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Jaakko Kaprio - One of the best experts on this subject based on the ideXlab platform.
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leisure time physical activity and intra abdominal Fat in young adulthood a monozygotic co twin control study
Obesity, 2016Co-Authors: Mirva Rottensteiner, Tuija Leskinen, Karoliina Vaisanen, Sari Aaltonen, Elina Jarvelareijonen, Jaakko Kaprio, Urho M KujalaAbstract:Objective To investigate differences in abdominal Fat compartments between young adult monozygotic twin pairs discordant for leisure-time physical activity. Methods Ten young adult male monozygotic twin pairs (age range 32-36 years) discordant for leisure-time physical activity during the past 3 years were systematically selected from a population-based Finnish twin cohort. Magnetic resonance image at the level of the L2-L3 intervertebral disc was used to predict Intra-Abdominal and subcutaneous abdominal Fat masses. Dietary intake was assessed with a 4-day food diary. Results Inactive twins had 31% more Intra-Abdominal Fat than their active co-twins (mean difference 0.52 kg, 95% CI 0.12 to 0.91, P = 0.016), whereas the difference in subcutaneous abdominal Fat was only 13% (P = 0.21) and 3% in body mass index (P = 0.28). Intraperitoneal Fat mass was 41% higher among inactive twins compared to their active co-twins (mean difference 0.41 kg, 95% CI 0.11 to 0.70, P = 0.012). Dietary intake did not differ between co-twins. Conclusions A lower level of physical activity is related to greater accumulation of Intra-Abdominal Fat among healthy adult males in their mid-30s. The findings highlight the importance of leisure-time physical activity independent of genes and diet in the prevention of Intra-Abdominal Fat accumulation from early adulthood onward.
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acquired obesity is associated with increased liver Fat intra abdominal Fat and insulin resistance in young adult monozygotic twins
American Journal of Physiology-endocrinology and Metabolism, 2005Co-Authors: Kirsi H Pietilainen, Jaakko Kaprio, Aila Rissanen, Sari Makimattila, Annamaija Hakkinen, Jukka Westerbacka, Jussi Sutinen, Satu Vehkavaara, Hannele YkijarvinenAbstract:We determined whether acquired obesity is associated with increases in liver or Intra-Abdominal Fat or impaired insulin sensitivity by studying monozygotic (MZ) twin pairs discordant and concordant...
Steven E Kahn - One of the best experts on this subject based on the ideXlab platform.
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2057-P: HDL-Cholesterol Concentration Independently Predicts Future Accumulation of Intra-Abdominal Fat in Japanese Americans
Diabetes, 2019Co-Authors: Sun Ok Song, Donna L Leonetti, Steven E Kahn, Wilfred Y. Fujimoto, You-cheol Hwang, Edward J. BoykoAbstract:Background: Both Intra-Abdominal Fat (IAF) and HDL cholesterol (HDL-C) are known to be associated with cardiometabolic health problems, with an inverse correlation between them. However, there is little information about the association between HDL-C concentration with future accumulation of IAF. We conducted a prospective study to evaluate whether baseline HDL-C concentration was associated with the accumulation of CT-measured Intra-Abdominal Fat (IAF) over 5 years. Methods: All participants were Japanese-American men and women between the ages of 34 to 74 years. HDL-C concentration and CT-measurements of IAF, abdominal (SCF) and thigh (TF) subcutaneous Fat cross-sectional areas were evaluated at baseline and 5 year follow-up visits. Data were analyzed to determine the association between HDL-C and future 5-year accumulation of IAF. Results: A total of 545 subjects with and without diabetes (296 men, 249 women, and mean age 53.6±11.4 and 54.0±12.0 years, respectively) were included. The mean (SD) HDL-C concentration was 1.3 mmol/L (0.4) in men and 1.7 mmol/L (0.4) in women and mean (SD) IAF was 102 cm 2 (53.8) in men and 74.5 cm 2 (46.8) in women. Baseline HDL-C concentration was inversely associated with Δ IAF over 5 years using multivariable regression analysis adjusting for age, sex, diabetes family history, weight change over 5 years, and baseline measurements of BMI, IAF, abdominal SCF, abdominal circumference, TF, and HOMA-IR. Conclusions: These results demonstrate that HDL-C concentration predicts significantly future accumulation of IAF over 5 years independent of age, sex, insulin sensitivity, and body composition in nondiabetic Japanese-American men and women. Disclosure S. Song: None. Y. Hwang: None. S.E. Kahn: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Intarcia Therapeutics, Inc., Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S. Consultant; Self; Neurimmune. Other Relationship; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S. D.L. Leonetti: None. W.Y. Fujimoto: None. E.J. Boyko: None. Funding National Institutes of Health DK31170, HL49293); University of Washington (DK017047, DK035816, RR-000037); VA Puget Sound Health Care System (to E.J.B., S.E.K.)
