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Alan L Shanske - One of the best experts on this subject based on the ideXlab platform.
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Interparietal Bone os incae in craniosynostosis
American Journal of Medical Genetics Part A, 2011Co-Authors: June K Wu, James T Goodrich, Chiemezie C Amadi, Todd S Miller, John B Mulliken, Alan L ShanskeAbstract:The Interparietal Bone, Os Incae, is formed in a persistent mendosal suture. This suture is a normal variant in the human skull, well-known in anatomy and radiology textbooks. We report 11 children with craniosynostosis in the presence of an Interparietal Bone, five from Children's Hospital at Montefiore and six children from Children's Hospital Boston. The true incidence of an Interparietal Bone in patients with craniosynostosis or craniofacial anomalies is not known; nor are there recognized sequelae of an Interparietal Bone (bathrocephaly). Hypotheses regarding mechanisms that may contribute to the formation of an Interparietal Bone are discussed. © 2010 Wiley-Liss, Inc.
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Interparietal Bone (Os Incae) in craniosynostosis.
American journal of medical genetics. Part A, 2010Co-Authors: June K Wu, James T Goodrich, Chiemezie C Amadi, John B Mulliken, Todd Miller, Alan L ShanskeAbstract:The Interparietal Bone, Os Incae, is formed in a persistent mendosal suture. This suture is a normal variant in the human skull, well-known in anatomy and radiology textbooks. We report 11 children with craniosynostosis in the presence of an Interparietal Bone, five from Children's Hospital at Montefiore and six children from Children's Hospital Boston. The true incidence of an Interparietal Bone in patients with craniosynostosis or craniofacial anomalies is not known; nor are there recognized sequelae of an Interparietal Bone (bathrocephaly). Hypotheses regarding mechanisms that may contribute to the formation of an Interparietal Bone are discussed.
Osama Al-amer - One of the best experts on this subject based on the ideXlab platform.
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Bone marker gene expression in calvarial Bones: different Bone microenvironments
Journal of Biological Research-Thessaloniki, 2017Co-Authors: Osama Al-amerAbstract:Background In calvarial mice, mesenchymal stem cells (MSCs) differentiate into osteoprogenitor cells and then differentiate into osteoblasts that differentiate into osteocytes, which become embedded within the Bone matrix. In this case, the cells participating in Bone formation include MSCs, osteoprogenitor cells, osteoblasts and osteocytes. The calvariae of C57BL/KaLwRijHsD mice consist of the following five Bones: two frontal Bones, two parietal Bones and one Interparietal Bone. This study aimed to analyse some Bone marker genes and Bone related genes to determine whether these calvarial Bones have different Bone microenvironments. Methods C57BL/KaLwRijHsD calvariae were carefully excised from five male mice that were 4–6 weeks of age. Frontal, parietal, and Interparietal Bones were dissected to determine the Bone microenvironment in calvariae. Haematoxylin and eosin staining was used to determine the morphology of different calvarial Bones under microscopy. TaqMan was used to analyse the relative expression of Runx2, OC, OSX, RANK, RANKL, OPG, N-cadherin, E-cadherin, FGF2 and FGFR1 genes in different parts of the calvariae. Results Histological analysis demonstrated different Bone marrow (BM) areas between the different parts of the calvariae. The data show that parietal Bones have the smallest BM area compared to frontal and Interparietal Bones. TaqMan data show a significant increase in the expression level of Runx2, OC, OSX, RANKL, OPG, FGF2 and FGFR1 genes in the parietal Bones compared with the frontal and Interparietal Bones of calvariae. Conclusion This study provides evidence that different calvarial Bones, frontal, parietal and Interparietal, contain different Bone microenvironments.
