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Marc Dhont - One of the best experts on this subject based on the ideXlab platform.
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induction of multiple follicular development by a single dose of long acting recombinant follicle stimulating hormone fsh ctp corifollitropin alfa for controlled ovarian stimulation before in vitro fertilization
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Peter Platteau, Nicole G M Beckers, Marc DhontAbstract:In a first feasibility study, the efficacy and safety of a single dose of recombinant long-acting FSH (FSH-CTP) were investigated in in vitro fertilization (IVF) patients undergoing controlled ovarian stimulation with a flexible GnRH antagonist protocol. Eligible subjects were randomized to receive a single dose of 120 μg (n = 25), 180 μg (n = 24), or 240 μg (n = 25) corifollitropin alfa (FSH-CTP) or to start daily fixed doses of 150 IU recombinant FSH (rFSH) (n = 24, reference). Subjects who received a single dose of FSH-CTP continued 1 wk after injection (treatment d 8) with fixed daily doses of 150 IU rFSH (Puregon/Follistim) until the day of triggering final oocyte maturation. The terminal half-life of FSH-CTP was, on average, 65 h and dose Independent. Cycle cancellation before human chorionic gonadotropin (hCG) administration occurred in only three subjects treated with FSH-CTP. The median duration of stimulation was 10.0 d in each FSH-CTP group and 9.0 d in the daily rFSH group. The total number of...
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induction of multiple follicular development by a single dose of long acting recombinant follicle stimulating hormone fsh ctp corifollitropin alfa for controlled ovarian stimulation before in vitro fertilization
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Peter Platteau, Nicole G M Beckers, Marc DhontAbstract:In a first feasibility study, the efficacy and safety of a single dose of recombinant long-acting FSH (FSH-CTP) were investigated in in vitro fertilization (IVF) patients undergoing controlled ovarian stimulation with a flexible GnRH antagonist protocol. Eligible subjects were randomized to receive a single dose of 120 micro g (n = 25), 180 microg (n = 24), or 240 microg (n = 25) corifollitropin alfa (FSH-CTP) or to start daily fixed doses of 150 IU recombinant FSH (rFSH) (n = 24, reference). Subjects who received a single dose of FSH-CTP continued 1 wk after injection (treatment d 8) with fixed daily doses of 150 IU rFSH (Puregon/Follistim) until the day of triggering final oocyte maturation. The terminal half-life of FSH-CTP was, on average, 65 h and dose Independent. Cycle cancellation before human chorionic gonadotropin (hCG) administration occurred in only three subjects treated with FSH-CTP. The median duration of stimulation was 10.0 d in each FSH-CTP group and 9.0 d in the daily rFSH group. The total number of follicles at least 11 mm at stimulation d 8 and at the day of hCG administration tended to increase with dose of FSH-CTP, although a significant dose-response relationship was revealed only for the number of follicles at least 15 mm on the day of hCG (P = 0.03). Serum estradiol levels and inhibin-B levels were not significantly different between the four groups on d 8 and on the day of hCG. In total, 12 subjects (17.6%) in the FSH-CTP groups and two subjects (8.3%) in the rFSH group experienced a premature LH rise (defined as LH >or= 10 IU/liter) before the start of the GnRH antagonist (P value not significant between groups). This relatively high incidence of women demonstrating an early LH rise in the FSH-CTP groups may be related to the higher initial rises of serum estradiol and the use of a flexible GnRH antagonist protocol. The mean number of oocytes recovered per started Cycle was higher in FSH-CTP-treated subjects compared with rFSH-treated subjects (significant at P = 0.03 for the 240- microg FSH-CTP group), but no difference could be noted between the number of good quality embryos (range of means, 3.8-4.8 per attempt), and equal numbers of embryos were available for embryo transfer. In summary, FSH-CTP appeared to be a potent inducer of multiple follicular growth; additional research will be needed to select the optimal FSH-CTP dose and treatment time interval.
Peter Platteau - One of the best experts on this subject based on the ideXlab platform.
