The Experts below are selected from a list of 33123 Experts worldwide ranked by ideXlab platform
Valerie Voon - One of the best experts on this subject based on the ideXlab platform.
-
Impulse Control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.
The Lancet Neurology, 2017Co-Authors: Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-faure, Anthony A Grace, Maria Rodriguez-oroz, Jose Obeso, Erwan Bezard, Pierre-olivier FernagutAbstract:Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and Impulse Control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse Control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists. These behaviours reflect the interactions of the dopaminergic medications with the individual's susceptibility, and the underlying neurobiology of Parkinson's disease. Parkinsonian rodent models show enhanced reinforcing effects of chronic dopaminergic medication, and a potential role for individual susceptibility. In patients with Parkinson's disease and Impulse Control disorders, impairments are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the relative balance of rewards and losses. Impairments appear to be more specific to decisional than motor impulsivity, which might reflect differences in ventral and dorsal striatal engagement. Emerging evidence suggests Impulse Control disorder subtypes have dissociable correlates, which indicate that individual susceptibility predisposes towards the expression of different behavioural subtypes and neurobiological substrates. Therapeutic interventions to treat patients with Parkinson's disease and Impulse Control disorders have shown efficacy in randomised Controlled trials. Large-scale studies are warranted to identify individual risk factors and novel therapeutic targets for these diseases. Mechanisms underlying Impulse Control disorders and dyskinesias could provide crucial insights into other behavioural symptoms in Parkinson's disease and addictions in the general population.
-
Impulse Control disorders in parkinson s disease decreased striatal dopamine transporter levels
Journal of Neurology Neurosurgery and Psychiatry, 2014Co-Authors: Valerie Voon, A Rizos, Riddhika Chakravartty, Nicola Mulholland, Stephanie Robinson, Nicholas A Howell, Neil A Harrison, Gill Vivian, Ray K ChaudhuriAbstract:Objective Impulse Control disorders are commonly associated with dopaminergic therapy in Parkinson's disease (PD). PD patients with Impulse Control disorders demonstrate enhanced dopamine release to conditioned cues and a gambling task on [11C]raclopride positron emission tomography (PET) imaging and enhanced ventral striatal activity to reward on functional MRI. We compared PD patients with Impulse Control disorders and age-matched and gender-matched Controls without Impulse Control disorders using [123I]FP-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT), to assess striatal dopamine transporter (DAT) density. Methods The [123I]FP-CIT binding data in the striatum were compared between 15 PD patients with and 15 without Impulse Control disorders using independent t tests. Results Those with Impulse Control disorders showed significantly lower DAT binding in the right striatum with a trend in the left (right: F(1,24)=5.93, p=0.02; left: F(1,24)=3.75, p=0.07) compared to Controls. Conclusions Our findings suggest that greater dopaminergic striatal activity in PD patients with Impulse Control disorders may be partly related to decreased uptake and clearance of dopamine from the synaptic cleft. Whether these findings are related to state or trait effects is not known. These findings dovetail with reports of lower DAT levels secondary to the effects of methamphetamine and alcohol. Although any regulation of DAT by antiparkinsonian medication appears to be modest, PD patients with Impulse Control disorders may be differentially sensitive to regulatory mechanisms of DAT expression by dopaminergic medications.
-
dopamine agonists and risk Impulse Control disorders in parkinson s disease
Brain, 2011Co-Authors: Valerie Voon, Jennifer Gao, Christina Brezing, Mkael Symmonds, Vindhya Ekanayake, Hubert H Fernandez, Raymond J Dolan, Mark HallettAbstract:Impulse Control disorders are common in Parkinson's; disease, occurring in 13.6% of patients. Using a pharmacological manipulation and a novel risk taking task while performing functional magnetic resonance imaging, we investigated the relationship between dopamine agonists and risk taking in patients with Parkinson's; disease with and without Impulse Control disorders. During functional magnetic resonance imaging, subjects chose between two choices of equal expected value: a ‘Sure’ choice and a ‘Gamble’ choice of moderate risk. To commence each trial, in the ‘Gain’ condition, individuals started at $0 and in the ‘Loss’ condition individuals started at −$50 below the ‘Sure’ amount. The difference between the maximum and minimum outcomes from each gamble (i.e. range) was used as an index of risk (‘Gamble Risk’). Sixteen healthy volunteers were behaviourally tested. Fourteen Impulse Control disorder (problem gambling or compulsive shopping) and 14 matched Parkinson's; disease Controls were tested ON and OFF dopamine agonists. Patients with Impulse Control disorder made more risky choices in the ‘Gain’ relative to the ‘Loss’ condition along with decreased orbitofrontal cortex and anterior cingulate activity, with the opposite observed in Parkinson's; disease Controls. In patients with Impulse Control disorder, dopamine agonists were associated with enhanced sensitivity to risk along with decreased ventral striatal activity again with the opposite in Parkinson's; disease Controls. Patients with Impulse Control disorder appear to have a bias towards risky choices independent of the effect of loss aversion. Dopamine agonists enhance sensitivity to risk in patients with Impulse Control disorder possibly by impairing risk evaluation in the striatum. Our results provide a potential explanation of why dopamine agonists may lead to an unconscious bias towards risk in susceptible individuals.