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Bone Marker Gene Expression in Calvarial Bones: Different Bone Microenvironments
Journal of Biological Research-thessaloniki, 2017Co-Authors: Osama Al-amerAbstract:In calvarial mice, mesenchymal stem cells (MSCs) differentiate into osteoprogenitor cells and then differentiate into osteoblasts that differentiate into osteocytes, which become embedded within the Bone matrix. In this case, the cells participating in Bone formation include MSCs, osteoprogenitor cells, osteoblasts and osteocytes. The calvariae of C57BL/KaLwRijHsD mice consist of the following five Bones: two frontal Bones, two parietal Bones and one Interparietal Bone. This study aimed to analyse some Bone marker genes and Bone related genes to determine whether these calvarial Bones have different Bone microenvironments. C57BL/KaLwRijHsD calvariae were carefully excised from five male mice that were 4–6 weeks of age. Frontal, parietal, and Interparietal Bones were dissected to determine the Bone microenvironment in calvariae. Haematoxylin and eosin staining was used to determine the morphology of different calvarial Bones under microscopy. TaqMan was used to analyse the relative expression of Runx2, OC, OSX, RANK, RANKL, OPG, N-cadherin, E-cadherin, FGF2 and FGFR1 genes in different parts of the calvariae. Histological analysis demonstrated different Bone marrow (BM) areas between the different parts of the calvariae. The data show that parietal Bones have the smallest BM area compared to frontal and Interparietal Bones. TaqMan data show a significant increase in the expression level of Runx2, OC, OSX, RANKL, OPG, FGF2 and FGFR1 genes in the parietal Bones compared with the frontal and Interparietal Bones of calvariae. This study provides evidence that different calvarial Bones, frontal, parietal and Interparietal, contain different Bone microenvironments.
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Tracking of individual myeloma cell homing to the calvarial Bone marrow using myeloma murine models
2015Co-Authors: Osama Al-amerAbstract:Multiple myeloma (MM) is a plasma cell malignancy that causes extensive osteolytic Bone disease mainly in the skull. To support our understanding of MM Bone disease, preclinical mouse models have been developed. C57BL/KaLwRijHsd mice develop a high frequency of monoclonal proliferative B-cell disorders. 5T33MM and 5TGM1 are the best characterized as myeloma models and used in most recent studies in this area. In this study, a combination of high-resolution confocal microscopy and two-photon video imaging was used to examine of individual myeloma cells in the calvarial Bone marrow of C57BL/KaLwRijHsd mice. This study demonstrated that myeloma cells home and reside in the calvarial Bone after 3 days of injection via mouse tail. In addition, this study showed a significant increase in the number of myeloma cells that colonize and home in the Interparietal Bone comparing to frontal and parietal Bones. This study provides evidence that the micro-anatomical site in the Interparietal Bone may have unique characteristics to study myeloma colonization in Bone and to study anti-myeloma therapies, particularly those targeting myeloma Bone disease.
June K Wu - One of the best experts on this subject based on the ideXlab platform.
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Interparietal Bone os incae in craniosynostosis
American Journal of Medical Genetics Part A, 2011Co-Authors: June K Wu, James T Goodrich, Chiemezie C Amadi, Todd S Miller, John B Mulliken, Alan L ShanskeAbstract:The Interparietal Bone, Os Incae, is formed in a persistent mendosal suture. This suture is a normal variant in the human skull, well-known in anatomy and radiology textbooks. We report 11 children with craniosynostosis in the presence of an Interparietal Bone, five from Children's Hospital at Montefiore and six children from Children's Hospital Boston. The true incidence of an Interparietal Bone in patients with craniosynostosis or craniofacial anomalies is not known; nor are there recognized sequelae of an Interparietal Bone (bathrocephaly). Hypotheses regarding mechanisms that may contribute to the formation of an Interparietal Bone are discussed. © 2010 Wiley-Liss, Inc.
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Interparietal Bone (Os Incae) in craniosynostosis.
American journal of medical genetics. Part A, 2010Co-Authors: June K Wu, James T Goodrich, Chiemezie C Amadi, John B Mulliken, Todd Miller, Alan L ShanskeAbstract:The Interparietal Bone, Os Incae, is formed in a persistent mendosal suture. This suture is a normal variant in the human skull, well-known in anatomy and radiology textbooks. We report 11 children with craniosynostosis in the presence of an Interparietal Bone, five from Children's Hospital at Montefiore and six children from Children's Hospital Boston. The true incidence of an Interparietal Bone in patients with craniosynostosis or craniofacial anomalies is not known; nor are there recognized sequelae of an Interparietal Bone (bathrocephaly). Hypotheses regarding mechanisms that may contribute to the formation of an Interparietal Bone are discussed.