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induction of multiple follicular development by a single dose of long acting recombinant follicle stimulating hormone fsh ctp corifollitropin alfa for controlled ovarian stimulation before in vitro fertilization
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Peter Platteau, Nicole G M Beckers, Marc DhontAbstract:In a first feasibility study, the efficacy and safety of a single dose of recombinant long-acting FSH (FSH-CTP) were investigated in in vitro fertilization (IVF) patients undergoing controlled ovarian stimulation with a flexible GnRH antagonist protocol. Eligible subjects were randomized to receive a single dose of 120 μg (n = 25), 180 μg (n = 24), or 240 μg (n = 25) corifollitropin alfa (FSH-CTP) or to start daily fixed doses of 150 IU recombinant FSH (rFSH) (n = 24, reference). Subjects who received a single dose of FSH-CTP continued 1 wk after injection (treatment d 8) with fixed daily doses of 150 IU rFSH (Puregon/Follistim) until the day of triggering final oocyte maturation. The terminal half-life of FSH-CTP was, on average, 65 h and dose Independent. Cycle cancellation before human chorionic gonadotropin (hCG) administration occurred in only three subjects treated with FSH-CTP. The median duration of stimulation was 10.0 d in each FSH-CTP group and 9.0 d in the daily rFSH group. The total number of...
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induction of multiple follicular development by a single dose of long acting recombinant follicle stimulating hormone fsh ctp corifollitropin alfa for controlled ovarian stimulation before in vitro fertilization
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Peter Platteau, Nicole G M Beckers, Marc DhontAbstract:In a first feasibility study, the efficacy and safety of a single dose of recombinant long-acting FSH (FSH-CTP) were investigated in in vitro fertilization (IVF) patients undergoing controlled ovarian stimulation with a flexible GnRH antagonist protocol. Eligible subjects were randomized to receive a single dose of 120 micro g (n = 25), 180 microg (n = 24), or 240 microg (n = 25) corifollitropin alfa (FSH-CTP) or to start daily fixed doses of 150 IU recombinant FSH (rFSH) (n = 24, reference). Subjects who received a single dose of FSH-CTP continued 1 wk after injection (treatment d 8) with fixed daily doses of 150 IU rFSH (Puregon/Follistim) until the day of triggering final oocyte maturation. The terminal half-life of FSH-CTP was, on average, 65 h and dose Independent. Cycle cancellation before human chorionic gonadotropin (hCG) administration occurred in only three subjects treated with FSH-CTP. The median duration of stimulation was 10.0 d in each FSH-CTP group and 9.0 d in the daily rFSH group. The total number of follicles at least 11 mm at stimulation d 8 and at the day of hCG administration tended to increase with dose of FSH-CTP, although a significant dose-response relationship was revealed only for the number of follicles at least 15 mm on the day of hCG (P = 0.03). Serum estradiol levels and inhibin-B levels were not significantly different between the four groups on d 8 and on the day of hCG. In total, 12 subjects (17.6%) in the FSH-CTP groups and two subjects (8.3%) in the rFSH group experienced a premature LH rise (defined as LH >or= 10 IU/liter) before the start of the GnRH antagonist (P value not significant between groups). This relatively high incidence of women demonstrating an early LH rise in the FSH-CTP groups may be related to the higher initial rises of serum estradiol and the use of a flexible GnRH antagonist protocol. The mean number of oocytes recovered per started Cycle was higher in FSH-CTP-treated subjects compared with rFSH-treated subjects (significant at P = 0.03 for the 240- microg FSH-CTP group), but no difference could be noted between the number of good quality embryos (range of means, 3.8-4.8 per attempt), and equal numbers of embryos were available for embryo transfer. In summary, FSH-CTP appeared to be a potent inducer of multiple follicular growth; additional research will be needed to select the optimal FSH-CTP dose and treatment time interval.
Nicole G M Beckers - One of the best experts on this subject based on the ideXlab platform.
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induction of multiple follicular development by a single dose of long acting recombinant follicle stimulating hormone fsh ctp corifollitropin alfa for controlled ovarian stimulation before in vitro fertilization
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Peter Platteau, Nicole G M Beckers, Marc DhontAbstract:In a first feasibility study, the efficacy and safety of a single dose of recombinant long-acting FSH (FSH-CTP) were investigated in in vitro fertilization (IVF) patients undergoing controlled ovarian stimulation with a flexible GnRH antagonist protocol. Eligible subjects were randomized to receive a single dose of 120 μg (n = 25), 180 μg (n = 24), or 240 μg (n = 25) corifollitropin alfa (FSH-CTP) or to start daily fixed doses of 150 IU recombinant FSH (rFSH) (n = 24, reference). Subjects who received a single dose of FSH-CTP continued 1 wk after injection (treatment d 8) with fixed daily doses of 150 IU rFSH (Puregon/Follistim) until the day of triggering final oocyte maturation. The terminal half-life of FSH-CTP was, on average, 65 h and dose Independent. Cycle cancellation before human chorionic gonadotropin (hCG) administration occurred in only three subjects treated with FSH-CTP. The median duration of stimulation was 10.0 d in each FSH-CTP group and 9.0 d in the daily rFSH group. The total number of...
