated patients is possibly related to the risk of osteoporotic fracture.
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Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment.
Endocrine journal, 2006Co-Authors: Atsushi Suzuki, M Kotake, Yasunaga Ono, Taiya Kato, Naohisa Oda, Nobuki Hayakawa, Shuji Hashimoto, Mitsuyasu ItohAbstract:The prevalence of Hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of Hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of Hypovitaminosis D (
Cédric Annweiler - One of the best experts on this subject based on the ideXlab platform.
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Hypovitaminosis D and orthostatic hypotension: a systematic review and meta-analysis
Journal of Hypertension, 2016Co-Authors: Francesca Ometto, Guillaume T. Duval, Wooyoung Jang, Kevin Mccarroll, Pinar Soysal, Conal Cunningham, Cédric Annweiler, Brendon Stubbs, Ahmet Turan IsikAbstract:OBJECTIVES: Orthostatic hypotension is a common condition among older adults and is associated with a range of deleterious outcomes. Recently, interest has developed in Hypovitaminosis D (defined as low 25 hydroxiyvitamin D levels) as a potential risk factor for orthostatic hypotension. We conducted a systematic review and meta-analysis examining the association of orthostatic hypotension between study participants with and without Hypovitaminosis D, including the adjustment of potential confounders (age, sex, BMI, renal function, comorbidities, seasonality, use of antihypertensive medications, and supplementation with cholecalciferol). METHODS: A systematic literature search of major electronic databases from inception until 09/2015 was made for articles providing data on orthostatic hypotension and Hypovitaminosis D. A random effects meta-analysis of cross-sectional studies investigating orthostatic hypotension prevalence comparing participants with vs. those without Hypovitaminosis D was undertaken, calculating the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Of 317 initial hits, five cross-sectional studies were meta-analysed including 3646 participants (1270 with Hypovitaminosis D and 2376 without). The participants with Hypovitaminosis D had a higher prevalence of orthostatic hypotension (OR = 1.88; 95% CI: 1.25-2.84; I = 68%) that was not affected by adjusting for a median of five potential confounders (OR = 2.03; 95% CI: 1.13-3.68; I = 73%). People with orthostatic hypotension had significantly reduced serum vitamin D concentrations (standardized mean difference = -0.42; 95% CI: -0.72 to -0.12). One longitudinal study confirmed the association between Hypovitaminosis D and orthostatic hypotension. CONCLUSION: Our meta-analysis highlights that Hypovitaminosis D is associated with orthostatic hypotension, independent of potential confounders. Further longitudinal studies and clinical trials are required to confirm these findings.
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Association between bullous pemphigoid and Hypovitaminosis D in older inpatients: Results from a case-control study.
European journal of internal medicine, 2016Co-Authors: M.e. Sarre, Cédric Annweiler, E. Legrand, L. Martin, Olivier BeauchetAbstract:Abstract Objectives To compare serum vitamin D status in older inpatients with bullous pemphigoid (BP) and matched inpatients without BP, and to examine whether Hypovitaminosis D, a high comorbidity burden or their combination were associated with BP. Methods This prospective case–control study was performed from November 2012 to February 2014. A total of 90 consecutive older inpatients (31 consecutive inpatients with a de novo diagnosis of active BP, and 59 matched controls without BP) were recruited in the Department of Dermatology of Angers University Hospital, France. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D (25OHD) concentration Results There was no significant difference between older inpatients with and without BP. Fully adjusted logistic regression showed a significant association between BP and Hypovitaminosis D (odds ratio [OR] = 3.7, P = 0.046). The analysis of interaction between Hypovitaminosis D and comorbidity burden showed that only the association of both was significantly associated with PB (OR = 3.1, P = 0.042). Conclusions BP was significantly associated with Hypovitaminosis D solely in patients with a high comorbidity burden among the older in-patients studied. This result suggests a complex interplay between Hypovitaminosis D and BP, explaining the mixed results reported previously in the literature.
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Derivation and Validation of a Clinical Diagnostic Tool for the Identification of Older Community-Dwellers With Hypovitaminosis D.
Journal of the American Medical Directors Association, 2015Co-Authors: Cédric Annweiler, Anastasiia Kabeshova, Mathilde Legeay, Bruno Fantino, Olivier BeauchetAbstract:Abstract Objectives Hypovitaminosis D is highly prevalent among seniors. Although evidence is insufficient to recommend routine vitamin D screening in seniors, universal vitamin D supplementation is not desirable either. To rationalize vitamin D determination, our objective was to elaborate and test a clinical diagnostic tool for the identification of seniors with Hypovitaminosis D without using a blood test. Design Derivation of a clinical diagnostic tool using artificial neural networks (multilayer perceptron; MLP) in randomized training subgroup of Prevention des Chutes, Reseau 4' cohort, and validation in randomized testing subgroup. Setting Health Examination Centers of health insurance, Lyon, France. Participants A total of 1924 community-dwellers aged ≥65 years without vitamin D supplements, consecutively recruited between 2009 and 2012. Measurements Hypovitaminosis D defined as serum 25-hydroxyvitamin (25OHD) concentration ≤ 75 nmol/L, ≤50 nmol/L, or ≤25 nmol/L. A set of clinical variables (age, gender, living alone, individual deprivation, body mass index, undernutrition, polymorbidity, number of drugs used daily, psychoactive drugs, biphosphonates, strontium, calcium supplements, falls, fear of falling, vertebral fractures, Timed Up and Go, walking aids, lower-limb proprioception, handgrip strength, visual acuity, wearing glasses, cognitive disorders, sad mood) were recorded. Several MLPs, based on varying amounts of variables according to their relative importance, were tested consecutively. Results A total of 1729 participants (89.9%) had 25OHD ≤75 nmol/L, 1288 (66.9%) had 25OHD ≤50 nmol/L, and 525 (27.2%) had 25OHD ≤25 nmol/L. MLP using 16 clinical variables was able to diagnose Hypovitaminosis D ≤ 75 nmol/L with accuracy = 96.3%, area under curve (AUC) = 0.938, and κ = 79.3 indicating almost perfect agreement. It was also able to diagnose Hypovitaminosis D ≤ 50 nmol/L with accuracy = 81.5, AUC = 0.867, and κ = 57.8 (moderate agreement); and Hypovitaminosis D ≤ 25 nmol/L with accuracy = 82.5, AUC = 0.385, and κ = 55.0 (moderate agreement). Conclusions We elaborated an algorithm able to identify, from 16 clinical variables, seniors with Hypovitaminosis D.
