The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform

Richardus B.m. Schasfoort - One of the best experts on this subject based on the ideXlab platform.

  • The ion-step Induced Response of membrane-coated ISFETs: theoretical description and experimental verification
    Biosensors and Bioelectronics, 2001
    Co-Authors: Richardus B.m. Schasfoort, Piet Bergveld, Rob P.h. Kooyman, Jan Greve
    Abstract:

    Recently a new method was introduced to operate an immunological field effect transistor (ImmunoFET). By changing the electrolyte concentration of the sample solution stepwise (the so-called ion-step), a transient diffusion of ions through the membrane-protein layer occurs, resulting in a transient membrane potential, which is measured by the ImmunoFET. It became apparent that the maximum of the membrane potential is a function of pH, owing to a pH-dependent charge density caused by the amphoteric nature of the embedded proteins in the membrane of the ImmunoFET. At a certain pH value, which is called the inversion point (pI'), the membrane potential changes sign. This inversion point is characteristic of the type of protein and the type of membrane and depends on the isoelectric point, the titration curve and the concentration of all amphoteric groups in the membrane. In this paper an attempt is made to establish a theoretical basis for the ion-step method. Because there i no model which describes ion transport in charged membranes and its dynamic behaviour as a result of the ion-step, an existing equilibrium theory has been adapted. The well-known Teorell-Meyer-Sievers (TMS) theory, which describes the membrane potential for charged membranes, is used as a framework. The adapted TMS model was verified by experimental data.

  • the ion step Induced Response of membrane coated isfets theoretical description and experimental verification
    Biosensors, 1991
    Co-Authors: Richardus B.m. Schasfoort, Piet Bergveld, Rob P.h. Kooyman, Jan Willem M Greve
    Abstract:

    Recently a new method was introduced to operate an immunological field effect transistor (ImmunoFET). By changing the electrolyte concentration of the sample solution stepwise (the so-called ion-step), a transient diffusionof ions through the membrane-protein layer occurs, resulting in a transient membrane potential, which is measured by the ImmunoFET. It became apparent that the maximum of the membrane potential is a function of pH, owing to a pH-dependent charge density caused by the amphoteric nature of the embedded proteins in the membrane of the ImmunoFET

Jan Greve - One of the best experts on this subject based on the ideXlab platform.

  • The ion-step Induced Response of membrane-coated ISFETs: theoretical description and experimental verification
    Biosensors and Bioelectronics, 2001
    Co-Authors: Richardus B.m. Schasfoort, Piet Bergveld, Rob P.h. Kooyman, Jan Greve
    Abstract:

    Recently a new method was introduced to operate an immunological field effect transistor (ImmunoFET). By changing the electrolyte concentration of the sample solution stepwise (the so-called ion-step), a transient diffusion of ions through the membrane-protein layer occurs, resulting in a transient membrane potential, which is measured by the ImmunoFET. It became apparent that the maximum of the membrane potential is a function of pH, owing to a pH-dependent charge density caused by the amphoteric nature of the embedded proteins in the membrane of the ImmunoFET. At a certain pH value, which is called the inversion point (pI'), the membrane potential changes sign. This inversion point is characteristic of the type of protein and the type of membrane and depends on the isoelectric point, the titration curve and the concentration of all amphoteric groups in the membrane. In this paper an attempt is made to establish a theoretical basis for the ion-step method. Because there i no model which describes ion transport in charged membranes and its dynamic behaviour as a result of the ion-step, an existing equilibrium theory has been adapted. The well-known Teorell-Meyer-Sievers (TMS) theory, which describes the membrane potential for charged membranes, is used as a framework. The adapted TMS model was verified by experimental data.

Aly Mousaad Aly - One of the best experts on this subject based on the ideXlab platform.

