The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform

Robert Penchovsky - One of the best experts on this subject based on the ideXlab platform.

  • engineering integrated digital circuits with allosteric ribozymes for scaling up molecular computation and diagnostics
    ACS Synthetic Biology, 2012
    Co-Authors: Robert Penchovsky
    Abstract:

    Here we describe molecular implementations of integrated digital circuits, including a three-Input AND logic gate, a two-Input Multiplexer, and 1-to-2 decoder using allosteric ribozymes. Furthermore, we demonstrate a Multiplexer–decoder circuit. The ribozymes are designed to seek-and-destroy specific RNAs with a certain length by a fully computerized procedure. The algorithm can accurately predict one base substitution that alters the ribozyme’s logic function. The ability to sense the length of RNA molecules enables single ribozymes to be used as platforms for multiple interactions. These ribozymes can work as integrated circuits with the functionality of up to five logic gates. The ribozyme design is universal since the allosteric and substrate domains can be altered to sense different RNAs. In addition, the ribozymes can specifically cleave RNA molecules with triplet-repeat expansions observed in genetic disorders such as oculopharyngeal muscular dystrophy. Therefore, the designer ribozymes can be empl...

  • Engineering Integrated Digital Circuits with Allosteric Ribozymes for Scaling up Molecular Computation and Diagnostics
    2012
    Co-Authors: Robert Penchovsky
    Abstract:

    Here we describe molecular implementations of integrated digital circuits, including a three-Input AND logic gate, a two-Input Multiplexer, and 1-to-2 decoder using allosteric ribozymes. Furthermore, we demonstrate a Multiplexer–decoder circuit. The ribozymes are designed to seek-and-destroy specific RNAs with a certain length by a fully computerized procedure. The algorithm can accurately predict one base substitution that alters the ribozyme’s logic function. The ability to sense the length of RNA molecules enables single ribozymes to be used as platforms for multiple interactions. These ribozymes can work as integrated circuits with the functionality of up to five logic gates. The ribozyme design is universal since the allosteric and substrate domains can be altered to sense different RNAs. In addition, the ribozymes can specifically cleave RNA molecules with triplet-repeat expansions observed in genetic disorders such as oculopharyngeal muscular dystrophy. Therefore, the designer ribozymes can be employed for scaling up computing and diagnostic networks in the fields of molecular computing and diagnostics and RNA synthetic biology

R R Mansour - One of the best experts on this subject based on the ideXlab platform.

  • a 60 channel superconductive Input Multiplexer integrated with pulse tube cryocoolers
    IEEE Transactions on Microwave Theory and Techniques, 2000
    Co-Authors: R R Mansour, G Thomson, Waicheung Tang, Chandra M Kudsia, B Jolley, S F Peik, T Romano, T Nast, B Williams, D Frank
    Abstract:

    This paper presents the measured results of a C-band 60-channel superconductive Input Multiplexer integrated with pulse-tube space-qualified cryocoolers. The Multiplexer is developed to duplicate the requirements of the INTELSAT 8 program. The channel filters are self-equalized ten-pole high-temperature superconductor (HTS) planar structures designed with drop-in cryogenic ferrite circulators and isolators. This paper presents details on RF design, packaging, and cryocooler integration, as well as an assessment of overall reliability of using HTS equipment in a space environment. This paper demonstrates that at least 50% reduction in mass and 65% reduction in size can be achieved by replacing the INTELSAT 8 C-band dielectric-resonator Input Multiplexer with a superconductive Multiplexer.

  • a c band superconductive Input Multiplexer for communication satellites
    International Microwave Symposium, 1994
    Co-Authors: R R Mansour, Van Dokas, G Thomson, Waicheung Tang, Chandra M Kudsia
    Abstract:

    The paper demonstrates the feasibility of building a fully integrated C-band 4-channel superconductive Multiplexer employing 8-pole hybrid dielectric/HTS thin film filters. Experimental results are presented for 4-pole and 8-pole externally-equalized superconductive filters having 1% bandwidth. The measured data for the integrated Multiplexer clearly indicates that C-band superconductive Multiplexers are approaching the performance requirements of typical satellite systems and have the potential of large reduction in mass and volume over conventional technologies. The critical design considerations of such type of superconductive Multiplexers are discussed

Jin Wu - One of the best experts on this subject based on the ideXlab platform.