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Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans
Hypertension, 2015Co-Authors: Catherine A. Sullivan, Donna L Leonetti, Tomoshige Hayashi, Steven E Kahn, Wilfred Y. Fujimoto, Edward J. BoykoAbstract:In Japanese Americans, Intra-Abdominal Fat area measured by computed tomography is positively associated with the prevalence and incidence of hypertension. Evidence in other populations suggests that other Fat areas may be protective. We sought to determine whether a change in specific Fat depots predicts the development of hypertension. We prospectively followed up 286 subjects (mean age, 49.5 years; 50.4% men) from the Japanese American Community Diabetes Study for 10 years. At baseline, subjects did not have hypertension (defined as blood pressure ≥140/90 mm Hg) and were not taking blood pressure or glucose-lowering medications. Mid-thigh subcutaneous Fat area, abdominal subcutaneous Fat area, and Intra-Abdominal Fat area were directly measured by computed tomography at baseline and 5 years. Logistic regression was used to estimate odds of incident hypertension over 10 years in relation to a 5-year change in Fat area. The relative odds of developing hypertension for a 5-year increase in Intra-Abdominal Fat was 1.74 (95% confidence interval, 1.28–2.37), after adjusting for age, sex, body mass index, baseline Intra-Abdominal Fat, alcohol use, smoking status, and weekly exercise energy expenditure. This relationship remained significant when adjusted for baseline fasting insulin and 2-hour glucose levels or for diabetes mellitus and pre–diabetes mellitus classification. There were no significant associations between baseline and change in thigh or abdominal subcutaneous Fat areas and incident hypertension. In conclusion, in this cohort of Japanese Americans, the risk of developing hypertension is related to the accumulation of Intra-Abdominal Fat rather than the accrual of subcutaneous Fat in either the thigh or the abdominal areas.
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Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans
Hypertension, 2015Co-Authors: Catherine A. Sullivan, Donna L Leonetti, Tomoshige Hayashi, Steven E Kahn, Wilfred Y. Fujimoto, Edward J. BoykoAbstract:In Japanese Americans, Intra-Abdominal Fat area measured by computed tomography is positively associated with the prevalence and incidence of hypertension. Evidence in other populations suggests that other Fat areas may be protective. We sought to determine whether a change in specific Fat depots predicts the development of hypertension. We prospectively followed up 286 subjects (mean age, 49.5 years; 50.4% men) from the Japanese American Community Diabetes Study for 10 years. At baseline, subjects did not have hypertension (defined as blood pressure ≥140/90 mm Hg) and were not taking blood pressure or glucose-lowering medications. Mid-thigh subcutaneous Fat area, abdominal subcutaneous Fat area, and Intra-Abdominal Fat area were directly measured by computed tomography at baseline and 5 years. Logistic regression was used to estimate odds of incident hypertension over 10 years in relation to a 5-year change in Fat area. The relative odds of developing hypertension for a 5-year increase in Intra-Abdominal Fat was 1.74 (95% confidence interval, 1.28–2.37), after adjusting for age, sex, body mass index, baseline Intra-Abdominal Fat, alcohol use, smoking status, and weekly exercise energy expenditure. This relationship remained significant when adjusted for baseline fasting insulin and 2-hour glucose levels or for diabetes mellitus and pre–diabetes mellitus classification. There were no significant associations between baseline and change in thigh or abdominal subcutaneous Fat areas and incident hypertension. In conclusion, in this cohort of Japanese Americans, the risk of developing hypertension is related to the accumulation of Intra-Abdominal Fat rather than the accrual of subcutaneous Fat in either the thigh or the abdominal areas.
