The Experts below are selected from a list of 35457 Experts worldwide ranked by ideXlab platform
Gila Moalemtaylor - One of the best experts on this subject based on the ideXlab platform.
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the neuro Immune balance in neuropathic pain involvement of inflammatory Immune cells Immune like glial cells and cytokines
Journal of Neuroimmunology, 2010Co-Authors: Paul J Austin, Gila MoalemtaylorAbstract:In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-Immune Disorder, since recent data indicate a critical involvement of innate and adaptive Immune responses following nerve injury. Activation of Immune and Immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the Immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.
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the neuro Immune balance in neuropathic pain involvement of inflammatory Immune cells Immune like glial cells and cytokines
Journal of Neuroimmunology, 2010Co-Authors: Paul J Austin, Gila MoalemtaylorAbstract:article i nfo In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-Immune Disorder, since recent data indicate a critical involvement of innate and adaptive Immune responses following nerve injury. Activation of Immune and Immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the Immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.
Paul J Austin - One of the best experts on this subject based on the ideXlab platform.
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the neuro Immune balance in neuropathic pain involvement of inflammatory Immune cells Immune like glial cells and cytokines
Journal of Neuroimmunology, 2010Co-Authors: Paul J Austin, Gila MoalemtaylorAbstract:In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-Immune Disorder, since recent data indicate a critical involvement of innate and adaptive Immune responses following nerve injury. Activation of Immune and Immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the Immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.
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the neuro Immune balance in neuropathic pain involvement of inflammatory Immune cells Immune like glial cells and cytokines
Journal of Neuroimmunology, 2010Co-Authors: Paul J Austin, Gila MoalemtaylorAbstract:article i nfo In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-Immune Disorder, since recent data indicate a critical involvement of innate and adaptive Immune responses following nerve injury. Activation of Immune and Immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the Immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.
D Roberton - One of the best experts on this subject based on the ideXlab platform.
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igg subclass deficiency
Pediatric Allergy and Immunology, 1991Co-Authors: Antonio Ferrante, L J Beard, D RobertonAbstract:The different biological properties of human IgG subclasses make each subclass unique in its functional role in either resistance to infection, autoImmune diseases or allergy. Not only are there marked differences in the relative concentrations of IgG subclasses in serum (IgG1 > IgG2 > IgG3/IgG4) but the distribution of the antibody responses in the 4 subclasses of IgG can vary markedly depending on the nature of the antigen, the type of infection, the degree of antigen exposure, the immunization regimens, the age of individual, the Immune Disorder and the allotype of the individual. Measurement of the IgG subclass distribution of antibodies can be informative in identifying an immunological deficiency, evaluating the production of host protective antibodies, and assessing pathophysiology. Determination of IgG subclass concentrations is essential in the diagnosis of immunodeficiencies. However, there is still uncertainty about the accuracy of measurements in relation to standards, monoclonal antibodies and assay types. For the paediatric population, a sensitive assay, such as an enzyme linked immunoabsorbent assay, is essential. A standardised definition of IgG subclass deficiency is yet to be accepted; however, values substantially below the 5th percentile for a normal healthy population of appropriate age measured by a defined assay system may be indicative of significant abnormality. There is emerging evidence that some subclass deficiencies are associated with increased susceptibility to infection. Such IgG subclass deficiencies may be amenable to treatment with intravenous gammaglobulin preparations, but further carefully designed and controlled studies are needed to ascertain treatment efficacy.
Antonio Ferrante - One of the best experts on this subject based on the ideXlab platform.
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igg subclass deficiency
Pediatric Allergy and Immunology, 1991Co-Authors: Antonio Ferrante, L J Beard, D RobertonAbstract:The different biological properties of human IgG subclasses make each subclass unique in its functional role in either resistance to infection, autoImmune diseases or allergy. Not only are there marked differences in the relative concentrations of IgG subclasses in serum (IgG1 > IgG2 > IgG3/IgG4) but the distribution of the antibody responses in the 4 subclasses of IgG can vary markedly depending on the nature of the antigen, the type of infection, the degree of antigen exposure, the immunization regimens, the age of individual, the Immune Disorder and the allotype of the individual. Measurement of the IgG subclass distribution of antibodies can be informative in identifying an immunological deficiency, evaluating the production of host protective antibodies, and assessing pathophysiology. Determination of IgG subclass concentrations is essential in the diagnosis of immunodeficiencies. However, there is still uncertainty about the accuracy of measurements in relation to standards, monoclonal antibodies and assay types. For the paediatric population, a sensitive assay, such as an enzyme linked immunoabsorbent assay, is essential. A standardised definition of IgG subclass deficiency is yet to be accepted; however, values substantially below the 5th percentile for a normal healthy population of appropriate age measured by a defined assay system may be indicative of significant abnormality. There is emerging evidence that some subclass deficiencies are associated with increased susceptibility to infection. Such IgG subclass deficiencies may be amenable to treatment with intravenous gammaglobulin preparations, but further carefully designed and controlled studies are needed to ascertain treatment efficacy.
D Lounsbury - One of the best experts on this subject based on the ideXlab platform.
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current therapy for lambert eaton myasthenic syndrome development of 3 4 diaminopyridine phosphate salt as first line symptomatic treatment
Current Medical Research and Opinion, 2010Co-Authors: A Quartel, S Turbeville, D LounsburyAbstract:AbstractBackground:Lambert–Eaton myasthenic syndrome (LEMS) is a rare pre-synaptic auto-Immune Disorder of neuromuscular transmission that is characterised by proximal muscle weakness, depressed tendon reflexes and autonomic dysfunction. This review summarises the clinical symptoms, aetiology, diagnosis and treatment options for LEMS. Focus is placed on symptomatic treatment with the potassium channel blocker 3,4-diaminopyridine (3,4-DAP).Research methods:English-language publications were searched in MEDLINE and EMBASE to retrieve relevant literature on LEMS. The data submitted to obtain regulatory approval of 3,4-DAP phosphate by the European Medicines Agency (EMA) were also used.Findings:LEMS is a rare disease with few treatment options which are generally categorised as anti-tumour, immunomodulating or immunosuppressing, and symptomatic treatments. Anti-tumour treatment is recommended for patients with the paraneoplastic form of LEMS. While several immunomodulating or immunosuppressing treatments have...