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induction of multiple follicular development by a single dose of long acting recombinant follicle stimulating hormone fsh ctp corifollitropin alfa for controlled ovarian stimulation before in vitro fertilization
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Peter Platteau, Nicole G M Beckers, Marc DhontAbstract:In a first feasibility study, the efficacy and safety of a single dose of recombinant long-acting FSH (FSH-CTP) were investigated in in vitro fertilization (IVF) patients undergoing controlled ovarian stimulation with a flexible GnRH antagonist protocol. Eligible subjects were randomized to receive a single dose of 120 micro g (n = 25), 180 microg (n = 24), or 240 microg (n = 25) corifollitropin alfa (FSH-CTP) or to start daily fixed doses of 150 IU recombinant FSH (rFSH) (n = 24, reference). Subjects who received a single dose of FSH-CTP continued 1 wk after injection (treatment d 8) with fixed daily doses of 150 IU rFSH (Puregon/Follistim) until the day of triggering final oocyte maturation. The terminal half-life of FSH-CTP was, on average, 65 h and dose Independent. Cycle cancellation before human chorionic gonadotropin (hCG) administration occurred in only three subjects treated with FSH-CTP. The median duration of stimulation was 10.0 d in each FSH-CTP group and 9.0 d in the daily rFSH group. The total number of follicles at least 11 mm at stimulation d 8 and at the day of hCG administration tended to increase with dose of FSH-CTP, although a significant dose-response relationship was revealed only for the number of follicles at least 15 mm on the day of hCG (P = 0.03). Serum estradiol levels and inhibin-B levels were not significantly different between the four groups on d 8 and on the day of hCG. In total, 12 subjects (17.6%) in the FSH-CTP groups and two subjects (8.3%) in the rFSH group experienced a premature LH rise (defined as LH >or= 10 IU/liter) before the start of the GnRH antagonist (P value not significant between groups). This relatively high incidence of women demonstrating an early LH rise in the FSH-CTP groups may be related to the higher initial rises of serum estradiol and the use of a flexible GnRH antagonist protocol. The mean number of oocytes recovered per started Cycle was higher in FSH-CTP-treated subjects compared with rFSH-treated subjects (significant at P = 0.03 for the 240- microg FSH-CTP group), but no difference could be noted between the number of good quality embryos (range of means, 3.8-4.8 per attempt), and equal numbers of embryos were available for embryo transfer. In summary, FSH-CTP appeared to be a potent inducer of multiple follicular growth; additional research will be needed to select the optimal FSH-CTP dose and treatment time interval.
Baby Phahladira - One of the best experts on this subject based on the ideXlab platform.
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rabies in the african civet an incidental host for lyssaviruses
Viruses, 2020Co-Authors: Claude T Sabeta, Denise A Marston, Daniel L Horton, Lorraine M Mcelhinney, Baby PhahladiraAbstract:In South Africa, canid rabies virus (RABV) infection is maintained in domestic and wildlife species. The identification of rabies in African civets raised the question of whether this wildlife carnivore is a potential reservoir host of RABVs of direct and ancestral dog origin (dog-maintained and dog-derived origins) with an Independent Cycle of transmission. Genetic analyses of African civet nucleoprotein sequences for 23 African civet RABVs and historically published sequences demonstrated that RABVs from African civets have two origins related to dog and mongoose rabies enzootics. The data support observations of the interaction of civets with domestic dogs and wildlife mongooses, mostly in Northern South Africa and North-East Zimbabwe. Within each host species clade, African civet RABVs group exclusively together, implying intra-species virus transfer occurs readily. The canid RABV clade appears to support virus transfer more readily between hosts than mongoose RABVs. Furthermore, these data probably indicate short transmission chains with conspecifics that may be related to transient rabies maintenance in African civets. Hence, it is important to continue monitoring the emergence of lyssaviruses in this host. Observations from this study are supported by ongoing and Independent similar cases, in which bat-eared foxes and black-backed jackal species maintain Independent rabies Cycles of what were once dog-maintained RABVs.
