The Experts below are selected from a list of 15324 Experts worldwide ranked by ideXlab platform
Yu Li - One of the best experts on this subject based on the ideXlab platform.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:BACKGROUND: Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. MATERIALS AND METHODS: The effects of triptolide on Complete Freund's Adjuvant-induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal-regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. RESULTS: These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal-regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. CONCLUSIONS: In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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Complete Freund’s adjuvant–induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2013Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yunqing Ma, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
Fei Xu - One of the best experts on this subject based on the ideXlab platform.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:BACKGROUND: Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. MATERIALS AND METHODS: The effects of triptolide on Complete Freund's Adjuvant-induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal-regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. RESULTS: These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal-regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. CONCLUSIONS: In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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Complete Freund’s adjuvant–induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2013Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yunqing Ma, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
Shuo Li - One of the best experts on this subject based on the ideXlab platform.
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Sinomenine attenuates chronic Inflammatory Pain in mice
Metabolic Brain Disease, 2016Co-Authors: Shuo Li, Dong-sheng Wang, Qi Yang, Bin Feng, Wen-bo Kang, Le Yang, Ming-gao ZhaoAbstract:Sinomenine, an alkaloid originally isolated from the roots of Sinomeniumacutum, is used as a traditional Chinese medicine for rheumatic arthritis. However, little is known about the neuronal mechanisms underlying the analgesic effects of sinomenine in animals with chronic Inflammatory Pain. In this study, we investigated the persistent Inflammatory Pain induced by hind paw injection of complete Freund’s adjuvant (CFA) in mice, which was reversed by sinomenine administration. In the anterior cingulate cortex (ACC), a region highly associated with chronic Pain processing, the upregulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors and Ca2+/calmodulin-dependent protein kinase II, total levels of GluA1, and phosphorylation of GluA1 at Ser831 (p-GluA1-Ser831) were reversed by systemically administrating sinomenine. Furthermore, sinomenine treatment downregulated the mammalian target of rapamycin (mTOR) pathway. Increases in p-mTOR, p-p70S6k, p-S6, and p-4EBP, which were induced by chronic inflammation, were all changed. However, sinomenine did not affect the levels of GluN2A-containing NMDA receptors and p-GluA1-Ser845, as well as the total levels of mTOR, p70S6k, S6, and 4EBP. In conclusion, results indicated that sinomenine reduced the chronic Inflammatory Pain induced by CFA, at least partially by regulating the GluN2B receptors and mTOR signals in the ACC.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:BACKGROUND: Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. MATERIALS AND METHODS: The effects of triptolide on Complete Freund's Adjuvant-induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal-regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. RESULTS: These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal-regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. CONCLUSIONS: In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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Complete Freund’s adjuvant–induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2013Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yunqing Ma, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
Barry J Sessle - One of the best experts on this subject based on the ideXlab platform.
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peripheral and central mechanisms of orofacial Inflammatory Pain
International Review of Neurobiology, 2011Co-Authors: Barry J SessleAbstract:Abstract Many orofacial Pain conditions involve inflammation of orofacial tissues and they range from acute pulpitis (toothache) and mucositis to chronic arthritic conditions affecting the temporomandibular joint (TMJ). This article reviews the peripheral and central neural mechanisms involved in orofacial Inflammatory Pain states, including the integral role that peripheral and central sensitization play in the Pain features that characterize these states. It also outlines the recent evidence for the contribution of non-neural processes, especially those involving glial cells.
Hong Zhao - One of the best experts on this subject based on the ideXlab platform.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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complete freund s adjuvant induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2014Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yu LiAbstract:BACKGROUND: Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. MATERIALS AND METHODS: The effects of triptolide on Complete Freund's Adjuvant-induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal-regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. RESULTS: These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal-regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. CONCLUSIONS: In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.
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Complete Freund’s adjuvant–induced acute Inflammatory Pain could be attenuated by triptolide via inhibiting spinal glia activation in rats
Journal of Surgical Research, 2013Co-Authors: Fei Xu, Youhan Li, Niansong Qian, Ning Zhao, Shuo Li, Hong Zhao, Yunqing Ma, Yu LiAbstract:Abstract Background Inflammatory Pain is one of the most common clinical symptoms, mechanical allodynia and thermal hypersensitivities are associated with proInflammatory cytokines, and proInflammatory cytokine antagonists could alleviate the hypersensitivity. Previous studies showed that a traditional Chinese medicine ingredient, triptolide could inhibit Inflammatory cytokines; however, it was still unknown whether triptolide had beneficial effects on treating Inflammatory Pain. Materials and methods The effects of triptolide on Complete Freund's Adjuvant–induced acute Inflammatory Pain were investigated using behavioral tests. The activation of spinal glia was morphologically observed by immunofluorescent histochemistry. The levels of OX42, glia fibrillary acidic protein, and phosphorylated extracellular signal–regulated kinase in the spinal cord were detected by Western blot, and the messenger RNA levels of interleukin 1β, interleukin 6, and tumor necrosis factor alpha were detected by real-time polymerase chain reaction. Results These results demonstrate that the triptolide effectively attenuates Inflammatory Pain induced by Complete Freund's Adjuvant, the underlying mechanism may regulate the phosphorylated extracellular signal–regulated kinase signaling pathway and inhibit the spinal glia activation, and then downregulate the proInflammatory cytokines; the triptolide may be clinically useful as a drug of anti-Inflammatory Pain. Conclusions In the present study, we first reported that repeated systemic administration of triptolide could safely prevent and reverse Inflammatory Pain. The triptolide may serve as a new potential compound for developing safe therapeutics for patients suffering Inflammatory Pain.