Amal Abd El-monsef Abou Elmagd - One of the best experts on this subject based on the ideXlab platform.
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Skeletal congenital abnormalities induced by nickel chloride hexahydrate on Balb/C albino mice embryos during organogenetic period
Toxicology and Environmental Health Sciences, 2020Co-Authors: Nancy Mohamed Aly El-sekily, Ahmed El-saeed Abou El-fetouh Ayad, Nesrine Mostafa El-homosany, Amal Abd El-monsef Abou ElmagdAbstract:Introduction Nickel is an essential metal, and its compounds are widely used in industry and commerce. The development of industrialization has led to increased emission of nickel into environment causing teratogenesis in the developing embryos. This study aimed to investigate the toxic and teratogenic effects of nickel on Balb/C albino mice embryos during organogenetic period. Materials and methods This study was carried out on forty pregnant female albino mice; they were randomly divided into four equal groups: group I (control group) received distilled water; groups II, III, and IV (experimental groups): each group contains ten mice received 46.125 mg, 92.25 mg, and 184 mg Ni/kg body weight, per day, respectively, by orogastric tube for successive 8 days started from the 6th gestational day. The extracted lived fetuses were examined externally then double-stained and prepared for skeletal examination by dissecting microscope. Results The numbers of live-birth pups decreased significantly ( p value for comparing between control and each other group, statistically significant at p ≤ 0.05). But there was significant increase in resorption sites in all nickel-treated groups compared to control group. Total number of resorption sites in all nickel-treated groups is 28: 15 resorption sites are present at left horn and 13 in the right horn. At the same time, there was significant increase in stillbirth fetuses in group IV. Double-stained fetal skeleton showed incomplete ossification of skull Bones, unossified Interparietal Bone, open arch of atlas, incomplete ossification of vertebrae, supernumerary lumbar rib, incomplete ossification of ribs and sternebrae, incomplete ossification of Bones of forelimb, incomplete ossification of Bones of hindlimb, unossified carpals, metacarpals, tarsals, metatarsals, and phalanges in nickel-treated groups, compared to control group. Conclusion Nickel results in number of skeletal congenital abnormalities indicating its teratogenic effect.
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Skeletal congenital abnormalities induced by nickel chloride hexahydrate on Balb/C albino mice embryos during organogenetic period
Toxicology and Environmental Health Sciences, 2020Co-Authors: Nancy Mohamed Aly El-sekily, Ahmed El-saeed Abou El-fetouh Ayad, Nesrine Mostafa El-homosany, Amal Abd El-monsef Abou ElmagdAbstract:Nickel is an essential metal, and its compounds are widely used in industry and commerce. The development of industrialization has led to increased emission of nickel into environment causing teratogenesis in the developing embryos. This study aimed to investigate the toxic and teratogenic effects of nickel on Balb/C albino mice embryos during organogenetic period. This study was carried out on forty pregnant female albino mice; they were randomly divided into four equal groups: group I (control group) received distilled water; groups II, III, and IV (experimental groups): each group contains ten mice received 46.125 mg, 92.25 mg, and 184 mg Ni/kg body weight, per day, respectively, by orogastric tube for successive 8 days started from the 6th gestational day. The extracted lived fetuses were examined externally then double-stained and prepared for skeletal examination by dissecting microscope. The numbers of live-birth pups decreased significantly (p value for comparing between control and each other group, statistically significant at p ≤ 0.05). But there was significant increase in resorption sites in all nickel-treated groups compared to control group. Total number of resorption sites in all nickel-treated groups is 28: 15 resorption sites are present at left horn and 13 in the right horn. At the same time, there was significant increase in stillbirth fetuses in group IV. Double-stained fetal skeleton showed incomplete ossification of skull Bones, unossified Interparietal Bone, open arch of atlas, incomplete ossification of vertebrae, supernumerary lumbar rib, incomplete ossification of ribs and sternebrae, incomplete ossification of Bones of forelimb, incomplete ossification of Bones of hindlimb, unossified carpals, metacarpals, tarsals, metatarsals, and phalanges in nickel-treated groups, compared to control group. Nickel results in number of skeletal congenital abnormalities indicating its teratogenic effect.