-
impulsive choice and response in dopamine agonist related Impulse Control behaviors
Psychopharmacology, 2010Co-Authors: Valerie Voon, Christina Brezing, Vindhya Ekanayake, Hubert H Fernandez, Raymond J Dolan, Marc N Potenza, Brady Reynolds, Cecile Gallea, Meliha Skaljic, Mark HallettAbstract:Rationale Dopaminergic medication-related Impulse Control disorders (ICDs) such as pathological gambling and compulsive shopping have been reported in Parkinson’s disease (PD).
Mark Hallett - One of the best experts on this subject based on the ideXlab platform.
-
dopamine agonists and risk Impulse Control disorders in parkinson s disease
Brain, 2011Co-Authors: Valerie Voon, Jennifer Gao, Christina Brezing, Mkael Symmonds, Vindhya Ekanayake, Hubert H Fernandez, Raymond J Dolan, Mark HallettAbstract:Impulse Control disorders are common in Parkinson's; disease, occurring in 13.6% of patients. Using a pharmacological manipulation and a novel risk taking task while performing functional magnetic resonance imaging, we investigated the relationship between dopamine agonists and risk taking in patients with Parkinson's; disease with and without Impulse Control disorders. During functional magnetic resonance imaging, subjects chose between two choices of equal expected value: a ‘Sure’ choice and a ‘Gamble’ choice of moderate risk. To commence each trial, in the ‘Gain’ condition, individuals started at $0 and in the ‘Loss’ condition individuals started at −$50 below the ‘Sure’ amount. The difference between the maximum and minimum outcomes from each gamble (i.e. range) was used as an index of risk (‘Gamble Risk’). Sixteen healthy volunteers were behaviourally tested. Fourteen Impulse Control disorder (problem gambling or compulsive shopping) and 14 matched Parkinson's; disease Controls were tested ON and OFF dopamine agonists. Patients with Impulse Control disorder made more risky choices in the ‘Gain’ relative to the ‘Loss’ condition along with decreased orbitofrontal cortex and anterior cingulate activity, with the opposite observed in Parkinson's; disease Controls. In patients with Impulse Control disorder, dopamine agonists were associated with enhanced sensitivity to risk along with decreased ventral striatal activity again with the opposite in Parkinson's; disease Controls. Patients with Impulse Control disorder appear to have a bias towards risky choices independent of the effect of loss aversion. Dopamine agonists enhance sensitivity to risk in patients with Impulse Control disorder possibly by impairing risk evaluation in the striatum. Our results provide a potential explanation of why dopamine agonists may lead to an unconscious bias towards risk in susceptible individuals.
-
impulsive choice and response in dopamine agonist related Impulse Control behaviors
Psychopharmacology, 2010Co-Authors: Valerie Voon, Christina Brezing, Vindhya Ekanayake, Hubert H Fernandez, Raymond J Dolan, Marc N Potenza, Brady Reynolds, Cecile Gallea, Meliha Skaljic, Mark HallettAbstract:Rationale Dopaminergic medication-related Impulse Control disorders (ICDs) such as pathological gambling and compulsive shopping have been reported in Parkinson’s disease (PD).
Laurence Steinberg - One of the best experts on this subject based on the ideXlab platform.
-
risky sexual behavior among arrested adolescent males the role of future expectations and Impulse Control
Journal of Research on Adolescence, 2020Co-Authors: Alissa Knowles, Laurence Steinberg, Jenny K Rinehart, Paul J Frick, Elizabeth CauffmanAbstract:The current study evaluates two predictors of adolescent sexual risk-taking, specifically whether Impulse Control or future expectations predict condom use and casual sex. We examine whether risky sex occurs among youth who tend to act without thinking about the future, or instead, youth who report low future expectations. We consider these relations longitudinally among a sample of sexually active justice-involved adolescent males (N = 752, M age = 15.58) a group at heightened risk for sexual risk-taking. We found that optimistic expectations for the future predict a higher likelihood of engaging in consistent condom use, whereas high Impulse Control is related to a lower likelihood of casual sex. Implications for intervention and research on positive sexual health are discussed.
