The Experts below are selected from a list of 62124 Experts worldwide ranked by ideXlab platform
Hak Soo Choi - One of the best experts on this subject based on the ideXlab platform.
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Multispectral Image-Guided Surgery in patients
Nature Biomedical Engineering, 2020Co-Authors: Hak Soo ChoiAbstract:An optical-imaging instrument that integrates multispectral imaging for the detection of fluorescence in the first and second near-infrared windows aids the surgical resection of liver tumours in patients.
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intraoperative biophotonic imaging systems for image guided interventions
Nanophotonics, 2018Co-Authors: Salar Sajedi, Hamid Sabet, Hak Soo ChoiAbstract:: Biophotonic imaging has revolutionized the operation room by providing surgeons intraoperative image-guidance to diagnose tumors more efficiently and to resect tumors with real-time image navigation. Among many medical imaging modalities, near-infrared (NIR) light is ideal for Image-Guided Surgery because it penetrates relatively deeply into living tissue, while nuclear imaging provides quantitative and unlimited depth information. It is therefore ideal to develop an integrated imaging system by combining NIR fluorescence and gamma-positron imaging to provide surgeons with highly sensitive and quantitative detection of diseases, such as cancer, in real-time without changing the look of the surgical field. The focus of this review is to provide recent progress in intraoperative biophotonic imaging systems, NIR fluorescence imaging and intraoperative nuclear imaging devices, and their future perspectives for Image-Guided interventions.
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real time imaging of brain tumor for image guided Surgery
Advanced Healthcare Materials, 2018Co-Authors: Shuang Hu, Homan Kang, Yoonji Baek, Georges El Fakhri, Anren Kuang, Hak Soo ChoiAbstract:The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue. Moreover, malignant brain tumors are even more difficult to distinguish from normal brain tissue, and resecting noncancerous tissue may create neurological defects after Surgery. To optimize the resection margin in brain tumors, a variety of intraoperative guidance techniques are developed, such as neuronavigation, magnetic resonance imaging, ultrasound, Raman spectroscopy, and optical fluorescence imaging. When combined with appropriate contrast agents, optical fluorescence imaging can provide the neurosurgeon real-time image guidance to improve resection completeness and to decrease surgical complications.
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fluorescence molecular imaging systems for intraoperative image guided Surgery
Applied Spectroscopy Reviews, 2018Co-Authors: Connor Obrien, Hak Soo Choi, Myung Yung JeongAbstract:ABSTRACTDespite advances in diagnostic and therapeutic technology of human diseases, cancer remains among the leading causes of morbidity and mortality worldwide. The development of molecular imaging has made it possible to diagnose and treat cancer at early stages, which increases the likelihood of survival. Nuclear medicine has played a key role in diagnosis and staging of human malignancy. However, most imaging technology can only be used in the preoperative diagnosis stage, and these methods are time consuming and often expose patients to a high amount of radiation. Combined with appropriate contrast agents, fluorescence molecular imaging is an easy-to-use imaging tool that can be implemented for intraoperative cancer Surgery to delineate tumor margins. In particular, near-infrared fluorescence is useful for Image-Guided cancer Surgery because of the relatively high tissue penetration, low tissue absorption and scattering, and reduced autofluorescence. In this review, the basic principles of fluoresce...
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synthesis and in vivo fate of zwitterionic near infrared fluorophores
Angewandte Chemie, 2011Co-Authors: Hak Soo Choi, Khaled Nasr, Yoshitomo Ashitate, Sergey Alyabyev, Dina Feith, Jeong Heon Lee, Soon Hee Kim, Hoon Hyun, Gabor PatonayAbstract:A longstanding problem in the field of Image-Guided Surgery is the development of ideal near-infrared (NIR) fluorophores. The heptamethine NIR fluorophore indocyanine green (ICG) has been used extensively for Image-Guided Surgery because of clinical availability and safety.[1-3] However, ICG is far from ideal because it exhibits high uptake in the liver, contaminates the gastrointestinal (GI) tract, provides moderate optical properties,[4] is unstable in aqueous media,[3,5] and is unable to conjugate covalently to targeting ligands.[2] Although several classes of novel molecules have been described,[6-13] none to date exhibit simultaneous low background binding, bifunctionality, excellent optical properties, low protein binding, and high serum stability. Although it is intuitive that physicochemical properties, i.e., positive/negative charge density, hydrophilicity/lipophilicity, and charge distribution, will impact in vivo performance, chemical structures that exhibit ideal characteristics have not yet been defined.
Yao Sun - One of the best experts on this subject based on the ideXlab platform.
