The Experts below are selected from a list of 4275 Experts worldwide ranked by ideXlab platform
Longlong Geng - One of the best experts on this subject based on the ideXlab platform.
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nanocage based porous metal organic frameworks constructed from Icosahedrons and tetrahedrons for selective gas adsorption
ACS Applied Materials & Interfaces, 2019Co-Authors: Dashuai Zhang, Yongzheng Zhang, Xiuling Zhang, Fei Wang, Jian Zhang, Jun Gao, Hui Yan, Huiling Liu, Longlong GengAbstract:Two isostructural nanocage-based porous Ni/Co(II)-MOFs have been hydrothermally synthesized, which were interestingly composed of Icosahedron and tetrahedron cages with a new (3,8)-connected 3D topology. Moreover, the stable Ni-MOF exhibits good selective CO2/CH4 and CO2/N2 adsorption owing to its exposed nitrogen active sites.
Trisha N Davis - One of the best experts on this subject based on the ideXlab platform.
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corrigendum design of a hyperstable 60 subunit protein Icosahedron
Nature, 2016Co-Authors: Yang Hsia, Jacob B Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K Fong, Una Nattermann, Possu Huang, Rashmi Ravichandran, Trisha N DavisAbstract:Nature 535, 136–139 (2016); doi:10.1038/nature18010 In this Letter, the 60-subunit protein assembly presented more strongly resembles a wireframe dodecahedron than an Icosahedron. We thank the reader who drew this to our attention and we agree that all instances of the word “Icosahedron” should be changed to “dodecahedron”.
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design of a hyperstable 60 subunit protein Icosahedron
Nature, 2016Co-Authors: Yang Hsia, Jacob B Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K Fong, Una Nattermann, Possu Huang, Rashmi Ravichandran, Trisha N DavisAbstract:The dodecahedron [corrected] is the largest of the Platonic solids, and icosahedral protein structures are widely used in biological systems for packaging and transport. There has been considerable interest in repurposing such structures for applications ranging from targeted delivery to multivalent immunogen presentation. The ability to design proteins that self-assemble into precisely specified, highly ordered icosahedral structures would open the door to a new generation of protein containers with properties custom-tailored to specific applications. Here we describe the computational design of a 25-nanometre icosahedral nanocage that self-assembles from trimeric protein building blocks. The designed protein was produced in Escherichia coli, and found by electron microscopy to assemble into a homogenous population of icosahedral particles nearly identical to the design model. The particles are stable in 6.7 molar guanidine hydrochloride at up to 80 degrees Celsius, and undergo extremely abrupt, but reversible, disassembly between 2 molar and 2.25 molar guanidinium thiocyanate. The dodecahedron [corrected] is robust to genetic fusions: one or two copies of green fluorescent protein (GFP) can be fused to each of the 60 subunits to create highly fluorescent ‘standard candles’ for use in light microscopy, and a designed protein pentamer can be placed in the centre of each of the 20 pentameric faces to modulate the size of the entrance/exit channels of the cage. Such robust and customizable nanocages should have considerable utility in targeted drug delivery, vaccine design and synthetic biology.
Dashuai Zhang - One of the best experts on this subject based on the ideXlab platform.
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nanocage based porous metal organic frameworks constructed from Icosahedrons and tetrahedrons for selective gas adsorption
ACS Applied Materials & Interfaces, 2019Co-Authors: Dashuai Zhang, Yongzheng Zhang, Xiuling Zhang, Fei Wang, Jian Zhang, Jun Gao, Hui Yan, Huiling Liu, Longlong GengAbstract:Two isostructural nanocage-based porous Ni/Co(II)-MOFs have been hydrothermally synthesized, which were interestingly composed of Icosahedron and tetrahedron cages with a new (3,8)-connected 3D topology. Moreover, the stable Ni-MOF exhibits good selective CO2/CH4 and CO2/N2 adsorption owing to its exposed nitrogen active sites.