-
sex differences in the developmental trajectories of Impulse Control and sensation seeking from early adolescence to early adulthood
Journal of Youth and Adolescence, 2015Co-Authors: Elizabeth P Shulman, Paige K Harden, Jason Chein, Laurence SteinbergAbstract:It has been proposed that high rates of risk-taking in adolescence are partly attributable to patterns of neurobiological development that promote an increase in sensation-seeking tendencies at a time when Impulse Control is still developing. It is not known, however, whether this pattern is the same for males and females. The present study investigates sex differences in the developmental trajectories of self-reported Impulse Control and sensation-seeking between the ages of 10 and 25 using longitudinal data from the National Longitudinal Study of Youth 1979 Child and Young Adult Survey (N = 8,270; 49 % female; 33 % Black, 22 % Hispanic, 45 % Non-Black, Non-Hispanic). Prior work has found that, consistent with the dual-systems model of adolescent neurobiological development, sensation-seeking rises and falls across this age span, whereas Impulse Control increases into the 20s. In the present study, we find that this same general pattern holds for both males and females, but with some key differences. As expected, males exhibit higher levels of sensation-seeking and lower levels of Impulse Control than females. Differences also emerged in the shapes of the developmental trajectories. Females reach peak levels of sensation-seeking earlier than males (consistent with the idea that sensation-seeking is linked to pubertal development) and decline in sensation-seeking more rapidly thereafter. Also, males increase in Impulse Control more gradually than females. Consequently, sex differences in both Impulse Control and sensation-seeking increase with age. The findings suggest that the window of heightened vulnerability to risk-taking during adolescence may be greater in magnitude and more protracted for males than for females. Language: en
-
Sex Differences in the Developmental Trajectories of Impulse Control and Sensation-Seeking from Early Adolescence to Early Adulthood
Journal of Youth and Adolescence, 2015Co-Authors: Elizabeth P Shulman, Jason Chein, K. Paige Harden, Laurence SteinbergAbstract:It has been proposed that high rates of risk-taking in adolescence are partly attributable to patterns of neurobiological development that promote an increase in sensation-seeking tendencies at a time when Impulse Control is still developing. It is not known, however, whether this pattern is the same for males and females. The present study investigates sex differences in the developmental trajectories of self-reported Impulse Control and sensation-seeking between the ages of 10 and 25 using longitudinal data from the National Longitudinal Study of Youth 1979 Child and Young Adult Survey (N = 8,270; 49 % female; 33 % Black, 22 % Hispanic, 45 % Non-Black, Non-Hispanic). Prior work has found that, consistent with the dual-systems model of adolescent neurobiological development, sensation-seeking rises and falls across this age span, whereas Impulse Control increases into the 20s. In the present study, we find that this same general pattern holds for both males and females, but with some key differences. As expected, males exhibit higher levels of sensation-seeking and lower levels of Impulse Control than females. Differences also emerged in the shapes of the developmental trajectories. Females reach peak levels of sensation-seeking earlier than males (consistent with the idea that sensation-seeking is linked to pubertal development) and decline in sensation-seeking more rapidly thereafter. Also, males increase in Impulse Control more gradually than females. Consequently, sex differences in both Impulse Control and sensation-seeking increase with age. The findings suggest that the window of heightened vulnerability to risk-taking during adolescence may be greater in magnitude and more protracted for males than for females.
Luk Warlop - One of the best experts on this subject based on the ideXlab platform.
-
inhibitory spillover increased urination urgency facilitates Impulse Control in unrelated domains
Psychological Science, 2011Co-Authors: Mirjam Tuk, Debra Trampe, Luk WarlopAbstract:Visceral states are known to reduce the ability to exert self-Control. In the current research, we investigated how self-Control is affected by a visceral factor associated with inhibition rather than with approach: bladder Control. We designed four studies to test the hypothesis that inhibitory signals are not domain-specific but can spill over to unrelated domains, resulting in increased Impulse Control in the behavioral domain. In Study 1, participants’ urination urgency correlated with performance on color-naming but not word-meaning trials of a Stroop task. In Studies 2 and 3, we found that higher levels of bladder pressure resulted in an increased ability to resist impulsive choices in monetary decision making. We found that inhibitory spillover effects are moderated by sensitivity of the Behavioral Inhibition System (Study 3) and can be induced by exogenous cues (Study 4). Implications for inhibition and Impulse-Control theories are discussed.