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novel dual function near infrared ii fluorescence and pet probe for tumor delineation and image guided Surgery
Chemical Science, 2018Co-Authors: Yao Sun, Xiaodong Zeng, Yuling Xiao, Hui Zhou, Changhao Liu, Hua Zhu, Ziyang Chen, Jule Wang, Mengyue ZhuAbstract:Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue, however, negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during Surgery. Intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing for the highly efficient and selective assembly of various thiol units in a protecting-group-free manner. The first small-molecule based αvβ3-targeted NIR-II/PET probe 68Ga-SCH2 was concisely generated via this strategy and subsequently evaluated in mice bearing the U87MG xenograft. Excellent imaging properties such as good tumor uptake, high tumor contrast and specificity, tumor delineation and Image-Guided Surgery were achieved in the small animal models. These attractive results of 68Ga-SCH2 allow it to be a promising αvβ3-targeted NIR-II/PET probe for clinical translation.
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novel bright emission small molecule nir ii fluorophores for in vivo tumor imaging and image guided Surgery
Chemical Science, 2017Co-Authors: Yao Sun, Mingmin Ding, Xiaodong Zeng, Yuling Xiao, Hui Zhou, Bingbing Ding, Wei Hou, Aga Erbu, Yejun ZhangAbstract:Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY ≈ 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible NIR-II probes: SXH, SDH, and H1 NPs were constructed via different chemical strategies based on H1, and then their potential to be used in in vivo tumor imaging and Image-Guided Surgery in the NIR-II region was explored. High levels of uptake were obtained for both passive and active tumor targeting probes SXH and SDH. Furthermore, high resolution imaging of blood vessels on tumors and the whole body of living mice using H1 NPs for the first time has demonstrated precise NIR-II Image-Guided sentinel lymph node (SLN) Surgery.
Samuel Achilefu - One of the best experts on this subject based on the ideXlab platform.
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3179282.pdf
2018Co-Authors: Missael Garcia, Christopher Edmiston, Timothy York, Radoslav Marinov, Suman Mondal, Nan Zhu, Gail Sudlow, Walter Akers, Julie Margenthaler, Samuel AchilefuAbstract:This document provides supplementary information to “A bio-inspired imager improves sensitivity for near-infrared fluorescence Image-Guided Surgery,” DOI. Figures for the imaging sensor block and timing diagram and the microfabrication procedure fo
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live demonstration a compact nir fluorescence imaging system design with goggle display for intraoperative guidance
International Symposium on Circuits and Systems, 2015Co-Authors: Shengkui Gao, Nan Zhu, Samuel Achilefu, Suman Modal, Rongguang Liang, Viktor GruevAbstract:This demonstration presents a compact and wearable NIR fluorescence imaging system (FIS) for image guided Surgery. The proposed FIS captures 27 frames per second of both NIR and visible spectrum data, allowing for minimum detection of 10nM of ICG concentration. The imaging system is currently used in clinical trials for imaging sentinel lymph nodes in breast cancer and melanoma patients.
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hands free wireless goggles for near infrared fluorescence and real time image guided Surgery
Surgery, 2011Co-Authors: Adam Q Bauer, Gail Sudlow, Walter J Akers, Kexian Liang, Duanwen Shen, Mikhail Y Berezin, Joseph P Culver, Samuel AchilefuAbstract:Background Current cancer management faces several challenges, including the occurrence of a residual tumor after resection, the use of radioactive materials or high concentrations of blue dyes for sentinel lymph node biopsy, and the use of bulky systems in surgical suites for image guidance. To overcome these limitations, we developed a real-time, intraoperative imaging device that, when combined with near infrared fluorescent molecular probes, can aid in the identification of tumor margins, guide surgical resections, map sentinel lymph nodes, and transfer acquired data wirelessly for remote analysis. Methods We developed a new compact, wireless, wearable, and battery-operated device that allows for hands-free operation by surgeons. A charge-coupled device–based, consumer-grade night vision viewer was used to develop the detector portion of the device, and the light source portion was developed from a compact headlamp. This piece was retrofitted to provide both near infrared excitation and white light illumination simultaneously. Wireless communication was enabled by integrating a battery-operated, miniature, radio-frequency video transmitter into the system. We applied the device in several types of oncologic surgical procedures in murine models, including sentinel lymph node mapping, fluorescence-guided tumor resection, and Surgery under remote expert guidance. Results Unlike conventional imaging instruments, the device displays fluorescence information directly on its eyepiece. When employed in sentinel lymph node mapping, the locations of sentinel lymph nodes were visualized clearly, even with tracer level dosing of a near infrared fluorescent dye (indocyanine green). When used in tumor resection, tumor margins and small nodules invisible to the naked eye were visualized readily. In a simulated, point-of-care setting, tumors were located successfully and removed under remote guidance using the wireless feature of the device. Importantly, the total cost of this prototype system ($1200) is substantially less than existing imaging instruments. Conclusion Our results demonstrate the feasibility of using the new device to aid surgical resection of tumors, map sentinel lymph nodes, and facilitate telemedicine.
