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Kaj Blennow - One of the best experts on this subject based on the ideXlab platform.

Hugo Juarez Olguin - One of the best experts on this subject based on the ideXlab platform.

  • clinical and laboratory characteristics of Infectious Mononucleosis by epstein barr virus in mexican children
    2012
    Co-Authors: Napoleon Gonzalez Saldana, Victor Antonio Monroy Colin, Georgina Pina Ruiz, Hugo Juarez Olguin
    Abstract:

    Background: Infectious Mononucleosis (IM) or Mononucleosis syndrome is caused by an acute infection of Epstein-Barr virus. In Latin American countries, there are little information pertaining to the clinical manifestations and complications of this disease. For this reason, the purpose of this work was to describe the clinical and laboratory characteristics of infection by Epstein-Barr virus in Mexican children with Infectious Mononucleosis. Methods: A descriptive study was carried out by reviewing the clinical files of patients less than 18 years old with clinical and serological diagnosis of IM by Epstein-Barr virus from November, 1970 to July, 2011 in a third level pediatric hospital in Mexico City. Results: One hundred and sixty three cases of IM were found. The most frequent clinical signs were lymphadenopathy (89.5%), fever (79.7%), general body pain (69.3%), pharyngitis (55.2%), hepatomegaly (47.2%). The laboratory findings were lymphocytosis (41.7%), atypic lymphocytes (24.5%), and increased transaminases (30.9%), there were no rupture of the spleen and no deaths among the 163 cases. Conclusions: Our results revealed that IM appeared in earlier ages compared with that reported in industrialized countries, where adolescents are the most affected group. Also, the order and frequency of the clinical manifestations were different in our country than in industrialized ones.

  • clinical and laboratory characteristics of Infectious Mononucleosis by epstein barr virus in mexican children
    2012
    Co-Authors: Napoleon Gonzalez Saldana, Victor Antonio Monroy Colin, Georgina Pina Ruiz, Hugo Juarez Olguin
    Abstract:

    Infectious Mononucleosis (IM) or Mononucleosis syndrome is caused by an acute infection of Epstein-Barr virus. In Latin American countries, there are little information pertaining to the clinical manifestations and complications of this disease. For this reason, the purpose of this work was to describe the clinical and laboratory characteristics of infection by Epstein-Barr virus in Mexican children with Infectious Mononucleosis. A descriptive study was carried out by reviewing the clinical files of patients less than 18 years old with clinical and serological diagnosis of IM by Epstein-Barr virus from November, 1970 to July, 2011 in a third level pediatric hospital in Mexico City. One hundred and sixty three cases of IM were found. The most frequent clinical signs were lymphadenopathy (89.5%), fever (79.7%), general body pain (69.3%), pharyngitis (55.2%), hepatomegaly (47.2%). The laboratory findings were lymphocytosis (41.7%), atypic lymphocytes (24.5%), and increased transaminases (30.9%), there were no rupture of the spleen and no deaths among the 163 cases. Our results revealed that IM appeared in earlier ages compared with that reported in industrialized countries, where adolescents are the most affected group. Also, the order and frequency of the clinical manifestations were different in our country than in industrialized ones.

Daniel Jons - One of the best experts on this subject based on the ideXlab platform.

Sreeram V Ramagopalan - One of the best experts on this subject based on the ideXlab platform.

  • an updated meta analysis of risk of multiple sclerosis following Infectious Mononucleosis
    2010
    Co-Authors: Adam E Handel, Alexander J Williamson, Giulio Disanto, Lahiru Handunnetthi, Gavin Giovannoni, Sreeram V Ramagopalan
    Abstract:

    Background: Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by Infectious Mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published.Methods/Principal Findings: We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97-2.39; p<10(-54)).Discussion: Our results establish firmly that a history of Infectious Mononucleosis significantly increases the risk of multiple sclerosis. Future work should focus on the mechanism of this association and interaction with other risk factors.

Henrik Hjalgrim - One of the best experts on this subject based on the ideXlab platform.

