Implant Material

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Yufeng Zheng - One of the best experts on this subject based on the ideXlab platform.

  • nanocrystalline ti49 2ni50 8 shape memory alloy as orthopaedic Implant Material with better performance
    Journal of Materials Science & Technology, 2019
    Co-Authors: F L Nie, Yufeng Zheng, Y Cheng, S C Wei, R Z Valiev
    Abstract:

    Abstract TiNi alloys, with their unique shape memory effects and super elastic properties, occupy an indispensable place in the family of metallic bioMaterials. In the past years, surface treatment is the main technique to improve the bioinert nature of microcrystalline TiNi alloys and inhibit on the release of toxic nickel ions to obtain excellent osteogenesis and osseointegration function. In the present study, nanocrystalline Ti49.2Ni50.8 alloy has been fabricated via equal channel angular pressing (ECAP), and the in vitro and in vivo studies revealed that it had enhanced cell viability, adhesion, proliferation, ALP (Alkaline phosphatase) activity and mineralization, and increased periphery thickness of new bone, in comparison to the commercial coarse-grained counterpart. These findings indicate that the reduction of grain size is beneficial to increasing the biocompatibility of Ti49.2Ni50.8 shape memory alloy.

  • microstructure mechanical properties in vitro degradation behavior and hemocompatibility of novel zn mg sr alloys as biodegradable metals
    Materials Letters, 2016
    Co-Authors: Yinghong Yang, Yufeng Zheng, F Y Zhou, Zhongjie Pu, L Li
    Abstract:

    Abstract The microstructure, mechanical properties, in vitro degradation behavior and hemocompatibility of novel Zn–1Mg–0.1Sr and Zn–1Mg–0.5Sr (wt%) ternary alloys were evaluated with pure Zn as control. The results indicated that Zn–Mg–Sr alloys exhibited much higher yield strength (YS), ultimate tensile strength (UTS), hardness and corrosion rate than those of pure Zn. But their elongation and hemolysis rates were reduced. Furthermore, the hot-rolled Zn–1Mg–0.1Sr alloy presented the superior mechanics performance (196.84±13.20 MPa, 300.08±6.09 MPa, 22.49±2.52%, 104.31±10.18 for YS, UTS, Elongation and hardness, respectively), appropriate corrosion rate (0.15±0.05 mm/year) and excellent hemocompatibility (hematolysis rate of 1.10±0.2% and no signs of thrombogenicity), showing a preferable candidate as the biodegradable Implant Material.

Michael Strong - One of the best experts on this subject based on the ideXlab platform.

  • influence of surface modification on the in vitro corrosion rate of magnesium alloy az31
    Journal of Biomedical Materials Research Part A, 2009
    Co-Authors: Joy Graymunro, Christine Seguin, Michael Strong
    Abstract:

    In recent years, magnesium alloys have been proposed as a new class of metallic bioabsorbable Implant Material. Unfortunately, the production of hydrogen gas and an increase in alkalinity are both by-products of the degradation process of these Materials. This necessitates the development of magnesium alloys with controlled degradation rates. Furthermore, biocompatible coatings that can delay the onset of corrosion would ensure that the mechanical integrity of the Implant remains intact in the early stages of healing. This article explores the influence of surface modification by biomimetic calcium phosphate coating, biodegradable polymer coatings, and acid etching on the corrosion rate of the AZ31 magnesium alloy in simulated body fluid. Our results indicate that all of these surface treatments have a positive impact on the corrosion rate of the Material and that in the early stages of Implantation it is possible to tailor the corrosion rate through an appropriate choice of surface treatment. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

Alexander R Horswill - One of the best experts on this subject based on the ideXlab platform.

  • biofilm dispersal of community associated methicillin resistant staphylococcus aureus on orthopedic Implant Material
    Journal of Orthopaedic Research, 2010
    Co-Authors: Katherine J Lauderdale, Cheryl L Malone, Blaise R Boles, Jose A Morcuende, Alexander R Horswill
    Abstract:

    Orthopedic Implant-related bacterial infections are associated with high morbidity that may lead to limb amputation and exert significant financial burden on the healthcare system. Staphylococcus aureus is a dominant cause of these infections, and increased incidence of community-associated methicillin-resistant S. aureus (CA-MRSA) is being reported. The ability of S. aureus to attach to the foreign body surface and develop a biofilm is an important determinant of resistance to antibiotic prophylaxis. To gain insight on CA-MRSA biofilm properties, USA300 biofilm maturation and dispersal was examined, and these biofilms were found to exhibit pronounced, quorum-sensing mediated dispersal from a glass surface. For comparison of biofilm maturation on different surface chemistries, USA300 biofilm growth was examined on glass, polycarbonate, and titanium, and minimal differences were apparent in thickness, total biomass, and substratum coverage. Importantly, USA300 biofilms grown on titanium possessed a functional dispersal mechanism, and the dispersed cells regained susceptibility to rifampicin and levofloxacin treatment. The titanium biofilms were also sensitive to proteinase K and DNaseI, suggesting the matrix is composed of proteinaceous Material and extracellular DNA. These studies provide new insights on the properties of CA-MRSA biofilms on Implant Materials, and indicate that quorum-sensing dispersion could be an effective therapeutic strategy. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:55–61, 2010

