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Fernando J Valbernal - One of the best experts on this subject based on the ideXlab platform.
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pagetoid dyskeratosis is a frequent Incidental Finding in hemorrhoidal disease
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Fernando J Valbernal, J. PintoAbstract:Abstract Background.—Pagetoid dyskeratosis is considered a selective keratinocytic response in which a small part of the normal population of keratinocytes is induced to proliferate. Pagetoid dyskeratosis has been found Incidentally in the squamous epithelium of the skin in various locations and in the ectocervix in uterine prolapse. In cases in which these pale cells are conspicuous, there is a hazard of overdiagnosis. It has been suggested that friction is the most probable inductor of the lesion. To the best of our knowledge, pagetoid cells have not been reported in surgically resected hemorrhoids. Objective and Design.—We here describe the location of pagetoid dyskeratosis in the squamous epithelium of hemorrhoids and the incidence of this lesion in a group of 100 unselected patients surgically treated for hemorrhoidal disease. In addition to the conventional histologic method, special staining procedures and an immunohistochemical study of cytokeratins were performed in selected cases. Results.—Paget...
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pagetoid dyskeratosis of the nipple epidermis an Incidental Finding mimicking paget s disease of the nipple
Apmis, 2008Co-Authors: Francisca M Garijo, Fernando J ValbernalAbstract:Pagetoid dyskeratosis (PD) is considered a selective keratinocytic response in which a small part of the normal population of pale keratinocytes is induced to proliferate. PD has been found Incidentally in the squamous epithelium of the skin and mucosas in various locations, but not in the nipple. In cases in which PD cells are conspicuous, there is the danger of overdiagnosis. In a retrospective study, we describe the location and incidence of PD and other pale cells in the nipple epidermis, in 288 mastectomy specimens from women operated on for breast carcinoma, in situ or infiltrating, selected consecutively from our histopathologic files. In addition to the conventional histologic methods an immunohistochemical study was performed in selected cases. PD was found in 184 (63.9%) cases and was a prominent Finding in 37 (12.8%) cases. Toker cells (TCs) were identified by standard light microscopy in 24 (8.3%) nipples. Paget carcinoma cells (PCCs) were found in 12 (4.2%) cases, and in 9 (3.1%) they were an Incidental Finding. The immunohistochemical profile of each type of pale cells was as follows: PD cells, EMA-,LMWCK-,CK7-,HMWCK+, CEA−, HER2/neu protein−, HMB45−, HPV−; TCs, EMA+, LMWCK+, CK7+, HMWCK−, CEA−, HER2/neu protein−, HMB45−, HPV−; PCCs, EMA+, LMWCK+, CK7+, HMWCK−, CEA+, HER2/neu protein+, HMB45−, HPV−. In conclusion, friction may be the stimulus for the appearance of PD cells. PD cells must be distinguished from TCs, PCCs, clear cells of Bowen's disease, pagetoid melanoma cells, cells of clear cell papulosis, koilocytes, artifactual clear cells, and glycogen-rich squamous cells. A combination of immunohistochemical markers is useful for this distinction; however, routine histologic study is usually adequate for recognizing PD. Pathologists should be familiar with the histologic features of PD in the nipple epidermis to avoid misdiagnosis.
Miriam I. Redleaf - One of the best experts on this subject based on the ideXlab platform.
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middle cranial fossa dehiscence as an Incidental Finding on ct
Annals of Otology Rhinology and Laryngology, 2016Co-Authors: Taher Valika, Miriam I. RedleafAbstract:OBJECTIVES This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age. METHODS High-resolution temporal bone CT scans, which had been obtained for any otologic complaint, were reviewed independent of all clinical history. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. The CTs from 183 patients (296 ears) were reviewed, blinded for age and body mass index (BMI). The MCF floor was divided into 7 regions and systematically inspected. Ages and BMIs of the patients were subsequently extracted from the medical record. RESULTS Logistic regression analysis confirmed increasing MCF dehiscence with age (P 30 (P < .003, P < .04, P = .03). CONCLUSION The increase of middle cranial fossa dehiscence with respect to age is statistically significant. Over all ages, approximately 32% of ears show dehiscence. Over 60 years, approximately 55% show dehiscence. The odds of having dehiscence double with a 10-year difference in age. The most common sites along the MCF floor are in the epitympanum over the malleus head and the additus ad antrum. There was a statistically significant increase in MCF dehiscence with age when patients with equivalent BMIs are compared.
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middle cranial fossa dehiscence as an Incidental Finding on ct
Otolaryngology-Head and Neck Surgery, 2014Co-Authors: Taher Valika, Miriam I. RedleafAbstract:Objectives:Determine the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans and establish its increase with age.Methods:All high-resolution temporal bone CT scans completed at a tertiary care center from 2011 to 2013, ordered by 1 otologist for any reason, were reviewed. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. A total of 183 patients (296 ears) were reviewed blinded for age. The MCF floor was divided into 7 regions and systematically inspected. Ages of the patients were subsequently extracted from the medical record.Results:Logistic regression analysis confirmed increasing MCF dehiscence with age (P < .05, odds ratio [OR] 1.07, R = 0.584). Overall ages (1-88 years; average 38.5 years), 32% of MCF floors were dehiscent at any one site. For age 60 years and over, 55% were dehiscent. For 226 paired ears, if one ear was dehiscent, there was a 66% chance the other ear was dehiscent as well. Superior canal dehiscence (SCD) was seen in 7%...