  • Multiple sclerosis after Infectious Mononucleosis.
    2007
    Co-Authors: Trine Rasmussen Nielsen, Klaus Rostgaard, Nete Munk Nielsen, Nils Koch-henriksen, Sven Haahr, Per Soelberg Sørensen, Henrik Hjalgrim
    Abstract:

    Background Infectious Mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about the characteristics of this association. Objective To assess the significance of sex, age at and time since Infectious Mononucleosis, and attained age to the risk of developing multiple sclerosis after Infectious Mononucleosis. Design Cohort study using persons tested serologically for Infectious Mononucleosis at Statens Serum Institut, the Danish Civil Registration System, the Danish National Hospital Discharge Register, and the Danish Multiple Sclerosis Registry. Setting Statens Serum Institut. Patients A cohort of 25 234 Danish patients with Mononucleosis was followed up for the occurrence of multiple sclerosis beginning on April 1, 1968, or January 1 of the year after the diagnosis of Mononucleosis or after a negative Paul-Bunnell test result, respectively, whichever came later and ending on the date of multiple sclerosis diagnosis, death, emigration, or December 31, 1996, whichever came first. Main Outcome Measure The ratio of observed to expected multiple sclerosis cases in the cohort (standardized incidence ratio). Results A total of 104 cases of multiple sclerosis were observed during 556 703 person-years of follow-up, corresponding to a standardized incidence ratio of 2.27 (95% confidence interval, 1.87-2.75). The risk of multiple sclerosis was persistently increased for more than 30 years after Infectious Mononucleosis and uniformly distributed across all investigated strata of sex and age. The relative risk of multiple sclerosis did not vary by presumed severity of Infectious Mononucleosis. Conclusions The risk of multiple sclerosis is increased in persons with prior Infectious Mononucleosis, regardless of sex, age, and time since Infectious Mononucleosis or severity of infection. The risk of multiple sclerosis may be increased soon after Infectious Mononucleosis and persists for at least 30 years after the infection.

  • characteristics of hodgkin s lymphoma after Infectious Mononucleosis
    2003
    Co-Authors: Henrik Hjalgrim, Klaus Rostgaard, Johan Askling, Mette Madsen, Nils Rosdahl, Stephen Hamiltondutoit, Morten Frisch, Jinsong Zhang, Helle Bossen Konradsen, Hans H Storm
    Abstract:

    Background Infectious Mononucleosis–related Epstein–Barr virus (EBV) infection has been associated with an increased risk of Hodgkin's lymphoma in young adults. Whether the association is causal remains unclear. Methods We compared the incidence rates of Hodgkin's lymphoma in two population-based Danish cohorts of patients who were tested for Infectious Mononucleosis: 17,045 with serologic evidence of having had acute EBV infection, and 24,614 with no such evidence. We combined the cohort of patients who had serologically verified Infectious Mononucleosis with a cohort of 21,510 Swedish patients with Infectious Mononucleosis (combined total, 38,555). Biopsy specimens of Hodgkin's lymphomas occurring during follow-up in this combined cohort were tested serologically for the presence of EBV. Using this information, we modeled the relative risk of EBV-negative and EBV-positive Hodgkin's lymphoma in different periods after the diagnosis of Infectious Mononucleosis and estimated the median incubation time for ...

  • risk of hodgkin s disease and other cancers after Infectious Mononucleosis
    2000
    Co-Authors: Henrik Hjalgrim, Per Soelberg Sørensen, Johan Askling, Mette Madsen, Nils Rosdahl, Hans H Storm, Stephen Hamiltondutoit, Lise Stener Eriksen, Morten Frisch, Anders Ekbom
    Abstract:

    Background: Infectious Mononucleosis, which is caused by the Epstein-Barr virus, has been associated with an increased risk for Hodgkin’s disease. Little is known, however, about how Infectious Mononucleosis affects longterm risk of Hodgkin’s disease, how this risk varies with age at Infectious Mononucleosis diagnosis, or how the risk for Hodgkin’s disease varies in different age groups. In addition, the general cancer profile among patients who have had Infectious Mononucleosis has been sparsely studied. Methods: Population-based cohorts of Infectious Mononucleosis patients in Denmark and Sweden were followed for cancer occurrence. The ratio of observed-toexpected numbers of cancers (standardized incidence ratio [SIR]) served as a measure of the relative risk for cancer. SIRs of Hodgkin’s disease in different subsets of patients were compared with the use of Poisson regression analysis. All statistical tests including the trend tests were two-sided. Results: A total of 1381 cancers were observed during 689 619 person-years of follow-up among 38 562 Infectious Mononucleosis patients (SIR = 1.03; 95% confidence interval [CI] = 0.98– 1.09). Apart from Hodgkin’s disease (SIR = 2.55; 95% CI = 1.87–3.40; n = 46), only skin cancers (SIR = 1.27; 95% CI = 1.13–1.43; n = 291) occurred in statistically significant excess. In contrast, the SIR for lung cancer was reduced (SIR = 0.71; 95% CI = 0.58–0.86; n = 102). The SIR for Hodgkin’s disease remained elevated for up to two decades after the occurrence of Infectious Mononucleosis but decreased with time since diagnosis of Infectious Mononucleosis (P for trend <.001). The SIR for Hodgkin’s disease tended to increase with age at diagnosis of Infectious Mononucleosis (P for trend = .05).