Asma Hassan - One of the best experts on this subject based on the ideXlab platform.
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Interparietal Bone variations in accordance with their ossification centres in human skulls
International Journal of Morphology, 2013Co-Authors: Aaijaz Ahmed Khan, Muzammil Ullah, Mohd Asnizam Asari, Asma HassanAbstract:El segmento Interparietal superior de la porcion escamosa del hueso occipital es de origen membranoso y la parte inferior supraoccipital se desarrolla en el cartilago. De acuerdo con la literatura disponible, el segmento Interparietal se osifica a partir de 2 a3 pares de centros y cada uno de estos centros cuenta con 2 nucleos. El hueso Interparietal se forma debido a la falta de fusion de estos centros y / o sus nucleos. Muchas variaciones de hueso Interparietal han sido reportados por investigadores. En el presente estudio, de 25 craneos humanos estudiados, seis craneos presentaban algunas variaciones interesantes de huesos Interparietales. Cuatro huesos Interparietales fueron encontrados en un craneo, dos huesos Interparietales en un craneo y cuatro craneos presentaban un solo hueso Interparietal (Os inca) en el lambda. Ademas, de los huesos Interparietales, en tres craneos se observaron huesos suturales. Estas variaciones estaban en relacion con los centros de osificacion de la parte membranosa del hueso occipital. Por su ubicacion y forma, se concluyo que los huesos se formaron debido a la falta de fusion entre si de los nucleos de los centros del tercer par de osificacion, con otros opuestos y con los centros del segundo par. Se concluye, ademas, que estos casos de huesos Interparietales eran diferentes de lo que se habia informado anteriormente por otros investigadores y esto nos impulso al estudio, el cual puede ser util para anatomistas, antropologos, radiologos y neurocirujanos.
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Interparietal Bone variations in accordance with their ossification centres in human skulls variaciones de los huesos Interparietales de acuerdo con sus centros de osificacion en craneos humanos
2013Co-Authors: Aaijaz Ahmed Khan, Muzammil Ullah, Asma HassanAbstract:& Asma HassanKHAN, A. A.; ULLAH, M.; ASARI, M. A. & HASSAN, A. Interparietal Bones variations in accordance with their ossification centresin human skulls. Int. J. Morphol., 31(2):546-552, 2013.SUMMARY: The upper Interparietal segment of the squamous part of the occipital Bone develops in membrane and the lowersupraoccipital part develops in cartilage. According to the available literature, the Interparietal segment is ossified from 2 to 3 pairs ofossification centres and each of these centres has 2 nuclei. Interparietal Bone is formed due to failure of fusion of these centres and/ortheir nuclei with each other. Many variations of Interparietal Bone have been reported by many investigators. In the present st udy, out of25 human skulls studied, six skulls had some interesting variations of Interparietal Bones. Four Interparietal Bones were found in oneskull, 2 Interparietal Bones were observed in another skull and the remaining four skulls had a single Interparietal (Os inca) Bone at thelambda. In addition to Interparietal Bones, some sutural Bones were also observed in three skulls. These variations were in accordancewith the ossification centres of the membranous part of the occipital Bone. By their location and shape it was concluded that they wereformed due to failure of fusion of nuclei of the third pair centres of ossification with each other, with opposite fellow and w ith the secondpair centers. It was further concluded that these cases of Interparietal Bones were different from what had been reported earli er by otherresearchers and this prompted the present report that may be found useful for anatomists, anthropologists, radiologists and neu rosurgeons.KEY WORDS: Centre; Interparietal; Occipital Bone; Ossification; Skull.