Yoshitomo Ashitate - One of the best experts on this subject based on the ideXlab platform.
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endocrine specific nir fluorophores for adrenal gland targeting
Chemical Communications, 2016Co-Authors: Yoshitomo Ashitate, Hoon Hyun, Andrew Levitz, Min Ho Park, Vivek Venugopal, Gwangli ParkAbstract:The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable Image-Guided Surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR Image-Guided resection or avoidance of the AGs during both open and minimally-invasive Surgery.
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synthesis and in vivo fate of zwitterionic near infrared fluorophores
Angewandte Chemie, 2011Co-Authors: Hak Soo Choi, Khaled Nasr, Yoshitomo Ashitate, Sergey Alyabyev, Dina Feith, Jeong Heon Lee, Soon Hee Kim, Hoon Hyun, Gabor PatonayAbstract:A longstanding problem in the field of Image-Guided Surgery is the development of ideal near-infrared (NIR) fluorophores. The heptamethine NIR fluorophore indocyanine green (ICG) has been used extensively for Image-Guided Surgery because of clinical availability and safety.[1-3] However, ICG is far from ideal because it exhibits high uptake in the liver, contaminates the gastrointestinal (GI) tract, provides moderate optical properties,[4] is unstable in aqueous media,[3,5] and is unable to conjugate covalently to targeting ligands.[2] Although several classes of novel molecules have been described,[6-13] none to date exhibit simultaneous low background binding, bifunctionality, excellent optical properties, low protein binding, and high serum stability. Although it is intuitive that physicochemical properties, i.e., positive/negative charge density, hydrophilicity/lipophilicity, and charge distribution, will impact in vivo performance, chemical structures that exhibit ideal characteristics have not yet been defined.
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nerve highlighting fluorescent contrast agents for image guided Surgery
Molecular Imaging, 2011Co-Authors: Summer L Gibbsstrauss, Khaled Nasr, Kenneth M Fish, Onkar V Khullar, Yoshitomo Ashitate, Tiberiu Mircea SiclovanAbstract:Nerve damage is the major morbidity of many surgeries, resulting in chronic pain, loss of function, or both. The sparing of nerves during surgical procedures is a vexing problem because surrounding tissue often obscures them. To date, systemically administered nerve-highlighting contrast agents that can be used for nerve-sparing Image-Guided Surgery have not been reported. In the current study, physicochemical and optical properties of 4,4’-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-benzenamine (BMB) and a newly synthesized, red-shifted derivative 4-[(1E)-2-[4-[(1E)-2-[4-aminophenyl]ethenyl]-3-methoxyphenyl]ethenyl]-benzonitrile (GE3082) were characterized in vitro and in vivo. Both agents crossed the blood-nerve barrier and blood-brain barrier, and rendered myelinated nerves fluorescent after a single systemic injection. Although both BMB and GE3082 also exhibited significant uptake in white adipose tissue, GE3082 underwent a hypsochromic shift in adipose tissue that provided a means to eliminate the unwanted signal using hyperspectral deconvolution. Dose and kinetic studies were performed in mice to determine the optimal dose and drug-imaging interval. Results were confirmed in rat and pig, with the latter used to demonstrate, for the first time, simultaneous fluorescence imaging of blood vessels and nerves during Surgery using the FLARE™ (Fluorescence-Assisted Resection and Exploration) imaging system. These results lay the foundation for the development of ideal nerve-highlighting fluorophores for Image-Guided Surgery.
Shuang Hu - One of the best experts on this subject based on the ideXlab platform.
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real time imaging of brain tumor for image guided Surgery
Advanced Healthcare Materials, 2018Co-Authors: Shuang Hu, Homan Kang, Yoonji Baek, Georges El Fakhri, Anren Kuang, Hak Soo ChoiAbstract:The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue. Moreover, malignant brain tumors are even more difficult to distinguish from normal brain tissue, and resecting noncancerous tissue may create neurological defects after Surgery. To optimize the resection margin in brain tumors, a variety of intraoperative guidance techniques are developed, such as neuronavigation, magnetic resonance imaging, ultrasound, Raman spectroscopy, and optical fluorescence imaging. When combined with appropriate contrast agents, optical fluorescence imaging can provide the neurosurgeon real-time image guidance to improve resection completeness and to decrease surgical complications.
