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Charles A. Mistretta - One of the best experts on this subject based on the ideXlab platform.
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The value of T2 relaxation times to characterize lumbar Intervertebral Disks: preliminary results.
AJNR. American journal of neuroradiology, 2006Co-Authors: J. Perry, Victor M. Haughton, Paul A. Anderson, Jason P. Fine, Charles A. MistrettaAbstract:BACKGROUND AND PURPOSE : The present standard for staging Intervertebral Disk Degeneration is a discrete scale, consisting usually of 5 stages. The purpose of this pilot study was to investigate the use of T2 measurements as a continuous measure of Intervertebral Disk Degeneration. METHODS : We obtained images in 5 volunteers with a 3D fast spin-echo sequence modified for the purpose of calculating T2 relaxation times from multiple echoes in the echo train. Disks were classified on the basis of conventional criteria into one of the 5 stages of Disk Degeneration. Average T2 values were calculated for stage II, III, and V Disks, which were identified in the volunteers. Differences between the Disk levels were analyzed with analysis of variance and differences between stages tested with a Student t test with significance set at the 0.01 level. RESULTS : In the 5 volunteers, 20 stage II, 4 stage III, and a single stage V Disk were found. Contour plots showed the highest T2 values in the nucleus pulposus near the vertebral endplates and lower T2 values in the intranuclear cleft region and peripheral annulus fibrosus. Average T2 values were significantly lower in the type III and V Disks than in the normal Disks. CONCLUSIONS : The study suggests that Intervertebral Disks can be characterized and classified accurately by means of T2 values. More studies are warranted to determine the range of T2 values for normal Disks.
Zeng-huan Zhou - One of the best experts on this subject based on the ideXlab platform.
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A cross-sectional study: serum CCL3/MIP-1α levels may reflect lumbar Intervertebral Disk Degeneration in Han Chinese people.
Journal of pain research, 2018Co-Authors: Yi-li Zhang, Zeng-huan ZhouAbstract:Background The macrophage inflammatory protein-1α (MIP-1α), also named chemokine cytokine ligand 3 (CCL3), has been detected in nucleus pulposus and increased following cytokine stimulation. Objective The current study was performed to explore the relationship between serum CCL3/MIP-1α levels with lumbar Intervertebral Disk Degeneration (IDD). Patients and methods A total of 132 Disk Degeneration patients confirmed by magnetic resonance imaging and 126 healthy controls were enrolled in the current study. Radiological evaluation of the IDD was conducted using a 3.0-T magnetic resonance imaging scanner for entire lumbar vertebra region. Degeneration of Intervertebral Disk was assessed by Schneiderman criteria. Serum CCL3/MIP-1α levels were investigated using a sandwich enzyme-linked immunosorbent assay. The Visual Analog Scale scores and Oswestry Disability Index index were recorded for clinical severity. Results Elevated concentrations of CCL3 in serum were found in IDD patients compared with asymptomatic volunteers. The case group included 49 IDD patients with grade 1, 42 with grade 2, and 41 with grade 3. Grade 3 and 2 had significantly higher CCL3 concentrations in serum compared with those with grade 1. The serum CCL3 levels were positively related to the degree of Disk Degeneration. In addition, the serum CCL3 levels also demonstrated a significant correlation with the clinical severity determined by Visual Analog Scale scores and Oswestry Disability Index index. Conclusion Serum CCL3 may serve as a biomarker of IDD.
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a cross sectional study serum ccl3 mip 1α levels may reflect lumbar Intervertebral Disk Degeneration in han chinese people
Journal of Pain Research, 2018Co-Authors: Yi-li Zhang, Bei Li, Zeng-huan ZhouAbstract:Background: The macrophage inflammatory protein-1α (MIP-1α), also named chemokine cytokine ligand 3 (CCL3), has been detected in nucleus pulposus and increased following cytokine stimulation. Objective: The current study was performed to explore the relationship between serum CCL3/MIP-1α levels with lumbar Intervertebral Disk Degeneration (IDD). Patients and methods: A total of 132 Disk Degeneration patients confirmed by magnetic resonance imaging and 126 healthy controls were enrolled in the current study. Radiological evaluation of the IDD was conducted using a 3.0-T magnetic resonance imaging scanner for entire lumbar vertebra region. Degeneration of Intervertebral Disk was assessed by Schneiderman criteria. Serum CCL3/MIP-1α levels were investigated using a sandwich enzyme-linked immunosorbent assay. The Visual Analog Scale scores and Oswestry Disability Index index were recorded for clinical severity. Results: Elevated concentrations of CCL3 in serum were found in IDD patients compared with asymptomatic volunteers. The case group included 49 IDD patients with grade 1, 42 with grade 2, and 41 with grade 3. Grade 3 and 2 had significantly higher CCL3 concentrations in serum compared with those with grade 1. The serum CCL3 levels were positively related to the degree of Disk Degeneration. In addition, the serum CCL3 levels also demonstrated a significant correlation with the clinical severity determined by Visual Analog Scale scores and Oswestry Disability Index index. Conclusion: Serum CCL3 may serve as a biomarker of IDD.