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Intra-Abdominal Fat accumulation is greatest at younger ages in Japanese-American adults §
Diabetes Research and Clinical Practice, 2010Co-Authors: Wilfred Y. Fujimoto, Donna L Leonetti, Steven E Kahn, Marguerite J Mcneely, John D. Brunzell, Edward J. BoykoAbstract:Aims We evaluated whether changes over 10–11 years in weight, subcutaneous abdominal Fat (SQAF), and Intra-Abdominal Fat (IAF) differ by age and contrasted age-related adiposity changes by gender.
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Intra-Abdominal Fat accumulation is greatest at younger ages in Japanese-American adults.
Diabetes Research and Clinical Practice, 2010Co-Authors: Christine G. Lee, Donna L Leonetti, Steven E Kahn, Marguerite J Mcneely, Wilfred Y. Fujimoto, John D. Brunzell, Edward J. BoykoAbstract:Aims We evaluated whether changes over 10–11 years in weight, subcutaneous abdominal Fat (SQAF), and Intra-Abdominal Fat (IAF) differ by age and contrasted age-related adiposity changes by gender.
Edward J. Boyko - One of the best experts on this subject based on the ideXlab platform.
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2057-P: HDL-Cholesterol Concentration Independently Predicts Future Accumulation of Intra-Abdominal Fat in Japanese Americans
Diabetes, 2019Co-Authors: Sun Ok Song, Donna L Leonetti, Steven E Kahn, Wilfred Y. Fujimoto, You-cheol Hwang, Edward J. BoykoAbstract:Background: Both Intra-Abdominal Fat (IAF) and HDL cholesterol (HDL-C) are known to be associated with cardiometabolic health problems, with an inverse correlation between them. However, there is little information about the association between HDL-C concentration with future accumulation of IAF. We conducted a prospective study to evaluate whether baseline HDL-C concentration was associated with the accumulation of CT-measured Intra-Abdominal Fat (IAF) over 5 years. Methods: All participants were Japanese-American men and women between the ages of 34 to 74 years. HDL-C concentration and CT-measurements of IAF, abdominal (SCF) and thigh (TF) subcutaneous Fat cross-sectional areas were evaluated at baseline and 5 year follow-up visits. Data were analyzed to determine the association between HDL-C and future 5-year accumulation of IAF. Results: A total of 545 subjects with and without diabetes (296 men, 249 women, and mean age 53.6±11.4 and 54.0±12.0 years, respectively) were included. The mean (SD) HDL-C concentration was 1.3 mmol/L (0.4) in men and 1.7 mmol/L (0.4) in women and mean (SD) IAF was 102 cm 2 (53.8) in men and 74.5 cm 2 (46.8) in women. Baseline HDL-C concentration was inversely associated with Δ IAF over 5 years using multivariable regression analysis adjusting for age, sex, diabetes family history, weight change over 5 years, and baseline measurements of BMI, IAF, abdominal SCF, abdominal circumference, TF, and HOMA-IR. Conclusions: These results demonstrate that HDL-C concentration predicts significantly future accumulation of IAF over 5 years independent of age, sex, insulin sensitivity, and body composition in nondiabetic Japanese-American men and women. Disclosure S. Song: None. Y. Hwang: None. S.E. Kahn: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Intarcia Therapeutics, Inc., Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S. Consultant; Self; Neurimmune. Other Relationship; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk A/S. D.L. Leonetti: None. W.Y. Fujimoto: None. E.J. Boyko: None. Funding National Institutes of Health DK31170, HL49293); University of Washington (DK017047, DK035816, RR-000037); VA Puget Sound Health Care System (to E.J.B., S.E.K.)
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Baseline estradiol concentration in community-dwelling Japanese American men is not associated with Intra-Abdominal Fat accumulation over 10 years.