  • pressure integration technique for predicting wind Induced Response in high rise buildings
    alexandria engineering journal, 2013
    Co-Authors: Aly Mousaad Aly
    Abstract:

    Abstract This paper presents a procedure for Response prediction in high-rise buildings under wind loads. The procedure is illustrated in an application example of a tall building exposed to both cross-wind and along-wind loads. The Responses of the building in the lateral directions combined with torsion are estimated simultaneously. Results show good agreement with recent design standards; however, the proposed procedure has the advantages of accounting for complex mode shapes, non-uniform mass distribution, and interference effects from the surrounding. In addition, the technique allows for the contribution of higher modes. For accurate estimation of the acceleration Response, it is important to consider not only the first two lateral vibrational modes, but also higher modes. Ignoring the contribution of higher modes may lead to underestimation of the acceleration Response; on the other hand, it could result in overestimation of the displacement Response. Furthermore, the procedure presented in this study can help decision makers, involved in a tall building design/retrofit to choose among innovative solutions like aerodynamic mitigation, structural member size adjustment, damping enhancement, and/or materials change, with an objective to improve the resiliency and the serviceability under extreme wind actions.

Jan Willem M Greve - One of the best experts on this subject based on the ideXlab platform.

  • the ion step Induced Response of membrane coated isfets theoretical description and experimental verification
    Biosensors, 1991
    Co-Authors: Richardus B.m. Schasfoort, Piet Bergveld, Rob P.h. Kooyman, Jan Willem M Greve
    Abstract:

    Recently a new method was introduced to operate an immunological field effect transistor (ImmunoFET). By changing the electrolyte concentration of the sample solution stepwise (the so-called ion-step), a transient diffusionof ions through the membrane-protein layer occurs, resulting in a transient membrane potential, which is measured by the ImmunoFET. It became apparent that the maximum of the membrane potential is a function of pH, owing to a pH-dependent charge density caused by the amphoteric nature of the embedded proteins in the membrane of the ImmunoFET

Rob P.h. Kooyman - One of the best experts on this subject based on the ideXlab platform.

  • The ion-step Induced Response of membrane-coated ISFETs: theoretical description and experimental verification
    Biosensors and Bioelectronics, 2001
    Co-Authors: Richardus B.m. Schasfoort, Piet Bergveld, Rob P.h. Kooyman, Jan Greve
    Abstract:

    Recently a new method was introduced to operate an immunological field effect transistor (ImmunoFET). By changing the electrolyte concentration of the sample solution stepwise (the so-called ion-step), a transient diffusion of ions through the membrane-protein layer occurs, resulting in a transient membrane potential, which is measured by the ImmunoFET. It became apparent that the maximum of the membrane potential is a function of pH, owing to a pH-dependent charge density caused by the amphoteric nature of the embedded proteins in the membrane of the ImmunoFET. At a certain pH value, which is called the inversion point (pI'), the membrane potential changes sign. This inversion point is characteristic of the type of protein and the type of membrane and depends on the isoelectric point, the titration curve and the concentration of all amphoteric groups in the membrane. In this paper an attempt is made to establish a theoretical basis for the ion-step method. Because there i no model which describes ion transport in charged membranes and its dynamic behaviour as a result of the ion-step, an existing equilibrium theory has been adapted. The well-known Teorell-Meyer-Sievers (TMS) theory, which describes the membrane potential for charged membranes, is used as a framework. The adapted TMS model was verified by experimental data.

  • the ion step Induced Response of membrane coated isfets theoretical description and experimental verification
    Biosensors, 1991
    Co-Authors: Richardus B.m. Schasfoort, Piet Bergveld, Rob P.h. Kooyman, Jan Willem M Greve
    Abstract:

    Recently a new method was introduced to operate an immunological field effect transistor (ImmunoFET). By changing the electrolyte concentration of the sample solution stepwise (the so-called ion-step), a transient diffusionof ions through the membrane-protein layer occurs, resulting in a transient membrane potential, which is measured by the ImmunoFET. It became apparent that the maximum of the membrane potential is a function of pH, owing to a pH-dependent charge density caused by the amphoteric nature of the embedded proteins in the membrane of the ImmunoFET