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rabies in the african civet an incidental host for lyssaviruses
Viruses, 2020Co-Authors: Claude T Sabeta, Denise A Marston, Daniel L Horton, Lorraine M Mcelhinney, Baby PhahladiraAbstract:In South Africa, canid rabies virus (RABV) infection is maintained in domestic and wildlife species. The identification of rabies in African civets raised the question of whether this wildlife carnivore is a potential reservoir host of RABVs of direct and ancestral dog origin (dog-maintained and dog-derived origins) with an Independent Cycle of transmission. Genetic analyses of African civet nucleoprotein sequences for 23 African civet RABVs and historically published sequences demonstrated that RABVs from African civets have two origins related to dog and mongoose rabies enzootics. The data support observations of the interaction of civets with domestic dogs and wildlife mongooses, mostly in Northern South Africa and North-East Zimbabwe. Within each host species clade, African civet RABVs group exclusively together, implying intra-species virus transfer occurs readily. The canid RABV clade appears to support virus transfer more readily between hosts than mongoose RABVs. Furthermore, these data probably indicate short transmission chains with conspecifics that may be related to transient rabies maintenance in African civets. Hence, it is important to continue monitoring the emergence of lyssaviruses in this host. Observations from this study are supported by ongoing and Independent similar cases, in which bat-eared foxes and black-backed jackal species maintain Independent rabies Cycles of what were once dog-maintained RABVs.
Muhammad M Rahman - One of the best experts on this subject based on the ideXlab platform.
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analysis of power and cooling cogeneration using ammonia water mixture
Energy, 2010Co-Authors: Gokmen Demirkaya, Ricardo Vasquez Padilla, Elias Stefanakos, Yogi D Goswami, Muhammad M RahmanAbstract:Development of innovative thermodynamic Cycles is important for the efficient utilization of low-temperature heat sources such as solar, geothermal and waste heat sources. This paper presents a parametric analysis of a combined power/cooling Cycle, which combines the Rankine and absorption refrigeration Cycles, uses ammonia-water mixture as the working fluid and produces power and cooling simultaneously. This Cycle, also known as the Goswami Cycle, can be used as a bottoming Cycle using waste heat from a conventional power Cycle or as an Independent Cycle using solar or geothermal energy. A thermodynamic study of power and cooling cogeneration is presented. The performance of the Cycle for a range of boiler pressures, ammonia concentrations and isentropic turbine efficiencies are studied to find out the sensitivities of net work, amount of cooling and effective efficiencies. The roles of rectifier and superheater on the Cycle performance are investigated. The Cycle heat source temperature is varied between 90-170 °C and the maximum effective first law and exergy efficiencies for an absorber temperature of 30 °C are calculated as 20% and 72%, respectively. The turbine exit quality of the Cycle for different boiler exit scenarios shows that turbine exit quality decreases when the absorber temperature decreases.
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Analysis of a combined power and cooling Cycle for low-grade heat sources
International Journal of Energy Research, 2010Co-Authors: Gokmen Demirkaya, Ricardo Vasquez Padilla, D. Yogi Goswami, Elias Stefanakos, Muhammad M RahmanAbstract:SUMMARY This paper presents a parametric analysis of a combined power/cooling Cycle, which combines the Rankine and absorption refrigeration Cycles, uses ammonia–water mixture as the working fluid and produces power and refrigeration, while power is the primary goal. This Cycle, also known as the Goswami Cycle, can be used as a bottoming Cycle using waste heat from a conventional power Cycle or as an Independent Cycle using low-temperature sources such as geothermal and solar energy. Optimum operating conditions were found for a range of ammonia concentration in the basic solution, isentropic turbine efficiency and boiler pressure. It is shown that the Cycle can be optimized for net work, cooling output, effective first law and exergy efficiencies. The effect of rectification cooling source (external and internal) on the Cycle output was investigated, and it was found that an internal rectification cooling source always produces higher efficiencies. When ammonia vapor is superheated after the rectification process, Cycle efficiencies increase but cooling output decreases. Copyright © 2010 John Wiley & Sons, Ltd.
