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H Van Den Berghe - One of the best experts on this subject based on the ideXlab platform.
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a genetic diagnostic survey in an Institutionalized Population of 262 moderately mentally retarded patients the borgerstein experience
Journal of Intellectual Disability Research, 2008Co-Authors: J P Fryns, P Volcke, M Haspeslagh, L Beusen, H Van Den BergheAbstract:. In this paper, the authors report the results of a genetic-diagnostic survey of 262 instutionalized moderately mentally retarded patients and compare these data with their previous studies of the severely mentally retarded. Special attention is given towards the nosology of X-linked mental retardation and familial mental retardation in general.
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a genetic diagnostic survey in an Institutionalized Population of 158 mentally retarded patients the viaene experience
Clinical Genetics, 2008Co-Authors: A M Dereymaeker, J P Fryns, J Haegeman, J Deroover, H Van Den BergheAbstract:In this report we summarize the results of a genetic-diagnostic survey of an Institutionalized Population of 158 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention to dysmorphology and neurological findings. In 72 patients a constitutional cause of their mental impairment was found: a chromosomal abnormality in 21, a Mendelian disorder in 36 (autosomal recessive disorder: 23; autosomal dominant: 12; and X-linked recessive: 1), a MCA/MR syndrome in 9, and a CNS malformation in 6 patients. In 33 patients, a pre- or perinatal cause was found, and 20 patients presented a pre- or perinatal infection of the CNS. Finally, no etiological diagnosis was detected in 28 patients; 6 of them presented a hitherto unclassifiable type of familial mental retardation.
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a genetic diagnostic survey in an Institutionalized Population of 173 severely mentally retarded patients
Clinical Genetics, 2008Co-Authors: J P Fryns, A Kleczkowska, A M Dereymaeker, M Hoefnagels, G Heremans, J Marien, H Van Den BergheAbstract:In this report we summarize the findings in a genetic-diagnostic survey of an Institutionalized Population of 173 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention for dysmorphology and neurological findings. A constitutional disorder, as the direct cause of the severe mental handicap, was found in 75 patients (43.35%). A detailed survey of the different data and findings are given, and compared with the results of previous studies.
J P Fryns - One of the best experts on this subject based on the ideXlab platform.
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a genetic diagnostic survey in an Institutionalized Population of 262 moderately mentally retarded patients the borgerstein experience
Journal of Intellectual Disability Research, 2008Co-Authors: J P Fryns, P Volcke, M Haspeslagh, L Beusen, H Van Den BergheAbstract:. In this paper, the authors report the results of a genetic-diagnostic survey of 262 instutionalized moderately mentally retarded patients and compare these data with their previous studies of the severely mentally retarded. Special attention is given towards the nosology of X-linked mental retardation and familial mental retardation in general.
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a genetic diagnostic survey in an Institutionalized Population of 158 mentally retarded patients the viaene experience
Clinical Genetics, 2008Co-Authors: A M Dereymaeker, J P Fryns, J Haegeman, J Deroover, H Van Den BergheAbstract:In this report we summarize the results of a genetic-diagnostic survey of an Institutionalized Population of 158 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention to dysmorphology and neurological findings. In 72 patients a constitutional cause of their mental impairment was found: a chromosomal abnormality in 21, a Mendelian disorder in 36 (autosomal recessive disorder: 23; autosomal dominant: 12; and X-linked recessive: 1), a MCA/MR syndrome in 9, and a CNS malformation in 6 patients. In 33 patients, a pre- or perinatal cause was found, and 20 patients presented a pre- or perinatal infection of the CNS. Finally, no etiological diagnosis was detected in 28 patients; 6 of them presented a hitherto unclassifiable type of familial mental retardation.
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a genetic diagnostic survey in an Institutionalized Population of 173 severely mentally retarded patients
Clinical Genetics, 2008Co-Authors: J P Fryns, A Kleczkowska, A M Dereymaeker, M Hoefnagels, G Heremans, J Marien, H Van Den BergheAbstract:In this report we summarize the findings in a genetic-diagnostic survey of an Institutionalized Population of 173 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention for dysmorphology and neurological findings. A constitutional disorder, as the direct cause of the severe mental handicap, was found in 75 patients (43.35%). A detailed survey of the different data and findings are given, and compared with the results of previous studies.
A M Dereymaeker - One of the best experts on this subject based on the ideXlab platform.
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a genetic diagnostic survey in an Institutionalized Population of 158 mentally retarded patients the viaene experience
Clinical Genetics, 2008Co-Authors: A M Dereymaeker, J P Fryns, J Haegeman, J Deroover, H Van Den BergheAbstract:In this report we summarize the results of a genetic-diagnostic survey of an Institutionalized Population of 158 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention to dysmorphology and neurological findings. In 72 patients a constitutional cause of their mental impairment was found: a chromosomal abnormality in 21, a Mendelian disorder in 36 (autosomal recessive disorder: 23; autosomal dominant: 12; and X-linked recessive: 1), a MCA/MR syndrome in 9, and a CNS malformation in 6 patients. In 33 patients, a pre- or perinatal cause was found, and 20 patients presented a pre- or perinatal infection of the CNS. Finally, no etiological diagnosis was detected in 28 patients; 6 of them presented a hitherto unclassifiable type of familial mental retardation.
