Immunoblastic Lymphadenopathy

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The Experts below are selected from a list of 78 Experts worldwide ranked by ideXlab platform

Ray E Stanford - One of the best experts on this subject based on the ideXlab platform.

Michael D Iseman - One of the best experts on this subject based on the ideXlab platform.

Marvin I Schwarz - One of the best experts on this subject based on the ideXlab platform.

Hisao Miura - One of the best experts on this subject based on the ideXlab platform.

  • Immunosuppressive factors detected during convalescence in a patient with severe serum sickness induced by carbamazepine
    International archives of allergy and immunology, 1993
    Co-Authors: Muneo Igarashi, Yuki Bando, Kaoru Shimanuki, Nozomi Hosoda, Wataru Sunaoshi, Hiroyuki Shirai, Hisao Miura
    Abstract:

    We report on a patient with severe serum sickness induced by carbamazepine in whom anticarbamazepine IgG antibodies were detected in the serum. The T cells of the patient showed impairment of phytohemagglutinin-induced proliferation, and hypergammaglobulinemia was evident. The clinical features and immunological abnormalities were compatible with Immunoblastic Lymphadenopathy. Immunosuppressive factors were also detected in the patient. Their molecular weights ranged from 20,000 to 30,000 as evaluated by Sephadex G-200 gel filtration. Such immunosuppressive cytokines were not detected in other patients with carbamazepine allergy who did not develop the clinical manifestations of Immunoblastic Lymphadenopathy. These results suggest that the T cell functional deficiency of Immunoblastic Lymphadenopathy is induced by these immunosuppressive cytokines.

M Tomonaga - One of the best experts on this subject based on the ideXlab platform.

  • Increased levels of interleukin-6 (IL-6) in serum and spontaneous in vitro production of IL-6 by lymph node mononuclear cells of patients with angio-Immunoblastic Lymphadenopathy with dysproteinemia (AILD), and clinical effectiveness of cyclosporin A
    Leukemia, 1996
    Co-Authors: Masaomi Yamamura, Honda M, Yasuaki Yamada, Takahiro Itoyama, Sohda H, Yubashi T, Saburo Momita, Kamihira S, Y Ohmoto, M Tomonaga
    Abstract:

    Serum levels of cytokines and in vitro cytokine production by lymph node mononuclear cells (LNMC) were studied in four patients with angio-Immunoblastic Lymphadenopathy with dysproteinemia (AILD) or AILD-type T cell lymphoma. An increased level of serum interleukin-6 (IL-6) was detected on initial diagnosis in both of two patients examined. Spontaneous production of IL-6 by LNMC was detected in all four patients studied. Immunosuppressive therapy with cyclosporin A (CsA) was attempted in a 68-year-old man, who was refractory to intensive combination chemotherapy. The increased level of IL-6 in this patient decreased to normal within 3 weeks of CsA administration and the patient became symptom-free. One and a half months later, the IL-6 level gradually increased along with clinical exacerbation. We also measured serum levels of IL-1 alpha, IL-2, IL-4, IFN-alpha, gamma and TNF-alpha in parallel with IL-6, but these factors were only sporadically detected. IL-6 production by LNMC was stimulated by IL-2 but inhibited by CsA. These observations suggest that IL-6 is one of the important cytokines to be involved in the pathophysiology of AILD and CsA is a useful reagent for relieving symptoms.

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