-
inhibitory spillover increased urination urgency facilitates Impulse Control in unrelated domains
Report, 2011Co-Authors: Mirjam Tuk, Debra Trampe, Luk WarlopAbstract:Visceral states are known to have a (detrimental) impact on our ability to exert self-Control. In the current research, we investigate the impact of a visceral factor associated with inhibition, rather than with approach: bladder Control. We argue that inhibitory signals are not domain specific, but can spill over to unrelated domains, resulting in increased Impulse Control in the behavioral domain. We show that urination urgency correlates with improved performance on color naming but not word meaning trials of a Stroop task (Study 1). In Study 2 and 3, we show that higher levels of bladder Control result in an increasing ability to resist more immediate temptations in monetary decision making. We show that inhibitory spillover effects are moderated by sensitivity of the behavioral inhibition system (BIS, Study 3), and can be induced by exogenous cues (Study 4). Implications for inhibition and Impulse Control theories are discussed.
Birger Puppe - One of the best experts on this subject based on the ideXlab platform.
-
Better, Not Just More—Contrast in Qualitative Aspects of Reward Facilitates Impulse Control in Pigs
Frontiers Media S.A., 2018Co-Authors: Manuela Zebunke, Maren Kreiser, Nina Melzer, Jan Langbein, Birger PuppeAbstract:Delay-of-gratification paradigms, such as the famous “Marshmallow Test,” are designed to investigate the complex cognitive concepts of self-Control and Impulse Control in humans and animals. Such tests determine whether a subject will demonstrate Impulse Control by choosing a large, delayed reward over an immediate, but smaller reward. Documented relationships between impulsive behavior and aggression in humans and animals suggest important implications for farm animal husbandry and welfare, especially in terms of inadequate social behavior, tail biting and maternal behavior. In a preliminary study, we investigated whether the extent of Impulse Control would differ between quantitatively and qualitatively different aspects of reward in pigs. Twenty female piglets were randomly divided into two groups, with 10 piglets each. After a preference test to determine individual reward preference among six different food items, a discrimination test was conducted to train for successful discrimination between different amounts of reward (one piece vs. four pieces) and different qualitative aspects of reward (highly preferred vs. least preferred food item). Then, an increasing delay (2, 4, 8, 16, 24, 32 s) was introduced for the larger/highly preferred reward. Each piglet could choose to get the smaller/least preferred reward immediately or to wait for the larger/highly preferred reward. Piglets showed clear differences in their preference for food items. Moreover, the “quality group” displayed faster learning in the discrimination test (number of sessions until 90% of the animals completed the discrimination test: “quality group”−3 days vs. “quantity group”−5 days) and reached a higher level of Impulse Control in the delay-of-gratification test compared to the “quantity group” (maximum delay that was mastered: “quality group”−24 s vs. “quantity group”−8 s). These results demonstrate that Impulse Control is present in piglets but that the opportunity to get a highly preferred reward is more valued than the opportunity to get more of a given reward. This outcome also underlines the crucial role of motivation in cognitive test paradigms. Further investigations will examine whether Impulse Control is related to traits that are relevant to animal husbandry and welfare
-
Table_4_Better, Not Just More—Contrast in Qualitative Aspects of Reward Facilitates Impulse Control in Pigs.XLSX
2018Co-Authors: Manuela Zebunke, Maren Kreiser, Nina Melzer, Jan Langbein, Birger PuppeAbstract:Delay-of-gratification paradigms, such as the famous “Marshmallow Test,” are designed to investigate the complex cognitive concepts of self-Control and Impulse Control in humans and animals. Such tests determine whether a subject will demonstrate Impulse Control by choosing a large, delayed reward over an immediate, but smaller reward. Documented relationships between impulsive behavior and aggression in humans and animals suggest important implications for farm animal husbandry and welfare, especially in terms of inadequate social behavior, tail biting and maternal behavior. In a preliminary study, we investigated whether the extent of Impulse Control would differ between quantitatively and qualitatively different aspects of reward in pigs. Twenty female piglets were randomly divided into two groups, with 10 piglets each. After a preference test to determine individual reward preference among six different food items, a discrimination test was conducted to train for successful discrimination between different amounts of reward (one piece vs. four pieces) and different qualitative aspects of reward (highly preferred vs. least preferred food item). Then, an increasing delay (2, 4, 8, 16, 24, 32 s) was introduced for the larger/highly preferred reward. Each piglet could choose to get the smaller/least preferred reward immediately or to wait for the larger/highly preferred reward. Piglets showed clear differences in their preference for food items. Moreover, the “quality group” displayed faster learning in the discrimination test (number of sessions until 90% of the animals completed the discrimination test: “quality group”−3 days vs. “quantity group”−5 days) and reached a higher level of Impulse Control in the delay-of-gratification test compared to the “quantity group” (maximum delay that was mastered: “quality group”−24 s vs. “quantity group”−8 s). These results demonstrate that Impulse Control is present in piglets but that the opportunity to get a highly preferred reward is more valued than the opportunity to get more of a given reward. This outcome also underlines the crucial role of motivation in cognitive test paradigms. Further investigations will examine whether Impulse Control is related to traits that are relevant to animal husbandry and welfare.
