The Experts below are selected from a list of 183 Experts worldwide ranked by ideXlab platform

Todd P. Margolis - One of the best experts on this subject based on the ideXlab platform.

  • a shining example of Interstitial Keratitis
    American Journal of Ophthalmology Case Reports, 2021
    Co-Authors: Michael A. Ullman, Christine E. Martinez, Todd P. Margolis
    Abstract:

    Abstract We present a case of Interstitial Keratitis, presumed to be herpetic, with a striking clinical appearance. A 67-year-old woman was initially diagnosed with viral conjunctivitis and ocular hypertension OD with conjunctival injection and elevated intraocular pressure (IOP). She later presented with a ‘spot on my right eye’ and, after referral, was diagnosed with presumed herpetic Keratitis. She was treated with oral valacyclovir and topical prednisolone acetate. The cornea improved, leaving radiating lines in the corneal stroma. This case illustrates an unusual appearance of presumed herpetic stromal Keratitis.

  • A “shining” example of Interstitial Keratitis
    American journal of ophthalmology case reports, 2020
    Co-Authors: Michael A. Ullman, Christine E. Martinez, Todd P. Margolis
    Abstract:

    Abstract We present a case of Interstitial Keratitis, presumed to be herpetic, with a striking clinical appearance. A 67-year-old woman was initially diagnosed with viral conjunctivitis and ocular hypertension OD with conjunctival injection and elevated intraocular pressure (IOP). She later presented with a ‘spot on my right eye’ and, after referral, was diagnosed with presumed herpetic Keratitis. She was treated with oral valacyclovir and topical prednisolone acetate. The cornea improved, leaving radiating lines in the corneal stroma. This case illustrates an unusual appearance of presumed herpetic stromal Keratitis.

  • Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease.
    Cornea, 2018
    Co-Authors: Asim V. Farooq, Grace L. Paley, Anthony J. Lubniewski, John A. Gonzales, Todd P. Margolis
    Abstract:

    To describe a case series of patients with unilateral, posterior Interstitial Keratitis presumed to be caused by herpes simplex virus.Retrospective case series.Five patients were found to have unilateral, posterior Interstitial Keratitis. Three of the involved eyes had decreased corneal sensation, and 2 eyes had corneal stromal neovascularization. All patients were treated with topical steroids and an oral antiviral, and among those with long-term follow-up, clinical improvement required treatment over an extended duration. A review of the literature revealed 1 reported case with a similar clinical appearance, although that case was attributed to Lyme disease.The clinical presentation of unilateral, posterior Interstitial Keratitis may be a rare manifestation of herpes simplex virus Keratitis.

George D Kymionis - One of the best experts on this subject based on the ideXlab platform.

  • characteristics of linear Interstitial Keratitis by in vivo confocal microscopy and anterior segment optical coherence tomography
    Cornea, 2018
    Co-Authors: Aleksandra Petrovic, Kattayoon Hashemi, Frank Blaser, Wolfgang Wild, George D Kymionis
    Abstract:

    PURPOSE To describe the findings of in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in a case of linear Interstitial Keratitis (IK), a very rare entity of unknown etiology. METHODS IVCM and AS-OCT were used in the case of the a 23-year-old patient with recurrent unilateral linear IK. RESULTS On AS-OCT, inflammation appeared confined to the anterior part of the stroma. Similar to color photography, inflammation appeared beaded. On IVCM, there was microcystic epithelial edema, dense fibrosis of the anterior stroma, highly reflective spiculated structures, and disorganization of the stromal architecture. CONCLUSIONS Although linear IK appeared as localized anterior stromal inflammation on AS-OCT, panstromal inflammation was revealed by IVCM.

Daniel W Steen - One of the best experts on this subject based on the ideXlab platform.

  • Interstitial Keratitis secondary to severe hidradenitis suppurativa: a case report and literature review.
    Cornea, 2010
    Co-Authors: Ana G. Alzaga Fernandez, Hakan Demirci, Deborah Darnley-fisch, Daniel W Steen
    Abstract:

    Purpose To report a patient who presented with bilateral Interstitial Keratitis in association with severe hidradenitis suppurativa. Methods Case report. Results An 18-year-old African American woman with severe active hidradenitis suppurativa of the axillae and groin presented with a 2-week history of bilateral blurry vision. On examination, best-corrected visual acuity was counting fingers in the right eye and 20/70 in the left eye. Slit-lamp examination revealed diffuse vascularization of the corneal stroma with surrounding infiltrates bilaterally. In the left eye, corneal thinning and an epithelial defect were present in an area of infiltrate. Our clinical impression at that time was bilateral Interstitial Keratitis with secondary bacterial Keratitis in the left eye. Topical therapy, prednisolone acetate 1% in the right eye, and ofloxacin in the left eye, was instituted. A systemic workup, including antinuclear antibody, rheumatoid factor, Lyme titer, cytoplasmatic staining antineutrophil cytoplasmic antibodies, perinuclear staining antineutrophil cytoplasmic antibodies, erythrocyte sedimentation rate, Venereal Disease Research Laboratory, rapid plasma reagin, basic metabolic panel, angiotensin-converting enzyme level, and a chest x-ray was negative. Topical steroids were used in the left eye after resolution of the bacterial Keratitis. The Interstitial Keratitis responded to topical steroids and remained in remission after steroid taper. However, bilateral Interstitial Keratitis recurred coincident with a severe flare of hidradenitis suppurativa within 1 month of discontinuing the topical steroids. A course of subcutaneous adalimumab injections (40 mg/mL every 2 weeks) for hidradenitis suppurativa was implemented. Both her dermatological and ocular conditions responded to this therapy and have remained in remission through 7 months of follow-up. Conclusions Hidradenitis suppurativa is a rare cause of bilateral Interstitial Keratitis. Patients may experience simultaneous exacerbations of both dermatological and ocular manifestations. Systemic treatment with adalimumab can improve both dermatological and ocular conditions.

A Kinder - One of the best experts on this subject based on the ideXlab platform.

  • A rare association of not so rare symptoms
    Archives of Disease in Childhood, 2012
    Co-Authors: Vm Shivamurthy, Arani Sridhar, P Houtman, A Kinder
    Abstract:

    A 13 year old boy presented to us with history of vomiting, dizziness, red eyes and lethargy. Within the next few days he was found to have unilateral sensori neural deafness. He was also found to have anterior uveitis which as the disease progressed turned out to be Interstitial Keratitis. He was extensively investigated for infectious, inflammatory, rheumatological and autoimmune diseases, but all came back as negative. He was started on steroids after discussion with a tertiary rheumatology centre, to which he responded well. He was steroid dependant, so was commenced on methotrexate. His deafness completely resolved and his vision was better whilst on methotrexate. He was diagnosed to have Cogan syndrome based on the association of audio vestibular symptoms and Interstitial Keratitis and after excluding other conditions. Cogan syndrome is a rare disorder characterised by association of audio vestibular and ocular symptoms particularly Interstitial Keratitis. There is no diagnostic test as a result of which the diagnosis may be delayed. The disease may also be associated with non-specific systemic symptoms. The ocular symptoms typically may present as Interstitial Keratitis but in some cases it may present as uveitis or iritis and eventually progress to Interstitial Keratitis. Steroids and methotrexate are used in the treatment of the disease. If the condition is not diagnosed early and treated promptly it can cause permanent damage such as hearing loss and vision loss. Key message: Cogan syndrome is characterised by audio vestibular and ocular symptoms. One has to think of Cogan syndrome as a possibility when there is such an association. As there is no diagnostic test, there may be delay in diagnosing the disease. But early detection and treatment may prevent the permanent damage such as hearing loss or loss of vision.

Sabia H - One of the best experts on this subject based on the ideXlab platform.

  • Subconjunctival Bevacizumab Injection for Corneal Neovascularization in Interstitial Keratitis
    Journal of Clinical & Experimental Ophthalmology, 2019
    Co-Authors: Anchal Thakur, Amit Gupta, Sabia H
    Abstract:

    We describe the use of subconjunctival Bevacizuamb as an adjunct in the treatment of viral Interstitial Keratitis in a 17-year-old boy. He presented with a 3 months history of gradually progressive diminution of vision. The presenting visual acuity was 20/120 in the right eye and counting fingers close to face in the left eye. Examination revealed bilateral disc shaped stromal edema with leash of blood vessels entering the superior quadrant of the cornea. Subconjunctival injection of 0.1 mL (2.5 mg) of commercially available Bevacizumab (100 mg/4 mL; Avastin) was given under topical anesthesia along with initiation of topical steroids in the form of Betamethasone 0.1%. After 2 weeks of injection there was a remarkable reduction in corneal edema as documented by AS-OCT with improvement in visual acuity. We report here our experience with subconjunctival injection of bevacizumab for corneal vascularization in a patient with Interstitial viral Keratitis.