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a genetic diagnostic survey in an Institutionalized Population of 173 severely mentally retarded patients
Clinical Genetics, 2008Co-Authors: J P Fryns, A Kleczkowska, A M Dereymaeker, M Hoefnagels, G Heremans, J Marien, H Van Den BergheAbstract:In this report we summarize the findings in a genetic-diagnostic survey of an Institutionalized Population of 173 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention for dysmorphology and neurological findings. A constitutional disorder, as the direct cause of the severe mental handicap, was found in 75 patients (43.35%). A detailed survey of the different data and findings are given, and compared with the results of previous studies.
Kyung Soo Kim - One of the best experts on this subject based on the ideXlab platform.
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prevalence of subjective olfactory dysfunction and its risk factors korean national health and nutrition examination survey
PLOS ONE, 2013Co-Authors: Woo Hyun Lee, Jee Hye Wee, Dong Kyu Kim, Chae Seo Rhee, Chul Hee Lee, Soyeon Ahn, Ju Hyun Lee, Yang Sun Cho, Kun Hee Lee, Kyung Soo KimAbstract:BACKGROUND: Population-based studies for olfactory dysfunction are lacking. The aim of this study is to evaluate the prevalence of subjective olfactory dysfunction and its risk factors in the Korean general Population. METHODS: The data were obtained from the 2009 Korea National Health and Nutrition Examination Survey (KNHANES), which was a cross-sectional survey of non-Institutionalized Population all around the country (n = 10,533). All interviewees underwent medical interviews, physical examinations, endoscopic examination and blood/urine tests. Whether sense of smell has been normal or abnormal during the last 3 months was asked. Complete olfaction data were obtained from 7,306 participants and the participants were divided into normosmic and hyposmic group. Multivariate logistic regression analyses were performed to identify its risk factors. RESULTS: The weighted prevalence of subjective olfactory dysfunction was 4.5%. Its increased prevalence was significantly associated with the increasing age for both men and women. In the multivariate analyses, low income (adjusted odds ratio [OR] = 1.43, 95% Confidence Interval [CI] = 1.01-2.03), habitual exposure to air pollutants (adjusted OR = 2.18, CI = 1.33-3.55), a history of hepatitis B (adjusted OR = 3.10, CI = 1.25-7.68), rhinitis (adjusted OR = 1.78, CI = 1.26-2.51) and chronic sinusitis (adjusted OR = 14.55, CI = 10.06-21.05) were risk factors of olfactory dysfunction. CONCLUSION: Our Population-based study showed that olfactory dysfunction was quite prevalent and several risk factors were associated with impaired sense of smell. Given its prevalence, further researches for its prevention and management are required.
Cristina Lasheras - One of the best experts on this subject based on the ideXlab platform.
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Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly Institutionalized Population
Clinical Biochemistry, 2004Co-Authors: José María Huerta, Sonia González, Mercedes Prada, Julia San Martín, Serafina Fernández, Ángeles M. Patterson, Elena Vigil, Cristina LasherasAbstract:Abstract Objective Total plasma homocysteine (tHcy) has been associated with an increased risk of cardiovascular disease in the general Population and elderly subjects are at high risk of elevated homocysteine because of an impaired vitamin status. The aim of the present study was to determine the independent and interactive association of adequate folate and cobalamin (intake and serum levels) with tHcy in elderly subjects who were not taking vitamin supplementation. Design and methods Cross-sectional analysis of a sample of 140 elderly recruited from seven nursing homes in Asturias (Northern Spain). Dietary intake was assessed by a food frequency questionnaire, and serum folate, cobalamin, and tHcy were determined in fasting blood samples. Results Mean tHcy concentration was 13.3 μmol/L (upper quartile of tHcy >16.0 μmol/L) and was inversely correlated with serum folate. Subjects with an adequate intake or serum levels of both folate and B 12 were at a reduced risk of being in the highest quartile of tHcy. In both cases, the reduction of high tHcy (upper quartile) risk was found to be greater than expected when subjects with high levels of both vitamins were considered together. Conclusions Adequate folate and cobalamin (both intake and serum levels) act synergistically to decrease the risk of high total plasma homocysteine levels in this elderly Population.
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dietary intake and biochemical indicators of nutritional status in an elderly Institutionalized and non Institutionalized Population
Nutrition Research, 1999Co-Authors: Cristina Lasheras, Ángeles M. Patterson, Celestino Gonzalez, Angela Garcia, Serafina FernándezAbstract:Abstract The nutritional status of 352 elderly men and women, 161 Institutionalized and 191 living in their own homes, was assessed. Subjects were free of clinically apparent terminal or wasting illness. Ingestion was evaluated by a food frequency questionnaire. Height, weight, body mass index, triceps skinfold, midarm circumference, mid-arm muscle circumference, mid-arm fat free mass area as well as serum albumin, total serum proteins and total lymphocyte count, were measured. Diet was low in carbohydrates and rich in fat. There was an intake deficiency of vitamins A, C and D. Individuals who were living independently had the highest percentage of inadequate ingestion, with the exception of vitamin C. Institutionalized subjects had less body fat. No differences were found in the biochemical parameters between the two groups, although the percentage of females with mild lymphocyte depletion was higher in the non-Institutionalized group. Nutrient intake in northern Spain is similar to other developed countries in Europe.