J. Pinto - One of the best experts on this subject based on the ideXlab platform.
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pagetoid dyskeratosis is a frequent Incidental Finding in hemorrhoidal disease
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Fernando J Valbernal, J. PintoAbstract:Abstract Background.—Pagetoid dyskeratosis is considered a selective keratinocytic response in which a small part of the normal population of keratinocytes is induced to proliferate. Pagetoid dyskeratosis has been found Incidentally in the squamous epithelium of the skin in various locations and in the ectocervix in uterine prolapse. In cases in which these pale cells are conspicuous, there is a hazard of overdiagnosis. It has been suggested that friction is the most probable inductor of the lesion. To the best of our knowledge, pagetoid cells have not been reported in surgically resected hemorrhoids. Objective and Design.—We here describe the location of pagetoid dyskeratosis in the squamous epithelium of hemorrhoids and the incidence of this lesion in a group of 100 unselected patients surgically treated for hemorrhoidal disease. In addition to the conventional histologic method, special staining procedures and an immunohistochemical study of cytokeratins were performed in selected cases. Results.—Paget...
Taher Valika - One of the best experts on this subject based on the ideXlab platform.
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middle cranial fossa dehiscence as an Incidental Finding on ct
Annals of Otology Rhinology and Laryngology, 2016Co-Authors: Taher Valika, Miriam I. RedleafAbstract:OBJECTIVES This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age. METHODS High-resolution temporal bone CT scans, which had been obtained for any otologic complaint, were reviewed independent of all clinical history. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. The CTs from 183 patients (296 ears) were reviewed, blinded for age and body mass index (BMI). The MCF floor was divided into 7 regions and systematically inspected. Ages and BMIs of the patients were subsequently extracted from the medical record. RESULTS Logistic regression analysis confirmed increasing MCF dehiscence with age (P 30 (P < .003, P < .04, P = .03). CONCLUSION The increase of middle cranial fossa dehiscence with respect to age is statistically significant. Over all ages, approximately 32% of ears show dehiscence. Over 60 years, approximately 55% show dehiscence. The odds of having dehiscence double with a 10-year difference in age. The most common sites along the MCF floor are in the epitympanum over the malleus head and the additus ad antrum. There was a statistically significant increase in MCF dehiscence with age when patients with equivalent BMIs are compared.
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middle cranial fossa dehiscence as an Incidental Finding on ct
Otolaryngology-Head and Neck Surgery, 2014Co-Authors: Taher Valika, Miriam I. RedleafAbstract:Objectives:Determine the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans and establish its increase with age.Methods:All high-resolution temporal bone CT scans completed at a tertiary care center from 2011 to 2013, ordered by 1 otologist for any reason, were reviewed. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. A total of 183 patients (296 ears) were reviewed blinded for age. The MCF floor was divided into 7 regions and systematically inspected. Ages of the patients were subsequently extracted from the medical record.Results:Logistic regression analysis confirmed increasing MCF dehiscence with age (P < .05, odds ratio [OR] 1.07, R = 0.584). Overall ages (1-88 years; average 38.5 years), 32% of MCF floors were dehiscent at any one site. For age 60 years and over, 55% were dehiscent. For 226 paired ears, if one ear was dehiscent, there was a 66% chance the other ear was dehiscent as well. Superior canal dehiscence (SCD) was seen in 7%...
Jennifer A. Hipp - One of the best experts on this subject based on the ideXlab platform.
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pulmonary cement embolization after kyphoplasty a case report and review of the literature
The Spine Journal, 2010Co-Authors: Kristen E Radcliff, Charles A Reitman, Lawrence A Delasotta, Joseph Hong, Timothy Diiorio, James Zaslavsky, Alexander R Vaccaro, Jennifer A. HippAbstract:Abstract Background context Kyphoplasty is performed for the treatment of osteoporotic compression fractures. A theoretical advantage of this technique is the reduced risk of embolization of cement. Study design/setting Case report of an Incidental Finding of cement pulmonary embolization after kyphoplasty of an osteoporotic vertebral compression fracture. Methods/results Here we report a patient who presented with an Incidental Finding of pulmonary embolization after kyphoplasty and review the relevant literature. Conclusions Patients who present with symptoms of respiratory distress after kyphoplasty should undergo workup for pulmonary embolism. Clinicians may consider routine postoperative chest radiographs after kyphoplasty to screen for embolic disease. Further research is necessary to identify the risk factors and possible long-term sequelae of cement embolization.