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Nanocage-Based Porous Metal–Organic Frameworks Constructed from Icosahedrons and Tetrahedrons for Selective Gas Adsorption
2019Co-Authors: Dashuai Zhang, Yongzheng Zhang, Xiuling Zhang, Fei Wang, Jian Zhang, Jun Gao, Hui Yan, Huiling LiuAbstract:Two isostructural nanocage-based porous Ni/Co(II)-MOFs have been hydrothermally synthesized, which were interestingly composed of Icosahedron and tetrahedron cages with a new (3,8)-connected 3D topology. Moreover, the stable Ni-MOF exhibits good selective CO2/CH4 and CO2/N2 adsorption owing to its exposed nitrogen active sites
Huiling Liu - One of the best experts on this subject based on the ideXlab platform.
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nanocage based porous metal organic frameworks constructed from Icosahedrons and tetrahedrons for selective gas adsorption
ACS Applied Materials & Interfaces, 2019Co-Authors: Dashuai Zhang, Yongzheng Zhang, Xiuling Zhang, Fei Wang, Jian Zhang, Jun Gao, Hui Yan, Huiling Liu, Longlong GengAbstract:Two isostructural nanocage-based porous Ni/Co(II)-MOFs have been hydrothermally synthesized, which were interestingly composed of Icosahedron and tetrahedron cages with a new (3,8)-connected 3D topology. Moreover, the stable Ni-MOF exhibits good selective CO2/CH4 and CO2/N2 adsorption owing to its exposed nitrogen active sites.
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Nanocage-Based Porous Metal–Organic Frameworks Constructed from Icosahedrons and Tetrahedrons for Selective Gas Adsorption
2019Co-Authors: Dashuai Zhang, Yongzheng Zhang, Xiuling Zhang, Fei Wang, Jian Zhang, Jun Gao, Hui Yan, Huiling LiuAbstract:Two isostructural nanocage-based porous Ni/Co(II)-MOFs have been hydrothermally synthesized, which were interestingly composed of Icosahedron and tetrahedron cages with a new (3,8)-connected 3D topology. Moreover, the stable Ni-MOF exhibits good selective CO2/CH4 and CO2/N2 adsorption owing to its exposed nitrogen active sites
Yang Hsia - One of the best experts on this subject based on the ideXlab platform.
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corrigendum design of a hyperstable 60 subunit protein Icosahedron
Nature, 2016Co-Authors: Yang Hsia, Jacob B Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K Fong, Una Nattermann, Possu Huang, Rashmi Ravichandran, Trisha N DavisAbstract:Nature 535, 136–139 (2016); doi:10.1038/nature18010 In this Letter, the 60-subunit protein assembly presented more strongly resembles a wireframe dodecahedron than an Icosahedron. We thank the reader who drew this to our attention and we agree that all instances of the word “Icosahedron” should be changed to “dodecahedron”.
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design of a hyperstable 60 subunit protein Icosahedron
Nature, 2016Co-Authors: Yang Hsia, Jacob B Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K Fong, Una Nattermann, Possu Huang, Rashmi Ravichandran, Trisha N DavisAbstract:The dodecahedron [corrected] is the largest of the Platonic solids, and icosahedral protein structures are widely used in biological systems for packaging and transport. There has been considerable interest in repurposing such structures for applications ranging from targeted delivery to multivalent immunogen presentation. The ability to design proteins that self-assemble into precisely specified, highly ordered icosahedral structures would open the door to a new generation of protein containers with properties custom-tailored to specific applications. Here we describe the computational design of a 25-nanometre icosahedral nanocage that self-assembles from trimeric protein building blocks. The designed protein was produced in Escherichia coli, and found by electron microscopy to assemble into a homogenous population of icosahedral particles nearly identical to the design model. The particles are stable in 6.7 molar guanidine hydrochloride at up to 80 degrees Celsius, and undergo extremely abrupt, but reversible, disassembly between 2 molar and 2.25 molar guanidinium thiocyanate. The dodecahedron [corrected] is robust to genetic fusions: one or two copies of green fluorescent protein (GFP) can be fused to each of the 60 subunits to create highly fluorescent ‘standard candles’ for use in light microscopy, and a designed protein pentamer can be placed in the centre of each of the 20 pentameric faces to modulate the size of the entrance/exit channels of the cage. Such robust and customizable nanocages should have considerable utility in targeted drug delivery, vaccine design and synthetic biology.