-
Video_2_Better, Not Just More—Contrast in Qualitative Aspects of Reward Facilitates Impulse Control in Pigs.MP4
2018Co-Authors: Manuela Zebunke, Maren Kreiser, Nina Melzer, Jan Langbein, Birger PuppeAbstract:Delay-of-gratification paradigms, such as the famous “Marshmallow Test,” are designed to investigate the complex cognitive concepts of self-Control and Impulse Control in humans and animals. Such tests determine whether a subject will demonstrate Impulse Control by choosing a large, delayed reward over an immediate, but smaller reward. Documented relationships between impulsive behavior and aggression in humans and animals suggest important implications for farm animal husbandry and welfare, especially in terms of inadequate social behavior, tail biting and maternal behavior. In a preliminary study, we investigated whether the extent of Impulse Control would differ between quantitatively and qualitatively different aspects of reward in pigs. Twenty female piglets were randomly divided into two groups, with 10 piglets each. After a preference test to determine individual reward preference among six different food items, a discrimination test was conducted to train for successful discrimination between different amounts of reward (one piece vs. four pieces) and different qualitative aspects of reward (highly preferred vs. least preferred food item). Then, an increasing delay (2, 4, 8, 16, 24, 32 s) was introduced for the larger/highly preferred reward. Each piglet could choose to get the smaller/least preferred reward immediately or to wait for the larger/highly preferred reward. Piglets showed clear differences in their preference for food items. Moreover, the “quality group” displayed faster learning in the discrimination test (number of sessions until 90% of the animals completed the discrimination test: “quality group”−3 days vs. “quantity group”−5 days) and reached a higher level of Impulse Control in the delay-of-gratification test compared to the “quantity group” (maximum delay that was mastered: “quality group”−24 s vs. “quantity group”−8 s). These results demonstrate that Impulse Control is present in piglets but that the opportunity to get a highly preferred reward is more valued than the opportunity to get more of a given reward. This outcome also underlines the crucial role of motivation in cognitive test paradigms. Further investigations will examine whether Impulse Control is related to traits that are relevant to animal husbandry and welfare.
-
Table_2_Better, Not Just More—Contrast in Qualitative Aspects of Reward Facilitates Impulse Control in Pigs.docx
2018Co-Authors: Manuela Zebunke, Maren Kreiser, Nina Melzer, Jan Langbein, Birger PuppeAbstract:Delay-of-gratification paradigms, such as the famous “Marshmallow Test,” are designed to investigate the complex cognitive concepts of self-Control and Impulse Control in humans and animals. Such tests determine whether a subject will demonstrate Impulse Control by choosing a large, delayed reward over an immediate, but smaller reward. Documented relationships between impulsive behavior and aggression in humans and animals suggest important implications for farm animal husbandry and welfare, especially in terms of inadequate social behavior, tail biting and maternal behavior. In a preliminary study, we investigated whether the extent of Impulse Control would differ between quantitatively and qualitatively different aspects of reward in pigs. Twenty female piglets were randomly divided into two groups, with 10 piglets each. After a preference test to determine individual reward preference among six different food items, a discrimination test was conducted to train for successful discrimination between different amounts of reward (one piece vs. four pieces) and different qualitative aspects of reward (highly preferred vs. least preferred food item). Then, an increasing delay (2, 4, 8, 16, 24, 32 s) was introduced for the larger/highly preferred reward. Each piglet could choose to get the smaller/least preferred reward immediately or to wait for the larger/highly preferred reward. Piglets showed clear differences in their preference for food items. Moreover, the “quality group” displayed faster learning in the discrimination test (number of sessions until 90% of the animals completed the discrimination test: “quality group”−3 days vs. “quantity group”−5 days) and reached a higher level of Impulse Control in the delay-of-gratification test compared to the “quantity group” (maximum delay that was mastered: “quality group”−24 s vs. “quantity group”−8 s). These results demonstrate that Impulse Control is present in piglets but that the opportunity to get a highly preferred reward is more valued than the opportunity to get more of a given reward. This outcome also underlines the crucial role of motivation in cognitive test paradigms. Further investigations will examine whether Impulse Control is related to traits that are relevant to animal husbandry and welfare.
