The Experts below are selected from a list of 93 Experts worldwide ranked by ideXlab platform
Choudhuri K - One of the best experts on this subject based on the ideXlab platform.
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Signaling and polarized communication across the T cell immunological synapse
'Annual Reviews', 2016Co-Authors: Dustin M, Choudhuri KAbstract:T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during development to respond to changes in peptides displayed by major histocompatibility complex proteins (pMHC) on the surface of antigen-presenting cells (APC). A key characteristic of pMHC for adaptive immunity is the ability to sample internal states of cells and tissues to sensitively detect changes associated with infection, cell derangement, or tissue injury. Physical T cell-APC contact sets up an axis for polarization of TCR, adhesion molecules, kinases, cytoskeletal elements, and organelles inherent in this mode of juxtacrine signaling. The discovery of further lateral organization of the TCR and adhesion molecules into radially symmetric compartments, the immunological synapse, revealed an Intersecting Plane of symmetry and potential for regulated symmetry breaking to control duration of T cell-APC interactions. In addition to organizing signaling machinery, the immunological synapse directs the polarized transport and secretion of cytokines and cytolytic agents across the synaptic cleft and is a site for the generation and exocytic release of bioactive microvesicles that can functionally affect recipient APC and other cells in the environment. This machinery is coopted by retroviruses, and human immune deficiency virus-1 may even use antigen-specific synapses for infection of healthy T cells. Here, we discuss recent advances in the molecular and cell biological mechanisms of immunological synapse assembly and signaling and its role in intercellular communication across the synaptic cleft. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 32 is October 06, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates
Elizabeth M. C. Hillman - One of the best experts on this subject based on the ideXlab platform.
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Design of a Second Generation Laser Scanning Intersecting Plane Tomography (LSIPT) System
Biomedical Optics 2014, 2014Co-Authors: Venkatakaushik Voleti, Matthew B. Bouchard, Elizabeth M. C. HillmanAbstract:We present recent development of a single-objective, high-speed volumetric microscopy method, including optimization via a comprehensive ray tracing model. L-SIPT is capable of in-vivo imaging of intact rodent brain and transgenic drosophila at >30 VPS.
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Laser-Scanning Intersecting Plane Tomography (L-SIPT) for High Speed 3D Optical Imaging and Microscopy
Biomedical Optics and 3-D Imaging, 2010Co-Authors: Matthew B. Bouchard, Lauren E. Grosberg, Sean A. Burgess, Elizabeth M. C. HillmanAbstract:We describe a new optical planar imaging geometry for high speed volumetric optical imaging. A diagram and raytracing simulations of the new imaging geometry as well as initial phantom and image reconstruction results are presented.
Kaushik Choudhuri - One of the best experts on this subject based on the ideXlab platform.
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Signaling and Polarized Communication Across the T Cell Immunological Synapse
Annual Review of Cell and Developmental Biology, 2016Co-Authors: Michael L. Dustin, Kaushik ChoudhuriAbstract:T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during development to respond to changes in peptides displayed by major histocompatibility complex proteins (pMHC) on the surface of antigen-presenting cells (APC). A key characteristic of pMHC for adaptive immunity is the ability to sample internal states of cells and tissues to sensitively detect changes associated with infection, cell derangement, or tissue injury. Physical T cell–APC contact sets up an axis for polarization of TCR, adhesion molecules, kinases, cytoskeletal elements, and organelles inherent in this mode of juxtacrine signaling. The discovery of further lateral organization of the TCR and adhesion molecules into radially symmetric compartments, the immunological synapse, revealed an Intersecting Plane of symmetry and potential for regulated symmetry breaking to control duration of T cell–APC interactions. In addition to organizing signaling machinery, the immunological synapse directs the polarized tran...
Alexey Arefiev - One of the best experts on this subject based on the ideXlab platform.
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Extreme Nonlinear Dynamics in Vacuum Laser Acceleration with a Crossed Beam Configuration
Physics of Plasmas, 2019Co-Authors: A. P. L. Robinson, Kavin Tangtartharakul, Kathleen Weichman, Alexey ArefievAbstract:A relatively simple model problem where a single electron moves in two relativistically-strong obliquely Intersecting Plane wave-packets is studied using a number of different numerical solvers. It is shown that, in general, even the most advanced solvers are unable to obtain converged solutions for more than about 100 fs in contrast to the single Plane-wave problem, and that some basic metrics of the orbit show enormous sensitivity to the initial conditions. At a bare minimum this indicates an unusual degree of non-linearity, and may well indicate that the dynamics of this system are chaotic.
Dustin M - One of the best experts on this subject based on the ideXlab platform.
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Signaling and polarized communication across the T cell immunological synapse
'Annual Reviews', 2016Co-Authors: Dustin M, Choudhuri KAbstract:T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during development to respond to changes in peptides displayed by major histocompatibility complex proteins (pMHC) on the surface of antigen-presenting cells (APC). A key characteristic of pMHC for adaptive immunity is the ability to sample internal states of cells and tissues to sensitively detect changes associated with infection, cell derangement, or tissue injury. Physical T cell-APC contact sets up an axis for polarization of TCR, adhesion molecules, kinases, cytoskeletal elements, and organelles inherent in this mode of juxtacrine signaling. The discovery of further lateral organization of the TCR and adhesion molecules into radially symmetric compartments, the immunological synapse, revealed an Intersecting Plane of symmetry and potential for regulated symmetry breaking to control duration of T cell-APC interactions. In addition to organizing signaling machinery, the immunological synapse directs the polarized transport and secretion of cytokines and cytolytic agents across the synaptic cleft and is a site for the generation and exocytic release of bioactive microvesicles that can functionally affect recipient APC and other cells in the environment. This machinery is coopted by retroviruses, and human immune deficiency virus-1 may even use antigen-specific synapses for infection of healthy T cells. Here, we discuss recent advances in the molecular and cell biological mechanisms of immunological synapse assembly and signaling and its role in intercellular communication across the synaptic cleft. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 32 is October 06, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates