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A cross-sectional study: serum CCL3/MIP-1α levels may reflect lumbar Intervertebral Disk Degeneration in Han Chinese people
Journal of Pain Research, 2018Co-Authors: Yi-li Zhang, Zeng-huan ZhouAbstract:Yi-Li Zhang,1,2,* Bei Li,1,2,* Zeng-Huan Zhou1 1School of Public Health, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 2School of Health Services Management, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China *These authors contributed equally to this work Background: The macrophage inflammatory protein-1α (MIP-1α), also named chemokine cytokine ligand 3 (CCL3), has been detected in nucleus pulposus and increased following cytokine stimulation. Objective: The current study was performed to explore the relationship between serum CCL3/MIP-1α levels with lumbar Intervertebral Disk Degeneration (IDD). Patients and methods: A total of 132 Disk Degeneration patients confirmed by magnetic resonance imaging and 126 healthy controls were enrolled in the current study. Radiological evaluation of the IDD was conducted using a 3.0-T magnetic resonance imaging scanner for entire lumbar vertebra region. Degeneration of Intervertebral Disk was assessed by Schneiderman criteria. Serum CCL3/MIP-1α levels were investigated using a sandwich enzyme-linked immunosorbent assay. The Visual Analog Scale scores and Oswestry Disability Index index were recorded for clinical severity. Results: Elevated concentrations of CCL3 in serum were found in IDD patients compared with asymptomatic volunteers. The case group included 49 IDD patients with grade 1, 42 with grade 2, and 41 with grade 3. Grade 3 and 2 had significantly higher CCL3 concentrations in serum compared with those with grade 1. The serum CCL3 levels were positively related to the degree of Disk Degeneration. In addition, the serum CCL3 levels also demonstrated a significant correlation with the clinical severity determined by Visual Analog Scale scores and Oswestry Disability Index index. Conclusion: Serum CCL3 may serve as a biomarker of IDD. Keywords: chemokine cytokine ligand 3, Intervertebral Disk Degeneration, cross-sectional stud
J. Perry - One of the best experts on this subject based on the ideXlab platform.
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ORIGINAL RESEARCH The Value of T2 Relaxation Times to Characterize Lumbar Intervertebral Disks: Preliminary Results
2015Co-Authors: J. Perry, V. Haughton, J. Fine, C. MistrettaAbstract:BACKGROUND AND PURPOSE: The present standard for staging Intervertebral Disk Degeneration is a discrete scale, consisting usually of 5 stages. The purpose of this pilot study was to investigate the use of T2 measurements as a continuous measure of Intervertebral Disk Degeneration. METHODS: We obtained images in 5 volunteers with a 3D fast spin-echo sequence modified for the purpose of calculating T2 relaxation times from multiple echoes in the echo train. Disks were classified on the basis of conventional criteria into one of the 5 stages of Disk Degeneration. Average T2 values were calculated for stage II, III, and V Disks, which were identified in the volunteers. Differences between the Disk levels were analyzed with analysis of variance and differences between stages tested with a Student t test with significance set at the 0.01 level. RESULTS: In the 5 volunteers, 20 stage II, 4 stage III, and a single stage V Disk were found. Contour plots showed the highest T2 values in the nucleus pulposus near the vertebral endplates and lower T2 values in the intranuclear cleft region and peripheral annulus fibrosus. Average T2 values were significantly lower in the type III and V Disks than in the normal Disks. CONCLUSIONS: The study suggests that Intervertebral Disks can be characterized and classified accurately by means of T2 values. More studies are warranted to determine the range of T2 values fo
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The value of T2 relaxation times to characterize lumbar Intervertebral Disks: preliminary results.
AJNR. American journal of neuroradiology, 2006Co-Authors: J. Perry, Victor M. Haughton, Paul A. Anderson, Jason P. Fine, Charles A. MistrettaAbstract:BACKGROUND AND PURPOSE : The present standard for staging Intervertebral Disk Degeneration is a discrete scale, consisting usually of 5 stages. The purpose of this pilot study was to investigate the use of T2 measurements as a continuous measure of Intervertebral Disk Degeneration. METHODS : We obtained images in 5 volunteers with a 3D fast spin-echo sequence modified for the purpose of calculating T2 relaxation times from multiple echoes in the echo train. Disks were classified on the basis of conventional criteria into one of the 5 stages of Disk Degeneration. Average T2 values were calculated for stage II, III, and V Disks, which were identified in the volunteers. Differences between the Disk levels were analyzed with analysis of variance and differences between stages tested with a Student t test with significance set at the 0.01 level. RESULTS : In the 5 volunteers, 20 stage II, 4 stage III, and a single stage V Disk were found. Contour plots showed the highest T2 values in the nucleus pulposus near the vertebral endplates and lower T2 values in the intranuclear cleft region and peripheral annulus fibrosus. Average T2 values were significantly lower in the type III and V Disks than in the normal Disks. CONCLUSIONS : The study suggests that Intervertebral Disks can be characterized and classified accurately by means of T2 values. More studies are warranted to determine the range of T2 values for normal Disks.
Suzanne E. Anderson - One of the best experts on this subject based on the ideXlab platform.
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Classification of Intervertebral Disk Degeneration with axial T2 mapping.
American Journal of Roentgenology, 2007Co-Authors: Atsuya Watanabe, Lorin Michael Benneker, Chris Boesch, Tomoko Watanabe, Takayuki Obata, Suzanne E. AndersonAbstract:OBJECTIVE. The aim of this study was to establish an MRI classification system for Intervertebral Disks using axial T2 mapping, with a special focus on evaluating early degenerative Intervertebral Disks.MATERIALS AND METHODS. Twenty-nine healthy volunteers (19 men, 10 women; age range, 20–44 years; mean age, 31.8 years) were studied, and axial T2 mapping was performed for the L3–L4, L4–L5, and L5–S1 Intervertebral Disks. Grading was performed using three classification systems for degenerative Disks: our system using axial T2 mapping and two other conventional classification systems that focused on the signal intensity of the nucleus pulposus or the structural morphology in sagittal T2-weighted MR images. We analyzed the relationship between T2, which is known to correlate with change in composition of Intervertebral Disks, and degenerative grade determined using the three classification systems.RESULTS. With axial T2 mapping, differences in T2 between grades I and II were smaller and those between grades...
James D Kang - One of the best experts on this subject based on the ideXlab platform.
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gene therapy for Intervertebral Disk Degeneration
Orthopedic Clinics of North America, 2011Co-Authors: Barrett I Woods, Gwendolyn Sowa, James D KangAbstract:Intervertebral Disk Degeneration is a common and potentially debilitating disease process affecting millions of Americans and other populations each year. Current treatments address resultant symptoms and not the underlying pathophysiology of disease. This has spawned the development of biologic treatments, such as gene therapy, which attempt to correct the imbalance between catabolism and anabolism within degenerating Disk cells. The identification of therapeutic genes and development of successful delivery systems have resulted in significant advances in this novel treatment. Continued investigation of the pathophysiology of Disk Degeneration, however, and safety mechanisms for the application of gene therapy are required for clinical translation.
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Identification of candidate serum biomarkers for Intervertebral Disk Degeneration in an animal model.
PM & R : the journal of injury function and rehabilitation, 2009Co-Authors: Gwendolyn Sowa, Barrett I Woods, Ed Westrick, Arun G. Rajasekhar, Steven Leckie, Paulo Coelho, Rebecca K. Studer, James D KangAbstract:Objective To examine serum markers of matrix turnover in an animal model of Disk Degeneration. Design Randomized prospective in vivo study. Setting Laboratory for Orthopaedic and Spine Research and Department of Large Animal Research. Participants Twenty-one New Zealand White rabbits. Intervention Rabbits were randomly grouped into control (n = 8), sham surgery (n = 5), or stab surgery (n = 8). The stab surgical group underwent annulotomy of L2-3, L3-4, and L4-5 to induce Intervertebral Disk Degeneration. The sham surgical group underwent surgical exposure without annulotomy, and the control group received no intervention. Outcome Measurements Lumbar spine magnetic resonance imaging (MRI) and serum samples were obtained before intervention and at 0, 3, 6, and 12 weeks thereafter. MRIs were analyzed for evidence of Intervertebral Disk Degeneration via measurement of MRI index. The serum was assayed at 0, 3, 6, and 12 weeks for the aggrecan biosynthesis marker CS846 and the C-telopeptide of collagen II (CTX-II). Results The stabbed Disks demonstrate Degeneration apparent by MRI criteria. CTX-II increased with time in the stabbed group compared to the control and sham surgery groups regardless of baseline levels. Aggrecan showed no statistically significant difference among groups. Conclusions CTX-II shows promise as a useful serum biomarker for Intervertebral Disk Degeneration.
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Gene therapy for the treatment of degenerative Disk disease.
The Journal of the American Academy of Orthopaedic Surgeons, 2008Co-Authors: Mark G. Hubert, Gwendolyn Sowa, Rebecca K. Studer, Gianluca Vadalà, James D KangAbstract:Recent biologic and biochemical advances have furthered our understanding of the complex environment of the Intervertebral Disk. This new understanding has allowed researchers to pursue novel treatments of Intervertebral Disk Degeneration, targeting the biochemical pathways involved in the degenerative cascade. Gene therapy has shown much promise in this regard. Many new targets for gene therapy in the Intervertebral Disk have been identified, such as TGF-beta1, TIMP-1, and LMP-1. In addition, new vectors, such as the adeno-associated virus, are being investigated for use in Intervertebral Disk applications. Cell-based therapy has also shown significant promise in the biologic treatment of Intervertebral Disk Degeneration. With continued efforts, gene therapy may prove to be an extremely powerful tool in the treatment of Intervertebral Disk Degeneration.