  • A 10-GS/s 8-bit SiGe ADC with Isolated 4×4 Analog Input Multiplexer
    2019 IEEE International Symposium on Circuits and Systems (ISCAS), 2019
    Co-Authors: Danyu Wu, Yinkun Huang, Jian Luan, Lei Zhou, Jin Wu
    Abstract:

    In this paper, a time-interleaved 10GS/s 8bit ADC fabricated in 0.18μm SiGe BiCMOS technology has been demonstrated. The proposed 4×4 Input Multiplexer allows the ADC to support 1/2/4-channel sampling modes with no compromised isolation and Input bandwidth. In the THA stage, a switched emitter follower (SEF) topology with delayed dummy clock is introduced to minimize the output overshot effect of the SEF. The measurement result shows that the ADC has a SFDR >43dBc over the entire Nyquist frequency. It has an effective number of bits (ENOB) about 6.6 at low frequency and dropping to 5.5 at 5GHz.

Chandra M Kudsia - One of the best experts on this subject based on the ideXlab platform.

  • a 60 channel superconductive Input Multiplexer integrated with pulse tube cryocoolers
    IEEE Transactions on Microwave Theory and Techniques, 2000
    Co-Authors: R R Mansour, G Thomson, Waicheung Tang, Chandra M Kudsia, B Jolley, S F Peik, T Romano, T Nast, B Williams, D Frank
    Abstract:

    This paper presents the measured results of a C-band 60-channel superconductive Input Multiplexer integrated with pulse-tube space-qualified cryocoolers. The Multiplexer is developed to duplicate the requirements of the INTELSAT 8 program. The channel filters are self-equalized ten-pole high-temperature superconductor (HTS) planar structures designed with drop-in cryogenic ferrite circulators and isolators. This paper presents details on RF design, packaging, and cryocooler integration, as well as an assessment of overall reliability of using HTS equipment in a space environment. This paper demonstrates that at least 50% reduction in mass and 65% reduction in size can be achieved by replacing the INTELSAT 8 C-band dielectric-resonator Input Multiplexer with a superconductive Multiplexer.

  • a c band superconductive Input Multiplexer for communication satellites
    International Microwave Symposium, 1994
    Co-Authors: R R Mansour, Van Dokas, G Thomson, Waicheung Tang, Chandra M Kudsia
    Abstract:

    The paper demonstrates the feasibility of building a fully integrated C-band 4-channel superconductive Multiplexer employing 8-pole hybrid dielectric/HTS thin film filters. Experimental results are presented for 4-pole and 8-pole externally-equalized superconductive filters having 1% bandwidth. The measured data for the integrated Multiplexer clearly indicates that C-band superconductive Multiplexers are approaching the performance requirements of typical satellite systems and have the potential of large reduction in mass and volume over conventional technologies. The critical design considerations of such type of superconductive Multiplexers are discussed

D Frank - One of the best experts on this subject based on the ideXlab platform.

  • a 60 channel superconductive Input Multiplexer integrated with pulse tube cryocoolers
    IEEE Transactions on Microwave Theory and Techniques, 2000
    Co-Authors: R R Mansour, G Thomson, Waicheung Tang, Chandra M Kudsia, B Jolley, S F Peik, T Romano, T Nast, B Williams, D Frank
    Abstract:

    This paper presents the measured results of a C-band 60-channel superconductive Input Multiplexer integrated with pulse-tube space-qualified cryocoolers. The Multiplexer is developed to duplicate the requirements of the INTELSAT 8 program. The channel filters are self-equalized ten-pole high-temperature superconductor (HTS) planar structures designed with drop-in cryogenic ferrite circulators and isolators. This paper presents details on RF design, packaging, and cryocooler integration, as well as an assessment of overall reliability of using HTS equipment in a space environment. This paper demonstrates that at least 50% reduction in mass and 65% reduction in size can be achieved by replacing the INTELSAT 8 C-band dielectric-resonator Input Multiplexer with a superconductive Multiplexer.