  • biofilm dispersal of community associated methicillin resistant staphylococcus aureus on orthopedic Implant Material
    Journal of Orthopaedic Research, 2010
    Co-Authors: Katherine J Lauderdale, Cheryl L Malone, Jose A Morcuende, Laise R Oles, Alexander R Horswill
    Abstract:

    Orthopedic Implant-related bacterial infections are associated with high morbidity that may lead to limb amputation and exert significant financial burden on the healthcare system. Staphylococcus aureus is a dominant cause of these infections, and increased incidence of community-associated methicillin-resistant S. aureus (CA-MRSA) is being reported. The ability of S. aureus to attach to the foreign body surface and develop a biofilm is an important determinant of resistance to antibiotic prophylaxis. To gain insight on CA-MRSA biofilm properties, USA300 biofilm maturation and dispersal was examined, and these biofilms were found to exhibit pronounced, quorum-sensing mediated dispersal from a glass surface. For comparison of biofilm maturation on different surface chemistries, USA300 biofilm growth was examined on glass, polycarbonate, and titanium, and minimal differences were apparent in thickness, total biomass, and substratum coverage. Importantly, USA300 biofilms grown on titanium possessed a functional dispersal mechanism, and the dispersed cells regained susceptibility to rifampicin and levofloxacin treatment. The titanium biofilms were also sensitive to proteinase K and DNaseI, suggesting the matrix is composed of proteinaceous Material and extracellular DNA. These studies provide new insights on the properties of CA-MRSA biofilms on Implant Materials, and indicate that quorum-sensing dispersion could be an effective therapeutic strategy.

Brigitte Vollmar - One of the best experts on this subject based on the ideXlab platform.

  • striated muscle microvascular response to silver Implants a comparative in vivo study with titanium and stainless steel
    Journal of Biomedical Materials Research, 2000
    Co-Authors: C N Kraft, M Hansis, Stephan Arens, Michael D Menger, Brigitte Vollmar
    Abstract:

    Local microvascular perfusion is the primary line of defense of tissue against microorganisms and plays a considerable role in reparative processes. The impairment of the microcirculation by a bioMaterial may therefore have profound consequences. Silver is known to have excellent antimicrobial activity and, although regional and systemic toxic effects have been described, silver is regularly discussed as an Implant Material in bone surgery. Because little is known about the influence of silver Implants on the adjacent host tissue microvasculature, we studied in vivo nutritive perfusion and leukocytic response, and compared these results with those of the conventionally used Materials titanium and stainless steel. Using the hamster dorsal skinfold chamber preparation and intravital microscopy, the Implantation of a commercially pure silver sample led to a distinct and persistent activation of leukocytes combined with a marked disruption of the microvascular endothelial integrity, massive leukocyte extravasation, and considerable venular dilation. Whereas animals with stainless-steel Implants showed a moderate increase in these parameters with a tendency to recuperate, titanium Implants caused only a transient increase of leukocyte–endothelial cell interaction within the first 120 min and no significant change in macromolecular leakage, leukocyte extravasation and venular diameter. After 3 days, five of six preparations with silver samples showed severe inflammation and massive edema. Thus, the use of silver as an Implant Material should be critically judged despite its bactericidal properties. The Implant Material titanium seems to be well tolerated by the local vascular system and currently represents the golden standard.© 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 49, 192–199, 2000.

Sheikh A Akba - One of the best experts on this subject based on the ideXlab platform.

  • review of zirconia based bioceramic surface modification and cellular response
    Ceramics International, 2016
    Co-Authors: Ginny Soo, Elinda Pingguanmurphy, Khin Wee Lai, Sheikh A Akba
    Abstract:

    Abstract Zirconia is gaining interest as a ceramic bioMaterial for Implant applications due to its biocompatibility and desirable mechanical properties. At present, zirconia-based ceramic is often seen in the applications of hip replacement and dental Implants. This paper briefly reviews different surface modification techniques that have been applied to zirconia such as polishing, sandblasting, etching, biofunctionalization, coating, laser treatment, and ultraviolet light treatment. The cellular response of osteoblast-like cell, osteoblast cell, fibroblast, and epithelial cell to the modified surface is discussed in terms of their adhesion, proliferation, and metabolic activity. The potential of surface modification to make zirconia a successful Implant Material in the future is highly dependent on the establishment of successful in vitro and in vivo studies. Hence, further effort should be made in order to deepen the understanding of tissue response to the Implant and the tissue regeneration process. The review concludes with future prospect of research and further challenges in developing better zirconia bioceramics.