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Vitamin D and Brain Imaging in the Elderly: Should we Expect Some Lesions Specifically Related to Hypovitaminosis D?
The open neuroimaging journal, 2012Co-Authors: Cédric Annweiler, Manuel Montero-odasso, Susan W Muir, Olivier BeauchetAbstract:Hypovitaminosis D is associated with cognitive decline in the elderly, but the issue of causality remains unresolved. Definitive evidence would include the visualization of brain lesions resulting from Hypovitaminosis D. The aim of the present article is to determine, through a literature review, the location and nature of possible brain disorders in Hypovitaminosis D. We found limited brain-imaging data, which reported ischemic infarcts and white matter hyperintensities in Hypovitaminosis D, though did not provide their specific location or report any focal atrophy. Based on the finding of executive dysfunctions (i.e., mental shifting and information updating impairments) in the presence of Hypovitaminosis D, we suggest that Hypovitaminosis D is associated with a dysfunction of the frontal-subcortical neuronal circuits, particularly the dorsolateral circuit. Further imaging studies are required to corroborate this assumption and to determine whether Hypovitaminosis D results in degenerative and / or vascular lesions.
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Association between Hypovitaminosis D and age-related macular degeneration: a case-control study
Acta Ophthalmologica, 2011Co-Authors: Martine Mauget-faÿsse, Cédric Annweiler, Olivier Beauchet, A Graffe, Dan MileaAbstract:Purpose To examine the association of low serum 25-hydroxyvitamin D (25OHD) concentration with age-related macular degeneration (AMD). Based on a case–control study. 31 patients with AMD (i.e., early, intermediate and advanced AMD) and 34 control patients without AMD were prospectively recruited. Ophthalmological examination, and funduscopic analysis was performed to determine AMD stage and serum 25OHD concentration was measured for each patient. Methods Hypovitaminosis D was defined by serum 25OHD concentration < 50nmol/L. Age, gender and season of blood collection were used as potential confounders. Results Compared to 28 subjects with normal 25OHD status (i.e., ≥50nmol/mL), subjects with Hypovitaminosis D (n=37) had more often AMD (P=0.029) all stages confused. Hypovitaminosis D was associated with AMD (unadjusted odds ratio (OR)=3.10 with P=0.031; adjusted OR=3.03 with P=0.041 for full model; adjusted OR=3.10 with P=0.031 for stepwise backward model). Conclusion Hypovitaminosis D may be associated with AMD.
Isabelle Chereau - One of the best experts on this subject based on the ideXlab platform.
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Hypovitaminosis D is associated with depression and anxiety in schizophrenia: results from the national FACE-SZ cohort. Running title: Hypovitaminosis D, depression and anxiety in schizophrenia
Psychiatry Research, 2018Co-Authors: Guillaume Fond, Ophélia Godin, Franck Schürhoff, Fabrice Berna, E. Bulzacka, M. Andrianarisoa, Lore Brunel, Bruno Aouizerate, Delphine Capdevielle, Isabelle ChereauAbstract:Objective Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of Hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors. Methods A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46–0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01–0.66], p = 0.02) compared to patients with Hypovitaminosis D. Conclusion Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with Hypovitaminosis D remain insufficiently treated.
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Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.
Psychiatry research, 2018Co-Authors: Guillaume Fond, Ophélia Godin, Franck Schürhoff, Fabrice Berna, E. Bulzacka, M. Andrianarisoa, Lore Brunel, Bruno Aouizerate, Delphine Capdevielle, Isabelle ChereauAbstract:Abstract Objective Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of Hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors. Methods A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level Results Hypovitaminosis D has been found in 21.4% of the subjects and none of them had received vitamin D supplementation in the previous 12 months. In multivariate analysis, Hypovitaminosis D has been significantly associated with respectively higher depressive symptoms (aOR = 1.18 [1.03–1.35], p = 0.02) and current anxiety disorder (aOR = 6.18 [2.15–17.75], p = 0.001), independently of age and gender. No association of Hypovitaminosis D with respectively positive and negative symptoms, cognitive scores or other biological variables has been found (all p > 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46–0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01–0.66], p = 0.02) compared to patients with Hypovitaminosis D. Conclusion Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with Hypovitaminosis D remain insufficiently treated.