Obesity Research & Clinical Practice, 2016Co-Authors: Beverly M. Kocarnik, Donna L Leonetti, Tomoshige Hayashi, Edward J. Boyko, Wilfred Y. Fujimoto, Alvin M. Matsumoto, Stephanie T. PageAbstract:Summary Problem The role of plasma estradiol in the accumulation of Intra-Abdominal Fat (IAF) in men is uncertain. Cross-sectional studies using imaging of IAF have shown either a positive or no association. In contrast, a randomised controlled trial using an aromatase inhibitor to suppress estradiol production found an association between oestrogen deficiency and short-term IAF accumulation. No longitudinal study has been conducted to examine the relationship between plasma estradiol concentration and the change in IAF area measured using direct imaging. Methods This is a longitudinal observational study in community-dwelling Japanese-American men ( n =215, mean age 52 years, BMI 25.4kg/m 2 ). IAF and subcutaneous Fat areas were assessed using computerized tomography (CT) at baseline, 5 and 10 years. Baseline plasma estradiol concentrations were measured using liquid chromatography-tandem mass spectrometry. Results Univariate analysis found no association between baseline estradiol concentration and baseline IAF, or 5- or 10-year changes in IAF area ( r =−0.05 for both time points, p =0.45 and p =0.43, respectively). Multivariate linear regression analysis of the change in IAF area by baseline estradiol concentration adjusted for age, baseline IAF area, and weight change found no association with either the 5- or 10-year IAF area change ( p =0.52 and p =0.55, respectively). Conclusions Plasma estradiol concentration was not associated with baseline IAF nor with change in IAF area over 5 or 10 years based on serial CT scans in community-dwelling Japanese-American men. These results do not support a role for oestrogen deficiency in IAF accumulation in men.
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Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans
Hypertension, 2015Co-Authors: Catherine A. Sullivan, Donna L Leonetti, Tomoshige Hayashi, Steven E Kahn, Wilfred Y. Fujimoto, Edward J. BoykoAbstract:In Japanese Americans, Intra-Abdominal Fat area measured by computed tomography is positively associated with the prevalence and incidence of hypertension. Evidence in other populations suggests that other Fat areas may be protective. We sought to determine whether a change in specific Fat depots predicts the development of hypertension. We prospectively followed up 286 subjects (mean age, 49.5 years; 50.4% men) from the Japanese American Community Diabetes Study for 10 years. At baseline, subjects did not have hypertension (defined as blood pressure ≥140/90 mm Hg) and were not taking blood pressure or glucose-lowering medications. Mid-thigh subcutaneous Fat area, abdominal subcutaneous Fat area, and Intra-Abdominal Fat area were directly measured by computed tomography at baseline and 5 years. Logistic regression was used to estimate odds of incident hypertension over 10 years in relation to a 5-year change in Fat area. The relative odds of developing hypertension for a 5-year increase in Intra-Abdominal Fat was 1.74 (95% confidence interval, 1.28–2.37), after adjusting for age, sex, body mass index, baseline Intra-Abdominal Fat, alcohol use, smoking status, and weekly exercise energy expenditure. This relationship remained significant when adjusted for baseline fasting insulin and 2-hour glucose levels or for diabetes mellitus and pre–diabetes mellitus classification. There were no significant associations between baseline and change in thigh or abdominal subcutaneous Fat areas and incident hypertension. In conclusion, in this cohort of Japanese Americans, the risk of developing hypertension is related to the accumulation of Intra-Abdominal Fat rather than the accrual of subcutaneous Fat in either the thigh or the abdominal areas.
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Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans
Hypertension, 2015Co-Authors: Catherine A. Sullivan, Donna L Leonetti, Tomoshige Hayashi, Steven E Kahn, Wilfred Y. Fujimoto, Edward J. BoykoAbstract:In Japanese Americans, Intra-Abdominal Fat area measured by computed tomography is positively associated with the prevalence and incidence of hypertension. Evidence in other populations suggests that other Fat areas may be protective. We sought to determine whether a change in specific Fat depots predicts the development of hypertension. We prospectively followed up 286 subjects (mean age, 49.5 years; 50.4% men) from the Japanese American Community Diabetes Study for 10 years. At baseline, subjects did not have hypertension (defined as blood pressure ≥140/90 mm Hg) and were not taking blood pressure or glucose-lowering medications. Mid-thigh subcutaneous Fat area, abdominal subcutaneous Fat area, and Intra-Abdominal Fat area were directly measured by computed tomography at baseline and 5 years. Logistic regression was used to estimate odds of incident hypertension over 10 years in relation to a 5-year change in Fat area. The relative odds of developing hypertension for a 5-year increase in Intra-Abdominal Fat was 1.74 (95% confidence interval, 1.28–2.37), after adjusting for age, sex, body mass index, baseline Intra-Abdominal Fat, alcohol use, smoking status, and weekly exercise energy expenditure. This relationship remained significant when adjusted for baseline fasting insulin and 2-hour glucose levels or for diabetes mellitus and pre–diabetes mellitus classification. There were no significant associations between baseline and change in thigh or abdominal subcutaneous Fat areas and incident hypertension. In conclusion, in this cohort of Japanese Americans, the risk of developing hypertension is related to the accumulation of Intra-Abdominal Fat rather than the accrual of subcutaneous Fat in either the thigh or the abdominal areas.
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Intra-Abdominal Fat accumulation is greatest at younger ages in Japanese-American adults §
Diabetes Research and Clinical Practice, 2010Co-Authors: Wilfred Y. Fujimoto, Donna L Leonetti, Steven E Kahn, Marguerite J Mcneely, John D. Brunzell, Edward J. BoykoAbstract:Aims We evaluated whether changes over 10–11 years in weight, subcutaneous abdominal Fat (SQAF), and Intra-Abdominal Fat (IAF) differ by age and contrasted age-related adiposity changes by gender.
Urho M Kujala - One of the best experts on this subject based on the ideXlab platform.
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leisure time physical activity and intra abdominal Fat in young adulthood a monozygotic co twin control study
Obesity, 2016Co-Authors: Mirva Rottensteiner, Tuija Leskinen, Karoliina Vaisanen, Sari Aaltonen, Elina Jarvelareijonen, Jaakko Kaprio, Urho M KujalaAbstract:Objective To investigate differences in abdominal Fat compartments between young adult monozygotic twin pairs discordant for leisure-time physical activity. Methods Ten young adult male monozygotic twin pairs (age range 32-36 years) discordant for leisure-time physical activity during the past 3 years were systematically selected from a population-based Finnish twin cohort. Magnetic resonance image at the level of the L2-L3 intervertebral disc was used to predict Intra-Abdominal and subcutaneous abdominal Fat masses. Dietary intake was assessed with a 4-day food diary. Results Inactive twins had 31% more Intra-Abdominal Fat than their active co-twins (mean difference 0.52 kg, 95% CI 0.12 to 0.91, P = 0.016), whereas the difference in subcutaneous abdominal Fat was only 13% (P = 0.21) and 3% in body mass index (P = 0.28). Intraperitoneal Fat mass was 41% higher among inactive twins compared to their active co-twins (mean difference 0.41 kg, 95% CI 0.11 to 0.70, P = 0.012). Dietary intake did not differ between co-twins. Conclusions A lower level of physical activity is related to greater accumulation of Intra-Abdominal Fat among healthy adult males in their mid-30s. The findings highlight the importance of leisure-time physical activity independent of genes and diet in the prevention of Intra-Abdominal Fat accumulation from early adulthood onward.
Tuija Leskinen - One of the best experts on this subject based on the ideXlab platform.
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leisure time physical activity and intra abdominal Fat in young adulthood a monozygotic co twin control study
Obesity, 2016Co-Authors: Mirva Rottensteiner, Tuija Leskinen, Karoliina Vaisanen, Sari Aaltonen, Elina Jarvelareijonen, Jaakko Kaprio, Urho M KujalaAbstract:Objective To investigate differences in abdominal Fat compartments between young adult monozygotic twin pairs discordant for leisure-time physical activity. Methods Ten young adult male monozygotic twin pairs (age range 32-36 years) discordant for leisure-time physical activity during the past 3 years were systematically selected from a population-based Finnish twin cohort. Magnetic resonance image at the level of the L2-L3 intervertebral disc was used to predict Intra-Abdominal and subcutaneous abdominal Fat masses. Dietary intake was assessed with a 4-day food diary. Results Inactive twins had 31% more Intra-Abdominal Fat than their active co-twins (mean difference 0.52 kg, 95% CI 0.12 to 0.91, P = 0.016), whereas the difference in subcutaneous abdominal Fat was only 13% (P = 0.21) and 3% in body mass index (P = 0.28). Intraperitoneal Fat mass was 41% higher among inactive twins compared to their active co-twins (mean difference 0.41 kg, 95% CI 0.11 to 0.70, P = 0.012). Dietary intake did not differ between co-twins. Conclusions A lower level of physical activity is related to greater accumulation of Intra-Abdominal Fat among healthy adult males in their mid-30s. The findings highlight the importance of leisure-time physical activity independent of genes and diet in the prevention of Intra-Abdominal Fat accumulation from early adulthood onward.
